• Title/Summary/Keyword: Process Safety Report

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Current Status, Challenges, Policies, and Bioethics of Biobanks

  • Kang, Byunghak;Park, Jaesun;Cho, Sangyun;Lee, Meehee;Kim, Namhee;Min, Haesook;Lee, Sooyoun;Park, Ok;Han, Bokghee
    • Genomics & Informatics
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    • v.11 no.4
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    • pp.211-217
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    • 2013
  • Many biobanks were established as biorepositories for biomedical research, and a number of biobanks were founded in the 1990s. The main aim of the biobank is to store and to maintain biomaterials for studying chronic disease, identifying risk factors of specific diseases, and applying personalized drug therapies. This report provides a review of biobanks, including Korean biobanks and an analysis of sample volumes, regulations, policies, and ethical issues of the biobank. Until now, the top 6 countries according to the number of large-scale biobanks are the United Kingdom, United States, Sweden, France, the Netherlands, and Italy, and there is one major National Biobank of Korea (NBK) and 17 regional biobanks in Korea. Many countries have regulations and guidelines for the biobanks, and the importance of good management of biobanks is increasing. Meanwhile, according to a first survey of 456 biobank managers in the United States, biobankers are concerned with the underuse of the samples in their repositories, which need to be advertised for researchers. Korea Biobank Network (KBN) project phase II (2013-2015) was also planned for the promotion to use biospecimens in the KBN. The KBN is continuously introducing for researchers to use biospecimens in the biobank. An accreditation process can also be introduced for biobanks to harmonize collections and encourage use of biospecimens in the biobanks. KBN is preparing an on-line application system for the distribution of biospecimens and a biobank accreditation program and is trying to harmonize the biobanks.

Effect of Complementary Medicine on Pain Relief and Wound Healing after Cesarean Section: A Systematic Review

  • Niazi, Azin;Moradi, Maryam;Askari, Vahid Reza;Sharifi, Neda
    • Journal of Pharmacopuncture
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    • v.24 no.2
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    • pp.41-53
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    • 2021
  • Objectives: Cesarean sections are one of the common surgical procedures around the world. Management of cesarean section side effects, including pain, hematoma, delayed wound healing, is of particular importance in maintaining maternal health and ability to care for the baby. The tendency to use complementary medicine strategies is on the rise because of the easy treatment with low side effects. The purpose of this study was to systematically review the efficacy and safety of clinical trials performed in Iran and worldwide on the effect of complementary medicine on pain relief and wound healing after cesarean section. Methods: PRISMA checklist was followed to prepare the report of this systematic review. The search process was carried out on databases on databases of Magiran, SID, Iran Medex, Scopus, Pub Med, Science direct, Medline and Cochrane library using keywords of cesarean, pain, wound healing, Herbal medicine, acupressure, massage, complementary medicine and their Persian equivalent and all possible combinations, from inception until February 2020. We used the Jadad scale to assess the quality of the searched articles. According to the Jadad scale, the articles with a score of at least 3 were included in the study. Results: Finally, 28 clinical trials (with a sample size of 3,245) scored at least 3 on the Jadad scale were included into the analysis. This article reviewed 13 articles on medicinal herbs, 4 articles on massage, 1 article on reflexology, 2 articles on acupressure. Conclusion: According to the present review, the use of medicinal herbs was the most common method of complementary medicine in pain relief and wound healing after cesarean section.

A Study on the Harmfulness of Silicon Oxide Dust and Measures for the Work Environment Improvement in Construction Sites (건설현장에서 발생하는 산화규소분진의 유해성 및 작업환경 개선대책에 관한 연구)

  • Hwang, Jeong-Suk
    • Journal of the Society of Disaster Information
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    • v.18 no.3
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    • pp.478-486
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    • 2022
  • Purpose: Although the working environment is measured at the construction site, only a few noise and vibration that are typically exposed for each process are performed without measuring the working environment by segmenting the exposed harmful factors. Therefore, it is intended to find the harmfulness of silicon oxide dust, which is most exposed at construction sites, and the complementary points of improvement measures currently being implemented at construction sites. Method: The status was analyzed using the actual condition survey report issued by the Korea Occupational Health Corporation and the Korea Occupational Health Association and data from the work environment measurement institution, and compared and analyzed with the rules on work environment measurement of the Occupational Safety and Health Act. Result: The harmfulness of silicon oxide dust was identified and improvement measures were derived. Conclusion: It is expected that occupational diseases against silicon dust can be reduced if the harmfulness of silicon oxide dust at construction sites is derived and improvement measures are actively applied at the site.

