• 한국지역지리학회지
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• 제21권4호
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• pp.704-715
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• 2015

도계지역은 경계하고 있는 시 도와 다층적인 지역적 네트워크가 형성되는 특성 때문에 비도계지역과는 차별화된 전략이 필요하다. 본 연구의 목적은 도계지역으로서 옥천이 갖는 지역적 네트워크 특성을 통근 통학자, 기업, 정부차원에서 분석하고 도계지역의 발전을 위한 정책적 시사점을 도출하는 것이다. 연구결과 옥천은 통근 통학자 네트워크 측면에서 대전과 지역적 네트워크가 가장 강하고, 호남과는 네트워크가 없는 것을 확인하였다. 기업측면에서는 대전, 경기, 충북과, 정부차원에서는 대전(동구, 대덕구)와 경기(부천)와 네트워크를 형성하고 있다. 본 연구는 도계지역을 새로운 정책대상으로 상정하고, 지역 네트워크 연구의 기초자료로서 인구주택총조사의 초광역적 통계데이터를 구축과 경계지역 기초자치단체 간 협력체계를 마련할 것을 제안한다.

• 한국환경복원기술학회지
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• 제26권1호
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• pp.35-46
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• 2023

The purpose of this research is to provide characteristics and satisfaction of visitors for Deoksan Provincial Park in Chungcheongnam-do. This study conducted face-to-face interview during Oct. to Nov. in 2022. Total sample size of this study was 521. This study used to implement frequency analysis, cross analysis and logit analysis via SPSS 21.0 version. The results showed most of visitors were one day visitors and visited with family and relatives. Many visitors visited the Deoksan Provincial Park to climb the mountain and relaxing/healing with the nature. The satisfaction level of factors such as nature, facility, access to information of the park was high with about more than 4-point on Likert scale. This study would be useful to develop site-specific policies to the management of provincial parks as this study identified the characteristics and satisfaction level of the visitors.

• Journal of Microbiology and Biotechnology
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• 제34권3호
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• pp.547-561
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• 2024

In this study, we aim to investigate the precise alterations in the gut microbiota during the onset and advancement of diabetic nephropathy (DN) and examine the impact of Ruminococcus gnavus (R. gnavus) on DN. Eight-week-old male KK-Ay mice were administered antibiotic cocktails for a duration of two weeks, followed by oral administration of R. gnavus for an additional eight weeks. Our study revealed significant changes in the gut microbiota during both the initiation and progression of DN. Specifically, we observed a notable increase in the abundance of Clostridia at the class level, higher levels of Lachnospirales and Oscillospirales at the order level, and a marked decrease in Clostridia_UCG-014 in DN group. Additionally, there was a significant increase in the abundance of Lachnospiraceae, Oscillospiraceae, and Ruminococcaceae at the family level. Moreover, oral administration of R. gnavus effectively aggravated kidney pathology in DN mice, accompanied by elevated levels of urea nitrogen (UN), creatinine (Cr), and urine protein. Furthermore, R. gnavus administration resulted in down-regulation of tight junction proteins such as Claudin-1, Occludin, and ZO-1, as well as increased levels of uremic toxins in urine and serum samples. Additionally, our study demonstrated that orally administered R. gnavus up-regulated the expression of inflammatory factors, including nucleotide-binding oligomerization domain-like receptor pyrin domain-containing protein 3 (NLRP3) and Interleukin (IL)-6. These changes indicated the involvement of the gut-kidney axis in DN, and R. gnavus may worsen diabetic nephropathy by affecting uremic toxin levels and promoting inflammation in DN.

• 한국인구학
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• 제26권2호
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• pp.1-32
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• 2003

