• Molecules and Cells
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• 제37권12호
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• pp.873-880
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• 2014

In our previous study, miRNA-183, a miRNA in the miR-96-182-183 cluster, was significantly over-expressed in esophageal squamous cell carcinoma (ESCC). In the present study, we explored the oncogenic roles of miR-183 in ESCC by gain and loss of function analysis in an esophageal cancer cell line (EC9706). Genome-wide mRNA micro-array was applied to determine the genes that were regulated directly or indirectly by miR-183. 3'UTR luciferase reporter assay, RT-PCR, and Western blot were conducted to verify the target gene of miR-183. Cell culture results showed that miR-183 inhibited apoptosis (p < 0.05), enhanced cell proliferation (p < 0.05), and accelerated G1/S transition (p < 0.05). Moreover, the inhibitory effect of miR-183 on apoptosis was rescued when miR-183 was suppressed via miR-183 inhibitor (p < 0.05). Western blot analysis showed that the expression of programmed cell death 4 (PDCD4), which was predicted as the target gene of miR-183 by microarray profiling and bioinformatics predictions, decreased when miR-183 was over-expressed. The 3'UTR luciferase reporter assay confirmed that miR-183 directly regulated PDCD4 by binding to sequences in the 3'UTR of PDCD4. Pearson correlation analysis further confirmed the significant negative correlation between miR-183 and PDCD4 in both cell lines and in ESCC patients. Our data suggest that miR-183 might play an oncogenic role in ESCC by regulating PDCD4 expression.

• 한국도서관정보학회지
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• 제52권2호
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• pp.107-126
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• 2021

4차산업혁명에 따라 새로운 교육 환경이 도래하는 상황 속에서 충청남도 교육청 소속 19개 공공도서관의 활성화를 위한 새로운 방향을 모색하기 위해 현황분석과 사서, 사서교사, 전문가 대상 포커스그룹인터뷰를 실시하였다. 연구방법을 통해 충청남도 교육청 소속 공공도서관의 비전으로 도서관 커뮤니티 스쿨을 통한 지식체험 에듀라이브러리를 설정하였다. 에듀라이브러리로서 공공도서관 서비스의 방향을 교육기능 특화 서비스, 생애주기 맞춤 서비스, 지식체험중심서비스, 4차산업혁명 지능정보사회 서비스로 나누어 살펴보았다. 도서관의 전통적 기능을 바탕으로 미래 공공도서관이 갖추어야 할 공간을 체험학습 공간으로 제시하였다. 본 연구에서 충남교육청 소속 도서관의 교육기능을 강화한 특화된 방향을 제시하였는데 이는 학교 및 학교도서관과 협력 방안 모색에 기여할 수 있을 것이며, 타 지역 교육청 소속 도서관의 방향성 마련에 기반을 제공할 수 있을 것이다.

• Safety and Health at Work
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• 제6권2호
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• pp.104-113
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• 2015

Background: Given the long hours on the road involving multiple and interacting work stressors (i.e., delivery pressures, irregular shifts, ergonomic hazards), commercial drivers face a plethora of health and safety risks. Researchers goal was to determine whether and to what extent long-haul trucker work schedules influence sleep duration and quality. Methods: Survey and biometric data collected from male long-haul truck drivers at a major truckstop in central North Carolina over a six month period. Results: Daily hours worked (mean = 11 hours, 55 minutes) and frequency of working over government-mandated daily HOS regulations (23.8% "frequently or always") were statistically significant predictors of sleep duration. Miles driven per week (mean = 2,812.61), irregular daily hours worked (63.8%), and frequency of working over the daily hour limit (23.8% "frequently or always") were statistically significant predictors of sleep quality. Conclusion: Implications of findings suggest a comprehensive review of the regulations and operational conditions for commercial motor vehicle drivers be undertaken.

• Journal of Preventive Medicine and Public Health
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• 제39권1호
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• pp.7-12
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• 2006

Throughout the century, based on the precedent set by Flexner in the United States, almost every subsequent report on the reform of medical education has pointed out the need for more prevention-oriented teaching in the curriculum. This has been particularly so in countries like Korea where the basic public health services have been so important for the improvement of health of the people. And, in fact, preventive medicine and public health have contributed a great deal to the prevention of communicable diseases and prolongation of life expectancy. Recently, however, along with the educational reform that emphasizing the interdisciplinary teaching, integration of basic science and clinical education, and centralization of responsibility for the medical education curriculum, concerns are being voiced by preventive medicine educators. These concerns are primarily centered around the fear that the implementation of interdisciplinary, centrally administered courses would result in a weakening of content and teaching expertise as well as a loss of departmental power and control. This paper foresees that preventive medicine and public health will be more important in Korea in the future and proposes that preventive medicine educators will have to step forward and turn the challenges of curricula restructuring into opportunities to expand the role of preventive medicine in the curricula of their institutions.

