• Asian Pacific Journal of Cancer Prevention
• /
• 제13권5호
• /
• pp.2021-2023
• /
• 2012

Purpose: DBC2 (Deleted in Breast Cancer 2) has been indicated to be a tumor suppressor gene in many cancers including lung adenocarcinoma recently. In this study, we aimed to explore the expression status of DBC2 in different subtypes of lung adenocarcinoma (from pre-invasive to invasive lesions), and to determine if downregulation becomes more marked with pathological progression. Methods: We collected 172 tissue samples from different subtypes of lung adenocarcinoma and investigated the frequency of DBC2 loss by immunohistochemistry. Results: Our results indicated that DBC2 downregulation is a relatively frequent event in lung adenocarcinoma. Moreover, as the adenocarcinoma subtype turns to be more invasive, more downregulation occurred. Conclusion: We conclude that loss of DBC2 expression is an early and progressive event in the pathogenesis of lung adenocarcinoma. Positive DBC2 immunohistochemistry may become an indicator for early stage disease and better prognosis of lung adenocarcinomas.

• 한국공작기계학회:학술대회논문집
• /
• 한국공작기계학회 2004년도 춘계학술대회 논문집
• /
• pp.149-154
• /
• 2004

In the semiconductor and the optical industry a new transport system which can replace the conventional sliding system is required. These systems are driven by magnetic field and conveyer belt. The magnetic field damages semiconductor and contact force scratches the optical lens. The ultrasonic wave driven system can solve these problem. In this paper, the relationship of transporting speed according to the change of flexural beam shape and the effect of transporting speed according to the change of weight and amplification voltage are verified. The vibration behavior of flexural beam in the ultrasonic transport system is experimented using Laser Scanning Vibrometer.

• 한국공작기계학회:학술대회논문집
• /
• 한국공작기계학회 2003년도 추계학술대회
• /
• pp.155-158
• /
• 2003

In the semiconductor and the optical industry a new transport system which can replace the conventional sliding system is required. These systems are driven by magnetic field and conveyer belt. The magnetic field damages semiconductor and contact force scratches the optical lens. The ultrasonic wave driven system can solve these problem. In this paper, the vibration behavior of flexural beam in the ultrasonic transport system is verified using Laser Scanning Vibrometer. The experiments for verifying vibration are performed in three conditions such as in the maximum transport speed, in the zero speed, and in the change of transport direction.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2003년도 추계학술대회논문집
• /
• pp.841-844
• /
• 2003

In the semiconductor and the optical industry a new transport system which can replace the conventional sliding system is required. These systems are driven by magnetic field and conveyer belt. The magnetic field damages semiconductor and contact force scratches the optical lens. The ultrasonic wave driven system can solve these problem. In this paper, the vibration behavior of flexural beam in the ultrasonic transport system is verified using Laser Scanning Vibrometer. The experiments for verifying vibration are performed in three conditions such as in the maximum transport speed, in the zero speed, and in the change of transport direction.

• Smart Structures and Systems
• /
• 제5권6호
• /
• pp.633-644
• /
• 2009

A simple method has been developed to detect the bonding condition of active fiber composites (AFC) adhered to the surface of a host structure. Large deformation actuating capability is one of important features of AFC. Edge delamination in adhesive layer due to large interfacial shear stress at the free edge is typically resulted from axial strain mismatch between bonded materials. AFC patch possesses very good flexibility and toughness. When an AFC patch is partially delaminated from host structure, there remains sensing capability in the debonded part. The debonding size can be determined through axial resonance measured by the interdigitated electrodes symmetrically aligned on opposite surfaces of the patch. The electrical impedance and modal response of the AFC patch in part adhered to an aluminum plate were investigated in a broad frequency range. Debonding ratio of the AFC patch is in inverse proportion to the resonant frequency of the fundamental mode. Feasibility of in-situ detecting the progressive delamination between AFC patch and host plate is demonstrated.

