• Macromolecular Research
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• 제14권2호
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• pp.173-178
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• 2006

Poly(3-(2-hydroxyethyl)thiophene) (P3HET) was synthesized using oxidative coupling polymerization that involved the protecting and deprotecting of hydroxyl groups but not the chlorine substitution or oxidative decomposition of the hydroxyl groups. The resulting P3HET exhibited good solubility in aprotic solvents, in contrast to the insoluble polymer product synthesized directly from the monomer, 3-(2-hydroxyethyl)thiophene (3HET). P3HET had low conductivity due to the strong hydrogen bonding of its hydroxyl groups. The ester-functionalized poly(3-(2-acetoxyethyl)thiophene) and poly(3-(4-pentylbenzoateethyl)thiophene) were also prepared with reasonably high molecular weights in order to examine how this functionalization modified the physical and chemical properties of P3HET. These polymers exhibited better solubility in common solvents and higher conductivity than P3HET. All these polymers exhibited bathochromic shifts of their film state absorption maxima with respect to those found in the UV-visible spectra of their solution phases. The extent of the bathochromic shift was found to vary with the lengths of the side chains of the ester-functionalized polymers.

• Journal of Microbiology and Biotechnology
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• 제23권11호
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• pp.1569-1576
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• 2013

In mice, supplementation of t10,c12 conjugated linoleic acid (CLA) increases liver mass and hepatic steatosis via increasing uptake of fatty acids released from adipose tissues. However, the effects of t10,c12 CLA on hepatic lipid synthesis and the associated mechanisms are largely unknown. Thus, we tested the hypothesis that gut microbiota-producing t10,c12 CLA would induce de novo lipogenesis and triglyceride (TG) synthesis in HepG2 cells, promoting lipid accumulation. It was found that treatment with t10,c12 CLA ($100{\mu}M$) for 72 h increased neutral lipid accumulation via enhanced incorporation of acetate, palmitate, oleate, and 2-deoxyglucose into TG. Furthermore, treatment with t10,c12 CLA led to increased mRNA expression and protein levels of lipogenic genes including SREBP1, ACC1, FASN, ELOVL6, GPAT1, and DGAT1, presenting potential mechanisms by which CLA may increase lipid deposition. Most strikingly, t10,c12 CLA treatment for 3 h increased phosphorylation of mTOR, S6K, and S6. Taken together, gut microbiota-producing t10,c12 CLA activates hepatic de novo lipogenesis and TG synthesis through activation of the mTOR/SREBP1 pathway, with consequent lipid accumulation in HepG2 cells.

• Journal of Microbiology and Biotechnology
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• 제22권10호
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• pp.1446-1451
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• 2012

Levodopa or L-3,4-dihydroxyphenylalanine (L-DOPA) is the precursor of the neurotransmitter dopamine. L-DOPA is a famous treatment for Parkinson's disease symptoms. In this study, electroenzymatic synthesis of L-DOPA was performed in a three-electrode cell, comprising a Ag/AgCl reference electrode, a platinum wire auxiliary electrode, and a glassy carbon working electrode. L-DOPA had an oxidation peak at 376 mV and a reduction peak at -550 mV. The optimum conditions of pH, temperature, and amount of free tyrosinase enzyme were pH 7, $30^{\circ}C$, and 250 IU, respectively. The kinetic constant of the free tyrosinase enzyme was found for both cresolase and catacholase activity to be 0.25 and 0.4 mM, respectively. A cyclic voltammogram was used to investigate the electron transfer rate constant. The mean heterogeneous electron transfer rate ($k_e$) was $5.8{\times}10^{-4}$ cm/s. The results suggest that the electroenzymatic method could be an alternative way to produce L-DOPA without the use of a reducing agent such as ascorbic acid.

• 한국생산제조학회지
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• 제5권4호
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• pp.82-89
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• 1996

In this study, to choose the drilling m/c with analysis model for dynamic design of machine tool strctures, are used substucture syntheis method for reduction to degrees of freedom of dynamic model and analysis evaluation of substructures The dynamic factors of substurctures are examined by substructure synthesis method. And that dynamic design of structures for energy balancing are performed. The computer program for calculated of the dynamic and energy distribution analysis was developed. Result of numerical analysis by developed program obtained to conclusion as following. The design of machine tool structures by dynamic avoid the resonances, and are known to considered based on the energy balancing. These methods can be used effectively for the performance evaluation, design modification and improvement of dynamic performance evaluation, design modification and improvement of dynamic performance of machine tools.

• Advances in materials Research
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• 제3권4호
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• pp.199-216
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• 2014

Noble metal nanoparticles (mainly Au, Ag, Pt and Pd) have received enormous attention owing to their unique and fascinating properties. In the past decades, many researchers have reported methods to control the shape and the size of these noble metal nanoparticles. They have consequently demonstrated outstanding and tunable properties and thus enabled a variety of applications such as surface plasmonics, photonics, diagnostics, sensing, energy storage and catalysis. This paper focuses on the recent advances in the solution-phase synthesis of shape- and size-controlled noble metal nanoparticles. The strategies and protocols for the synthesis of the noble metal nanoparticles are introduced with discussion of growth mechanisms and important parameters, to present the general criteria needed for producing desirable shapes and sizes. This paper reviews their remarkable properties as well as their shape- and size- dependence providing insights on the manipulation of shape and size of metal nanoparticles, necessary for appropriate applications. Finally, several applications using the shape- and size-controlled noble metal nanoparticles are highlighted.

