• 한국산학기술학회논문지
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• 제18권4호
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• pp.504-510
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• 2017

본 논문은 소형 가전기기를 위한 AC DC 파워모듈 설계를 제시하고 효율과 신뢰성 및 안정성 특성을 나타낸다. 제안하는 파워모듈은 PCB 테스트보드에서 PWM 제어 IC 칩, 파워모스 소자, 트랜스포머, 각종 수동소자 (저항, 커패시터, 인덕터)를 사용하여 제작하였다. 본 논문에서 제시한 AC DC 파워모듈 회로 시뮬레이션 결과를 토대로 측정한 실험에서 입력전압은 상용전원 전압 220 V (RMS), 주파수 60 HZ의 교류전압(VAC : Voltage alternating current)을 사용 하였으며, 출력전압, OCP (over current protection), EMI(electromagnetic interference), PWM 신호 펄스, 효율 측정, 패키징 여부에 따른 발열측정 등을 실시하였다. 또한 파워모듈의 온도에 따른 특성변화와 트랜스포머 기준으로 1차측의 회로와 2차측 회로의 절연상태 확인을 하기 위한 내전압 테스트 등의 신뢰성테스트를 실시하였다. 효율 및 신뢰성 측정결과, AC DC 파워 모듈이 5 V의 출력전압, 200 mV의 리플, 약 73 %의 효율, 온도 약 $80^{\circ}C$ 까지 안정적으로 동작함을 확인하였으며, 4.2 kV의 크기로 60초 동안 견디는 내압 성능을 보였다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2004년도 학술대회지
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• pp.455-459
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• 2004

Electrostatic discharge(ESD) is a serious reliability concern. It causes approximately most of all field failures of integrated circuits. Inevitably, future IC technologies will shrink the dimensions of interconnects, gate oxides, and junction depths, causing ICs to be increasingly susceptible to ESD-induced damage [1][2][3]. This thesis shows the optimization of the ESD protection circuit based on the tested results of MM (Machine Model) and HBM (Human Body Model), regardless of existing Reference in fully silicided 0.18 um CMOS process. His thesis found that, by the formation of silicide in a source and drain contact, the dimensions around the contact had a less influence on the ESD robustness and the channel width had a large influence on the ESD robustness [8].

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6535-6539
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• 2015

This study was designed to assess, whether a new chemotherapeutic microtubule inhibitor, Epothilone B (EpoB, Patupilone), can induce DNA damage in normal ovarian cells (MM14.Ov), and to evaluate if such damage could be repaired. The changes were compared with the effect of paclitaxel (PTX) commonly employed in the clinic. The alkaline comet assay technique and TUNEL assay were used. The kinetics of DNA damage formation and the level of apoptotic cells were determined after treatment with IC50 concentrations of EpoB and PTX. It was observed that PTX generated significantly higher apoptotic and genotoxic changes than EpoB. The peak was observed after 48 h of treatment when the DNA damage had a maximal level. The DNA damage induced by both tested drugs was almost completely repaired. As EpoB in normal cells causes less damage to DNA it might be a promising anticancer drug with potential for the treatment of ovarian tumors.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 춘계학술대회 논문집 전기기기 및 에너지변환시스템부문
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• pp.125-127
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• 2008

기존의 LED(Light Emitting Diode)를 이용한 LCD(Liquid Crystal Display) 백라이트 유닛은 LED에 과전류가 흐르면 소자의 파손이 발생하고 무부하시 불필요한 전력소모가 발생하는 경우가 있어 보호회로가 필요하였다. 그래서 본 논문은 보호회로를 이용한 LCD 백라이트 유닛용의 LED 구동회로를 제안한다. 제안된 보호회로는 2가지로 첫 번째 보호회로는 무부하시 소비전력을 줄이는 보호회로 이다. 시뮬레이션 결과 무부하시 피드백 제어부 IC(Integrated Circuit)의 전원전압 $V_{cc}$를 UVLO(Under Voltage Lock Out)전압 이하로 강하시켰다. 그래서 무부하시 소비되는 전력을 줄일 수 있었다. 두번째 보호회로는 과전류시 보호회로 이다. 시뮬레이션 결과 과전류시 SCR이 온 되어 피드백 제어부 IC의 전원전압 $V_{cc}$를 UVLO전압 이하로 강하시켰다. 따라서 과전류시 LED 동회로 소자의 파손을 방지할 수 있는 장점이 있다.

