• The Bulletin of The Korean Astronomical Society
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• v.44 no.1
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• pp.38.2-38.2
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• 2019

S0 galaxies are mostly known to be formed in dense environments from spiral progenitors. Recently, however, a new formation scenario has been suggested that field S0s can be formed from elliptical progenitors. The Sombrero galaxy (M104, NGC 4594) is a massive disk galaxy located in the field environment, and its morphological type has been controversial from Sa to E. Thus, it is an ideal target to test the new scenario. We trace the giant halo of M104 with globular clusters to test this scenario. From the wide images obtained with CFHT/MegaCam, we find a large number of globular clusters in this galaxy. We also confirm their membership by measuring the radial velocities from the spectra obtained with MMT/Hectospec. The color distribution of these globular clusters is bimodal, and blue (metal-poor) globular clusters are more spatially widely spread than red (metal-rich) globular clusters. This indicates that M104 hosts a giant metal-poor halo as well as an inner metal-rich halo. Combining this result with the fact that M104 is unusually massive and brighter than other spiral galaxies, we infer that M104 was indeed a massive elliptical galaxy that had formed a metal-rich halo by gas-rich mergers and a metal-poor halo by gas-poor mergers. In addition, we find young star clusters around the disk of M104, which shows that the disk formed after the spheroidal halos had formed. In conclusion, we suggest that M104 was originally a massive elliptical galaxy and was transformed to a lenticular galaxy by acquiring its disk later.

• Molecules and Cells
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• v.46 no.10
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• pp.611-626
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• 2023

Acute myeloid leukemia (AML) is a heterogeneous disease caused by distinctive mutations in individual patients; therefore, each patient may display different cell-type compositions. Although most patients with AML achieve complete remission (CR) through intensive chemotherapy, the likelihood of relapse remains high. Several studies have attempted to characterize the genetic and cellular heterogeneity of AML; however, our understanding of the cellular heterogeneity of AML remains limited. In this study, we performed single-cell RNA sequencing (scRNAseq) of bone marrow-derived mononuclear cells obtained from same patients at different AML stages (diagnosis, CR, and relapse). We found that hematopoietic stem cells (HSCs) at diagnosis were abnormal compared to normal HSCs. By improving the detection of the DNMT3A R882 mutation with targeted scRNAseq, we identified that DNMT3A-mutant cells that mainly remained were granulocyte-monocyte progenitors (GMPs) or lymphoid-primed multipotential progenitors (LMPPs) from CR to relapse and that DNMT3A-mutant cells have gene signatures related to AML and leukemic cells. Copy number variation analysis at the single-cell level indicated that the cell type that possesses DNMT3A mutations is an important factor in AML relapse and that GMP and LMPP cells can affect relapse in patients with AML. This study advances our understanding of the role of DNMT3A in AML relapse and our approach can be applied to predict treatment outcomes.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.56.1-56.1
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• 2015

We are at the initial performance-verification phase of our KMTNet Supernova Project (KSP) using the three wide-field telescopes of the KMTNet in the southern hemisphere. The primary science objectives of KSP, which take advantage of its unique 24-hour continuous sky coverage, are to study early (i.e., within a few hours from explosion) and rare/peculiar (e.g. fast decay) supernovae (SNe), SN progenitors, explosion mechanisms, as well as other exotic optical transients. We present the initial status/results of the program, along with the program strategy, science objectives, target fields, and future plan. While the target field selection will be made based on the performance of the system and consideration of various scientific merits, the initial target fields are focused on nearby galaxies with increased cadence and filter coverage.

• BMB Reports
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• v.51 no.8
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• pp.418-423
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• 2018

Emergency granulopoiesis is a very important strategy to supply efficient neutrophil number in response to infection. However, molecular mechanism involved in this process remains unclear. Here, we found that administration of WKYMVm, an immune modulating peptide, to septic mice strongly increased neutrophil number through augmented emergency granulopoiesis. WKYMVm-induced emergency granulopoiesis was blocked not only by a formyl peptide receptor 2 (FPR2) antagonist (WRW4), but also by FPR2 deficiency. As progenitors of neutrophils, $Lin^-c-kit^+Sca-1^-$ cells expressed FPR2. WKYMVm-induced emergency granulopoiesis was also blocked by a phospholipase C inhibitor (U-73122). These results suggest that WKYMVm can stimulate emergency granulopoiesis via FPR2 and phospholipase C enzymatic activity.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.13
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• pp.73-76
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• 1973