• Journal of Advanced Marine Engineering and Technology
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• 제24권2호
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• pp.97-103
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• 2000

Gas pulsation discharged from the cylinder causes noise in the rotary compressor. Mufflers are usually used to reduce the noise generated by the gas pulsation. The muffler has been designed to maximize the acoustic transmission loss of the muffler. The gas which went through muffler is discharged to the cavity in compressor. Thus, the acoustic characteristics of cavity should be taken into account in muffler design. In this paper, the program for the acoustic substructure synthesis method is developed. This program can be interfaced with SYSNOISE which is commercial acoustic package. Several types of mufflers designed to have the better acoustic performance are suggested in this work and compared with the existing commerical muffler in the compressor. The acoustic performance of mufflers taking into consideration of the cavity in the compressor is also carried out by the developed program.

• 정보과학회 논문지
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• 제44권9호
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• pp.986-991
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• 2017

본 논문에서는 주어진 입 출력 예제로부터 명령형 프로그램을 합성하는 방법을 제시한다. 프로그램 합성기의 입력으로 (1) 입 출력 예제, (2) 불완전한 프로그램, (3) 사용될 변수 및 정수가 주어지면, 합성기는 주어진 입 출력 예제를 모두 만족하는 완성된 프로그램을 출력한다. 기본 알고리즘은 정답 프로그램을 찾을 때까지, 가능한 모든 프로그램을 나열하는 것이다(enumerative search). 이 경우 탐색 공간이 매우 크므로 오랜 시간이 걸린다는 문제점이 있다. 시간을 효과적으로 단축하기 위한 우리의 방법은, 코드 최적화 기법을 이용해 문법은 다르지만 같은 의미의 프로그램들을 확인함으로써, 불필요한 중복탐색을 피하는 것이다. 20개의 입문자 교육용 프로그래밍 문제들을 대상으로 합성 알고리즘 성능을 평가한 결과, 우리의 방법이 기본 탐색 알고리즘의 성능을 약 10배 향상시킴을 확인하였다.

• Journal of Advanced Marine Engineering and Technology
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• 제38권6호
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• pp.666-673
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• 2014

유한요소법은 구조해석과 진동해석을 하는데 필수적인 수단이 된지 이미 오래다. 그러나 범용 프로그램은 그 가격이 비싸고 사용 방법 또한 간단하지 않다. 여기에서는 Matlab을 이용하여 가장 사용하기 쉽고 범용성이 높고 편리한 유한요소해석법을 개발하였다. 그 편리성과 계산 효율을 높이기 위하여 구조물을 해석하기 쉬운 몇 개의 부분 구조로 나누어 해석하는 기법을 사용하였다. 각 부분구조 별로 모드해석을 수행한 뒤 결합하여 전체 구조물의 진동해석을 하고, 주파수응답함수를 그리고, 모드 형상을 출력하는 과정을 최소한의 입력으로 수행하는 프로그램을 개발하였다. 개발한 프로그램의 신뢰도를 확인하기 위하여 평판 구조물에 적용하여서 실험과 해석 결과를 비교하였고, 매우 좋은 결과를 얻었다. 이 프로그램 개발의 더 큰 목적은 개인에게 공개하여 쉽게 구조해석과 진동해석을 하게 하는데 있다.

• Journal of Microbiology and Biotechnology
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• 제11권2호
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• pp.329-332
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• 2001

It has been known that, in enzymatic synthesis of cephalexin, the conversion yield was reduced by high loading of ampicillin acylase. In order to elucidate this phenomena, pH-controlled synthesis of cephalexin was examined using a purified Acetobacter turbidans acylase. When the pH of the reaction mixture was maintained at $6.20{\pm}0.04$, the reduction of the maximal conversion rate was not observed even with high enzyme loading. The kinetic parameters also suggest that pH drop during the enzymatic synthesis of cephalexin was mainly attributed to the rapid hydrolysis of D-${\alpha}$-phenylglycine methyl ester to D-${\alpha}$-phenylglycine, rather than the disappearance of 7-amino-3-deacetoxycephalosporanic acid for cephalexin synthesis. At higher molar ratio of two substrates, [D-${\alpha}$-phenylglycine methyl ester]/[7-amino-3-deacetoxycephalosporanic acid], the conversion rate was also elevated under pH-controlled enzymatic synthesis, which implies that the main reason for the pH drop is due to the production of D-${\alpha}$-phenylglycine methyl easter, the effect of a water-methanol cosolvent system on the ester, the effect of a water-methanol cosolvent system on the conversion profile was also examined. Even the though the conversion rate was increased in 10% methanol solution, a higher than 16% methanol in the reaction mixture caused an inactivation of enzyme.

• 산업공학
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• 제24권2호
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• pp.156-163
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• 2011

The radiopharmaceutical synthesis for PET (positron emission tomography) is composed of chemical reactions using automated synthetical equipment. Due to the radioactive material, the automated equipment is being frequently developed to replace human operators who conduct dangerous, repetitive and dexterous operations. As to operation, the manipulating program is commonly coded using the spread sheet while the whole actuators are mapped in every step. The process map (program) is changed according to such parameters as temperature of reactor, keeping time, mixture sequence and amount of reagent. In cases of customizing the automated synthetical equipment or developing the new radiopharmaceuticals, lots of experiments should be conducted and the programming mistake is not allowed as it can lead abnormal control of the equipment to leak the radioactive materials. The exact process map has depended on trial and error manner. Thus, this study developed the methodology to tabulate the synthetical process to convert the process map automatically while the synthetical module formation is represented by a network model. The proposed method is validated using the actual radiopharmaceutical synthetical procedure.