• Molecular & Cellular Toxicology
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• v.3 no.4
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• pp.215-221
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• 2007

Neuronal cell toxicity induced by decreased nitric oxide (NO) production may be caused by modulation of constitutive neuronal NO synthase (nNOS). We used lead acetate ($Pb^{2+}$) to modulate physiological NO release and the related pathways of protein kinases like PKC, CaM-KII, and PKA in CATH.a cells, a dopaminergic cell line that has constitutive nNOS activity. In the cells treated with $Pb^{2+}$, cell viability and modulation (phosphorylation) levels of nNOS were determined by MTT assay and Western blot analysis, respectively. nNOS reductase activity (cytochrome c) was also assessed to compare the phosphorylation site-specific nNOS activity. nNOS activity was also determined by NADPH consumption rates. $Pb^{2+}$ treatment alone increased the phosphorylation of nNOS with decreased reductase activity. The phosphorylation levels increased markedly with decreased nNOS reductase activity, when $Pb^{2+}$ was combined with inhibitors for two (PKC and CaM-KII) or three (PKA, PKC and CaM-KII) protein kinases. Interestingly, when the cells were exposed to $Pb^{2+}$ plus PKC or CaM-KII inhibitor, the nNOS was phosphorylated strongly with the lowest activity. However, the levels of phosphorylated nNOS following $Pb^{2+}$ treatment decreased significantly after combined treatment with the PKA inhibitor, and $Pb^{2+}$-induced suppression of reductase activity did not occur. These results demonstrate that physiological NO release in the neuronal cells exposed to $Pb^{2+}$ can be decreased by PKA-mediated nNOS phosphorylation that may be caused by interactions with PKC and/or CaM-KII.

• The Journal of Korean Association of Computer Education
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• v.19 no.4
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• pp.45-58
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• 2016

This paper tried to analyze cases of one year team-based project of gifted students who spent two year programs in a math-IT integrated class as part of formative evaluation and extracted the factors associated with future enhancement for the program. The researcher as an advisory professor tried to guide the students as minimally as possible considering their levels of IT skills so that they could self-directedly perform the IT-fused project on a team basis. The data collection included documents, annual report, photos, video, artifacts and interview data with the students for the whole team project carried out between February and December, 2015. The overall pattern of the project activities has been stabilized in the middle of the course compared to the initial stages of brainstorming and design work even though the students revealed the differences of their programming skills and preferences toward the project theme. Their project outcomes were qualitatively analyzed according to the 9 steps of R&E model and has shown individual differences according to low, middle and high level. At the end, the analysis suggested several implications for further improvement of the mentorship program.

• The Journal of Korean Society for School & Community Health Education
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• v.25 no.3
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• pp.17-37
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• 2024

Objectives: The purpose of this study was to explore school counselors' experiences with the Support Project for School Visits by Mental Health Experts. Methods: Focus Group Interview were conducted with 13 school counselors to explore the experience of Support Project for School Visits by Mental Health Experts. Reseults: The effectiveness of the project were identified as "Changing school and parental perceptions and attitudes", "Strengthening the capacity of school counselors", "Improving school mental health response capabilities". The facilitating factors and barriers to the effectiveness of the program were identified. And the following improvements were suggested. Conclusion: Based on this, suggestions were made for differentiating the mental health professional school visitation support project and the role of mental health professionals in revitalizing the project.

• Journal of Fisheries and Marine Sciences Education
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• v.28 no.4
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• pp.1114-1132
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• 2016

The objective of present study is to compare the similarities and differences between the two projects and extract implications for the improvement of higher education quality in other countries. To meet this objective, The study compared and analyzed "The Project of Higher Education Quality Development and Educational Reform of China" and "Technical Education Quality Improvement Programme" of government of India. by using the method of literature research, contents analysis and comparison analysis, this paper employed multi-source materials to examine background and targets, measures and outcomes, deficiencies and future direction of these two projects, and compared the similarities and diversities on each matters by utilizing secondary data from national surveys, government statistics, databases, and third-party agencies. The findings led us to suggest that the well-coordinated and standardized administrative system is a primary guarantee for ensuring the smooth implementation of the programme, and sharing educational resources among higher education institutions is an effective means for promoting their joint development. The improvement of higher education quality relies on the reform of the entire higher education system and the efficient networking between higher education institutions.

• Architectural research
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• v.11 no.2
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• pp.35-42
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• 2009

Recently, intensive urban redevelopment concentrated on new towns has reduced the number of settled population, and weakened various functions such as commercial, culture, education and welfare in old towns, and made the stagnation and declination of the entire or some parts of old towns. Urban regeneration project means renewing cities' functions in terms of physical, environmental, social, cultural, industrial and economic aspects or revitalizing the existing functions through improvement project in the entire or part of a city, which is now drawing keen attention from the public. However, urban regeneration project is huge in scale, needs long construction period and various complex facilities, and also characterized by complicated relations with many stakeholders. Due to such characteristics, there are many risks in the project. Therefore, systematic risk management is absolutely necessary to efficiently manage various risk factors inherent in urban regeneration project. The purpose of this research proposes a basic model to establish risk management plan and work process in order to help project participants to perform risk management more systematically and rationally in the development phase of urban regeneration project.

