• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4235-4238
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• 2013

Glucoraphanin is the main glucosinolate found in broccoli and other cruciferous vegetables (Brassicaceae). The objective of the study was to evaluate whether glucoraphanin and its breakdown product sulforaphane, are potent modulators of various phase I and phase II enzymes involved in carcinogen-metabolising enzyme systems in vitro. The glucosinolate glucoraphanin was isolated from cruciferous vegetables and exposed to human hepatoma cell line HepG2 at various concentrations (0-25 ${\mu}M$) for 24 hours. Glucoraphanin at higher concentration (25 ${\mu}M$) decreased dealkylation of methoxyresorufin, a marker for cytochrome P4501 activity; supplementation of the incubation medium with myrosinase (0.018 U), the enzyme that converts glucosinolate to its corresponding isothiocyanate, showed minimal induction in this enzyme activity at concentration 10 ${\mu}M$. Quinone reductase and glutathione S-transferase activities were unaffected by this glucosinolate; however, supplementation of the incubation medium with myrosinase elevated quinone reductase activity. It may be inferred that the breakdown product of glucoraphanin, in this case sulforaphane, is superior than its precursor in modulating carcinogen-metabolising enzyme systems in vitro and this is likely to impact on the chemopreventive activity linked to cruciferous vegetable consumption.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.183-187
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• 2016

Rhizomes of Boesenbergia pandurata (Roxb.) Schlecht have been reported to contain active compounds with anticancer properties. This research was carried out to examine anti-proliferative and apoptotic induction against HeLa and Vero cells-line. Dried powder of B. pandurata rhizomes was extracted by a maceration method using 90% ethanol. Cytotoxic assays to determine $IC_{50}$ and anti-proliferative effects were carried out by MTT methods. Observation of apoptosis was achieved with double staining using acridine orange and ethidium bromide. The results showed that ethanolic extract of B. pandurata was more cytotoxic against HeLa cells ($IC_{50}$ of $60{\mu}g/mL$) than Vero cells ($IC_{50}$ of $125{\mu}g/mL$). The extract had higher anti-proliferative activity as well as apoptotic induction in HeLa than Vero cells. Therefore, it was concluded that the ethanolic extract of B. pandurata had anti-proliferative as well as apoptosis induction activity dependent on the cell type.

• 한국재난정보학회 논문집
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• 제15권4호
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• pp.502-513
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• 2019

연구목적: 본 연구는 기업재난관리표준의 요구사항에 대한 재해경감활동계획 수립절차와 재해경감활동관리체계를 검토하고자 한다. 연구방법: 기업재난관리표준의 적용범위에 규정된 재난관리 단계별 각 활동을 포함한 요구사항을 파악하고 'A'기관의 운용사례를 검토하였으며 요구사항에 맞는 업무연속계획 대상을 검토하였다. 연구결과: 기업재난관리표준의 요구사항인 재난관리 단계별 내용과 절차를 명확히 정의하고, 4단계별 활동에 대한 업무연속성계획 수립이 필요한 것으로 검토되었다. 결론: 기업재난관리표준 요구사항에 대하여 재난관리활동 각 단계별 활동을 포함한 PDCA모델을 제시하였고, 재난의 예방 및 대비계획을 포함하는 광의의 재난관리 개념의 재해경감활동관리체계 모델을 제안하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2599-2605
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• 2013

