• BMB Reports
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• v.51 no.11
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• pp.545-546
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• 2018

With emerging evidence on the importance of non-cell autonomous toxicity in neurodegenerative diseases, therapeutic strategies targeting modulation of key immune cells. including microglia and Treg cells, have been designed for treatment of ALS and other neurodegenerative diseases. Strategy switching the patient's environment from a pro-inflammatory toxic to an anti-inflammatory, and neuroprotective condition, could be potential therapy for neurodegenerative diseases. Mesenchymal stem cells (MSCs) regulate innate and adaptive immune cells, through release of soluble factors such as $TGF-{\beta}$ and elevation of regulatory T cells (Tregs) and T helper-2 cells (Th2 cells), would play important roles, in the neuroprotective effect on motor neuronal cell death mechanisms in ALS. Single cycle of repeated intrathecal injections of BM-MSCs demonstrated a clinical benefit lasting at least 6 months, with safety, in ALS patients. Cytokine profiles of CSF provided evidence that BM-MSCs, have a role in switching from pro-inflammatory to anti-inflammatory conditions. Inverse correlation of $TGF-{\beta}1$ and MCP-1 levels, could be a potential biomarker to responsiveness. Thus, additional cycles of BM-MSC treatment are required, to confirm long-term efficacy and safety.

• Journal of Applied Biological Chemistry
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• v.56 no.4
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• pp.249-255
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• 2013

Recently, algae has been considered as a potential anti-inflammatory source due to its distinctive habitat environment exposing to light and high oxygen concentration. In present study, anti-inflammatory effect of brown alga, Sargassum fullvellum ethanol extract (SFEE), was examined. SFEE inhibited not only the production of nitric oxide and pro-inflammatory cytokines (IL-6, IL-$1{\beta}$, TNF-${\alpha}$) but also the expression of inducible nitric oxide synthase and cyclooxygenase 2 in LPS-induced RAW 264.7 cells without affecting cell viability. SFEE also suppressed the expression of nuclear factor kappa B (NF-${\kappa}B$), suggesting that SFEE could affect the expression of inflammation related cytokines and proteins through the regulation of NF-${\kappa}B$. Furthermore, formation of edema of the ear was 40% lower in mice treated with the highest dose (250 mg/kg) of SFEE than in the control mice. Thus, our study showed that SFEE may be a potential therapeutic anti-inflammatory drug.

• Hwankyungkyoyuk
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• v.12 no.1
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• pp.276-293
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• 1999

An environmentally hot issue has arisen from the plan of Young-Wall Dam Construction at Tong river in Korea lately. The point at issue is which value is bigger between the water conservation for human use in future and the ecosystem protection for the intrinsic value of nature including animals and plants there. The purpose of this study is in the qualitative understanding of college students' critical thinking ability and opinion and the environmental values of them through the analysis of their writings. Various environmental values written in the 7th revised national curriculum of Korea are used as a criteria to investigate students' environmental values in their written opinions. Various environmental values are shown up to be handled such as the anthropocentrism, ecocentrism, pro-technology etc. Students of Dept. of Environment Teaching in the Kongju National University are the subject of this study. It shows that they have a deep understanding of the Young-Wall Dam issue and assert their opinions objectively and critically. Most of them(89.5%, n=17) are against the constructional plan of the Young-Wall Dam. Students who are for the plan are proved to have pro-technology value only and the others who are against to have various values including deer ecology.

• Archives of Pharmacal Research
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• v.29 no.1
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• pp.1-15
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• 2006

Vascular endothelial cell injury or dysfunction has been implicated in the onset and' progression of cardiovascular diseases including atherosclerosis. A number of previous studies have demonstrated that the pro-oxidative and pro-inflammatory pathways within vascular endothelium play an important role in the initiation and progression of atherosclerosis, Recent evidence has provided compelling evidence to indicate that interleukin-4 (IL-4) can induce proc inflammatory environment via oxidative stress-mediated up-regulation of inflammatory mediators such as cytokine, chemokine, and adhesion molecules in vascular endothelial cells. In addition, apoptotic cell death within vascular endothelium has been hypothesized to be involved in the development of atherosclerosis. Emerging evidence has demonstrated that IL-4 can induce apoptosis of human vascular endothelial cells through the caspase-3-dependent pathway, suggesting that IL-4 can increase endothelial cell turnover by accelerated apoptosis, the event which may cause the dysfunction of the vascular endothelium. These studies will have a high probability of revealing new directions that lead to the development of clinical strategies toward the prevention and/or treatment for individuals with inflammatory vascular diseases including atherosclerosis.

• Journal of Internet Computing and Services
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• v.5 no.2
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• pp.85-95
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• 2004

The web-based project is seriously not efficient area at software engineering. In order to develop a web-based system, UI(User Interface) designers usually first design display layout and then business logic developers bring to complete the coding of the display layout source. In the case of maintenance, it goes through the same process, This kinds of web-based software development method were proposed by the various methods same as the tag library of JSP, But there are many problems to apply them and they are low productive comparing to the CIS based software development method, WFS(Neb Form System), which is suggested on this thesis, separates UI design from business logic on a web project and offers the better environment to develop web based software, Eventually WFS will improve the productivity to develop web based software.