• The Korean Journal of Community Living Science
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• v.14 no.3
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• pp.3-11
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• 2003

The objectives of the study were to analyze the current conditions of the“NONGCHON ILGAM GATCI”project (an income generating project for rural areas) and to suggest possible improvements. Among the 567 business which have been supported by the project, implemented in 1990 by the Department of Rural-Home-Improvement of the Rural Development Administration, 361 (63.7%) can be categorized as being in the self-supporting stage. Another 126 (22.2%) can be said to be in the incubation stage. Data for the case study was collected from 20 project sites. The“NONGCHON ILGAM GATCI”project has been progressing successfully when compared with other rural development projects. However, there are still some problems. Among the problems are the lack of a business mindset and management abilities in individuals, and the fact that the businesses and their products are not well hewn on the market. To remedy these problems, education toward improving business and management skills, a unified public relations system, and institutional support from the government are greatly needed.

• The Journal of Economics, Marketing and Management
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• v.12 no.4
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• pp.77-85
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• 2024

Purpose: The purpose of this study was to investigate the effect of organizational management competency according to the personality types of Project Management Office (PMO) leader on the Project Performance and to further verify the mediating effect of positive psychological capital. Research design, data and methodology: The collected data of this study was statistically checked using SPSS 25.0 program and AMOS 25.0, and the result analysis and hypothesis verification were conducted by applying demographic frequency analysis, descriptive statistics, model fit, reliability, validity, correlation analysis, and structural equation modeling. Results: The personality types of the project Management Office (PMO) leader had an effect on positive psychological capital and positive psychological capital had a mediating effect between project performance. Conclusion: Since the essence of project Management Office (PMO) leadership for organizational management exists in a smooth mutual relationship between the leader and the project members, it is necessary to expand the leadership education that strengthens the positive psychological capital and to manage the communication ability of the PMO leader continuously in terms of personnel management practice.

• Journal of The Korean Association of Information Education
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• v.14 no.1
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• pp.79-87
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• 2010

To support the expansion of diversity for schooling and make a plan for systematic robot education Ministry of Knowledge Economy did Pilot Project of Hands-on Robot at 68 Elementary Schools after building up the supporting system for teachers to practically use robots such as training course with Hands-on Robot. According to this, this paper will be shown about the analysis results of preliminary data about next expansion project of Hands-on Robot through analyzing the current status of Pilot Project of Hands-on Robot at Elementary After-School. For this, status of offered lesson and usage of teaching aids and materials, the number of regular/part-time teachers, students' satisfaction and so on at schools which are listed for the Pilot Project. The results show that at most of elementary schools students' creativity and interests about robots was increased and they tried to take the classes actively with high concentration. In spite of these positives, improvement needs for textbooks were also ascertained, therefore proper textbooks for student and teaching aids to bring on variable activities of students shall be based on additionally for the success.

• Hwankyungkyoyuk
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• v.19 no.2 s.30
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• pp.147-158
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• 2006

The purpose of this study is to closely examine the changes of food and drink waste amounts, and student's environmental literacy. By using creative methods, discretional activity classes, and programs to dispose of food and drink waste from students schoolmeals, and at the same time conduct and teach environmental education classes. To achieve this, students were given ten class lessons in creative discretional activities. Students were given flowerpots containing earthworms and were instructed to raise them, using food and drink waste from school meals. Four classes who were participating in project were examined for changes from March to July 2005. As a result the environmental education classes through creative discretional activities didn't have any significant influence on the students environmental literacy. However it did make a difference to the student's in-terms of their ecological knowledge. The project using earthworms to dispose of food and waste drink showed a decrease of 15% of the amount of waste food and drink from school meals. Moreover student's environmental literacy had been significantly influenced about environmental sensibility, value and causes. Through this study I found that the project using earthworms to dispose of waste food and drink, and creative discretional activities as a lesson decreased the amount of food and drink waste at the school, and the changes to students concerns and understanding about environmental sensibility, value and the various causes of waste food and drink.

• Journal of Digital Convergence
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• v.18 no.8
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• pp.485-492
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• 2020

The purpose of this study is to find the mediative effects of social capital in the effective path of the satisfaction of education welfare project on school adaptation, and to find out the path difference between elementary and middle school students. We surveyed 153 elementary and 124 middle school students in Gangwondo. These data analyzed by multiple group analysis of structural equation. Elementary school students realized that social capital has an effect on school adaptation. Middle school students realized that the satisfaction of education welfare project has an effect on school adaptation, and social capital has an effect on school adaptation. There is not a mediative effect of school capital on the effect of the satisfaction on school adaptation for two groups. Based on these results, implications to improve the school adaptation for elementary and middle school students were suggested.