• Asian-Australasian Journal of Animal Sciences
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• 제19권9호
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• pp.1335-1341
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• 2006

We selected a Lactobacillus spp. from Korean healthy infant feces based upon their antioxidant activity. This strain was identified as Lactobacillus gasseri by 16S rDNA sequencing, and named Lactobacillus gasseri NLRI-312. In the present study, we investigate the protective effect of this strain on the $H_2O_2$ induced damage to cellular membrane lipid and DNA in Jurkat cells. To estimate the extent of cellular lipid peroxidation inhibition, MDA (malondialdehyde) was measured, and DNA damage was tested by the comet assay. We also examined probiotic properties including tolerance to acid and bile, antibiotic resistance. From the results obtained, the supplementation of Jurkat cells with NLRI-312 decreased in DNA damage, while no effect was shown on MDA decrease. In probiotic properties, this strain was resistance to both acid and bile, showed considerably higher survival when incubated in pH 2 or 1% bile salts (w/v). We concluded that the NLRI-312 could be used as potential probiotic bacteria, with the effect of reducing DNA damage induced by $H_2O_2$.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2006년도 춘계학술대회논문집
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• pp.1223-1228
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• 2006

This paper presents an experimental investigation of a recently developed Kronecker Product (KP) method to determine the type, location, and intensity of structural damage from an identified state-space model of the system. Although this inverse problem appears to be highly nonlinear, the system mass, stiffness, and damping matrices are identified through a series of transformations, and with the aid of the Kronecker product, only linear operations are involved in the process. Since a state-space model can be identified directly from input-output data, an initial finite element model and/or model updating are not required. The test structure is a two-degree-of-freedom torsional system in which mass and stiffness are arbitrarily adjustable to simulate various conditions of structural damage. This simple apparatus demonstrates the capability of the damage detection method by not only identifying the location and the extent of the damage, but also differentiating the nature of the damage. The potential applicability of the KP method for structural damage identification is confirmed by laboratory test.

• 한국포장학회지
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• 제13권1호
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• pp.25-28
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• 2007

Physical damage on fruits and vegetables caused by shock degrades the value of product in the fresh market. In order to design a product/package system to protect the product, the peak acceleration or G force to the product that causes shock damage needs to be determined. Shock cushion packaging is applied to protect goods of all kinds. It can be adapted in their shape to any product to be packed, so that its shock absorbing properties is determined by geometry of the product. The shape of a cushion can be adapted to the expected shock loads. To analyze the response properties of cushion materials for packaging of the pears for optimum packaging design during transportation, shock tests were carried out. Shock acceleration that is happened in pears were appeared very high by $25{\sim}30G$ in the input shock acceleration of 14.1618 G that was measured in transportation road. This means that the pears receive the shock acceleration more than maximum double itself and the damage by this can happen and the shock acceleration increase in case use PE tray cup and PE net in fruits, the use of corrugated fiberboard pad may become one method that it can reduce the damage by the shock in packaging of fruits.

• 의료법학
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• 제21권3호
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• pp.77-116
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• 2020

현대 과학의 경험과 성과가 반영된 의약품의 사용으로 인류에게 질병의 치료와 건강 상태의 개선이라는 혜택이 주어지고 있다. 그러나 의약품은 질병의 치료라는 혜택 이외에도 본질적으로 피할 수 없는 부작용도 내포한다. 각국은 부작용으로 인한 피해의 최소화를 위해 시장진입 규제나 시판후조사 등의 조치를 취하고 있으나, 부작용의 발생은 피할 수 없다. 부작용으로 인한 손해의 발생이 불가항력이라도 그 점이 사전에 알려진 것이었다면, 의약품의 종류와 사용 형태에 따라서 처방한 의사나 복약지도를 담당하는 약사 등이 손해를 배상해야 한다. 의약품에 결함이 있어 손해가 발생하는 경우도 있는데, 손해 배상의 일반원칙을 그대로 적용해서는 결함으로 인한 부작용 피해자가 손해를 배상받기 쉽지 않다. 우리나라를 비롯한 여러 나라가 제조물 책임법을 통하여 피해자의 보호를 도모하고 있으며, 의약품도 제조물에 포섭되기 때문에 제조물 책임법을 통한 손해배상을 문의할 수 있는데, 이 때 주로 설계상의 결함이나 표시상의 결함이 문제될 수 있다. 제조물 책임법이 제정·시행되기 이전에도 의약품의 부작용으로 인한 손해는 발생하여왔다. 이러한 경우를 위해서 판례는 제조물 책임법과 유사한 법리를 발전시켜 왔고, 의약품 결함은 혈액제제와 관련하여 판례가 형성되어 왔다. 제조물 책임법 시행 이전에 제조된 의약품으로 인한 손해는 향후에도 발생할 수 있기에 판례 법리는 중요한 검토의 대상이다.