Case Studies of Indirect Coupled Behavior of Rock for Deep Geological Disposal of Spent Nuclear Fuel (사용후핵연료 심층처분을 위한 암석의 간접복합거동 연구사례)

  • Hoyoung, Jeong;Juhyi, Yim;Ki-Bok, Min;Sangki, Kwon;Seungbeom, Choi;Young Jin, Shin
    • Tunnel and Underground Space
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    • v.32 no.6
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    • pp.411-434
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    • 2022
  • In deep geological disposal concept for spent nuclear fuel, it is well-known that rock mass at near-field experiences the thermal-hydraulic-mechanical (THM) coupled behavior. The mechanical properties of rock changes during the coupled process, and it is important to consider the changes into the analysis of numerical simulation and in-situ tests for long-term stability evaluation of nuclear waste disposal repository. This report collected the previous studies on indirect coupled behaviors of rock. The effects of water saturation and temperature on some mechanical properties of rock was considered, while the change in hydraulic conductivity of rock due to stress was included in the indirect coupled behavior.

The Technological Competitiveness Analysis of Evolving Artificial Intelligence by Using the Patent Information (특허 분석을 통한 인공지능 기술경쟁력 변화 과정에 관한 연구 - 주요 5개국을 중심으로 -)

  • Huang, Minghao;Nam, Eun Young;Park, Se Hoon
    • Journal of the Korean Society of Systems Engineering
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    • v.18 no.1
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    • pp.66-83
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    • 2022
  • Artificial Intelligence (AI) is to assumed to be one of next generation technology which determine technological competitiveness and strategic advantage of a certain country. By using the patent data, this study aims to have a comparative analysis of the technological competitiveness of evolving artificial intelligence at different stages of development among the five largest intellectual property offices in the world (IP5). For the analysis data, all AI technology patent data from 1956 to 2019 were utilized according to the classification system presented in the "WIPO 2019 Technology Trend: Artificial Intelligence" report published by the World Intellectual Property Organization (WIPO) in 2019. The results shows that China has already surpassed the United States in terms of the number of patent applications in the field of artificial intelligence technology. However, in the domains of the United States, Europe, Japan, and Korea, the technology competitiveness of the United States is far ahead of China. Interestingly, the rate of increase of Korea's technology competitiveness is also very fast, and it has been shown that the technology strength is ahead of China in non-Chinese domains. The significance of this study can be found in the fact that the temporal and spatial change process of technological competitiveness of significant countries in the field of artificial intelligence technology artificial intelligence was viewed as a macro-framework using the technology index (TS) the differences were compared.

The Effectiveness of 448-kHz Capacitive Resistive Monopolar Radiofrequency for Subcutaneous Fat Reduction in a Porcine Model

  • Kwon, Tae-Rin;Lee, Sung-Eun;Kim, Jong Hwan;Jeon, Yong Jae;Jang, You Na;Yoo, Kwang Ho;Kim, Beom Joon
    • Medical Lasers
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    • v.8 no.2
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    • pp.64-73
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    • 2019
  • Background and Objectives The effectiveness of many physiotherapy modalities in reducing subcutaneous fat has been investigated in numerous previous studies. However, to the best of our knowledge, there have been no attempts to determine the effectiveness of physiotherapy modalities in body contouring. The present report determined the effect of 448-kHz capacitive resistive monopolar radiofrequency (CRMRF) in a porcine model. Materials and Methods This study investigated the effect of selective destruction of the subcutaneous fat layer in abdominal fat tissue using CRMRF. The effects of two types of CRMRF (capacitive electric transfer (CET) and resistive electric transfer (RET)) treatment were evaluated using regular digital photography in addition to thermal imaging evaluation, ultrasound measurement, hematological evaluation, and histologic analyses (H&E (hematoxylin and eosin), Oil red O, and immunohistochemistry staining). Results Preclinical evaluation was performed to obtain the data for comparison of the safety and efficacy of the subcutaneous fat reduction after applying CRMRF using CET and RET. After treatment, the thermal transmission was effective, and a 42-47℃ temperature change was observed in the fat layer while an approximately temperature of 42℃ was confirmed on the skin surface. Moreover, after the application of both types of CRMRF treatment, fibrotic septa were observed in the adipose tissue induced by heat at the treatment sites. TUNEL staining was also performed to confirm the process of apoptosis in the adipocytes. Conclusion These results suggest that both CET and RET for CRMRF treatment are safe and effective for subcutaneous fat reduction in a porcine model.