• Korean Journal of Occupational Health Nursing
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• v.28 no.4
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• pp.285-292
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• 2019

Purpose: This study aimed to examine the factors associated with behavior that reduces exposure to environmental hormones among nursing students. Methods: Data were collected from 160 nursing students in D and B cities, using self-report questionnaires. Data were analyzed using SPSS 22.0, and the analyses included descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient test, and stepwise multiple regression. Results: Behavior that reduces exposure to environmental hormones differed significantly in terms of the participants' knowledge about environmental hormones. Behavior that reduces exposure to environmental hormones was negatively correlated with knowledge of environmental hormones, attitude towards pro-environmental behavior, and environmental self-efficacy; these factors were significant predictors of behavior that reduces exposure to environmental hormones, and accounted for 27.0% of the variance. Conclusion: Environmental self-efficacy was identified as the most significant factor affecting behavior that reduces exposure to environmental hormones in nursing students. Therefore, it is necessary to develop programs to improve pro-environmental behavior and environmental self-efficacy in nursing students.

• East Asian Journal of Business Economics (EAJBE)
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• v.9 no.4
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• pp.29-41
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• 2021

Purpose - The current study explores pro-environment human resource management attributes like an organization's leadership support, training, empowerment, and motivation practices to encourage employees to adopt an environmentally friendly lifestyle, leading to the success of the pro-environmental initiatives pursued by the organization. Research design, data, and methodology - The research subject is a considerable determinant that helps the research choose which qualitative textual analysis will suit that specific research. This study is suitable to conduct qualitative textual research because the justification for the qualitative content analysis used by a researcher is guided by the subject of the research, the available funds, the available time, and the research objectives. Result - Various solutions have been identified to ensure that all interventions taken by an organization, especially in educating and training their employees, are efficient, effective, and impactful. They revolve around the individual group, organizational, societal, and government policy approaches. Solutions will create a dedication to developing sustainability and ensuring that employees are positive when dealing with the surrounding. Conclusion - Consequently, combined efforts involving employees, society, organizations, and the government are necessary for formulating and implementing a practical course of action. This is to end the ongoing environmental degradation and foster positive behavioral change that involves activities and initiatives that will improve environmental performance for current and future generations.

• Journal of Astronomy and Space Sciences
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• v.39 no.3
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• pp.109-116
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• 2022

The small-scale magnetospheric and ionospheric plasma experiment (SNIPE) is a mission initiated by the Korea Astronomy and Space Science Institute (KASI) in 2017 and comprises four 6U-sized nano-satellites (Korea Astronomy and Space Science Institute Satellite-1, KASISat-1) flying in formations. The main goal of the SNIPE mission is to investigate the space environment in low Earth orbit at 500-km. Because Iridium & GPS Board (IGB) is installed on the KASISat-1, a communication simulation is required to analyze the contact number and the duration. In this study, communication simulations between the Iridium satellite network and KASISat-1 are performed using STK Pro (System Tool Kit Pro Ver 11.2) from the AGI (Analytical Graphics, Inc.). The contact number and durations were analyzed by each orbit and date. The analysis shows that the average access number per day is 38.714 times, with an average of 2.533 times per orbit for a week. Furthermore, on average, the Iridium satellite communication is linked for 70.597 min daily. Moreover, 4.625 min is the average duration of an individual orbit.

• KIEAE Journal
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• v.3 no.3
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• pp.11-18
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• 2003

The purpose of this study was to find out awareness of the environment-friendly planning elements for residential unit space among practitioners. The respondents in this questionnaire survey were 140 practitioners in architecture and interior design field. The major findings of this study were as follows; most of the respondents were aware of the impact of indoor built environment on residents' wellness. In addition, the survey respondents viewed that the factors for planning environment-friendly high-rise apartments were represented by gardening and energy-saving while their perception on the concept excluded comprehensive components affecting residents' life quality. Over 50% of respondents had an experience of applying environment-friendly planning elements in their works, and high frequency appeared on the general planning elements which had been applied special awareness as pro-environmental features. The respondents considered environment-friendly planning elements as important. Specially, space planning and system were considered more likely important in interior design field. In application of environment-friendly planning elements, cost, lack of consumers' awareness of and underdevelopment of environment-friendly materials were of concern. Therefore, the consumer's cognition needs to be improved for wide application about environment-friendly planning element, and then consumers are willing to pay additional construction cost of environment-friendly apartments. At the same time, the current practice that housing developers pass the additional cost on to residents needs to be changed. Then, the quality of life in high-rise residential settings can be improved. More importantly, the exchange and development of the reliable information on environment-friendly planning elements need to be made, and technical support and long-term policy for the development are required. This research showed current status of knowledge and practice in sustainable planning of unit apartment and proved basic information for future direction.

• Journal of the Korean Society for Marine Environment & Energy
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• v.18 no.2
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• pp.123-132
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• 2015

In this study, an arrangement design process for multiple wind turbines, placed on the 10MW class floating wave-offshore wind hybrid power generation system, was presented, and the aerodynamic performance was evaluated by using a computational fluid dynamics. An arrangement design, which produces a maximum power in the site wind field, was found by using a commercial program, WindPRO, based on a blade element momentum theory, then the effect of wake interference on the system between multiple wind turbines was studied and evaluated by using ANSYS CFX.