• 약학회지
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• 제50권5호
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• pp.326-331
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• 2006

We designed and synthesized new benzylpiperidinyl ether derivatives as beta-amyloid aggregation inhibitors for the development of novel anti-Alzheimer's disease agents. As starting material, 4-hydroxypiperidine was used. For protection of the amine group in piperidine (2), di-tert-butyl dicarbonate was reacted with 4-hydroxypiperidine in the presence of triethylamine. For introduction of benzyl group, benzylbromide was treated with compound 2 in dioxane. After deprotection of Boc group on amine in compound 3, ester (5) was synthesized by addition of ethyl-4-chlorobutyrate. The alcohol 6 was synthesized by hydride reduction of 5 using $LiAlH_4$. To obtain final products (7-14), the alcohol 6 was condensed with each of substituted benzoic acids. To screen beta-amyloid aggregation inhibition of the products, thioflavinT assay was performed using $A{\beta}1-42\;at\;37^{\circ}C$ for 26 h incubation, in vitro. From the result of screening, compound 8, 9, 11 and 12 showed effective activity about $65{\sim}85\;{\mu}M\;as\;IC_{50}$ value. Among the prepared compounds, 4-[4-(benzyloxy)piperidino]butyl-4-chlorobenzoate (8) was the most effective inhibitor having $IC_{50}\;of\;65.4{\mu}M$.

• 정보보호학회논문지
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• 제23권2호
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• pp.329-337
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• 2013

산업제어시스템의 사이버위협 특징은 의도하지 않았다고 하더라도 피해범위가 특정 시스템뿐만 아니라 네트워크의 서비스 제공을 위협하는 수준에 도달했다는 점이다. '보안'의 일부 범위는 단지 테러리스트나 사이버 해커의 고의적인 공격에 대한 시스템의 보호를 포함하지만, 종종 더 큰 피해는 의도적인 공격보다 부주의에 의한 설정 오류 또는 장비고장 등의 비고의적인 행위로 이루어 진다. 본 논문은 고의적 공격, 실수, 장비 고장 및 소프트웨어 문제를 포함한 ICS의 모든 비정상 행위에 대한 분류를 제안하였다. ICS의 비정상 행위 분류 기준은 고의적인 공격뿐만 아니라 부주의한 행동의 공통점과 중요한 특징을 강조하기 위해 선정되었다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2008년도 하계종합학술대회
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• pp.463-464
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• 2008

As the demands of LCD and PDP TV are increasing, the high performance HVICs(High Voltage Gate Driver ICs) technology is becoming more necessary. In this paper, we designed the HVIC that has enhanced noise immunity and high driving capability. It can operate at 500KHz switching frequency and permit 600V input voltage. High-side level shifter is designed with noise protection circuit and schmitt trigger. Therefore it has very high dv/dt immunity, the maximum being 50V/ns. The HVIC was designed using $1{\mu}m$ BCD 650V process and verified by Spectre and PSpice of Cadence inc. simulation.

