• Journal of Pharmaceutical Investigation
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• 제32권3호
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• pp.185-190
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• 2002

To improve the solubility of poorly water-soluble drug and to develop a sustained release tablets, the need for the technique, the formation of solid dispersion with polymeric materials that can potentially enhance the dissolution rate and extent of drug absorption was considered in this study. The 1:1, 1:4, and 1:5 solid dispersions were prepared by spray drying method using PVP K30, ethanol and methylene chloride. The dissolution test was carried out at in phosphate buffer solution at $37^{\circ}C$ in 100 rpm. Solid dispersed drugs were examined using differential scanning calorimetry and scanning electron microscopy, wherein it was found that felodipine is amorphous in the PVP K30 solid dispersion. Felodifine SR tablets were prepared by direct compressing the powder mixture composed of solid dispersed felodipine, lactose, Eudragit and magnesium stearate using a single punch press. In order to develop a sustained-release preparation containing solid dispersed felodipine, a comparative dissolution study was done using commercially existing product as control. The dissolution rate of intact felodipine, solid dispersed felodipine and its physical mixture, respectively, were compared by the dissolution rates for 30 minutes. The dissolution rates of felodipine for 30 minutes from 1:1, 1:4, 1:5 PVP K30 solid dispersion were 70%, 78% and 90%. However, dissolution rate offelodipine from the physical mixture was 5% of drug for 30 minutes. Our developed product Felodipine SR Tablet showed dissolution of 17%, 50% and 89% for 1, 4, and 7 hours. This designed oral delivery system is easy to manufacture, and drug releases behavior is highly reproducible and offers advantages over the existing commercial product. The dissolution rate of felodipine was significantly enhanced, following the formation of solid dispersion. The solid dispersion technique with water-soluble polymer could be used to develop a solid dispersed felodipine SR tablet.

• Computers and Concrete
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• 제22권3호
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• pp.337-353
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• 2018

The present study focuses on examining the structural behaviour of steel-fibre-reinforced concrete (SFRC) beams under high rates of loading largely associated with impact problems. Fibres are added to the concrete mix to enhance ductility and energy absorption, which is important for impact-resistant design. A simple, yet practical non-linear finite-element analysis (NLFEA) model was used in the present study. Experimental static and impact tests were also carried out on beams spanning 1.3 meter with weights dropped from heights of 1.5 m and 2.5 m, respectively. The numerical model realistically describes the fully-brittle tensile behaviour of plain concrete as well as the contribution of steel fibres to the post-cracking response (the latter was allowed for by conveniently adjusting the constitutive relations for plain concrete, mainly in uniaxial tension). Suitable material relations (describing compression, tension and shear) were selected for SFRC and incorporated into ABAQUS software Brittle Cracking concrete model. A more complex model (i.e., the Damaged Plasticity concrete model in ABAQUS) was also considered and it was found that the seemingly simple (but fundamental) Brittle Cracking model yielded reliable results. Published data obtained from drop-weight experimental tests on RC and SFRC beams indicates that there is an increase in the maximum load recorded (compared to the corresponding static one) and a reduction in the portion of the beam span reacting to the impact load. However, there is considerable scatter and the specimens were often tested to complete destruction and thus yielding post-failure characteristics of little design value and making it difficult to pinpoint the actual load-carrying capacity and identify the associated true ultimate limit state (ULS). To address this, dynamic NLFEA was employed and the impact load applied was reduced gradually and applied in pulses to pinpoint the actual failure point. Different case studies were considered covering impact loading responses at both the material and structural levels as well as comparisons between RC and SFRC specimens. Steel fibres were found to increase the load-carrying capacity and deformability by offering better control over the cracking process concrete undergoes and allowing the impact energy to be absorbed more effectively compared to conventional RC members. This is useful for impact-resistant design of SFRC beams.

• 시큐리티연구
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• 제7호
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• pp.233-285
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• 2004