• 대한안전경영과학회지
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• 제7권3호
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• pp.109-120
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• 2005

A company is liable for its products and has the responsibility to make good on any loss or damage incurred by the user of its product. The purpose of the Product Liability Act(PLA) is to protect consumers against damage caused by defective products, and contribute to the safety of the citizen's life and the sound development of the national economy by regulating the liability of manufacturers, etc. for damages caused by the defectiveness of their products. In this study, the cognition levels of consumers and producers for PLA were surveyed. The cognition levels of four factors of acknowledgement, comprehension, necessity and impact for PLA were assessed. The results were as follows : i) Acknowledgement and comprehension levels of consumer were assessed low but they assessed necessity and impact of PLA high; ii) Producers assessed necessity and impact of PLA higher than their acknowledgement and comprehension levels; iii) Overall cognition levels of producers were higher than those of consumers.

• 한국기계가공학회지
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• 제21권6호
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• pp.67-73
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• 2022

Industrial inverters are used in a variety of fields for electric power supply. They may be exposed to vibration and heat once they are installed. This study focused on a framework of accelerated life testing of an industrial inverter considering fatigue damage as the primary source of deterioration. Instead of analyzing detailed failure mechanisms and the product's vulnerability to them, the potential of fatigue failure is considered using the fatigue damage spectrum calculated from the environmental vibration signals. The acceleration and temperature data were gathered using field measurement and spectral analysis was conducted to calculate the vibration signal's power spectral density (PSD). The fatigue damage spectrum is then calculated from the input PSD data and is used to design an accelerated fatigue life testing. The PSD for the shaker table test is derived that has the equivalent fatigue damage to the original input signal. The tests were performed considering the combined effect of random vibration and elevated temperature, and the product passed all the planned tests. It was successfully demonstrated that the inverter used in this study could survive environmental vibration up to its guarantee period. The fatigue damage spectrum can effectively be used to design accelerated fatigue life testing.

• Journal of Biosystems Engineering
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• 제32권6호
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• pp.416-421
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• 2007

Physical damage to fruits and vegetables caused by shock degrades the value of product in the fresh market. In order to design a product/packaging system to protect the product, the G-factor to the product that causes shock damage needs to be determined. The shock fragility of organisms such as fruits with a concept correspondent to the G-factor of industrial products was calculated and we defined the allowable bio-shock fragility index as the value divided peak acceleration that was generated in safe drop height by standard acceleration of gravity. We did modeling for safe drop hight that would prevent fruits from damage by drop tests and tried to estimate the allowable bio-shock fragility index of pears and apples for optimum packaging design. The bio-shock fragility index of pears was in the range of $0.74{\sim}2.29\;G$, while apples had a slightly higher value than that of pears, of $0.51{\sim}2.98\;G$. This result shows accordance with the general fact that apples have a firmer structure and get less damage from the same impact. Based on this result, it is possible to create an optimum packaging design by providing a damage standard by impact.

• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.142-160
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• 2003

Most consumers have noted hair damage following coloring treatments. Proper evaluation of hair bleaching products must be performed using quantitative assessments of hair damage, though they are difficult, because of the slight fluctuations in hair composition. In the present study, we utilized a sensitive evaluation method for hair damage and found that the amount of soluble protein fraction extracted from hair under a reducing condition, termed labile protein, dramatically increased after bleaching.(omitted)

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1996년도 춘계학술발표회논문집(2)
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• pp.637-642
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• 1996

This paper presents the analysis results for the core degradation processes and the fission product release of the PHEBUS FPT0 experiment using MELCOR1.8.3. The objective of this study is to assess models associated with the core damage and fission product behavior in MELCOR. The calculation results were much improved through sensitivity studies. Thermal/hydraulic behavior in the core and the circuit was well predicted under the intact core geometry. In non-eutectic model case. the UO$_2$ dissolution model in the MELCOR always showed such a tendency that the resulting dissolved UO$_2$ mass was small at the highly oxidized condition due to the model logic. Total H$_2$ generation mass was underpredicted because the stiffner was not modeled and the liner in the shroud was not allowed to be oxidized in MELCOR. Some difficulties were found in modeling the activation product were solved by manipulating the RN input associated with the initial fission product inventory. These problem were occurred because there are no control rod model in MELCOR. Generally the fission product release ratio showed a similar trend compared with the measured data except the activation product. which have no model to simulate in MELCOR.

• 산업경영시스템학회지
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• 제9권14호
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• pp.35-43
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• 1986

PL(product liability) is a major social, market, and economic force. The legal obligation of manufacturers and sellers to compensate for injury or damage caused by defective products is not a recent phenomenon. The concept of Product liability has been in existence for many years, but its emphasis has changed recently. This PL prevention program has shown that the two area of product quality assurance one is a PLD(product liability defense) and the other is a PLP(product liability prevention.