• Molecules and Cells
• /
• v.40 no.8
• /
• pp.523-532
• /
• 2017

Functional near-infrared spectroscopy (fNIRS) is a noninvasive optical imaging technique that indirectly assesses neuronal activity by measuring changes in oxygenated and deoxygenated hemoglobin in tissues using near-infrared light. fNIRS has been used not only to investigate cortical activity in healthy human subjects and animals but also to reveal abnormalities in brain function in patients suffering from neurological and psychiatric disorders and in animals that exhibit disease conditions. Because of its safety, quietness, resistance to motion artifacts, and portability, fNIRS has become a tool to complement conventional imaging techniques in measuring hemodynamic responses while a subject performs diverse cognitive and behavioral tasks in test settings that are more ecologically relevant and involve social interaction. In this review, we introduce the basic principles of fNIRS and discuss the application of this technique in human and animal studies.

• Korean Journal of Biological Psychiatry
• /
• v.4 no.1
• /
• pp.24-28
• /
• 1997

Visual perception is a complex process engaging many different aspects of brain functioning. Like other cognitive functions, the extensive cortical distribution and complexity of visual perceptional activites make them hihgly vulnerable to brain injury. Dectection and characterization of perceptual disorders require a careful clinical assessment as well as the application of selected neuropsychological tests. In this article we reviewed neuropsychological assessment of visual perception and constructional abilities. And the principal visuospatial disorders are discussed, the associated neuropsychiatric disorders are presented.

• Journal of Biomedical Engineering Research
• /
• v.30 no.5
• /
• pp.355-361
• /
• 2009

Mitochondria play a key role in maintaining life by producing ATP and heat. Recent researches have demonstrated that degenerative diseases such as heart failure, obesity/diabetes, cardiovascular disease, and psychiatric diseases are accompanied by mitochondria dysfunction. In this sense, mitochondria medicine considers the significance of mitochondria in human pathology and tries to explain degenerative diseases as a fatal consequence of mitochondria dysfunction. Here, I introduce the fundamentals of mitochondria physiology and present examples showing the relationship between mitochondria dysfunction and chronic complex diseases. Although mitochondria medicine uses a molecular biological approach predominantly, a biomedical engineering approach might play a critical role in unveiling the complexity of mitochondria medicine and in its application to the diagnosis and treatment of chronic diseases. Thus, I also briefly review the prospects of research using biomedical engineering methods.

• Proceedings of the KOSOMBE Conference
• /
• v.1995 no.11
• /
• pp.117-120
• /
• 1995

The electronencephalogram (EEG) is a complex electrical signal which reflects generalized brain activity. The EEG is utilized in the clinical assesment of many neurological and psychiatric disorders and offers promise for monitoring of patients undergoing operation. This paper describes a technique for quantitative analysis of EEG signals which is based on an eigenspace. Examples of the application approach to simulated and clinical EEG data illustrate the capabilities.

• Proceedings of the KOSOMBE Conference
• /
• v.1997 no.05
• /
• pp.395-397
• /
• 1997

We have applied the neural network method for the neural networkmethod for the automatic scoring of the sleep stage. 17 features are extracted from the recorded EEG, EOG and EMG signals. These features are inputed to tile multilayer perceptron model. Neural network was trained with error-back propagation method. Results are compared with manual scoring of the experts, and show the possibility of application of automatic method in sleep stage scoring.

• Journal of Korean Academy of Addiction Psychiatry
• /
• v.18 no.1
• /
• pp.17-22
• /
• 2014

Virtual reality (VR) provides an immersive and interactive 3-dimensional system, which allows an individual to become immersed in a computer-generated situation. VR technology has been administered in the exposure-based treatment of a variety of psychiatric disorders, including acrophobia, fear of flight, and post-traumatic stress disorder. Furthermore, VR systems have also been developed for the use of research and treatment in addiction. They might have advantages in cue exposure therapy, by increasing the salience of cues, as well as assessments of cue reactivity in addiction. This article summarizes the application of VR in the field of psychiatry. More importantly, it suggests the possibilities of clinical use of VR technology, in the treatment of addiction.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.34 no.4
• /
• pp.192-203
• /
• 2023