‘Defined legally as a violation of law' (Sutherland, E. H. Principles of Criminology, Lippincott, Chicago, 1939) Crime within the group is essentially and primarily antisocial in that the criminal who is welfare of his group acts instead against it and breaks the principles of social solidarity not merely by not doing what these principles prescribe, but by doing something exactly opposites. Any program set up to attack crime and delinquent behavior at their sources. A program of his nature needs the constant and comprehensive collaboration of psychiatrists, social works, educations, lawmakers, and public officials, since crime is a social problem and it should be treated as such. Some crime preventives which should be mentioned are as follows, (1) The insurance that every child will be decently born and that his home life be socially and economically adequate; without socially mature parents the chid is handicapped at the start; thus parental education, integrated with the public school system, should be developed now. (2) A more meaningful educational program which would emphasize ideals of citizenship, moral integrity, and respect for the law and the police. (3) A periodic check made for potential delinquents throughout the public schools and treatment provided if possible; and if not, proper segregation in institutions. (4) Careful attention paid to press, movies, and radio so that crime may no longer appear to be glamorous. This can be done by women's clubs, civic bodies, and other educational groups exerting pressure on the movie syndicates and broadcasting companies to free their productions of the tawdry and lurid characteristics of crime and criminals. Aggression associated with the phallic stage of development, The child ordinarily comprehends sexual intercourse as an aggressive and sadistic act on the part of the male, and specifically on the part of the penis. Evidence that the penis is phantasied as a weapon of violence and destruction come from unconscious productions of normal adults. Limerick, for instance, often refer to the penis as square, or too large, etc., so that intercourse is dangerous and painful for the partner, This may wall be a projection of the male's own fear of coitus. A certain portion of the death-instinct always remains within the person; it is called 'primal sadism' and according to Freud is identical with masochism. 'After the chief part of it(the death instinct) has been directed outwards towards objects, there remains as a residuum within the organism the true erotogenic masochism, which on the one hand becomes a component of the libido and on the other still has the subject itself for a object.' Criminalism, compulsive-neurotic frequent repetition of criminal acts in a compulsive manner. Like most symptoms of the compulsive-neurotic, such antisocial act are closely rated to feelings of hostility and aggression, often against the father. Because these acts are symptomatic, they afford only temporary relief and are therefore repeated. One patient with compulsive-neurotic criminalism was apprehended after breaking into hardware store and stealing money. He later confessed to many similar incidents over the preceding two years. At the same time it was apparent that he stole only for the sake of stealing. He did not need the money he thus obtained and had no special plans for using it.

• 한국언론정보학보
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• 제42권
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• pp.205-248
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• 2008

국제적인 권위를 자랑하는 뉴욕타임스와 월스트리트저널과 같은 미국 언론에 대한 한국사회의 정보의존성은 외환위기 이후 더욱 심화되고 있다. 그러나 전쟁과 같은 군사 안보분야가 아닌 경제, 무역, 금융 분야의 국제적 현안에 있어 이들 언론과 국가이익간의 관계를 다룬 연구는 많지 않다. 이 연구는 이에 1990년대 말부터 최근까지 이어지고 있는 국제통화체제 위기에 대한 미국 엘리트 언론의 보도를 분석함으로써 달러체제의 위기라는 합의된 국가이익에 있어 미국 언론이 자국 정부와 어떤 관계를 맺고 있는가를 분석했다. 이를 위해 먼저 아시아외환위기, 아시아통화기금, 말레이시아위기 및 신국제통화체제를 다룬 기획, 분석, 의견기사 152개를 '미디어프레임, 보도태도, 전문적의견제공자 및 담론전략'으로 구분해 분석했다. 그 다음, 미국 언론과 다른 엘리트간의 협력관계를 살펴보기 위해 이들 보도에서 확인된 전문의견제공자들의 인터뷰, 정책보고서 밑 연구논문을 분석했다. 분석 결과, 미국 언론은 국가이익을 달성하기 위해 전략적으로 채택된 대외정착을 보도함에 있어 미국정부와 밀접하게 협력하고 있는 것으로 밝혀졌다. 더욱이 이들은 이 과정에서 '특정기사에 대한 사회적 의미부여하기, 특정한 방식으로 틀짓기, 특정한 잣대로 평가하기 및 전략적인 정보원의 활용'과 같은 담론전략을 취함으로써 언론의 신뢰도를 훼손하지 않으면서 대중외교관(public diplomat)의 역할을 수행하는 것으로 드러났다. 연구자는 이를 토대로 국가이익으로부터 자유롭지 않은 강대국의 언론에 무차별적으로 노출된 한국사회에서 국가이익을 수호하고 실현하기 위한 언론과 정부의 바람직한 관계와 언론이 취해야 할 담론전략이 무엇일까에 대한 고민의 계기를 마련하고자 했다.