• 한국학교ㆍ지역보건교육학회지
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• 제20권1호
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• pp.85-95
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• 2019

Objectives: This study is to examine the influences of three sub-factors of resilience on academic burn out among a group of university students, with low resilience, majored in public health. Methods: The survey was made during January 1 to 13, 2017 and after checking the resilience scores of 166 respondents and the questionnaires of 115 respondents, whose scores were less than 195, an average score of Korea, were selected and analyzed using AMOS. Results: The average resilience and academic burn-out scores were 173 and 2.96, respectively. The goodness-of-fit of proposed model showed RMSEA=0.068, GFI=0.916, NFI=0.901, IFI=0.963, CFI=0.962 so, final measurement model was selected. The analysis of the suggested model showed that among three sub-factors of resilience, only self-control ability had a negative(-) effect on academic burnout and two others were shown to have no effects. Conclusion: By researching and introducing a education method that could enhance self-control ability, it would effectively reduce academic burnout in university students with low resilience and majored in public health.

• Child Health Nursing Research
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• 제11권2호
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• pp.221-228
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• 2005

Purpose: The purpose of this study was to determine the effect of an education program promoting safety knowledge and safety practice for mothers with infants. Method: This education was provided at two public health centers in Kyunggi Province. A non-equivalent control group pretest-post test design was used, and the participants were 95 mothers in the experimental group, and 44 mothers in the control group. Data were collected using a questionnaire, and were analyzed with the SPSS program. Results: After the group education sessions on safety management at the public health centers, the mean scores for knowledge and practice of safety in the experimental group were significantly higher than that of mothers in the control group mothers. Also, after the safety education, mothers in the experimental group perceived a higher priority in safety in child care than they had before the education program. Conclusion: The education for mothers with infants regarding the child safety was effective in promoting knowledge and practice of safety for infants.

• 한국환경교육학회지:환경교육
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• 제20권1호
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• pp.106-117
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• 2007

The purpose of this study was to evaluate the environmental education of public servants in National Institute of Environmental Human Resource Development(NIERD). Based on CIPP model, Evaluation areas and items were made. The data were collected through interviews, questionnaires and training and development team's internal information from November, 2005 to January, 2006. Based on the interviews and survey of 11 employee from training and development team, context factors, input factors, process factors, product factors were evaluated. The major findings of this study were as follows: First, the problem of the environmental education of environmental officials indicated lack of interest about education of Ministry of Environment, lack of education expense, lack of expertise of employee in training and development team, and so on. Second, the curriculum for environmental officials was not considered the environmental officials' readiness for education, developmental level and competency. Suggestions for future research were offered.

• 한국인터넷방송통신학회논문지
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• 제18권1호
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• pp.105-111
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• 2018

공교육의 STEAM과 S/W 교육은 융합 인재와 4차산업혁명 시대의 인재 양성에 효과적이며 이를 위한 전담교사의 확충과 다양한 학습자료의 발굴 및 적용, 융합인재 교육을 위한 교육환경 개선이 필요하다. 그리고, 개방형 학습 플랫폼은 사교육비 절감과 공교육의 보완에 효과적이다. 특히 교실 수업(오프라인)과 결합된 플립러닝에 유용하며 이럴 경우 교사의 역할이 능동적인 교수활동과 연구 활동으로 전환되어 공교육의 정상화를 앞당기고 사교육을 줄일 수 있다. 특히, 초등교육을 위한 MOOC 플랫폼 운영의 핵심 기능으로 '창의적 교수설계와 콘텐츠 개발 기능', '디지털 교수 학습 큐레이션 기능', '빅데이터 기반 학습자 맞춤화 기능', '학습 참여 촉진 플립러닝 및 소셜러닝 기능'을 제시한다. 본 연구를 통해 초등교육을 포함한 청소년의 진로 및 입시교육 MOOC의 도입에 대한 논의의 장이 마련되고 한국형 청소년 MOOC 플랫폼이 구축되어 교육민주화의 세계적 선진 모델로 발전될 수 있기를 기대한다.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2004년도 International Conference Current Challenges and Advances in Environmental Health
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• pp.88-88
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• 2004

• 정보교육학회논문지
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• 제18권4호
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• pp.633-644
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• 2014

본 논문에서는 공공데이터의 활용과 SNS의 소통 기능을 중점적으로 활용하여 PC와 모바일 웹에서 사용할 수 있도록 교육 프로그램을 구현하였다. 프로그램의 특징은 친구와 문제를 주고받으며 짧은 글을 함께 전송하여 풀어보는 방식이다. 각각 방명록으로 소통의 공간을 마련하였고, 공지사항, 질문게시판, 자유게시판, 자료실을 두어 소통의 기능을 확대하고, 친구 찾기 및 추천 공간을 마련해 아는 사람 외에 프로그램을 이용하는 다른 사용자와 함께 학습할 수 있도록 설계하였다. 구현된 프로그램으로 초등학생과 고등학생에게 학습과 교우관계에 미치는 영향에 대해 설문을 통해 조사하고 반응을 분석하였다. 이러한 조사를 바탕으로 교육프로그램의 활용방안을 제시하였다.