• Journal of the Korean association of regional geographers
• /
• v.21 no.4
• /
• pp.704-715
• /
• 2015

Provincial boundary regions need differentiated strategies from non-provincial boundary regions because they form multilayered regional networks with boundary cites and provinces. This paper aims to analyze the attributions of provincial boundary regions' regional networks in the dimensions of commuters, companies, and government and to explore their political strategies. At commuters level, Okcheon, a case study area, forms the strongest regional networks with Daejeon and does not have any regional network with Honam region. At companies level, it forms the regional network with Daejeon, Gyeonggi, and Chungbuk, and with Daejeon(Donggu, Daedukgu), and Gyeonggi(Bucheon) at government level. This paper suggests the following conclusive policies. First, provincial boundary regions should be postulated as the new policy targets. Second, Population and Housing Census should be constructed pan-regionally as the base data of regional network studies. Lastly, cooperation system among local government of the provincial boundary regions should be constructed.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.26 no.1
• /
• pp.35-46
• /
• 2023

The purpose of this research is to provide characteristics and satisfaction of visitors for Deoksan Provincial Park in Chungcheongnam-do. This study conducted face-to-face interview during Oct. to Nov. in 2022. Total sample size of this study was 521. This study used to implement frequency analysis, cross analysis and logit analysis via SPSS 21.0 version. The results showed most of visitors were one day visitors and visited with family and relatives. Many visitors visited the Deoksan Provincial Park to climb the mountain and relaxing/healing with the nature. The satisfaction level of factors such as nature, facility, access to information of the park was high with about more than 4-point on Likert scale. This study would be useful to develop site-specific policies to the management of provincial parks as this study identified the characteristics and satisfaction level of the visitors.

• Journal of Microbiology and Biotechnology
• /
• v.34 no.3
• /
• pp.547-561
• /
• 2024

In this study, we aim to investigate the precise alterations in the gut microbiota during the onset and advancement of diabetic nephropathy (DN) and examine the impact of Ruminococcus gnavus (R. gnavus) on DN. Eight-week-old male KK-Ay mice were administered antibiotic cocktails for a duration of two weeks, followed by oral administration of R. gnavus for an additional eight weeks. Our study revealed significant changes in the gut microbiota during both the initiation and progression of DN. Specifically, we observed a notable increase in the abundance of Clostridia at the class level, higher levels of Lachnospirales and Oscillospirales at the order level, and a marked decrease in Clostridia_UCG-014 in DN group. Additionally, there was a significant increase in the abundance of Lachnospiraceae, Oscillospiraceae, and Ruminococcaceae at the family level. Moreover, oral administration of R. gnavus effectively aggravated kidney pathology in DN mice, accompanied by elevated levels of urea nitrogen (UN), creatinine (Cr), and urine protein. Furthermore, R. gnavus administration resulted in down-regulation of tight junction proteins such as Claudin-1, Occludin, and ZO-1, as well as increased levels of uremic toxins in urine and serum samples. Additionally, our study demonstrated that orally administered R. gnavus up-regulated the expression of inflammatory factors, including nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) and Interleukin (IL)-6. These changes indicated the involvement of the gut-kidney axis in DN, and R. gnavus may worsen diabetic nephropathy by affecting uremic toxin levels and promoting inflammation in DN.

