• Title/Summary/Keyword: Prevention model

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Association between the Epidermal Growth Factor 61*A/G Polymorphism and Hepatocellular Carcinoma Risk: a Meta-Analysis

  • Sun, Shuang;Jin, Guo-Jiang;Zhao, Yan;Kang, Hui
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.7
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    • pp.3009-3014
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    • 2015
  • The epidermal growth factor (EGF) may play a pathological role in hepatocellular carcinoma (HCC). However, the conclusions of published reports on the relationship between the EGF $61^*A/G$ polymorphism and HCC risk remain controversial. To derive a more precise estimation we performed a meta-analysis based on 14 studies that together included 2,506 cases and 4,386 controls. PubMed, EMBASE, Web of Knowledge and the Chinese National Knowledge Infrastructure (CNKI) databases were used to retrieve articles up to August 1, 2014. The crude odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated to evaluate the association. Meta-analysis results showed a significant association between the EGF $61^*A/G$ polymorphism and HCC risk in all four genetic models (allele model: OR=1.25, 95%CI=1.12-1.40; dominant model: OR=1.32, 95%CI=1.14-1.54; recessive model: OR=1.33, 95%CI=1.12-1.58; ho-mozygous model: OR=1.59, 95%CI=1.33-1.90). Moreover, significant associations were observed when stratified by ethnicity, source of controls, etiology and genotype methods. Thus, this meta-analysis suggests that the G-allele of the EGF $61^*A/G$ polymorphism is associated with an increased risk of HCC, especially in Asians and Caucasians, without influence from the source of controls or etiological diversity. Further studies with larger population sizes are needed to confirm these results.

The NQO1 rs1800566 Polymorphism and Risk of Bladder Cancer: Evidence from 6,169 Subjects

  • Guo, Zhan-Jing;Feng, Chang-Long
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.12
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    • pp.6343-6348
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    • 2012
  • Objective: The NAD(P)H:quinone oxidoreductase 1 (NQO1) rs1800566 polymorphism, leading to proline-toserine amino-acid and enzyme activity changes, has been implicated in bladder cancer risk, but individually published studies showed inconsistent results. We therefore here conducted a meta-analysis to summarize the possible association. Methods: A systematic literature search up to August 27, 2012 was carried out in PubMed, EMBASE and Wanfang databases, and the references of retrieved articles were screened. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analyzed for homozygote contrast (TT vs. CC), additive model (T vs. C), dominant model (TT+CT vs. CC), and recessive model (TT vs. CC+CT) to assess the association using fixed- or random-effect models. Results: We identified 12 case-control studies including 3,041 cases and 3,128 controls for the present meta-analysis. Significant association between NQO1 rs1800566 genetic polymorphism and risk of bladder cancer was observed in the additive model (OR = 1.15, 95% CI = 1.01-1.30, p = 0.030). Moreover, in the subgroup analysis stratified by ethnicity, significant associations were observed in Asians (OR = 1.26, 95% CI = 1.08-1.47, p = 0.003 for T vs. C; OR = 1.68, 95% CI = 1.21-2.32, p = 0.002 for TT vs. CC; OR = 1.50, 95% CI = 1.13-1.98, p = 0.005 for TT vs. CT+CC) but not in Caucasians. Conclusions: The results suggest that NQO1 rs1800566 genetic polymorphism may contribute to bladder cancer development, especially in Asians.

Study on primary officer military counseling model (초급간부 군 상담모델 개발 연구)

  • Seo, Seon Woo
    • Convergence Security Journal
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    • v.16 no.6_1
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    • pp.75-83
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    • 2016
  • Soldiers management is the core of military combat power to preserve and accident prevention. But in unforeseen times and places did the unthinkable soldier causes an accident, the inexperienced primary officer were upset, and can often be quite nervous. And various accidents prevention is also win the war, the reason for existence in the military for combat readiness as a precondition for perfection. There are primary officers at the forefront of this critical mission. However, in spite of the lack of time to work for combat readiness, orders from higher units of troops management and that's level giving a lot of pressure to primary officer. So I made the primary officer military counseling model ike this. Using Primary officer counseling model is possible to rapid and efficient counseling advice against the target client soldier. The efficient counseling is must take precedence on understanding on client soldier deeply. Depth understanding someone needs a lot of effort and time. However, to Primary officer, it is true that they have a lack of condition that are enough to give the time and effort. Therefore, effective counseling and accident prevention is possible to use counseling model through choice and concentration activities.

