• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.4873-4878
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• 2012

Apoptosis is programmed cell death which is essential for development and survival of living organisms. It is a sequentially regulated suicidal programme where cells activate certain enzymes which dissolute their own nuclear component and various protein component of nucleus and cytoplasm. Disturbance of this regulatory pathway may lead to various diseases like autoimmune diseases, neurodegenerative diseases and cancers. The potential mechanisms of apoptosis and its role in cancer are discussed. The ability of apoptosis to modulate the life or death of a cell is also recognized for its immense therapeutic potential. Understanding the mechanisms from this review will give us better insight to the pathogenesis of various diseases including cancer and will open new horizons to therapeutic approaches.

• International Journal of Oral Biology
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• v.35 no.4
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• pp.203-207
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• 2010

A number of bacterial species coexist in oral cavities as a biofilm rather than a planktonic arrangement. By forming an oral biofilm with quorum sensing properties, microorganisms can develop a higher pathogenic potential and stronger resistance to the host immune system and antibiotics. Hence, the inhibition of biofilm formation has become a major research issue for the future prevention and treatment of oral diseases. In this study, we investigated the effects of pentose on biofilm formation and phenotypic changes using wild type oral bacteria obtained from healthy human saliva. D-ribose and D-arabinose were found to inhibit biofilm formation, but have no effects on the growth of each oral bacterium tested. Pentoses may thus be good candidate biofilm inhibitors without growth-inhibition activity and be employed for the future prevention or treatment of oral diseases.

• Journal of dental hygiene science
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• v.19 no.2
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• pp.77-85
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• 2019

In the past gut microbiome has been the main focus of microbiome research. Studies about the microbiome inside oral cavities and other organs are underway. Studies about the relationship between noninfectious diseases and periodontal diseases, and the negative effects of harmful oral microbes on systemic health have been published in the recent past. A lot of attention is being paid towards fostering a healthy oral microbial ecosystem. This study aimed to understand the roles and effects of the microbiome inside the human body can potentially help cure various diseases including inflammatory bowel diseases with no known cure such as Crohn's disease, atopic dermatitis, obesity, cancer, diabetes, brain diseases and oral diseases. The present study examined technological trends in the correlation between the human microbiome and diseases in the human body, interactions between the human body's immunity, the metabolic system, and the microbiome, and research trends in other countries. While it has been proven that human microbiome is closely correlated with human diseases, most studies are still in the early stage of trying to compare the composition of microbiomes between health and patient groups. Since the oral environment is a dynamic environment that changes due to not only food intake but also other external factors such as lifestyle, hygiene, and drug intake, it is necessary to continue in-depth research on the microbiome composition characteristics to understand the complex functions of oral microorganisms. Analyzing the oral microbiome using computational technology may aid in disease diagnosis and prevention.

• The Korean Journal of Health Service Management
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• v.10 no.3
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• pp.113-122
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• 2016

Objectives : This study analyzed the influencing relationship among oral health belief, prevention of oral diseases, and quality of life subject in adults over 20 years of age. Methods : This study enrolled 237 participants who visited Y hospital located in the Gyeongnam district as the final subjects for the analysis. From the collected data, multiple regression analysis was conducted to identify the relative influence of oral health belief on each parameter using SPSS 18.0. Results : Based on the regression analysis results, it was found that the factor in oral health belief with the strongest influence on the intention to prevent oral disease was importance. The behavior for prevention of oral disease was influenced by sensitivity, and the quality of life was affected by self-efficacy. Conclusions : These results, suggest that in order to promote oral health in adults, continuous support from oral health professionals is required to make patients recognize the importance and the sensitivity of oral health and reduce sensitivity.

• Journal of Korean society of Dental Hygiene
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• v.17 no.6
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• pp.1135-1145
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• 2017

Objectives: The objective of the study was to review the correlation between self-perceived oral health status and periodontal diseases in elderly Koreans, using data from the $6^{th}$ (2nd year) Korea National Health and Nutrition Examination Survey (2014). Methods: The subjects for this study were a total of 1,454 elderly people aged 65 years or older who responded to the health questionnaires of the $6^{th}$ (2nd year) Korea National Health and Nutrition Examination Survey conducted in 2014. Their general characteristics were analyzed using frequency analysis, while a cross-tabulation analysis (${\chi}^2-test$) was performed to understand the correlation with periodontal diseases. To clarify any effect of self-perceived oral health status on periodontal diseases, the selected variables were controlled and subsequently analyzed according to the logistic regression analysis. Results: In terms of the difference between elderly people with periodontal disease and those without periodontal disease, higher prevalence rates of periodontal diseases were found in women, those of younger age, those with lower educational and income levels, those with poorer subjective oral health status, those in the presence of chewing discomfort, those who had a toothbrushing frequency of twice per day, and/or those who had received no oral examination over the previous one year. Regarding the effect of self-perceived oral health status on periodontal diseases, 1.78-fold and 1.74-fold higher prevalence rates of periodontal diseases were shown with poorer subjective oral health status and in the presence of chewing discomfort, respectively. Conclusions: Based upon the results above, it is considered that a better understanding of self-perceived oral health status is necessary for a healthy life of the elderly. Furthermore, constant relevant studies and effective prevention programs intended to moderate the progress of or prevent periodontal diseases in the elderly in communities should be performed and implemented for the sake of better quality of life and oral health.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4621-4625
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• 2013

