• Journal of Construction Engineering and Project Management
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• 제3권2호
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• pp.21-34
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• 2013

Various risk factors affect construction projects. Due to the uncertainties created by risk factors, actual activity durations frequently deviate from the estimated durations in either favorable or adverse direction. For this reason, evaluation of schedule uncertainty is required to make decisions accurately when managing construction projects. In this regard, this paper presents a new computer simulation model - the Repetitive Schedule Risk Analysis Model (RSRAM) - to evaluate unit-based repetitive building project schedules under uncertainty when activity durations and risk factors are correlated. The proposed model utilizes Monte Carlo Simulation and a Critical Path Method based repetitive scheduling procedure. This new procedure concurrently provides the utilization of resources without interruption and the maintenance of network logic through successive units. Furthermore, it enables assigning variable production rates to the activities from one unit to another and any kind of relationship type with or without lag time. Details of the model are described and an example application is presented. The findings show that the model produces realistic results regarding the extent of uncertainty inherent in the schedule.

• Bulletin of the Korean Chemical Society
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• 제29권9호
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• pp.1723-1728
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• 2008

An efficient synthetic route for carbocyclic versions of stavudine analogues and their evaluation on antiviral activity are described. The construction of an ethynylated quaternary carbon at the 4'-position of carbocyclic nucleosides was accomplished using Claisen rearrangement of 11 and ring-closing metathesis (RCM) of dienyne 14 as key transformations. An antiviral evaluation of the synthesized compounds, 20, 21, 22, and 25 against HIV-1, HSV-1, HSV-2, and HCMV showed that only the guanine analogue 25 is moderately active against HIV-1 in the MT-4 cell line ($EC_{50}$ = 11.91 $\mu$mol).

• 약학회지
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• 제51권2호
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• pp.103-107
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• 2007

In these study novel 1,4-disubstituted carbocyclic nucleoside analogues were synthesized as potential antiviral agents. The coupling reaction of the alcohol 8${\alpha}$ with natural bases using Mitsunobu reaction afforded the target nucleosides 13, 14. The synthesized compounds were evaluated for their antiviral activity against various viruses such as HIV-1, HSV-1, HSV-2 and HCMV. Cytosine derivative 13 exhibited moderate antiviral activity against HIV-1 (EC$_{50}$=16.4 ${\mu}$M).

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2007년도 정기학술발표대회 논문집
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• pp.947-952
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• 2007

건설 프로젝트는 개별공종으로 구성되며 개별공종은 개별작업으로 이루어지므로 개별작업의 성과는 프로젝트 성과에 영향을 주는 최소단위이다. 그러므로 개별 작업에 대한 체계적인 성과측정 및 평가가 이루어져야 한다. 그러나 기존 성과측정은 기업 또는 프로젝트 단위에서 성과측정만 주로 이루어지고 있고 개별 작업을 측정하는 국내 ${\cdot}$ 외 공사관리체계에서는 지표에 대한 분석 및 활용이 미흡하다. 따라서 본 연구에서는 개별 작업을 측정하기 위해 PPC(Percent Plan Complete)를 성과지표로 선정하였고 통계적 분석 방법을 통해 목표지향적인 작업관리와 지속적인 개선이 이루어 질 수 있도록 지표의 분석 방법을 제안하였다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1994년도 춘계학술대회 and 제3회 신약개발 연구발표회
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• pp.145-152
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• 1994

• Journal of information and communication convergence engineering
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• 제7권4호
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• pp.570-575
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• 2009

This paper describes an implementation of project-based learning in routing design course. The total students who enrolled in the class were 48 and were divided into groups of 3~4 students. At the beginning of the course, a survey was conducted to check the student's level of back ground knowledge acquired from the prerequisite courses. At the end of the curse, we also conducted a survey to evaluate the effect of project-based learning. According to the end of course survey, the course was helpful to identify the problems to solve by themselves, to develop the problem solving ability, and to understand the global picture of the subject by integrating knowledge of each chapter into a project. The survey also shows that students recognized the importance of the teamwork skill throughout the project activity.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 춘계학술대회 논문집
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• pp.1505-1510
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• 2007

When developers conduct a systems engineering approach the first problems that they will be faced are how to define and analyze the operational concept. In case of practical use project of MAGLEV train, those problems are also important since end products of practical use project must be assured for commercial service level. Lack of domestic developer's experience on systems engineering activity can cause a confusion a progress of the project. This study will propose a guide to establish an operational concept of project to develop or construct urban transit system.

• 경영과학
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• 제12권3호
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• pp.45-60
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• 1995

This study examines a normative model of project management systems, PPMS, to provide information for directing R&D activity in order to increase R&D productivity. The PPMS (Project Process Management System) is a disciplined and systematic framework to manage R&D projects effectively and efficiently under the assumption of a strategic decision making and long-range planning. The purpose of PPMS is to provide for the management of research organization at different levels an effective management tool; first, for the planning system which deals with rational selection and authorization of R&D projects, second, for the control system which concerns monitoring and controlling the execution of R&D projects, and finally, for the evaluation system which attains evaluation of the performance results of R&D projects and determination of the necessary follow-up. A view for the future development of project management within the context of a project-performing organization is also elaborated to exhibit the progress and phase description of the project management system.

• Parasites, Hosts and Diseases
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• 제44권4호
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• pp.373-378
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• 2006

To evaluate whether iron concentration in TYM medium influence on hydrogenosomal enzyme gene expression and hydrogenosomal membrane potential of Trichomonas vaginalis, trophozoites were cultivated in iron-depleted, normal and iron-supplemented TYM media. The mRNA of hydrogenosomal enzymes, such as pyruvate ferredoxin oxidoreductase (PFOR), hydrogenase, ferredoxin and malic enzyme, was increased with iron concentrations in T. vaginalis culture media, measured by RT-PCR. Hydrogenosomal membrane potentials measured with $DiOC_6$ also showed similar tendency, e.g. T. vaginalis cultivated in iron-depleted and iron-supplemented media for 3 days showed a significantly reduced and enhanced hydrogenosomal membrane potential compared with that of normal TYM media, respectively. Therefore, it is suggested that iron may regulate hydrogenosomal activity through hydrogenosomal enzyme expression and hydrogenosomal membrane potential.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2000년도 춘계 학술대회 및 국제 감성공학 심포지움 논문집 Proceeding of the 2000 Spring Conference of KOSES and International Sensibility Ergonomics Symposium
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• pp.389-393
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• 2000

Ethnography, a major research method in Anthropology, has been recently applied in human-centered design research. Since ethnography has empirical, naturalistic, holistic and eclectic characteristics, it is needed a guideline to apply ethnography into design research in accordance with a characteristic of project. Design project in which ethnography is applied can be categorized by two criteria; degree of newness of project goal(existing user-potential user) and limitedness of worksite(site-oriented-work-oriented). Among work-site activities, technology in use, and user group culture, it should be decided which content to content to focus more than others and thus what kinds of research techniques to apply in the ethnographic research.Case study was to design an interior of a Korean express train. This project is site-oriented and has an existing-potential users. Therefore, video ethnography was effectively applied to obtain chronological data of activity potential users. Therefore, video ethnography was effectively applied to obtain chronological data of activity flow, and participant observation was applied to obtain statistical data of synchronous activities. Case study shows a concrete process example of how to apply ethnography into design research.