• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.12
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• pp.1871-1876
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• 2004

We demonstrate a novel fabrication technology for the microneedle array that can be used in the medical test field, which is transdermal drug delivery and blood analyte sampling. Previous researchers have used silicon-processed micromachining, a reactive ion etching, and molding techniques for the fabrication of microneedle array. However, these fabrication techniques have somewhat limitations apply to the microneedle array fabrication according to its application. Inclined LIGA process is suggested to overcome these problems. This process provides easier, sharper and longer out-of-plane microneedle array structure than conventional silicon-processed fabrication method did. Additionally, because of the advantage of the LIGA process based on mold fabrication for mass production, the polymer, PMMA(PolyMethylMethAcrylate), based microneedle array is useful as the mold base of nickel electroplating process; on the other hand, silicon-processed microneedle array is used in itself. In this research, we fabricate different types of out-of-plane microneedle array, which have different shape of tip, base and hole structure, using the inclined LIGA process. The fabricated microneedles have proper mechanical strength, height and sharpness to puncture human hand epidermis or dermis with less pain and without needle tip break during penetrating the skin.

• IE interfaces
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• v.17 no.4
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• pp.472-481
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• 2004

In this paper, we propose a linear programming model of supply planning process for the supply chain collaboration strategy of a company. The amount of its supplying quantity relies on outsourcing suppliers heavily. Conversely, the revenues of those suppliers are highly dependent on the supplying quota from the supply network planning of the company. In order to keep the supply stable through collaboration, the company builds such a policy to guarantee the fairness on revenue between the supplies. For this, the supply network plan should keep the capacity utilization ratio even for all the suppliers. But the production capacities are different and the distribution of molds is disproportional through suppliers, so the supply network plan is not easily established with simple arithmetic processes. Therefore, we developed the linear programming model with those target function and constraints minimizing the costs for holding inventory and penalty of delayed delivery, simultaneously guaranteeing the even capacity utilization through suppliers. The proposed model has been applied to real case and the evaluation for the planning result from the model would be followed in order to make sure that our model guarantee on extracting the supply network plan subordinated to the policy. Also we mention about further studies for improvement of the model.

• IMMUNE NETWORK
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• v.10 no.1
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• pp.5-14
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• 2010

Background: There have been several reports describing the capability of ginseng extracts as an adjuvant. In this study, we tested if ginsan, a polysaccharide extracted from Panax ginseng, was effective in enhancing antibody response to orally delivered Salmonella antigen. Methods: Ginsan was treated before oral salmonella antigen administration. Salmonella specific antibody was determined by ELISA. mRNA expression was determined by RT-PCR. Cell migration was determined by confocal microscopy and flow cytometry. COX expression was detected by western blot. Results: Ginsan treatment before oral Salmonella antigen delivery significantly increased both secretory and serum antibody production. Ginsan increased the expression of COX in the Peyer's patches. Various genes were screened and we found that CCL3 mRNA expression was increased in the Peyer's patch. Ginsan increased dendritic cells in the Peyer's patch and newly migrated dendritic cells were mostly found in the subepithelial dome region. When COX inhibitors were treated, the expression of CCL3 was reduced. COX inhibitor also antagonized both the migration of dendritic cells and the humoral immune response against oral Salmonella antigen. Conclusion: Ginsan effectively enhances the humoral immune response to orally delivered antigen, mediated by CCL3 via COX. Ginsan may serve as a potent vaccine suppliment for oral immunization.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.16 no.1
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• pp.269-283
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• 2005

Research and Development projects sponsored by the government are one of the main production sectors of academic and research information in domestic area. The access control and information service of R&D outcomes should be considered as a critical factor of nation-wide knowledge-based IS management. This study focused on the practical utilities of three IPR legislations of the government projects and analyzed if they are good enough to support the information service in recent digital network environment. Some suggestions in different perspectives were provided for the improvement of the existed IPR legislation.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2003.04a
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• pp.93-98
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• 2003

High speed precision machines have been introduced to the CNC industry in order to improve productivity, shorten the appointed date of delivery and reduce the prime cost. High speed machines have more functions then general machines, and they were proved in performance. The production and sales of the high speed machines have been increased not only in domestic market but also all over the world. Accordingly, machines are faster, there are lots of problems to be solved. One of the most difficult problems is the thermal displacement on the main spindle due to generated heat while the spindle is rotated in high speed. Since the thermal displacement directly effects the quality of the machined parts, utmost efforts to minimize the thermal displacement have to be given from the beginning of designing machines. In practice, variety of methods are attempted and practiced to minimize the thermal displacement such as design of symmetrical frame, adoption of high speed bearings, application of compensation system using non-contact sensor and use of forced circulating lubrication system with oil cooler. Even if these variable methods have been practically used in the industrial field, generated heat has not been Perfectly Prevented lienee, in this paper, the characteristics of thermal displacement were investigated when several kinds of oil were tested for a high speed machine with forced circulating lubrication system within the same atmosphere and under the same conditions.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.13 no.2
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• pp.47-53
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• 2004