• 한국소음진동공학회논문집
• /
• 제19권4호
• /
• pp.386-392
• /
• 2009

This paper reports on the research which investigates acoustic signals acquired in progressive compressing, hole blanking, shearing and burr compacting process. The work piece is the head pin of the electric connector, whose raw material is the preformed steel bar. An acoustic sensor was set on the bed of hydraulic press. Because the acquired signals include the dynamic characteristics generated for all the processes, it is required to investigate signal characteristics corresponding to unit process. The corresponding dynamic characteristics to the respective process were first studied by analyzing the signals respectively acquired from compressing, blanking and compacting process. The combined signals were then periodically analyzed from the grinding to the grinding in the sound frequency domain and in the ultrasonic wave. The frequency of around 9 kHz in the sound frequency domain was much correlated to the tool wear. The characteristic frequency in the acoustic emission domain between 100 kHz and 500 kHz was not only clearly observed right after tool grinding but its amplitude was also related to the wear. The frequency amplitudes of 160 kHz and 320 kHz were big enough to be classified by the noise. The noise amplitudes are getting bigger, and their energy was much bigger as coming to the next regrinding. The signal analysis was based on the real time data and its frequency spectrum by Fourier Transform. As a result, the acousto-ultrasonic signals were much related to the tool wear progression.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2005년도 춘계학술대회 논문집
• /
• pp.1332-1336
• /
• 2005

It could make the LIghtweight Piezoelectric Composite Actuator (LIPCA) damageable by the cyclic large deformation. If the progressive microvoid coalescence of LIPCA interlaminar took place, the decrease of the stiffness and the weakness of stress transmission and fiber bridging effect would make the fatigue characteristics worse suddenly. Therefore, it is required to study the variation of fatigue behavior and interlaminar condition in LIPCA under resonant frequencies. These studies such as the changeable fatigue phase and interlaminar behavior of LIPCA affected by the resonant frequencies should be carried out due to the strong anisotropy of CFRP layer. Hence, these studies are as follows. 1) The residual stresses distribution of interlaminar in LIPCA using the Classical Lamination Theory (CLT). 2) Comparative analysis of interlaminar behavior for the intact LIPCA versus LIPCA containing an artificial delamination during resonant frequency.

• 한국해양공학회지
• /
• 제10권4호
• /
• pp.10-16
• /
• 1996

The vibration due to progressive ocean waves is analyzed for a typical footing-type offshore airport platform. The platform is modelled as a spring-supported Euler beam and buoyancy change due to wave is considered as excitation force, under the assumption that the wave propagates without distortion by the structure. The results show that the natural frequencies of this structure are distributed very closely and are little affected by boundary conditions and that the response charateristics due to ocean waves are quite different according to the wave frequency. In this study, the wave frequencies are divided into three regions; the resonance region at which the response is governed by the resonance between the natural mode at the wave frequency and the corresponding modal component of the wave excitation force, the bending governed region at which the response is governed by the bending stiffness, and the spring (buoyancy) governed region at which the response is governed by the spring constant ahd therefore is same as the incident wave form.

• 대한조선학회지
• /
• 제18권1호
• /
• pp.19-27
• /
• 1981

The surge motion of a freely-floating sphere in a regular wave is studied within the framework of a linear potential theory. The fluid is assumed to be perfect and only the steady-state harmonic motion in a water of infinite depth is considered. A velocity potential describing the fluid motion is decomposed into three parts; the incident wave potential, the diffraction potential and the radiation potential. In this paper the diffraction potential and the radiation potential are analysed by using multipole expansion method. Upon calculating pressures over the immersed surface of the sphere, the hydrodynamic forces are evaluated in terms of Froude-Krylov, diffraction, added mass and damping forces as functions of the frequency of the incident wave. Finally the frequency dependence of two pertinent parameters, the amplitude ratio and the phase lag between the motion of the sphere and that of the incident wave is derived from the equation of motion. As for numerical results the general tendency of the present calculation shows good agreement with Kim's work who also treated this problem utilizing the Green's function method.

• 한국건축시공학회지
• /
• 제9권2호
• /
• pp.47-54
• /
• 2009

Integrated construction site management using RFID(Radio Frequency Identification) and facility maintenance introducing USN (Ubiquitous Sensor Network) have been widely used in the mega construction project sites. But, the validation on performance of RFID systems after introducing those has not been carried out. Given that the use of RFID systems have been increased, the construction industry as well as other industries needs the evaluation of the RFID system. By regarding the necessities for evaluation, a research to the satisfaction and importance evaluation of RFID system from the end-users' view point for site management was conducted. Satisfaction-importance matrix of satisfaction standards and importance standards was created (organised) according to the analysis result of a survey, proposed improvement methods and analysis about the items presented by each region like areas of sustainable maintenance, maintenance, progressive improvement and priority improvement. The result would contribute to enhance the utilization of system and its performance.