• 한국지형학회지
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• 제19권2호
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• pp.99-111
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• 2012

본 연구는 대전분지에 있어서 청동기시대에서 원삼국시대로의 이행과정에서 나타나는 주거지의 지리적(또는 지형적) 입지환경 변화와 그 원인을 밝히는 것이다. 이를 위하여 (1) '유적그룹(또는 주거지밀집유적)의 주거지 총수 비교'그리고 (2) '두 시대의 주거지를 모두 포함하고 있는 특정유적에서 주거지 총 수 비교'로 구분하여 시대변천에 따른 주거지의 표고, 경사도, 용수하천거리 및 용수하상비고 측면에서 입지환경을 상호 비교하였다. 그 결과는 다음과 같다. 1. 개별 인자의 변화를 보면, 표고는 상승했으며, 경사도는 증가했다. 용수하천거리는 소급하천의 경우 감소 내지 증가했으며, 중급하천의 경우 거의 차이가 없거나 증가했다. 그리고 용수하상비고는 소급하천의 경우 증가했으며, 중급하천의 경우 증가 내지 감소했다. 2. 개별 인자를 상호 비교하면, 경사도, 표고 및 용수하상비고의 증감이 대체로 유사한 경향을 띠며, 특히 경사도의 증가가 표고와 용수하상비고의 증가에 영향을 미치는 것으로 나타났다. 그리고 용수하천거리의 증감은 경사도, 표고 및 용수하상비고의 증감과 다른 경향을 나타내는 것으로 나타났다. 3. 이상으로부터 대전분지 내에 분포하는 저구릉의 미지형적 특성(예 : 경사도 특성)과 저구릉을 둘러싸고 있는 풍부한 수계환경이 서로 맞물려 당시의 주거지 입지선정에 영향을 미쳤다는 것을 알 수 있었다. 특히 당시 거주민들에게 주거지 입지 선정시 '경사도와 용수하천거리'가 '표고와 용수하상비고'에 비해 상대적으로 중요한 주거지 선정 인자였던 것으로 밝혀졌다.

• Molecules and Cells
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• 제26권5호
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• pp.462-467
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• 2008

TPA is known to cooperate with an activated Ras oncogene in the transformation of rodent fibroblasts, but the biochemical mechanisms responsible for this effect have not been established. In the present study we used c-fos promoter-luciferase constructs as reporters, in transient transfection assays, in NIH3T3 cells to assess the mechanism of this cooperation. We found a marked synergistic interaction between TPA and a transfected v-Ha-ras oncogene in the activation of c-fos promoter and SRE. SRE has binding sites for TCF and SRF. A dominant-negative Ras (ras-N17) inhibited the TPA-Ras synergy by blocking the PKC-MAPK-TCF pathway. Dominant-negative RhoA and Rac1 (but not Cdc42Hs) inhibited the TPA-Ras synergy by blocking the Ras-Rho-SRF signaling pathway. Constitutively active $PKC{\alpha}$ and $PKC{\varepsilon}$ showed synergy with v-Ras. These results suggest that the activation of two distinct pathways such as Ras-Raf-ERK-TCF pathway and Rho-SRF pathway are responsible for the induction of c-fos by TPA and Ras in mitogenic signaling pathways.

• 천문학회지
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• 제37권5호
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• pp.517-525
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• 2004

We present an update on our proposal that during the 'quasar era' (1.5 $\le$ z $\le$ 3), powerful radio galaxies could have played a major role in the enhanced global star-formation, and in the widespread magnetization and metal pollution of the universe. A key ingredient of this proposal is our estimate that the true cosmological evolution of the radio galaxy population is likely to be even steeper than what has been inferred from flux-limited samples of radio sources with redshift data, when an allowance is made for the inverse Compton losses on the cosmic microwave background which were much greater at higher redshifts. We thus estimate that a large fraction of the clumps of proto-galactic material within the cosmic web of filaments was probably impacted by the expanding lobes of radio galaxies during the quasar era. Some recently published observational evidence and simulations which provide support for this picture are pointed out. We also show that the inverse Compton x-ray emission from the population of radio galaxies during the quasar era, which we inferred to be largely missing from the derived radio luminosity function, is still only a small fraction of the observed soft x-ray background (XRB) and hence the limit imposed on this scenario by the XRB is not violated.