High speed precision machines have been introduced to the CNC industry in order to improve productivity, shorten the appointed date of delivery and reduce the prime cost. High speed machines have more functions then general machines, and they were proved in performance. The production and sales of the high speed machines have been increased not only in domestic market but also all over the world. Accordingly, machines are faster, there are lots of problems to be solved. One of the most difficult problems is the thermal displacement on the main spindle due to generated heat while the spindle is rotated in high speed. Since the thermal displacement directly effects the quality of the machined parts, utmost efforts to minimize the thermal displacement have to be given from the beginning of designing machines. In practice, variety of methods are attempted and practiced to minimize the thermal displacement such as design of symmetrical frame, adoption of high speed bearings, application of compensation system using non-contact sensor and use of forced circulating lubrication system with oil cooler. Even if these variable methods have been practically used in the industrial field, generated heat has not been perfectly prevented. Hence, in this paper, the characteristics of thermal displacement were investigated when several kinds of oil were tested for a high speed machine with forced circulating lubrication system within the same atmosphere and under the same conditions.

• Journal of the Korea Safety Management & Science
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• v.15 no.1
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• pp.193-198
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• 2013

Warehouse Management System was a helper of business in past, but it is perceived as a core competitive power and a tool for generating new business. It have been come out some new prospects for WMS due to generalization of global outsourcing and extension of the range of supply chain. In China, H automobile company construct the new WMS for providing the production extension and increment of part demand for A/S. This paper deals with the location management in warehouse, warehouse management, delivery management of goods from a warehouse, inventory management organizing WMS for construction of A/S warehouse in H motor in China. Then we identified the several problems of existing warehouse and constructed the driving organization and methods for overcoming these problems. We continually gather data for analysing the effects of new A/S warehouse and WMS construction.

• The Journal of the Korea Contents Association
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• v.10 no.1
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• pp.325-333
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• 2010

Prevalence of female uterine myoma was determined using ultrasound diagnosis instrument, and correlation between health-related factors and uterine myoma was analyzed to investigate concrete factors for production of uterine myoma. Subjects in uterine myoma group and control group were asked to answer the questionnaire survey. The results were determined that prevalence of uterine mayma was 29.7%, and 40~49 aged group showed the highest level of uterine myoma by 41.4%. (p<0.05). The analysis showed that there were significant correlations between uterine myoma and collected variables such as age, marital status, occupational activity level, satisfaction level of life, weight, obesity, delivery history, breast feeding, abortion, and contraceptive experience (p<0.05).

• Journal of Korean Society of Industrial and Systems Engineering
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• v.42 no.1
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• pp.21-32
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• 2019

The flow of the $4^{th}$ Industrial Revolution calls for the innovation of the traditional business models of the manufacturers. Servitization is a corporate strategy to respond to changes in the business environment. These days, the value that the market demands can be created on the basis of the product-service integration. Thus the manufacturers must pursue the fundamental innovation of the current strategy and business models. It is necessary to create common values with customers through providing product-service integrated offerings beyond the development, production, and delivery. The purpose of this study is to develop the evaluation indicators for selecting suppliers when the manufacturer who offers the value of product-service integration needs to obtain the resources from outside. The case company in this study is the manufacture firm conducting the retail IoT business as a new business. The Delphi method is used to develop the evaluation indicators for selecting suppliers. This study suggests the academic implications providing the perspective of Servitizaiton by using Delphi method, and the practical implications applying the creating value method of Servitization by collecting the opinions from both value providers and value consumers in the process of developing the evaluation indicators.

• Journal of Institute of Convergence Technology
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• v.13 no.1
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• pp.19-22
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• 2023

The rise of electrification and the advancement of autonomous driving technologies are leading to new forms of mobility, such as serving and delivery robots. However, due to factors such as the small-scale production of various products and the high cost of autonomous driving sensors, product prices have risen, limiting accessibility to consumers. To improve this, we developed a multi-purpose mobility platform that is mass-producible, based on inexpensive, reliable sensors and a configurable human tracking system. As a result, the unit price is approximately 50% of the launch prices of other mobility products, and additional cost savings are possible through component optimization in the future. In addition, more added value will be created through the distribution of integrated mobility platforms that can be combined with various usable modules to meet a variety of user needs, such as cargo transportation, wheelchair power kits, and mobile monitors.