시도의 사망원인별 사망력 분석은 정책수립에 필수적인 정보를 제공하고, 각종 질병 및 사망 원인에 대한 가설을 설정하게 한다. 사회경제적, 문화적, 의료적, 생태학적 이유 등 다양한 원인이 시도의 사망원인별 사망수준에 복합적으로 영향을 주지만, 이 연구에서는 시도의 사망원인별 사망력에 대한 설명보다는 공통점과 차이점 파악을 주 목적으로 하였다. 이를 위하여 1998년 기준 사망신고 및 주민등록인구 자료를 활용하여, 시도별로 지연신고와 영아사망 신고누락을 보완하고, 연령표준화사망률과 생명표를 작성하였다. 모든 사인에 의한 사망수준 관련 주요 결과는 다음과 같다: (1) 남녀전체를 합하여 서울이 가장 낮은 사망수준을 전남은 가장 높은 사망수준을 보였다: (2) 시도간 사망수준의 차이가 여자보다 남자에게서, 65세 이상보다 604세 이하 연령층에서 더 컸다. 사망원인별 사망력 관련 남녀별 및 남녀 전체를 합하여 연령표준화 사망률이나 출생시 사망확률이라는 지표 모두에서 일관된 유형을 보이는 주요 결과는 다음과 같다: (1) 심장질환에 의한 사망수준은 부산에서 최고, 강원도에서 최저를 나타냈고: (2) 간질환에 의한 사망수준은 전남에서 최고를; (3) 운수사고에 의한 사망수준은 충남에서 최고 인천에서 최저로 나타났다. 시도의 사망수준 차이에는 다양한 요인이 관련되어 있으므로 사회경제적 변수를 포함한 25개의 설명 변수와 총90개의 사망력 변수에 대한 탐색적 통계분석을 실시하였다. 모든 사인에 의한 사망력은 사회경제적 변수와 밀접한 관련이 있으며, 사망원인별로는 간질환 및 운수사고에 의한 사망력이 사회경제적 변수와 관련이 있는 것으로 나타났다. 끝으로 사망신고 자료의 질 개선 필요성을 논의하고 있다.

• 농약과학회지
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• 제14권3호
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• pp.241-246
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• 2010

찰옥수수를 가해하는 조명나방의 피해에 대한 요방제 수준을 설정하고자 페로몬 트랩을 이용한 성충의 유살량 조사와 처리구별로 피해율을 조절하여 포장시험을 수행하였다. 춘천 등 도내 5개 지역에 설치한 페로몬 트랩에 조명나방 성충이 찰옥수수 전 생육기간에 걸쳐 유인되었으며, 유살량은 춘천, 철원, 홍천 순으로 많았고, 이에 따른 찰옥수수의 피해율도 같은 경향을 나타냈다. 찰옥수수 출사기에 조명나방의 피해주율을 조절하여 수확기에 처리별로 수량을 조사한 결과, 출사기 피해주율이 11~15%일 때부터 찰옥수수상품수량이 급격히 감소하여 경제적 피해 허용수준을 초과하였으며 따라서 이 수준을 요방제 수준으로 설정하였다.

• Parasites, Hosts and Diseases
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• 제55권2호
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• pp.167-174
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• 2017

China still has more than 30,000 patients of advanced schistosomiasis while new cases being reported consistently. D-dimer is a fibrin degradation product. As ascites being the dominating symptom in advanced schistosomiasis, the present study aimed to explore a prediction model of ascites with D-dimer and other clinical easy-achievable indicators. A case-control study nested in a prospective cohort was conducted in schistosomiasis-endemic area of southern China. A total of 291 patients of advanced schistosomiasis were first investigated in 2013 and further followed in 2014. Information on clinical history, physical examination, and abdominal ultrasonography, including the symptom of ascites was repeatedly collected. Result showed 44 patients having ascites. Most of the patients' ascites were confined in the kidney area with median area of $20mm^2$. The level of plasma D-dimer and pertinent liver function indicators were measured at the initial investigation in 2013. Compared with those without ascites, cases with ascites had significantly higher levels of D-dimer ($0.71{\pm}2.44{\mu}g/L$ vs $0.48{\pm}2.12{\mu}g/L$, P=0.005), as well ALB (44.5 vs 46.2, g/L) and Type IV collagen (50.04 vs $44.50{\mu}g/L$). Receiver operating characteristic curve analyses indicated a moderate predictive value of D-dimer by its own area under curve (AUC) of 0.64 (95% CI: 0.54-0.73) and the cutoff value as $0.81{\mu}g/L$. Dichotomized by the cutoff level, D-dimer along with other categorical variables generated a prediction model with AUC of 0.76 (95% CI: 0.68-0.89). Risks of patients with specific characteristics in the prediction model were summarized. Our study suggests that the plasma D-dimer level is a reliable predictor for incident ascites in advanced schistosomiasis japonica patients.