Digital therapeutics based on software, such as artificial intelligence, virtual reality, games, and smartphone applications, are in the spotlight as new therapeutic alternatives in child and adolescent psychiatry. It draws attention to overcoming conventional therapeutics' limitations, such as toxicity, cost, and accessibility, and encourages patients to participate in the treatment attractively. The growth potential of the digital therapeutics market for psychiatric disorders in children and adolescents in Korea and abroad has been highlighted. Clinical studies and Food and Drug Administration approvals for digital therapeutics have increased, and cases approved by the Ministry of Food and Drug Safety have emerged in Korea. As seen above, digital transformation in child and adolescent psychiatry will change treatment paradigms significantly. Therefore, as this new field has just begun to emerge, it is necessary to verify the effectiveness and scope of the application of digital therapeutics and consider preparing a compensation system and institutional arrangements. Accordingly, this study analyzed the development trends and application status of digital therapeutics in children and adolescents and presented limitations and development directions from the perspective of application in healthcare. Further, the study is expected to identify the utility and limitations of digital therapeutics for children and adolescents and establish effective application measures.

• The Journal of Korean Medicine
• /
• v.39 no.3
• /
• pp.17-27
• /
• 2018

Objectives: Ukgan-san does not appear in Traditional Korean Medicine classics. However, it has been used in research and clinical applications in Korea. In this paper, we are aiming to examine the records concerned with Ukgan-san to the present, and announce the present usage state in Korea. Methods: We searched and summarized the contents of previous medical books about Ukgan-san. In order to investigate the current status of utilization of Ukgan-san in Korea, a bibliographic database of Korea, a database of clinical researches, and a database of pharmaceuticals of the Korea Food and Drug Administration were searched. Results: As a result of searching Ukgan-san related documents, Ukgan-san has been developed in China (Ming dynasty). However, its clinical application has been expanded by modern Japanese kampo medicine doctors. In Korea, cases of Parkinson's disease, other movement disorders, and psychiatric disorders have been reported, and randomized controlled trials had been done and planned. In addition, some extracts which are consisted of Ukgan-san are also available. Conclusions: In Korea, Ukgan-san has been influenced by Japan and has been used for clinical and research purposes. The utilization rate in Korea is still small, but the utilization rate will increase according to the results of clinical studies.

• The Journal of the Korea Contents Association
• /
• v.20 no.2
• /
• pp.594-606
• /
• 2020

On the contrary to the steady rise of social problems about depression, only a few take care of mental health themselves due to their negative perception of psychotherapy. In this study, we propose service design and user interface design of mobile applications that introduce an automatic emotional recognition system to prevent leaving depression unattended. First, we have come up with improvements in the usability of existing apps through literature research and case analysis, and draw out Personas from surveys and in-depth interviews of young people. As an essential element of the design of the Depression Improvement Service, we recommend having three components: writing a diary to manage schedule, recognize users' emotional state through avatar management, and tracking down emotional points to improve the cognitive system. Through this proposal, we want to prevent the development of depression and help to resolve the changes in perception of depression and longitude depression on our own. Ultimately, we publicize the necessity of mental health care application design and expect to lower the personal and social costs for psychiatric care.

• Korean Journal of Biological Psychiatry
• /
• v.4 no.1
• /
• pp.136-145
• /
• 1997

We are report on three cases of typical clinical characterstics and treatment response in neuroleptic maligant syndrome(NMS), and reviewed the literatures of NMS. NMS was first recognized as a life-threatening complication of dopamine receptor antagonists, and defined as a catatonic-like states associated with fever, obtundation, muscle rigidity, and unstable vital sign in patients taking neuroleptic agents. Concepts of NMS have changed because medications other than classic neuroleptic drugs have been implicated as triggering agents and syndromes identical to NMS have been observed in other conditions. The important neurochemical features are probably functional dopamine deficiency and ensuing hyperactivity of excitatory amino acid neurotransmission in the basal ganglia and hypothalamus. Recognition of NMS and early discontinuation of neuroleptics are the most important step in its management. Supportive care includes management of hyperthermia and fluid replacement. Controversial therapeutic measures include the application of dopamine receptor agonists, excitatory amino acid antagonists, or dantrolene. Psychiatric patients with a history on NMS and psychotic relapse necessitating antipsycotics do not commonly redevelop NMS.