• Biomolecules & Therapeutics
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• v.4 no.2
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• pp.205-207
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• 1996

Clonidine, an antihypertensive drug, stimulates postsynaptic alpha-2 adrenergic receptors in the central nervous system and lowers arterial pressure through the effects on both cardiac output and peripheral resistance. However, many patients experience that sedation and xerostomia occur upon oral administration of clonidine. These side effects are due to high plasma peak concentration and can be avoided when clonidine is given transdermally. In this study, we tested the antihypertensive effects of trandermal administration of clonidine patch on spontaneously hypertensive rat (SHR) which is a model animal for human essential hypertension. Forty eight SHR (male) were divided into six groups according to the dose levels, respectively. After transdermal administration of clonidine patch of each dose, systolic blood pressure and heart rate were measured. Clonidine patch produced maximal antihypertensive and bradycardiac effects 48 hrs after administration and antihypertensive effects showed dose-dependency. We suggest that antihypertensive effects of clonidine patch are similar to those of orally given clonidine and clonidine patch can be used instead of clonidine tablet.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.5
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• pp.61-68
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• 2021

Movable weirs with multi-stage control are necessary in many Korean rivers to actively control the water storage level. A mesh dependency test was performed to determine the appropriate number of meshes for structural analysis of movable weirs. The standing angles of movable weirs were set to 60°, 45°, 30°, and 15° for stress analysis. The standing angle of 0° was excluded from the analysis because it was unloaded. Changes in the standing angle led to changes in the water depth, maximum pressure, maximum strain, and maximum stress. The maximum average stress and the structural safety of the multi-stage control movable weir were computed and tested using the Ansys FEA software package.

• Transactions of the Korean hydrogen and new energy society
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• v.25 no.5
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• pp.550-559
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• 2014

Hydraulic performance of the 1 inch ball valve have been analyzed based on the three-dimensional Reynolds-averaged Navier-Stokes analysis and an experiment. The experimental test rig of the 1 inch ball valve has been developed to investigate pressure drop for the 1 inch ball valve. The numerical model, which has reliability and effectiveness, has been constructed through the grid dependency test and validation with the results of the experiment. Shear stress transport turbulence model has been used to enhance an accuracy of the turbulence prediction in the pipeline and ball valve, respectively. Effects of the ball valve angle on the flow characteristics and friction performance have been evaluated.

• 한국전산유체공학회:학술대회논문집
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• 2010.05a
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• pp.320-325
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• 2010

A multiphase CFD analysis is performed to investigate the effect of near-wall grid for simulating a subcooled boiling flow in vertical tube. The multiphase flow model used in this CFD analysis is the two-fluid model in which liquid(water) and vapor(steam) are considered as continuous and dispersed fluids, respectively. A wall boiling model is also used to simulate the subcooled boiling heat transfer at the heated wall boundary. The diameter and heated length of tube are 0.0154 m and 2 m, respectively. The system pressure in tube is 4.5 MPa and the inlet subcooling is 60 K. The near-wall grid size in the non-dimensional wall unit ($y_{w}^{+}$) was examined from 64 to 172 at the outlet boundary. The CFD calculations predicted the void distributions as well as the liquid and wall temperatures in tube. The predicted axial variations of the void fraction and the wall temperature are compared with the measured ones. The CFD prediction of the wall temperature is shown to slightly depend on the near-wall grid size but the axial void prediction has somewhat large dependency. The CFD prediction was found to show a better agreement with the measured one for the large near-wall grid, e.g., $y_{w}^{+}$ > 100.

• Journal of computational fluids engineering
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• v.15 no.3
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• pp.24-31
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• 2010

boiling flow in vertical tube. The multiphase flow model used in this CFD analysis is the two-fluid model in which liquid(water) and gas(vapour) are considered as continuous and dispersed fluids, respectively. A wall boiling model is also used to simulate the subcooled boiling heat transfer at the heated wall boundary. The diameter and heated length of tube are 0.0154 m and 2 m, respectively. The system pressure in tube is 4.5 MPa and the inlet subcooling is 60 K. The near-wall grid size in the non-dimensional wall unit for lqiuid phase ($y^+_{w,l}$) was examined from 101 to 313 at the outlet boundary. The CFD calculations predicted the void distributions as well as the liquid and wall temperatures in tube. The predicted axial variations of the void fraction and the wall temperature are compared with the measured ones. The CFD prediction of the wall temperature is shown to slightly depend on the near-wall grid size but the axial void prediction has somewhat large dependency. The CFD prediction was found to show a better agreement with the measured one for the large near-wall grid, e.g., $y^+_{w,l}$ > 300 at the tube exit.