• Molecules and Cells
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• 제27권6호
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• pp.697-701
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• 2009

We previously identified cancer-upregulated gene 2 (CUG2) as a commonly up-regulated gene in various human cancer tissues, especially in ovary, liver, and lung (Lee et al., 2007a). CUG2 was determined to be a nuclear protein that exhibited high proto-oncogenic activities when overexpressed in NIH3T3 mouse fibroblast cells. To identify other cellular functions of CUG2, we performed yeast two-hybrid screening and identified CENP-T, a component of CENP-A nucleosome complex in the centromere, as an interacting partner of CUG2. Moreover, CENP-A, the principle centromeric determinant, was also found in complex with CENP-T/CUG2. Immunofluorescent staining revealed the co-localization of CUG2 with human centromeric markers. Inhibition of CUG2 expression drastically affected cell viability by inducing aberrant cell division. We propose that CUG2 is a new component of the human centromeric complex that is required for proper chromosome segregation during mitosis.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.15-20
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• 2013

Urinary bladder squamous cell carcinoma (SCC), one of the most common neoplasms in Egypt, is attributed to chronic urinary infection with Schistosoma haematobium (Schistosomiasis). The proto-oncogene c-KIT, encoding a tyrosine kinase receptor and implicated in the development of a number of human malignancies, has not been studied so far in schistosomal urinary bladder SCCs. We therefore determined immunohistochemical (IHC) expression of c-KIT in paraffin sections from 120 radical cystectomies of SCCs originally obtained from the Pathology Department of Suez Canal University (Ismailia, Egypt). Each slide was evaluated for staining intensity where the staining extent of >10% of cells was considered positive. c-KIT overexpression was detected in 78.3% (94/120) of the patients, the staining extents in the tumor cells were 11-50% and >50% in 40 (42.6%) and 54 (57.4%) respectively. The positive cases had 14.9%, 63.8%, 21.3% as weak, moderate and strong intensity respectively. Patients with positive bilharzial ova had significantly higher c-KIT expression than patients without (95.2% vs. 38.9%, P=0.000). Mutation analysis of exons 9-13 was negative in thirty KIT positive cases. The high rate of positivity in SBSCC was one of the striking findings; However, CD117 may be a potential target for site specific immunotherapy to improve the outcome of this tumor.

• Journal of Electrical Engineering and Technology
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• 제1권1호
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• pp.106-109
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• 2006

In this paper, the design and characteristics of a novel ultrasonic motor are investigated. Such a motor is appropriate far use in the optical zoom or auto focusing functions of the lens system in mobile phones. Its design and simulation of performances are carried out by FEM commercial software (ATILA). The shape of the motor is similar to a square without one side, on which an optical lens can be mounted. Two sheets of piezoelectric ceramics are adhered to both sides of two legs of the elastic body, respectively To drive the ultrasonic motor, the voltage is applied to two sheets of piezoelectric ceramics bonded to one leg. The rotation direction can be easily changed by switching the piezoelectric sheets bonded to the other leg, to which voltage is applied. A proto type of the motor is fabricated and its outer size is $10^*10^*2[mm3]$ including the camera lens of which the diameter is 7.5(mm). Its power consumption is about 0.3[W] and the speed of rotation is adjustable from 10 to 200[rpm] according to the applied voltage

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년도 춘계학술대회논문집
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• pp.252-255
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• 2008

