• Journal of Pharmaceutical Investigation
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• v.35 no.2
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• pp.75-80
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• 2005

A promising application of Lactococcus lactis is its use as live vehicles for production and delivery of heterologous proteins of vaccines and therapeutic substances. Because L. lactis has GRAS ('generally regarded as safe') status, we tested whether L. lactis could function as the carrier of the Ll protein of human papillomavirus (HPV) type 16. The RNA level expression of Ll gene was detected in L. Lactis. The Ll protein was expressed in L. lactis with Ll gene. The growth of strains L. lactis with an empty plasmid (pAMJ328) and L. lactis with Ll-encoding plasmid (pAMJ328-Ll) was slightly decreased in comparison with the growth of strains L. lactis (wild type). However, all the three strains of L. lactis maintained the ability to ferment sugars primarily into lactic acid, indicating that Ll protein did not affect the biochemical property of L. lactis. These results suggest that L. lactis, capable of carrying Ll protein, might be further developed as a biocompatible oral protein delivery system.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.816-820
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• 2005

Polysaccharide-based dressings have increasingly become viable alternatives to somewhat less biocompatible and often problematic cotton or viscose gauzes traditionally used for wound dressings. Polysaccharide which is particularly abundunt in Agaricus blazei Murill is known as the bioactive materials. Polysaccharide extracted from Agaricus blazei Murill enhances the recovery of the damaged epidermal tissue and the production of epithelial cell growth factors which are necessary to heal the burn and wound on the epidermal tissue. In this study, the biopolymer delivery system of polysaccharide extracted from Agaricus blazei Murill into epidermal tissue was elucidated using the skin permeating enhancer in vitro. The enhancing effects of various penetration enhancers and some other enhancers on the permeation of ${\beta}-glucan$ were evaluated using Franz diffusion cell. Permeation of polysaccharide in nomal and burn skin was compared. Polysaccharide was studied for the burn and wound healing activity in the epidermal tissue on rats.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2007.11a
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• pp.3-6
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• 2007

In the traditional inventory problem, market parameters such as demand and selling price are exogenous. But incorporating these factors into the model can provide an opportunity for increasing the total profit. So we investigate the joint price-inventory policy in a supply chain consisting of a single retailer and a single manufacturer. Demand at the retailer depends on the retail price. The retailer and the manufacturer cooperate closely each other to maximize overall profit of the supply chain. The mathematical model is presented and the solution procedure is developed in order to jointly determine the optimal policy including the retail price, the production lot sizes, and the delivery frequency from the manufacturer to the retailer.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.40
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• pp.147-167
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• 2008

This paper investigates changing business transaction under the e-commerce environment and their implications on freight transport industry with some case studies. It shows that an efficient and reliable delivery system is essential for e-commerce as business industries are faced with the stricter and more diversified demands of customer. In addition, many aspects of business practices such as small batch, customized production and just-in-time distribution in the e-commerce environment, in turn, bring about a number of changes in the volume and service patterns of freight transport. E-commerce requires longer transport distances and often higher delivery frequencies. It also entails to a certain extent a modal shift towards truck and air freight transport modes. On the one hand, the logistical requirements of e-commerce goods may stimulate greater complexity in existing supply chain management, causing higher costs. However it is true that the increased visibility of goods through more efficient information flow allows more efficient and effective transport management in the logistics system.

• BMB Reports
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• v.55 no.1
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• pp.3-10
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• 2022

Extracellular vesicles (EVs) released from different types of kidney cells under physiologic conditions contribute to homeostasis maintenance, immune-modulation, and cell-to-cell communications. EVs can also negatively affect the progression of renal diseases through their pro-inflammatory, pro-fibrotic, and tumorigenic potential. Inhibiting EVs by blocking their production, release, and uptake has been suggested as a potential therapeutic mechanism based on the significant implication of exosomes in various renal diseases. On the other hand, stem cell-derived EVs can ameliorate tissue injury and mediate tissue repair by ameliorating apoptosis, inflammation, and fibrosis while promoting angiogenesis and tubular cell proliferation. Recent advancement in biomedical engineering technique has made it feasible to modulate the composition of exosomes with diverse biologic functions, making EV one of the most popular drug delivery tools. The objective of this review was to provide updates of recent clinical and experimental findings on the therapeutic potential of EVs in renal diseases and discuss the clinical applicability of EVs in various renal diseases.