Protein spectra from 6 species of Gossypium were obtained by disc electraphoresis of seed extracts. Protein extracts were made by soaking 0.5g. of seed in 15ml of Tris-glycine buffer for 24 hours. Gels 24 hours. Gels were stained in 0.5% Amido Black solution for 1 hour, and destained in 7% acetic acid for 72 hours. Nine to 15 bands were visible in each gel. Homologies of Protein bands among the species were determined by migration velocity. Evidences obtained from electrophoretic separation of seed Protein were consistent with those from genetic, cytological, morphological and Phenogenetic methods regarding the origin of New World cultivated cottons. Possibility, however, does not exist to exclude Gossypium herbaceum from one of the Progenitors of New World cultivated cottons from electrophoretic evidences alone.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.2
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• pp.48.3-49
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• 2015

Scaling relations of early-type galaxies (ETG) provide a deep insight into their formation and evolution. Interestingly enough, most relations extending into the dwarf regimes display non-linear or broken-linear features, unlike the linear relations for normal (i.e., intermediate-mass to giant) ETGs only. Here we investigate the mass-size scaling relation of ETGs using a massive database of galaxies from SDSS DR12. We divide ETGs into two groups by the indication of star formation such as colors, and examine their distinction along the mass-size relation. We find that the mass-size distribution of blue, young normal galaxies is in good agreement with that of dwarf ETGs. Our result suggests that blue, young normal ETGs may serve as links between (passive) normal ETGs and dwarfs. We discuss the possibility of blue, young ETGs being progenitors of dwarf ETGs.

• Biomedical Science Letters
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• v.23 no.4
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• pp.295-302
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• 2017

Mononuclear osteoclast precursors derived from hematopoietic progenitors fuse together and then become multinucleated mature osteoclasts by macrophage-colony stimulating factor (M-CSF) and receptor activator of nuclear factor-${\kappa}B$ ligand (RANKL). Especially, the binding of RANKL to its receptor RANK provides key signals for osteoclast differentiation and bone-resorbing function. RANK transduces intracellular signals by recruiting adaptor molecules such as TNFR-associated factors (TRAFs), which then activate mitogen activated protein kinases (MAPKs), Src/PI3K/Akt pathway, nuclear factor-${\kappa}B$ (NF-${\kappa}B$) and finally amplify NFATc1 activation for the transcription and activation of osteoclast marker genes. This review will briefly describe RANKL-RANK signaling pathways and key molecules critical for osteoclast differentiation.

• Proceedings of the KSAR Conference
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• 2002.06a
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• pp.84-84
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• 2002

This study was to investigate generation of the specific neuronal cell in vitro from the neural progenitors derived from human embryonic stem (hES, MB03) cells. For the neural progenitor cell formation, we produced embryoid bodies (EB: for 5 days, without mitogen) from hES cells and then neurospheres (for 7-10 days, 20 ng/㎖ of bFGF added N2 medium) from EB. And then for the differentiation into neuronal cells, neural progenitor cells were cultured in N2 medium (without bFGF) supplemented with brain derived neurotrophic factor (BDNF, 5 ng/㎖) or platelet derived growth factor-bb (pDGF-bb, 20ng/㎖) for 2 weeks. (omitted)

• Journal for History of Mathematics
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• v.19 no.3
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• pp.57-70
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• 2006

In this paper, we study the meaning and symbols of the number three and the structure of dividing into three parts in the religions, views of the world and the nature. Also we investigate the meaning of the number three, and the structure of dividing into three in the Samsung myth. According to legend, the 'Three Names' (Samsung-Yang, Ko and Pu) which are three demi-gods emerged from Samsung-hyeol(called Moheung-hyeol), and became the progenitors of the Jeju people who founded the Kingdom of Tamna.

• Clinical and Experimental Pediatrics
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• v.48 no.8
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• pp.806-812
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• 2005

Repair mechanisms in the postnatal and mature central nervous system(CNS) have long been thought to be very limited. However recent works have shown that the mature CSN contains neural progenitors, precursors, and stem cells that are capable of generating new neurons, astrocytes, and oligodendrocytes especially in germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus of the hippocampus. These findings raise the possibilities for the development of novel neural repair strategies via mobilization and replacement for dying neurons of neural stem cells in situ. Indeed recent reports have provided evidences that endogenous stem cells are activated in response to various injuries, and in some injury models, limited neuronal replacement occurs in the CNS. Here, current understandings for endogenous neurogenesis and induction neurogeneis in postnatal CNS including neonatal brain are summarized and discussed.