• Strategy21
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• 통권38호
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• pp.287-320
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• 2015

On October 27, 2015, USS Lassen(DDG82), a 9,200 ton class Aegis destroyer of the United States Navy, began its operations within 12 nautical miles of Subi Reef, one of the seven artificial islands that China has built and claimed sovereignty over. The maneuver was joined by anti-submarine patrol airplanes such as P-8A and P-3. The White House press secretary mentioned that the President of the United States approved the operation. In response, China announced that it warned the US Navy ship about the 'illegal violation' by sending two destroyers(PLAN Lanzhou and Taizhou). This event represents a close call case where tension between the United States and China in the South China Sea might have been elevated to a conflict between the two navies. Moreover, considering that this happened only one month after Chinese president Xi's state visit to the United States, the event shows that the positions of the two countries have become starkly different to the extent that they are so hard to be reconciled. The United States' position is different from those of Vietnam and the Philippines. Countries like Vietnam and the Philippines have been directly involved in disputes with regard to sovereignty claims across the waters in the South China sea. As for the United States, being a third party in the disputes, it still cannot be a by-stander watching the whole waters in the region fall under the influence of China. Accordingly, the United States maintains that all countries bear the rights of innocent passage and military operations in the Exclusive Economic Zones(EEZ) as stipulated by the United Nations Convention on the Law of the Sea(UNCLOS). In contrast, China claims that, historically, the South China sea has been part of China's territorial waters, and that foreign countries are not allowed to conduct military operations within the waters. It strongly accuses that such military operations are illegal. Against this background, this paper tracks the different positions of the United States and China on the issues regarding the South China sea. It also carefully looks at the possibility that, in the process of dealing with the issues, the two countries may get into an armed conflict as the phrase 'Thucydides Trap' predicts.

• Steel and Composite Structures
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• 제29권2호
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• pp.273-286
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• 2018

In recent years, significant progress has been made in developing design rules for stainless steel members, while the investigation on bolted connections is relatively limited, in particular at elevated temperatures. In this paper, experimental and numerical investigations on stainless steel bolted connections at ambient and elevated temperatures from the literature were reviewed. Firstly, the research program that focused on structural behavior of cold-formed stainless steel (CFSS) bolted connections at elevated temperatures carried out by the authors were summarized. Over 400 CFSS single shear and double shear bolted connection specimens were tested. The tests were conducted in the temperature ranged from 22 to $950^{\circ}C$ using both steady state and transient state test methods. It is shown that the connection strengths decrease as the temperature increases in the similar manner for the steady state test results and the transient state test results. Generally, the deterioration of the connection strengths showed a similar tendency of reduction to those of the material properties for the same type of stainless steel regardless of different connection types and different configurations. It is also found that the austenitic stainless steel EN 1.4571 generally has better resistance than the stainless steel EN 1.4301 and EN 1.4162 for bolted connections at elevated temperatures. Secondly, extensive parametric studies that included 450 specimens were performed using the verified finite element models. Based on both the experimental and numerical results, bearing factors are proposed for bearing resistances of CFSS single shear and double shear bolted connections that subjected to bearing failure in the temperature ranged from 22 to $950^{\circ}C$. The bearing resistances of bolted connections obtained from the tests and numerical analyses were compared with the nominal strengths calculated from the current international stainless steel specifications, and also compared with the predicted strengths calculated using the proposed design equations. It is shown that the proposed design equations are generally more accurate and reliable than the current design rules in predicting the bearing resistances of CFSS (EN 1.4301, EN 1.4571 and EN 1.4162) bolted connections at elevated temperatures. Lastly, the proposed design rules were further assessed by the available 58 results of stainless steel bolted connections subjected to bearing failure in the literature. It is found that the proposed design rules are also applicable to the bearing resistance design of other stainless steel grades, including austenitic stainless steel (EN 1.4306), ferritic stainless steel (EN 1.4016) and duplex stainless steel (EN 1.4462).

• Advances in environmental research
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• 제2권1호
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• pp.9-17
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• 2013

Urine is a widely used matrix in biomonitoring studies on the assessment of human exposure to environmental chemicals such as phthalate esters and bisphenol A (BPA). In addition to the need to apply valid analytical techniques, assurance of specimen integrity during collection and storage is an important prerequisite for the presentation of accurate and precise analytical data. One of the common issues encountered in the analysis of non-persistent contaminants is whether shipping and storage temperature and time since collection have an effect on sample integrity. In this study, we investigated the stability of phthalate metabolites and BPA in spiked and unspiked urine samples stored at room temperature ($20^{\circ}C$) or at $-80^{\circ}C$ for up to 8 weeks. Concentrations of phthalate metabolites declined, on average, by 3% to 15%, depending on the compounds, and BPA declined by ~30% after 4 weeks of storage of spiked urine samples at $20^{\circ}C$. In a test of 30 unspiked urine samples stored at $20^{\circ}C$ and at $-80^{\circ}C$ for 8 weeks, the concentrations of phthalate metabolites and BPA decreased by up to 15% to 44%, depending on the compound and on the samples. It was found that the small reduction in phthalate concentrations observed in urine, varied depending on the samples. In a few urine samples, concentrations of phthalate metabolites and BPA did not decline even after storage at $20^{\circ}C$ for 8 weeks. We found a significant relationship between concentrations of target analytes in urine stored at $20^{\circ}C$ and at $-80^{\circ}C$ for 8 weeks. We estimated the half-lives of phthalate metabolites and BPA in urine stored at $20^{\circ}C$. The estimated half-life of monoethyl phthalate (mEP) and mono (2-ethyl-5-carboxyphentyl) phthalate (mECPP) in urine stored at $20^{\circ}C$ was over two years, of mono (2-ethyl-5-oxohexyl) phthalate (mEOHP) and monobenzyl phthalate (mBzP) was approximately one year, and of other phthalate metabolites was approximately 6 months. The estimated half-life of BPA in urine stored at $20^{\circ}C$ was approximately 3 months, which is much longer than that reported for aquatic ecosystems.