In this study, the characteristics of crossing a river of Ground Armored Vehicle (GAV) were evaluated by numerical method and real size tests. 3-D hybrid mesh systems were constructed by 3-D models of the GAV, and a commercial software, FLUENT, was used in numerical analysis. In order to deal with multi-phase problem (air and water), Volume Of Fluid (VOF) method was used, and Moving and Deforming Mesh (MDM) was adapted for unsteady motion of GAV. There were two steps in this research. Firstly, stability of the GAV which cruised a river was evaluated by changing several shapes of water-proof-front-wing of the GAV in steady state, and compared results (free surface shape and drag value in 10km/h) with those of real size tests. Secondly, results of unsteady analysis considering weight and moment of inertia of the GAV were presented. There were showed a maximum velocity with a designed water jet and dynamic stability including pitch, roll, and yaw moment. Based on these results, the optimal shape of water-proof-front-wing of the GAV was determined for a proto-type of the GAV.

• 천문학회지
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• 제11권1호
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• pp.1-30
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• 1978

The four dimensional classification of globular dusters with the parameters, Z, Y, age and HB type is presented defining two new parameters. $(B-V)_{1/2}\;and\;S_{3/2}$ which are shown to be tightly correlated with Kinman's spectral types and the helium abundances obtained from the R-method, respectively. The Z- and Y- abundances are derived from $(B-V)_{1/2}\;and\;S_{3/2}$, respectively, and the latter parameters determine the age class of clusters with help of Dickens' HB type, which is a function of Z. Y and age. For the examined forty two globular clusters the computed range at Z and Y are $1.5{\times}10^{-4}{\leq}Z{\leq}4.5{\times}10^{-2}\;and\;0.23<Y{\leq}0.41$. The age difference between the oldest (HB type 1) and the youngest (HB type 7) clusters is roughly estimated to be $2-4{\times}10^9$ years. Using these four parameters the known anomalous C-M diagrams seem to be reasonably interpreted without taking into account some complicate parameters such as unusually overabundant heavy elements, mass loss and mass spread, etc. The four dimensional scheme strongly suggests the slow successive collapses of the proto-Galaxy rather than a single fast collapse, and by this slow collapse model the inversion of chemical abundance gradient in the Galaxy can be explained. It is also shown that the clump position along the RGB near the HB level removes down to the fainter magnitude as the Z(Y)- abundance increases (decreases).

• 콘크리트학회논문집
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• 제11권3호
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• pp.141-152
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• 1999

Precast prestressed double-tee slab may be designed by the PCI Design Handbook. It is based on the bridge construction and is required for reorganization for the use of buildings in the domestic construction environments. Much enhanced sections are developed from the reforming process on the determined design factors in the previous experimental works on double tees. Pre-determined shape, reinforcement detail, and 5000 psi concrete strength can not be expected as the best solution for the domestic construction requirements because large amount of use on that systems are anticipated. Flexural tests are performed on four full-scale 12.5m proto-type models, "least depth double tee", which are resulted from the optimization process. Domestic superimposed live load regulation, domestic material properties which is available to product, building design requirements and economy in construction are considered as the main factors to establish. the first two sections are double tee section for 1.2 ton/$\m^2$ market live load with straight and one-point depressed strands and the second two are for 0.6 ton/$\m^2$ parking live load with those strand types. All of the specimens tested fully comply with the flexural strength requirements as specified by ACI 318-95. However, the research has shown that following improved considerations are needed for better result in practice. The locations and method of connection for the lowest bottom mild bar, connection method between precast and cast-in-place concrete, and dap-end reinforcement are need to be improved.

• 한국초전도ㆍ저온공학회논문지
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• 제10권3호
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• pp.27-31
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• 2008

In order to cool the SMES coil to the operating temperature, conduction cooling is generally used. However, it often consumes a large amount of electric power because of it's continuous cryocooler operation. This can also lead to poor thermal stability and serious protection problems of the system. Solid nitrogen (SN2) can counter those disadvantages in the conduction cooling system because it has a large heat capacity. Particularly, a large amount of enthalpy with a minimal weight to the cold body of SN2 makes a compact and portable system by increase a recooling to recooling time period (RRTP) value. A conceptual design of the proto-type SN2 cooling system for a portable HTS superconducting magnetic energy storage (SMES) system will be introduced in this paper.