• Journal of Power Electronics
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• 제11권3호
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• pp.271-278
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• 2011

This paper presents a LLC resonant controller IC for secondary side control without external active devices to achieve low profile and low cost LED back light units. A gate driving transformer is adopted to isolate the primary side and the secondary side instead of an opto-coupler. A new integrated dimming circuitry is proposed to improve the dynamic current control characteristic and the current density of a LED for the brightness modulation of a large screen LCD. A dual-slope clock generator is proposed to overcome the frequency error due to the under shoot in conventional approaches. This chip is fabricated using 0.35 ${\mu}m$ BCD technology and the die size is $2{\times}2\;mm^2$. The frequency range of the clock generator is from 50 kHz to 500 kHz and the range of the dead time is from 50 ns to 2.2 ${\mu}s$. The efficiency of the LED driving circuit is 97 % and the current consumption is 40 mA for a 100 kHz operation frequency from a 15 V supply voltage.

• Natural Product Sciences
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• 제26권4호
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• pp.268-278
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• 2020

In this study, we investigated the chemical profile and effects of RW0117 (Artemisia argyi 65 .5 % ethanol extract) on gastric lesions in rats. We optimized and validated a method to obtain the chemical profile of RW0117. We then investigated the antioxidant and anti-inflammatory effects in vitro, and the protective effects on gastric lesions in vivo. The IC50 of 2,2-diphenyl-1-picrylhydrazyl free radical scavenging considering the antioxidant effects of RW0117 was 166.55 ㎍/mL, and the IC50 of nitric oxide scavenging considering the anti-inflammatory effects was 41.16 ㎍/mL. Oral administration of RW0117 at lower concentrations (25, 50, 100 mg/kg) had similar or greater effects than the daily intake conversion concentration (115mg/kg) of a health functional food (Avexol®) in the acetic acid-induced ulcer and the ethanol-induced gastric injury rat models. In addition, oral administration of RW0117 increased the expression of prostaglandin E2, which enhances the protective effect in the gastric mucosa in the ethanol-induced gastric injury rat model. These results suggest that RW0117 may have potential therapeutic uses in the protection of the gastric mucosa.

• 한국환경보건학회지
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• 제28권2호
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• pp.109-116
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• 2002

The purpose of this study was to evaluate a new sampling and analytical method for the determination of airborne hexavalent chromium, Cr(Ⅵ), in a field plating operation. The procedures of this new method (Shin & Paik's Method) are as the following: Airborne hexavalent chromium is collected on polyvinyl chloride (PVC) filter according to the National Institute iota Occupational Safety and Health (NIOSH) Method 7600, and the filler sample is placed in a screw-capped vial and soaked with 2% NaOH/3% Na₂CO₃ solution immediately after sampling. The Cr(Ⅵ) sample is analyzed by ion chromatography/visible spectrophotometry (IC/VS) according to the U.S. Environmental Protection Agency (EPA) Method 218.6. The airborne Cr(Ⅵ) concentrations measured by this method were compared with those determined by three reference methods: One (NIOSH/EPA Method) consisted of sampling airborne Cr(Ⅵ) on PVC filters and storing the sample filters in strew-capped vials according to the NIOSH method, and analyzing Cr(Ⅵ) in samples using IC/VS according to the EPA method. The second method (Impinger Method/NaHCO₃) consisted of absorbing airborne Cr(Ⅵ) into 0.02 M NaHCO₃ solution in midget impinger, and analyzing the Cr(Ⅵ) in samples using IC/VS. The third method was the OSHA Method ID-215. Using these four different methods, lour replicates of air samples were collected at an electroplating process and analyzed simultaneously. Two-way ANOVA and paired t-test were used to test difference among values determined by the methods. There was no significant difference and a strong correlation (r²:0.99) between Cr(Ⅵ) concentrations measured by the Shin & Paik's Method and an impinger method (p>0.05). However, Cr(Ⅵ) concentrations determined by Shin & Paik's Method were significant1y different from those by the NIOSH/EPA Method (p<0.05) or the OSHA method (p<0.05). The Cr(Ⅵ) concentrations of Shin & Paik's Method were significantly higher than those of the NIOSH/EPA Method or the OSHA method. This result indicated that the Shin & Paik's Method may prevent Cr(Ⅵ) losses caused by reduction and give more reliable results of airborne Cr(Ⅵ) concentrations in work environments.