• Journal of the Korean Geotechnical Society
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• v.18 no.3
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• pp.105-112
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• 2002

Increases in excess pore water pressure without change of surcharge load were reported in clay underneath embankment at Berthierville and Olga sites after the end of construction. These abnormal phenomena could not be explained by classical consolidation theory. This paper presents a nonlinear viscoplastic model to interpret an increase in pore water pressure on natural clay, The proposed model can consider the combined processes of pore water pressure dissipation according to Darcy's law and pore water pressure generation due to viscoplastic strain, as well as time-dependent viscoplastic behaviour and strain rate dependency of preconsolidation pressure. The calculated results using numerical analysis are compared with measured ones under embankments built on soft clay at Berthierville and Olga in Quebec, Canada. It may be possible to explain the phenomenon of excess pore water pressure increase after the end of construction using the proposed nonlinear viscoplastic model.

• Wind and Structures
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• v.5 no.2_3_4
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• pp.165-176
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• 2002

Results of measurements of surface pressure and of velocity field made on a full-scale 6 m cube in natural wind are reported. Comparisons are made with results from boundary-layer wind-tunnel studies reported in the literature. Two flow angles are reported; flow normal to a face of the cube (the $0^{\circ}$ case) and flow at $45^{\circ}$. In most comparisons, the spread of wind-tunnel results of pressure measurements spans the full-scale measurements. The exception to this is for the $0^{\circ}$ case where the roof and side-wall pressures at full-scale are more negative, and as a result of this the leeward wall pressures are also lower. The cause of this difference is postulated to be a Reynolds Number scale effect that affects flow reattachment. Measurements of velocity in the vicinity of the cube have been used to define the mean reattachment point on the roof centre line for the $0^{\circ}$ case, and the ground level reattachment point behind the cube for both $0^{\circ}$ and $45^{\circ}$ flow. Comparisons are reported with another full-scale experiment and also with wind-tunnel experiments that indicate a possible dependency on turbulence levels in the approach flow.

• BMB Reports
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• v.34 no.5
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• pp.457-462
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• 2001

Using the monomolecular film technique, we compared the interfacial properties of Staphylococcus simulans lipase (SSL) and Staphylococcus aureus lipase (SAL). These two enzymes act specifically on glycerides without any detectable phospholipase activity when using various phospholipids. Our results show that the maximum rate of racemic dicaprin (rac-dicaprin) hydrolysis was displayed at pH 8.5, or 6.5 with Staphylococcus simulans lipase or Staphylococcus aureus lipase, respectively The two enzymes interact strongly with egg-phosphatidyl choline (egg-PC) monomolecular films, evidenced by a critical surface pressure value of around $23\;mN{\cdot}m^{-1}$. In contrast to pancreatic lipases, $\beta$-lactoglobulin, a tensioactive protein, failed to inhibit Staphylococcus simulans lipase and Staphylococcus aureus lipase. A kinetic study on the surface pressure dependency, stereoselectivity, and regioselectivity of Staphylococcus simulans lipase and Staphylococcus aureus lipase was performed using optically pure stereoisomers of diglycerides (1,2-sn-dicaprin and 2,3-sn-dicaprin) and a prochiral isomer (1,3-sn-dicaprin) that were spread as monomolecular films at the air-water interface. Both staphylococcal lipases acted preferentially on distal carboxylic ester groups of the diglyceride isomer (1,3-sn-dicaprin). Furthermore, Staphylococcus simulans lipase was found to be markedly stereoselective for the sn-3 position of the 2,3-sn-dicaprin isomer.

• Tribology and Lubricants
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• v.27 no.1
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• pp.7-12
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• 2011

Interest in advanced machining process such as AJM(abrasive jet machining) and CMP(chemical-mechanical polishing) using micro/nano-sized abrasives has been on the increasing demand due to wide use of super alloys, composites, semiconductor and ceramics, which are difficult to or cannot be processed by traditional machining methods. In this paper, the effects of pressure, wafer moving velocity and fluid viscosity were investigated by 2-dimensional finite element analysis method considering slurry fluid flow. From the investigation, it could be found that the simulation results quite corresponded well to the Preston's equation that describes pressure/velocity dependency on material removal. The result also revealed that the stress and corresponding material removal induced by the collision of particle may decrease under relatively high wafer moving speed due to the slurry flow resistance. In addition, the increase in slurry fluid viscosity causes the reduction of material removal rate. It should be noted that the viscosity effect can vary with the shape of abrasive particle.

• Journal of the Korean Ceramic Society
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• v.37 no.8
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• pp.817-823
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• 2000

A solid-state electrochemicall cell for sensing CO2 gas was fabricated using a solid electrolyte of Li2CO3-Li3PO4-Al2O3 mixture and a reference electrode of LiMn2O4. The e.m.f. (electromotive force) of sensor showed a good accordance with theoretical Nernst slope (n=2) for CO2 gas concentration range of 100-10000 ppm above 35$0^{\circ}C$. The e.m.f. of sensor was constant regardless of oxygen partial pressure at the high temperature above 0.1 atm. It was, however, a little depended on oxygen partial pressure as the pressure decreased below 0.1 atm. The oxygen-dependency of our sensor gradually disappeared as the operating temperature increased. The sensing behavior of our CO2 sensor was affected by the presence of water vapor, but its effect was small comparing with other sensors.