A Proposal of the Disaster Mitigation Activity Management System Model for Strengthening Disaster Prevention Activities (재난 예방활동 강화를 위한 재해경감활동관리체계 모델 제안)

  • Kim, Sang Duk;Kim, Chang Soo
    • Journal of the Society of Disaster Information
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    • v.15 no.4
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    • pp.502-513
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    • 2019
  • Purpose: This study intends to review the procedures for the establishment of the plan for disaster mitigation activities and the system for the management of disaster mitigation activities for the requirements of the enterprise disaster management standard. Method: The requirements, including the activities of each stage of disaster management defined within the scope of the corporate disaster management standard, were identified, the operational cases of 'A' institution were reviewed, and the targets of continuous planning were reviewed to meet the requirements. Result: It was reviewed that the contents and procedures of each phase of disaster management, which is a requirement of the enterprise disaster management standard, are clearly defined, and a task continuity plan is established for each stage of activity. Conclusion: Conclusion : The PDCA model including the activities of each stage of disaster management activities was presented for the requirements of the enterprise disaster management standard, and the disaster mitigation activity management system model of the broad concept of disaster management including prevention and preparedness plans for disasters was presented.

Forecasting Model Design of Fire Occurrences with ARIMA Models (ARIMA모델에 기반한 화재발생 빈도 예측모델의 설계)

  • Ahn, Sanghun;Kang, Hoon;Cho, Jaehoon;Kim, Tae-Ok;Shin, Dongil
    • Journal of the Korean Institute of Gas
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    • v.19 no.2
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    • pp.20-28
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    • 2015
  • A suitable monitoring method is necessary for successful policy implementation and its evaluation, required for effective prevention of abnormal fire occurrences. To do this, there were studies for applying control charts of quality management to fire occurrence monitoring. As a result, it was proved that more fire occurs in winter and its trend moves yearly-basis with some patterns. Although it has trend, if we apply the same criteria for each time, inefficient overreacting fire prevention policy will be accomplished in winter, and deficient policy will be accomplished in summer. Thus, applying different control limits adaptively for each time would enable better forecasting and monitoring of fire occurrences. In this study, we treat fire occurrences as time series model and propose a method for configuring its coefficients with ARIMA model. Based on this, we expect to carry out advanced analysis of fire occurrences and reasonable implementation of prevention activities.

Analysis of Debris Flow Affected Area Using Hyper KANAKO Model (Hyper KANAKO 모형을 이용한 토석류 피해지 분석)

  • Kang, Bae Dong;Jun, Kye Won;Kim, Young Hwan
    • Journal of Korean Society of Disaster and Security
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    • v.14 no.1
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    • pp.51-59
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    • 2021
  • In Korea, where 64% of the soil is mountainous, typhoons and local rains concentrated in the summer season are frequent in mountainous disasters such as landslides and debris flow. The area of study was the area where the damage to the debris flow was caused by typhoon Mitag in October 2019, and all the houses located in the downstream area were damaged. In this study, numerical simulations were conducted on the area where the damage of earth and stone flow occurred using Hyper KANAKO model that can consider erosion and sedimentation, and the applicability of the model was examined by comparing the actual damage area and the analysis results of the model. As a result of the numerical simulation, the damage area of the debris flow in the target area was 53,875 m2, the maximum flow depth was 2.4 m, and the average flow depth was 1.7 m.

Design of Static Output Feedback Controllers for Rollover Prevention (차량 전복 방지를 위한 정적 출력 피드백 제어기 설계)

  • Yim, Seongjin;Oh, Dongho
    • Transactions of the Korean Society of Automotive Engineers
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    • v.22 no.1
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    • pp.20-28
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    • 2014
  • This paper presents static output feedback LQ and $H_{\infty}$ controllers for rollover prevention. Linear quadratic static output feedback controllers have been proposed for rollover prevention in such a way to minimize the lateral acceleration and the roll angle. Rollover prevention capability can be enhanced if $H_{\infty}$ controller is designed. To avoid full-state measurement for feedback requirement or sensitiveness of an observer to nonlinear model error, static output feedback is adopted. To design static output feedback controllers, Kosut's method is adopted because it is simple to calculate. Differential braking and active anti-roll bar are adopted as actuators that generate yaw and roll moments, respectively. The proposed method is shown to be effective in preventing rollover through the simulations on nonlinear multi-body dynamic simulation software, CarSim.