• 농촌지도와개발
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• 제2권2호
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• pp.95-108
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• 1995

Localization trends in Korea and trade liberalization in the world are the important challenges to agricultural extension services in Korea, and strategic directions in terms of system, organization, programs and conciousness would be necessary for adapting to the new circunstances. Some of the measures to improve and activate agricultural extension services in Korea should include the following: 1) Modification of extension personnel appointment regulations to secure specialized extension agents by the provincial administrators and county directors at the provincial and county level rural extension services. 2) Flexible organization and operation of county level rural guidance offices to meet the specific needs of local areas. 3) Strenghening the central government's financial support for effective local extension services in terms of facility and manpower. 4) Expansion of agricultural extension programs for women and urban people and quality inservice training for extension personnel.

• 한국조경학회지
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• 제35권5호
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• pp.73-81
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• 2007

The purpose of this study is to derive policy suggestions and new orientations for biotope mapping in Korea from a review of case studies on the classification of biotope typesin Germany. This study was conducted in the following manner: First, the related literature and data on biotopes in Germany was collected. Second, the representative examples at the provincial government level and urban and residential areas were selected. Finally, the characteristics of biotope types, biotope classification systems, and biotope classification criteria were reviewed. The results of reviewing the case examples in Germany are as follows: First, the biotope types at the provincial government level were composed of patterns which existed mostly in natural areas and the corresponding areas of their conditions. Those in urban and residential areas were made up of patterns which were distributed in urban areas and their peripheries. Second, the biotope classification systems at the provincial government level consisted of three steps:large, medium and small. Those in urban and residential areas were made up of two steps: medium and small. However, it is strongly recommended to introduce the biotope classification system composed of three steps. Third, the biotope classification criteria at the provincial government level considered ecological factors and anthropogenic factors except land use forms. Those in urban and residential areas reflected mostly anthropogenic factors and ecological factors. In conclusion, this study suggests that future biotope surveys and mapping in Korea should be investigated not only in urban areas but also in natural and semi-natural areas. In addition, a specified biotope type classification system should be established in Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.821-824
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• 2013

The aim of this study was to investigate the diagnostic value of superoxide dismutase (SOD) in tuberculous pleural effusions (TPEs) and malignant pleural effusions (MPEs). Pleural effusion (PE) samples from 100 patients were classified on the basis of diagnosis as TPE (n=57) and MPE (n=43). The activity of SOD was determined by pyrolgallol assay. A significant difference was observed in SOD activity (P<0.01) between TPE and MPE, levels of being significantly higher in TPE compared to MPE. With a threshold value of 41 U/L, the area under the ROC curve was 0.653, SOD had a sensitivity of 61.4% and a specificity of 61.0% for differential diagnosis. Thus, SOD activity in PE was not a good biomarker in differentiating TPE and MPE. To the best of our knowledge, five SOD isoforms may be present in PE. Identification of which SOD contributes to the difference of SOD level between TPE and MPE is very important for illustrating mechanisms and improving the differential diagnostic value.

• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4685-4688
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• 2013

We aimed to investigate the mechanism and effects of autophagy on cisplatin (DDP)-induced apoptosis in human gastric cancer cell line SGC7901. After SGC7901 cells were treated with DDP and/or chloroquine, cell proliferation was measured using MTT assay; cell apoptosis was determined by flow cytometry; autophagy and apotosis-related proteins expression were detected by Western blot; and quantitative analysis of autophagy after monodansylcadaverine (MDC) staining was performed using fluorescence microscopy. We found after treatment with 5 mg/L DDP for 24 h, the rates of cell apoptosis were ($21.07{\pm}2.12$)%. Autophagy, characterized by an increase in the number of autophagic vesicles and the level of LC3-II protein was observed in cells treated with DDP. After inhibition of autophagy by chloroquine, the rates of cell apoptosis were increased to ($30.16{\pm}3.54$)%, and the level of Caspase-3 and P53 protein were increased, and Bcl-2 protein was decreased. Therefore, autophagy protects human gastric cancer cell line SGC7901 against DDP-induced apoptosis, inhibition of autophagy can promote apoptosis, and combination therapy with DDP and chloroquine may be a promising therapeutic strategy for gastric cancer.