• Korea journal of population studies
• /
• v.26 no.2
• /
• pp.1-32
• /
• 2003

An analysis on cause-specific mortality at the provincial level provides essential information for policy formulation and makes it possible to draw hypotheses regarding various diseases and causes of death. Although the mortality level and causes of death at the provincial level are determined by the multiple effects of socioeconomic, cultural, medical and ecological factors, this study primarily intends to examine similarities and differences of cause-specific mortality at the provincial level. Utilizing the registered death and the registered population as of 1998, the delayed death registration and unreported infant deaths were supplemented at the provincial level and age-standardized death rates and life tables were calculated. Regarding the mortality level due to all causes, major findings were as follow: (1) For both sexes as a whole, Seoul showed the lowest mortality level, and Jeonnam showed the highest mortality level; and (2) The differences of the mortality level among provinces were greater for males than females and for those less than 65 years than those 65 years and over. Regarding the cause-specific mortality level revealed in all indicators (cause-specific age-standardized mortality rates and the probability of dying at birth due to a specific cause for males, females, and both sexes combined respectively), the major findings were as follow: (1) The mortality level due to heart diseases was the highest in Busan and the lowest in Gangweon; (2) The mortality level due to liver diseases was the highest in Chonnam; and (3) The mortality level due to traffic accidents was the highest in Chungnam and the lowest in Inchon. As the mortality differentials at the provincial level are related to various factors, exploratory statistical analysis is attempted for the 25 explanatory variables including socioeconomic variables and 90 mortality variables. Mortality due to all causes are related to socioeconomic variables. Among cause-specific mortality, mortality due to liver diseases and traffic accidents is related to socioeconomic variables. Finally, the need to improve the quality of death certificate is discussed.

• The Korean Journal of Pesticide Science
• /
• v.14 no.3
• /
• pp.241-246
• /
• 2010

Field experiments were carried out to establish economic threshold for com borer (Ostrinia furnacalis (Guen$\'{e}$e)) on waxy com plants by examining the number of adult insects caught in pheromone traps and the injury levels of waxy com which were artificially controlled. Adult com borers were lured into the pheromone traps during the whole growth period in five areas in Gangwon province including Chuncheon. The number of com borers trapped was the greatest in Chuncheon followed by Cheolwon and Hongcheon, and the same trend was observed for injury level of waxy com. Based on marketable yield data of waxy com plants related to the artificially-controlled injury levels at tassel stage, spray threshold was determined as the injury level of 11~15%, where the injury of com plants exceeded the economically admitting level.

• Parasites, Hosts and Diseases
• /
• v.55 no.2
• /
• pp.167-174
• /
• 2017

China still has more than 30,000 patients of advanced schistosomiasis while new cases being reported consistently. D-dimer is a fibrin degradation product. As ascites being the dominating symptom in advanced schistosomiasis, the present study aimed to explore a prediction model of ascites with D-dimer and other clinical easy-achievable indicators. A case-control study nested in a prospective cohort was conducted in schistosomiasis-endemic area of southern China. A total of 291 patients of advanced schistosomiasis were first investigated in 2013 and further followed in 2014. Information on clinical history, physical examination, and abdominal ultrasonography, including the symptom of ascites was repeatedly collected. Result showed 44 patients having ascites. Most of the patients' ascites were confined in the kidney area with median area of $20mm^2$. The level of plasma D-dimer and pertinent liver function indicators were measured at the initial investigation in 2013. Compared with those without ascites, cases with ascites had significantly higher levels of D-dimer ($0.71{\pm}2.44{\mu}g/L$ vs $0.48{\pm}2.12{\mu}g/L$, P=0.005), as well ALB (44.5 vs 46.2, g/L) and Type IV collagen (50.04 vs $44.50{\mu}g/L$). Receiver operating characteristic curve analyses indicated a moderate predictive value of D-dimer by its own area under curve (AUC) of 0.64 (95% CI: 0.54-0.73) and the cutoff value as $0.81{\mu}g/L$. Dichotomized by the cutoff level, D-dimer along with other categorical variables generated a prediction model with AUC of 0.76 (95% CI: 0.68-0.89). Risks of patients with specific characteristics in the prediction model were summarized. Our study suggests that the plasma D-dimer level is a reliable predictor for incident ascites in advanced schistosomiasis japonica patients.