The purpose of this study was to construct a protein-protein interaction (PPI) network related to oral squamous cell carcinoma (OSCC). Each protein was ranked and those most associated with OSCC were mined within the network. First, OSCC-related genes were retrieved from the Online Mendelian Inheritance in Man (OMIM) database. Then they were mapped to their protein identifiers and a seed set of proteins was built. The seed proteins were expanded using the nearest neighbor expansion method to construct a PPI network through the Online Predicated Human Interaction Database (OPHID). The network was verified to be statistically significant, the score of each protein was evaluated by algorithm, then the OSCC-related proteins were ranked. 38 OSCC related seed proteins were expanded to 750 protein pairs. A protein-protein interaction nerwork was then constructed and the 30 top-ranked proteins listed. The four highest-scoring seed proteins were SMAD4, CTNNB1, HRAS, NOTCH1, and four non-seed proteins P53, EP300, SMAD3, SRC were mined using the nearest neighbor expansion method. The methods shown here may facilitate the discovery of important OSCC proteins and guide medical researchers in further pertinent studies.

• Journal of Korean society of Dental Hygiene
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• v.10 no.5
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• pp.925-933
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• 2010

Objectives : This study aimed to research subjective recognition of oral health, oral disease prevention, and knowledge of oral health among high school students to provide basic data necessary to develop an oral health education program for helping them prevent oral diseases and improve oral health in the future. Methods : Respondents' general characteristics and knowledge of oral health were estimated at frequency and percentage, and chi-square $(x^2)$ test was carried out to make a comparison for subjective recognition of oral health and oral disease prevention by general characteristics. ANOVA was used to get scores concerning knowledge of oral health care by general characteristics, and Pearson correlation was used to analyze correlation between recognition of oral health, oral disease prevention, and knowledge of oral health. Results : The findings of the study were as follows: 1. The percentage of those who had visited a dental clinic (hospital) within the previous one year (p<0.01) and had a regular oral examination (p<0.05) was higher in female students than in male ones, and percentage of those who had experienced oral health education (p<0.01) and who had regular oral examination (p<0.001) was highest in 11th graders. The percentage of those who used oral health products (p<0.01) and had pit and fissure sealing (p<0.01) was significantly higher among low-grade students, and the percentage of those who had scaling (p<0.01) was significantly higher among high-grade students. 2. Knowledge of oral health management was higher in female students (12.6) than in male ones (11.2) (p<0.001). Conclusions : A systematic oral health education program is necessary to help high school students improve recognition, prevention, and knowledge concerning oral health care, and continuous attention and efforts must be given to activate continuous oral health care implemented at the elementary level by inducing secondary school students to go on with it.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3611-3614
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• 2016

Background: Propolis based preparations have a wide range of applications in various specialties of dentistry. The aim of this clinical trial was to test the efficacy of propolis as a mouthwash in the reduction of chemotherapy induced oral mucositis (OM) in a single center. Materials and Methods: In this randomised, controlled study patients undergoing chemotherapy were included consecutively and randomised to an experimental group receiving propolis mouthwash (n = 20) and a control group receiving diluted water (n=20). Oral mucositis, erythema and eating and drink ability were assessed at baseline and after 3 and 7 days using the World Health Organization (WHO) scale and the oral mucositis assessment scale (OMAS). Results: There were significant differences in OM, wound and erythema in propolis group compared to placebo, but no significant difference in eating and drink ability. However, it was interesting that 65% of the patients in the propolis group were completely healed at day 7 of the trial. No significant adverse events were reported by the patients. Conclusions: This study found that oral care with propolis as mouthwash for patients undergoing chemotherapy is an effective intervention to improve oral health. Our findings shouldlencourage health practitioners to apply propolis mouth rinse for the oral care of patients under chemotherapy.

• The Journal of the Korean dental association
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• v.48 no.5
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• pp.350-354
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• 2010

Tuberculosis has re-emerged as serious infectious diseases, and oral tuberculosis, though uncommon, can be seen in both the primary and secondary tuberculosis. The aim of the present review is to describe the pathogenesis of tuberculosis and the characteristics of oral tuberculosis. The oral tuberculosis lesion may present as a diagnostic challenge for the clinician. In particular, the risk of tuberculosis transmission in dental practises is potentially increasing, the dentists and dental providers must exercise strict tuberculosis prevention.

• Journal of Korean Academy of Oral Health
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• v.42 no.4
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• pp.101-108
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• 2018

Objectives: The Korea National Health and Nutrition Examination Survey (KNHANES) is a national surveillance system that has been assessing the health and nutritional status of Koreans since 1998. Based on the National Health Promotion Act, the surveys have been conducted by the Korea Centers for Disease Control and Prevention (KCDC). Methods: An oral examination as part of The National Health and Nutrition Examination was proposed to calculate the sample design and survey participation. The surveying system was presented by classifying the measurement environment, screening, and survey items by year, and the merits and limitations of using the data were suggested by examining the status of survey quality management and the process of disclosing raw data. Results: This nationally representative cross-sectional survey samples approximately 10,000 individuals each year and collects information on oral examinations and oral health interviews. Data for the oral health component of KNHANES was obtained to assess the oral health status of Koreans and determine the prevalence of dental caries and periodontitis. The oral health data quality control of KNHANES was composed of three parts: "Education Program" and "Field Training Program" for quality control of oral health examiners (dentists) by the professional academy, and "Data management" by the KCDC. After completion of the three-step data check, the indicators of dental caries, periodontal disease, and oral health behavior were published in the National Health Statistics. Conclusions: To achieve the goals of oral health indicators, we will continue to monitor so that we can use it as basic data for oral policies and carry out various linkage analyses related to oral diseases.