Development of a Safety Education Guideline Book for Teachers of Elementary School Students (초등학생을 위한 교사용 안전교육 지침서 개발)

  • Kim, Shin-Jeong;Kim, Sung-Hee
    • Child Health Nursing Research
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    • v.15 no.2
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    • pp.145-154
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    • 2009
  • Purpose: The purpose of this study was to develop a guide book on safety education for teachers to use in education classes for elementary school students. Methods: Dick & Carey's teaching model and Keller's ARCS theory were used in the development of this guide book. Results: This guide book was developed for lower grade (1st$\sim$3rd) and higher grade (4th$\sim$6th) elementary school students. The content consisted of subjects, worksheets, content for teachers, statistical data, case studies, and a safety letter to the parents. The 10 subjects were as follows: "Importance of injury prevention", "Safety at home", "Accident prevention at school", "Violence prevention", "Vehicles safety", "Water safety", "Prevention of Fires & Burns", "Safety of Toys & home supplies", "Safety in Sports & Recreation activity", "Prevention of injury caused by animals". Statistical data was presented by graphs and case studies were presented of cases of real occurrences of accidents. Worksheets contain various activities for students. Safety letters were composed for each student's parents. Conclusion: This guide book presents effective material for safety education classes in elementary school and the authors hope it will be widely used in elementary schools.

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Study on Theoretical Models of Regional Humanity Lung Cancer Hazards Assessment

  • Zhang, Chuan;Gao, Xing
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.5
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    • pp.1759-1764
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    • 2015
  • Purpose: To establish the concept of lung cancer hazard assessment theoretical models, evaluating the degree of lung cancer risk of Beijing for regional population lung cancer hazard assessment to provide a basis for technical support. Materials and Methods: ISO standards were used to classify stratified analysis for the entire population, life cycle, processes and socioeconomic management. Associated risk factors were evaluated as lung cancer hazard risk assessment first class indicators. Study design: Using the above materials, indicators were given the weight coefficients, building lung cancer risk assessment theoretical models. Regional data for Beijing were entered into the theoretical model to calculate the parameters of each indicator and evaluate the degree of local lung cancer risk. Results: Adopting the concept of lung cancer hazard assessment and theoretical models for regional populations, we established a lung cancer hazard risk assessment system, including 2 first indicators, 8 secondary indicators and 18 third indicators. All indicators were given weight coefficients and used as information sources. Score of hazard for lung cancer was 84.4 in Beijing. Conclusions: Comprehensively and systematically building a lung cancer risk assessment theoretical model for regional populations in conceivable, evaluating the degree of lung cancer risk of Beijing, providing technical support and scientific basis for interventions for prevention.

Cost-Benefit Analysis of Electrical Safety Speed-call Service Using Electrical Fire Statistics Analysis and Outcome Analysis Logic Model (전기화재 통계 및 성과 분석 모델을 이용한 전기안전 긴급출동 고충처리 서비스의 비용 편익 분석)

  • Jeon, Jeong Chay;Yoo, Jae-Geun
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.65 no.11
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    • pp.1943-1947
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    • 2016
  • Korea Electrical Safety Cooperation(KESCO) have provided the electrical safety speed-call service from 2007 year. Purpose of the service is to reduce discomfort of electricity use and to prevent electrical accident like as electrical fire and shock accident by providing emergency treatment service on fault of the residential electrical facilities notified in the specific house like as a lower-income group and a social welfare facility. But efficiency and economic evaluation of the electrical safety speed-call service is impossible because analysis on the quantitative effect of the service is difficult. This paper presents cost-benefit analysis method and result of the electrical safety speed-call service. The presented cost-benefit analysis method has a two-step process: the first step is to measure quantitative electrical fire prevention effect of the service by using electrical accident statistics and developing outcome analysis logic model of the service effect, and the second step is to analysis cost-benefit(B/C)of the service by calculating quantitative benefit analysis on the measured quantitative electrical fire prevention effect. The results showed that cost-benefit(B/C)of the electrical safety speed-call service is over 4 after 2010 year.