• Journal of Agricultural Extension & Community Development
• /
• v.2 no.2
• /
• pp.95-108
• /
• 1995

Localization trends in Korea and trade liberalization in the world are the important challenges to agricultural extension services in Korea, and strategic directions in terms of system, organization, programs and conciousness would be necessary for adapting to the new circunstances. Some of the measures to improve and activate agricultural extension services in Korea should include the following: 1) Modification of extension personnel appointment regulations to secure specialized extension agents by the provincial administrators and county directors at the provincial and county level rural extension services. 2) Flexible organization and operation of county level rural guidance offices to meet the specific needs of local areas. 3) Strenghening the central government's financial support for effective local extension services in terms of facility and manpower. 4) Expansion of agricultural extension programs for women and urban people and quality inservice training for extension personnel.

• Journal of the Korean Institute of Landscape Architecture
• /
• v.35 no.5
• /
• pp.73-81
• /
• 2007

The purpose of this study is to derive policy suggestions and new orientations for biotope mapping in Korea from a review of case studies on the classification of biotope typesin Germany. This study was conducted in the following manner: First, the related literature and data on biotopes in Germany was collected. Second, the representative examples at the provincial government level and urban and residential areas were selected. Finally, the characteristics of biotope types, biotope classification systems, and biotope classification criteria were reviewed. The results of reviewing the case examples in Germany are as follows: First, the biotope types at the provincial government level were composed of patterns which existed mostly in natural areas and the corresponding areas of their conditions. Those in urban and residential areas were made up of patterns which were distributed in urban areas and their peripheries. Second, the biotope classification systems at the provincial government level consisted of three steps:large, medium and small. Those in urban and residential areas were made up of two steps: medium and small. However, it is strongly recommended to introduce the biotope classification system composed of three steps. Third, the biotope classification criteria at the provincial government level considered ecological factors and anthropogenic factors except land use forms. Those in urban and residential areas reflected mostly anthropogenic factors and ecological factors. In conclusion, this study suggests that future biotope surveys and mapping in Korea should be investigated not only in urban areas but also in natural and semi-natural areas. In addition, a specified biotope type classification system should be established in Korea.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.2
• /
• pp.821-824
• /
• 2013

The aim of this study was to investigate the diagnostic value of superoxide dismutase (SOD) in tuberculous pleural effusions (TPEs) and malignant pleural effusions (MPEs). Pleural effusion (PE) samples from 100 patients were classified on the basis of diagnosis as TPE (n=57) and MPE (n=43). The activity of SOD was determined by pyrolgallol assay. A significant difference was observed in SOD activity (P<0.01) between TPE and MPE, levels of being significantly higher in TPE compared to MPE. With a threshold value of 41 U/L, the area under the ROC curve was 0.653, SOD had a sensitivity of 61.4% and a specificity of 61.0% for differential diagnosis. Thus, SOD activity in PE was not a good biomarker in differentiating TPE and MPE. To the best of our knowledge, five SOD isoforms may be present in PE. Identification of which SOD contributes to the difference of SOD level between TPE and MPE is very important for illustrating mechanisms and improving the differential diagnostic value.

• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.8
• /
• pp.4685-4688
• /
• 2013

We aimed to investigate the mechanism and effects of autophagy on cisplatin (DDP)-induced apoptosis in human gastric cancer cell line SGC7901. After SGC7901 cells were treated with DDP and/or chloroquine, cell proliferation was measured using MTT assay; cell apoptosis was determined by flow cytometry; autophagy and apotosis-related proteins expression were detected by Western blot; and quantitative analysis of autophagy after monodansylcadaverine (MDC) staining was performed using fluorescence microscopy. We found after treatment with 5 mg/L DDP for 24 h, the rates of cell apoptosis were ($21.07{\pm}2.12$)%. Autophagy, characterized by an increase in the number of autophagic vesicles and the level of LC3-II protein was observed in cells treated with DDP. After inhibition of autophagy by chloroquine, the rates of cell apoptosis were increased to ($30.16{\pm}3.54$)%, and the level of Caspase-3 and P53 protein were increased, and Bcl-2 protein was decreased. Therefore, autophagy protects human gastric cancer cell line SGC7901 against DDP-induced apoptosis, inhibition of autophagy can promote apoptosis, and combination therapy with DDP and chloroquine may be a promising therapeutic strategy for gastric cancer.