The study aimed to evaluate immune-stimulating effects of a well-known Thai folkloric remedy when used for adjuvant therapy with conventional chemotherapeutics for treatment of breast cancer. Immunostimulating influence of the remedy (215 mg/kg body weight per day) on NK cell activity and TNF-${\alpha}$ release from the monocytes/macrophages were investigated in a total of 15 healthy women and 13 female patients with breast cancer (Group 1). The effect of breast tumor surgery on NK cell activity was further investigated in 18 female patients with breast cancer (Group 2). NK cell cytotoxic activity was determined by chromium release cytotoxic assay using K562, an erythroleukemic cell line. TNF-${\alpha}$ release from monocytes/macrophages separated from blood samples was determined through a biological assay using actinomycin D-treated L929 mouse fibroblast cells in the presence and absence of LPS. Baseline NK cell activity of the monocytes/macrophages separated from Group 2 patients expressed as %cytotoxicity was significantly lower than in the healthy subjects at E:T ratios of 100:1 and 25:1. In healthy subjects, there was no change in NK cell cytotoxic activity (%cytotoxicity or LU) following 1 and 2 weeks of treatment with the remedy compared with the baseline at various E:T ratios but the binding activity (%binding) was significantly increased after 2 weeks of treatment. The addition of one or two conventional chemotherapeutic regimens did not significantly reduce the NK cytotoxic activity but did affect release of TNF-${\alpha}$ in both unstimulated and LPS-stimulated samples. Surgery produced a significant suppressive effect on NK cell activity. The use of the remedy as an adjunct therapy may improve therapeutic efficacy and safety profiles of conventional chemotherapeutic regimens through stimulation of the immune system in cancer patients.

• 융합보안논문지
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• 제16권7호
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• pp.51-59
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• 2016

기업의 정보시스템에 대한 내 외부의 위협이 증가되고 있으며 이를 감소시키기 위해 많은 돈과 인력을 투자하고 있다. 하지만 이러한 투자에도 불구하고 보안위협과 사고는 지속적으로 발생하고 있다. 본 연구는 기업의 사고 방지를 위한 다양한 정보보호 활동을 예방 지향적과 억제 지향적으로 구분하고 건강신념모델을 이용하여 기업의 정보보안 활동이 구성원들에게 어떤 영향을 미치고 정보보안 정책을 준수하도록 하는지 연구하였다. 연구결과 예방 지향적 활동은 심각성에, 억제 지향적 활동은 유익성에 유의미한 영향을 주고, 심각성과 유익성은 각각 준수의도에 영향을 주었다. 이러한 결과로 미루어보아, 기업에서 교육, 홍보, 모니터링 등 사전적인 활동을 시행할 경우 미 준수로 발생할 수 있는 부정적인 결과에 대해 강조하여야 하며, 감사, 처벌 등 사후적인 활동을 통해 보안을 유지하고자 할 경우 기업의 의지를 보임으로써 보안 정책을 준수하는 것이 유익할 것이라는 판단을 구성원 스스로 하도록 하는 것이 더욱 효과적인 정보보안 활동이 될 것이다.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.245.1-245.1
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• 2002

It has been known that resveratrol, a phytoalexin present in grapes mainly, has antioxidant. anti-inflammatory, and cancer chemopreventive activity. One mechanism of its anti-inflammation and cancer prevention is considered to modulate cyclooxygense-2 (COX-2) activity. Since COX-2 plays an important role in inflammation and carcinogenesis, the potential COX-2 inhibitors have been considered as anti-inflammatory or cancer chemopreventive agents. (omitted)

• 융합정보논문지
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• 제9권12호
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• pp.71-80
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• 2019

본 연구는 노인요양시설 간호제공자의 골다공증 관련 지식과 골다공증 예방활동을 파악하기 위한 서술적 조사연구이다. 연구대상자는 S시와 Y시의 노인요양시설 4곳에서 근무 중인 간호제공자 142명이며 자료 수집기간은 2019년 7월 1일부터 7월 20일까지이다. 연구 자료는 SPSS 24.0 Version을 이용하였으며 t-test, ANOVA, Pearson's correlation coefficient를 실시하였다. 연구결과, 간호제공자의 골다공증 관련 지식은 중간수준으로 간호제공자의 학력, 골다공증 관리 교육 경험, 입소자 수, 노인 뼈 건강 중요도 인식에 따라 차이를 보였으며, 골다공증의 예방활동은 골다공증 관리 교육 경험, 노인 뼈 건강 중요도 인식에 따라 차이를 보였다. 연구대상자의 골다공증 관련 지식과 골다공증 예방활동은 정적 상관이 있었다. 따라서 노인 요양시설 간호제공자의 노인 골다공증 관리와 노인 뼈 건강 중요도 인식을 향상시키기 위한 교육 프로그램의 개발과 그에 따른 교육이 필요하며, 향후 교육의 효과를 확인하는 추가연구가 필요하다.