Gender and healthcare issues related to the Protected Birth Act in Korea (보호출산제 시행과 젠더 및 보건의료 이슈)

  • Jiah Jeong
    • Women's Health Nursing
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    • v.30 no.2
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    • pp.101-106
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    • 2024
  • This paper discusses the implications of the birth notification system and the Protected Birth Act in Korea. Aiming to prevent infanticide and abandonment of infants, the law will enter into force on July 19, 2024 in South Korea. The birth notification system mandates that both parents and the head of the medical institution where the birth occurred must report the event. In parallel, the Protected Birth Act will be implemented, allowing pregnant women in crisis who wish to remain anonymous, the option to give birth outside of a hospital setting in a way that safeguards the life and health of the child. However, many issues are being raised in Korean society in advance of the implementation of the Protected Birth Act. There is widespread concern that the Protected Birth Act fails to protect either women or children, especially as it raises issues regarding the need for legislation to protect children with disabilities and to address gaps for migrant women and children. This paper examines the gender and healthcare issues relating to the Protected Birth Act, focusing on women's health and human rights. The Act continues to perpetuate discrimination against out-of-wedlock pregnancies and upholds the ideology of the traditional family model. Furthermore, the legislative process did not address protective measures for the various reasons behind child abandonment. Critical issues such as women's autonomy, safe pregnancy termination, and paternal responsibility in childbirth are also notably absent. However, with the Act set to take effect soon, it is crucial for healthcare providers to comprehend the rationale and procedures associated with birth notification and the Protected Birth Act, and to prepare for its nationwide implementation. The law defines the socially vulnerable as its main beneficiaries, and it is necessary to strengthen social safety nets to improve their access to healthcare, eliminate prejudice and discrimination against out-of-wedlock pregnancies, and embrace the diversity of our society. We eagerly anticipate future discussions on gender and healthcare issues, as well as amendments to the law that reflect real-world circumstances to provide genuine protection for pregnant women in crisis and their infants.

Essential Guidelines for Manufacturing and Application of Organoids

  • Sun-Ju Ahn;Sungin Lee;Dayeon Kwon;Sejeong Oh;Chihye Park;Sooyeon Jeon;Jin Hee Lee;Tae Sung Kim;Il Ung Oh
    • International Journal of Stem Cells
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    • v.17 no.2
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    • pp.102-112
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    • 2024
  • An organoid is a self-organized three-dimensional structure derived from stem cells that mimics the structure, cell composition, and functional characteristics of specific organs and tissues and is used for evaluating the safety and effectiveness of drugs and the toxicity of industrial chemicals. Organoid technology is a new methodology that could replace testing on animals testing and accelerate development of precision and regenerative medicine. However, large variations in production can occur between laboratories with low reproducibility of the production process and no internationally agreed standards for quality evaluation factors at endpoints. To overcome these barriers that hinder the regulatory acceptance and commercialization of organoids, Korea established the Organoid Standards Initiative in September 2023 with various stakeholders, including industry, academia, regulatory agencies, and standard development experts, through public and private partnerships. This developed general guidelines for organoid manufacturing and quality evaluation and for quality evaluation guidelines for organoid-specific manufacturing for the liver, intestines, and heart through extensive evidence analysis and consensus among experts. This report is based on the common standard guideline v1.0, which is a general organoid manufacturing and quality evaluation to promote the practical use of organoids. This guideline does not focus on specific organoids or specific contexts of use but provides guidance to organoid makers and users on materials, procedures, and essential quality assessment methods at end points that are essential for organoid production applicable at the current technology level.