• Journal of the Korean Society of Industry Convergence
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• v.12 no.2
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• pp.85-90
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• 2009

The Toyota production system (TPS) developed by Toyota corporation is a management principle and production model to improve values added through elimination of waste. Since the oil shock in 1970s, the TPS has drawn the worldwide attentions as a main factor of competitiveness of Japanese manufacturing system and has been studied and implemented in many countries regardless of size and types of industry. For the correspondence to various customer's requirement, it is required to establish on time delivery procedure and to shorten lead time. Therefore it intended to establish TPS which is adopted to 7 losses reduction and JIT(Just in Time). In this paper, the automatic production line for color TV manufacturing by TPS was developed and proved to push up two times of productivity, to reduce the 25 workers at a time, and to widen the flexibility of manufacturing from 14" to 25" TV.

• International conference on construction engineering and project management
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• 2024.07a
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• pp.25-32
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• 2024

Conventional construction methods face significant challenges in reducing carbon emissions and promoting environmental sustainability. Off-Site Construction (OSC) method is widely recognized as a low-carbon, high-efficiency alternative construction method. However, in practice, it often fails to deliver the expected benefits, leading to issues such as excessive carbon emissions, unpunctual delivery, and cost overruns in OSC projects. In order to ensure the carbon benefits of OSC and further its development,this study conducts an in-depth analysis of embodied carbon emissions in the precast production process, proposes a multi-objective optimization model based on the permutation flow shop scheduling problem, and designs an automated solution algorithm using NSGA-II to derive Pareto optimal schedules. Through the analysis of real-world case data, the proposed approach, compared to conventional scheduling methods, is estimated to reduce embodied carbon emissions by approximately 6 % while simultaneously cutting tardiness/earliness penalty by 75%. This study offers a model for precast production scheduling, effectively enhancing production efficiency and reducing carbon emissions, enabling construction component enterprises to engage in low-carbon, cost-effective, and efficient production, thereby fostering sustainable development in the construction industry.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2002.02a
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• pp.95-102
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• 2002

With recent trends leaning towards product miniaturization, the advent of new material and speedy delivery times, old style conventional trial-and-error methods have been only serving to weaken corporate competitiveness. Reliant on tiny increments of time-consuming experience, this antiquated approach begets a delayed delivery of product development, cost loss and quality depreciation. To solve such problems, the Dedicated Injection Molding CAPA (Computer Aided Plastics Application) performs a preliminary examination on problems rising from every stage of creation - from appropriate material selection and mold design to mass production - through a computer system. Thus, it determines the optimum design variables and process conditions while diagnosing and solving defective molds.

• Journal of The Korean Digital Architecture Interior Association
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• v.8 no.1
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• pp.75-80
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• 2008

The purpose of this paper is to find the preconditions of BIM based new design process. As BIM technology improves, investigating new design process will become a greater priority. Our traditional, linear and fragmented design process is not freed from a long-pending questions of poorly coordinated drawings and low production efficiencies. Rather the traditional process is one of the major causes of such issues of low productivity. AIA and NIST proposed new design process to fulfill clients' need for fast and precise delivery recently. The common goal of these two should be better, faster and more precise project delivery created by integration. And we need to create collaborative concurrent design process to optimize the design efforts, But our local AE industry's circumstances are quite different with foreign countries. Therefore, integrated project system cannot be adopted as it stands in foreign countries. This paper will investigate preconditions to expedite the progress of BIM based design process in Korea.

• International conference on construction engineering and project management
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• 2015.10a
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• pp.28-29
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• 2015

The tire production facility is a large-scale construction with the complexity of a manufacturing process. The process utilities should be wide-ranging as an effective arrangement of them is highly important. All the necessary information should be clarified together with the manufacturer at the basic planning stage, and this design should be developed to comply with the local culture and regulations. It is important to carry out more advanced engineering in terms of process, cost and quality, even if it is difficult to standardize due to the cultural and geographical conditions and regulations. The key point is to reflect all the given conditions and make a clear design during the design stage, to eliminate the problems after the construction has begun. Another key point is the delivery system, which must be totally managed from the initial design stage until the construction stage by proven companies. Flexibility, quick action, and single responsibility will be the fundamental features in all the steps of the project.