• 한국환경과학회지
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• 제27권11호
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• pp.957-966
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• 2018

This study intend to induce citizen's voluntary preliminary disaster prevention activity to reduce damage of typhoon that occurs every year. For this purpose, a survey was conducted to develop Typhoon information contents. The number of samples used in the survey was set to 500 people, and citizens living in Jeju, Busan, and Jeonlanam-do were surveyed for areas with high typhoon disasters in order to develop practical and efficient information. The survey consisted of perception about natural disaster, how to get and use weather information, satisfaction with typhoon information and requirements. The general public perceived the typhoon as the first natural disaster. As a result of responding to the method of obtaining and utilizing weather information, the frequency of collecting weather information at the time of issuance of typhoon special report is higher than usual. The purpose of using weather information is clear and the response rate is high for the purpose of disaster prevention. The medium mainly collecting weather information is Internet portal site and mobile phone besides television. The current satisfaction with typhoon weather information is 34.8%, in addition to the accuracy of prediction, it is necessary to improve the information (that is content) provided. Specific responses to the content were investigated not only for single meteorological factors, but also for possible damage and potential countermeasures in the event of a disaster such as a typhoon. As can be seen from the above results, people are requested to provide information that can be used to detect and cope with disasters. The development of new content using easy accessible media will contribute to the reduction of damages caused by the typhoon that will occur in the future, and also to the disaster prevention activity.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.351-360
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• 2012

Background: Identification of reliable predictors of leisure time physical activity (LTPA) will enable healthcare providers to intervene and change the patterns of LTPA in the population to improve community health. Objectives: The objectives of this study were to determine prevalence and pattern of LTPA among adult Saudis aged 18-65 years, and to define the socio-demographic determinants that correlate with LTPA in Al-Hassa, Saudi Arabia. Subjects and Methods: A cross-sectional study of 2176 adult Saudis attending urban and rural primary health care centers were selected using a multistage proportionate sampling method. Participants were personally interviewed to gather information regarding socio-demographics, physical activity pattern using the Global Physical Activity Questionnaire (GPAQ). Physical activity (PA) in each domain was expressed in metabolic equivalents (METs). Results: The median total METs minutes/week for LTPA for both genders was 256, higher for men (636 METs minutes/week) compared to women (249METs minutes/week). Overall, only 19.8% of the total PA was derived from LTPA. Of the sampled population 50.0% reported doing no leisure activity. Using the cut off of 600 METs-minutes/day or 150 minutes of moderate intensity over 5 or more days/week, only 21.0% of the included sample were considered as being sufficiently active and 10.4% were in the high active category with beneficial health effects. Multivariate regression analysis showed that male, younger age (<35 years), absence of chronic disease conditions and moderate level of total PA were significant predictors for being active in the LTPA domain. Conclusion: The prevalence and intensity of LTPA among the included sample demonstrated low levels. Nearly 80% of the included sample population did not achieve the recommended LTPA level with beneficial health effects. Female gender, urban residence and associated chronic diseases correlated with a low LTPA.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.4083-4088
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• 2016

Background: Physical inactivity has been identified as the fourth leading risk factor for global mortality and is associated with increased breast cancer diagnosis and recurrence. Purpose: To examine the association between adult lifetime physical activity and breast cancer risk in a case-control analysis. Materials and Methods: This study involved 122 cases of breast cancer and 121 controls in the state of Kelantan in Malaysia. A comprehensive measure of lifetime physical activity was used to assess occupational, household, and recreational/sports activity. For every type of activity, a metabolic equivalent (MET) score was assigned using the compendium of physical activities. MET-hours/week per year for all types of activities at different levels of intensities for different age groups were calculated. Logistic regression analysis was used to estimate odds ratios between various measures of physical activity and breast cancer risk. Conclusions: The mean MET-hours/week per year for all activities were 120.0 and 132.9 of MET-hours/week per year for cases and controls respectively. Household activities accounted for about 70% of the total lifetime physical activities. Only about 2.5% of the total lifetime physical activities were in the form of recreational/sports. This study found no association between lifetime occupational and recreational/sports physical activities with breast cancer risk among Kelantanese women. However, higher intensity lifetime household activities seemed to significantly reduce risk of breast cancer.