Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Application of Functional Near-Infrared Spectroscopy to the Study of Brain Function in Humans and Animal Models

  • Kim, Hak Yeong (Department of Brain and Cognitive Sciences, DGIST) ;
  • Seo, Kain (Department of Brain and Cognitive Sciences, DGIST) ;
  • Jeon, Hong Jin (Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University, School of Medicine) ;
  • Lee, Unjoo (Department of Electronic Engineering, Hallym University) ;
  • Lee, Hyosang (Department of Brain and Cognitive Sciences, DGIST)
  • Received : 2017.07.31
  • Accepted : 2017.08.03
  • Published : 2017.08.31
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Abstract

Functional near-infrared spectroscopy (fNIRS) is a noninvasive optical imaging technique that indirectly assesses neuronal activity by measuring changes in oxygenated and deoxygenated hemoglobin in tissues using near-infrared light. fNIRS has been used not only to investigate cortical activity in healthy human subjects and animals but also to reveal abnormalities in brain function in patients suffering from neurological and psychiatric disorders and in animals that exhibit disease conditions. Because of its safety, quietness, resistance to motion artifacts, and portability, fNIRS has become a tool to complement conventional imaging techniques in measuring hemodynamic responses while a subject performs diverse cognitive and behavioral tasks in test settings that are more ecologically relevant and involve social interaction. In this review, we introduce the basic principles of fNIRS and discuss the application of this technique in human and animal studies.

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References

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