Understand the Current Status of Teaching and Learning Informatization and Develop Indicators in the 4th Industrial Revolution (4차산업혁명 시대를 대비한 대학의 교수학습 정보화 현황 파악 및 지표 개발)

  • Kim, Sang-Woo;Lee, Myung-Suk
    • Journal of Digital Convergence
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    • v.18 no.4
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    • pp.67-74
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    • 2020
  • The purpose of this study has developed a teaching and learning informatization indicator that provides the basis for utilizing or disseminating the beneficial teaching and learning informatization environment promoted by each university. The research method analyzes various informatization indicators developed by KERIS from 2002 to 2015 and recent environment such as Edutech, future education report, teaching and learning field report, and reflects them in indicator development. The development of the third indicator was completed by dividing it into Input, Process, Output stages by reflecting expert opinions in the first and second indicators. As a result, the core words of the university's teaching-learning informatization infrastructure building, sharing of educational resources, open development and sharing, joint purchase of resources, information safety system and literacy education, current status grasping, and resource utilization were derived. In the future, I will fill out the questionnaire to supplement the question through a pilot test and to grasp the current status of teaching and learning informatization in the entire university.

How to Reflect Sustainable Development in Overseas Investment including Equator Principles (해외투자(海外投資)와 지속가능발전 원칙 - 적도원칙(赤道原則)(Equator Principles)을 중심으로 -)

  • Park, Whon-Il
    • 한국무역상무학회:학술대회논문집
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    • 2006.06a
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    • pp.45-72
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    • 2006
  • The Equator Principles are a set of voluntary environmental and social guidelines for ethical project finance. These principles commit banks and other signatories to not finance projects that fail to meet these guidelines. The principles were conceived in 2002 on an initiative of the International Finance Corporation and launched in 2003. Since then, dozens of major banks have adopted the Principles, and with these banks among them accounting for more than three quarters of all project loan market volume the Principles have become the de facto standard for all banks and investors on how to deal with potential social and environmental effects of projects to be financed. While regarding the Principles an important initiative, NGOs have criticised the Principles for not producing real changes in financing activities and for allowing projects to go through that should have been screened out by the Principles, such as the Sakhalin-II oil and gas project in Russia. In early 2006, a process of revision of the principles was begun. The Equator Principles state that endorsing banks will only provide loans directly to projects under the following circumstances: - The risk of the project is categorized in accordance with internal guidelines based upon the environmental and social screening criteria of the International Finance Corporation (IFC). - For all medium or high risk projects (Category A and B projects), sponsors complete an Environmental Assessment, the preparation of which must meet certain requirements and satisfactorily address key environmental and social issues. - The Environmental Assessment report addresses baseline environmental and social conditions, requirements under host country laws and regulations, applicable international treaties and agreements, sustainable development and use of renewable natural resources, protection of human health, cultural properties, and biodiversity, including endangered species and sensitive ecosystems, use of dangerous substances, major hazards, occupational health and safety, fire prevention and life safety, socio-economic impacts, land acquisition and land use, involuntary resettlement, impacts on indigenous peoples and communities, cumulative impacts of existing projects, the proposed project, and anticipated future projects, participation of affected parties in the design, review and implementation of the project, consideration of feasible environmentally and socially preferable alternatives, efficient production, delivery and use of energy, pollution prevention and waste minimization, pollution controls (liquid effluents and air emissions) and solid and chemical waste management. - Based on the Environmental Assessment, Equator banks then make agreements with their clients on how they mitigate, monitor and manage those risks through an 'Environmental Management Plan'. Compliance with the plan is required in the covenant. If the borrower doesn't comply with the agreed terms, the bank will take corrective action, which if unsuccessful, could ultimately result in the bank canceling the loan and demanding immediate repayment. - For risky projects, the borrower consults with stakeholders (NGO's and project affected groups) and provides them with information on the risks of the project. - If necessary, an expert is consulted. The Principles only apply to projects over 50 million US dollars, which, according to the Equator Principles website, represent 97% of the total market. In early 2006, the financial institutions behind the Principles launched stakeholder consultations and negotiations aimed at revising the principles. The draft revised principles were met with criticism from NGO stakeholders, who in a joint position paper argued that the draft fails by ignoring the most serious critiques of the principles: a lack of consistent and rigorous implementation.

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