• 한국문헌정보학회지
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• 제25권
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• pp.151-183
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• 1993

As many Korean libraries has begun to be automated and become a part of the worldwide, open library system, they need a new management. Therefore, the purpose of this paper is to explore the library management in automated libraries and to establish a theory of the library management in information society, The automated libraries could be well explained by the systems theory and the environment of the libraries could be well explained by the contingency theory, The following hypothesis were set to direct this research. 1. As the libraries are automated and become a part of one big, worldwide library system, the libraries interact closely with the environment so that the library and the environment become one. 2. As the libraries are automated and become a part of one big, worldwide library system, the librarians need to work in the environment for the library networks, standardization of cataloging, or government information policy making. 3. As the libraries are automated and become a part of one big, worldwide library system, the librarians only manage the library, The various other library staffs take over the traditional library services directly related to books. The data were gathered from the research done previously, Also the date were collected from the American and Japanese libraries. The findings were as follows: The environment of the library integrated all types of the library services such as school library, university library, etc. And it also integrated all the services of the media centers and the press centers, etc. to library services. And the new library services began in the environment. Librarians worked for these new services. In the library, the librarians distingushed the library system from the environment by planning : mission, goal, objectives, policy, procedures and rules. Library organization became temporary such as forming task forces or matrix or free form. The environment controlled the library. Staffs were controlled by plans or computers. And the professional librarians were controlled by their ability to solve problems raised outside the libraries. Library leaders brought in the technology to the library from its environment. The librarians led the formal and informal organizations so that the staffs cooperated well in their work. And librarians tought the library procedures to the partime workers or the temporary staffs. Participative management and management by objectives were the means of motivating staffs. Budget was based on the ever changing environment. The zero based budget method was applied. Therfore, in the information society, the professional librarians become the able managers in the library and global librarians in the environment.

• 한국문헌정보학회지
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• 제6권
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• pp.137-163
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• 1979

The Purpose of this study is analyzed that (l) How the public Libraries under the Japanese Rule since the end of the Yi-Dynasty were recepted and generated by the people and (2) How they were organiged and managed. (3) Also it examined that how they affected the development of the libraries of today. 1. The following are the analyzed results: Three types of the public Libraries under the Japanese Rule for a period of 36 years engaged busily in colonization were Private's Public Libraries, Local Self-Government's Libraries and the Central Governmental Libraries, and were in order established. 2. They were eatablished by individuals, Confucian School Foundation, Young Men's Clubs, School Associations, Korean brethren residing abroad, or The Press Centering around the Local Self-Governments and the Japanese Government-General. 3. In 1932 of the period of the Japanese Rule, the number of Libraies gained the summit and reached 80 Libraries. The Public Libraries including the Central Governmental Libraries remained in existence until the end of the War had been kept up the functions of the Libraries, but the Private Libraries operated by the Koreans were very small and poor. As a result, most of them were closed up and some Libraries transferred their controls to the public. Until the end of the war, only a little over 10 Private Libraries were Kept up. From the aspects of it's organization system, the most of their libraries replaced their chief librarians with non-professional county-headmen or Local supporters. From the aspect of collections, they wate mainly consists of Japanese books for the proper quidance of the public thought based on the ideology of Japanese Rule to Korea and on the industrial promotion rather than books about Koreanology or Western books. At that time, the Library users were with the jobless men and students as the central figures. And the next ranking by the social position of readers was children, farmers, merchants, industrialists, public servants, miscellaneous and educators. Their reading tendencies laid stress on linguistics and literature, physical sciences and medicine, While the reading trend of military sciences and medicine, while the reading trend of military sciences and engineering were very inactive. This was because the Japanese Government-General had not kept the military collections on file. Besides, they were reluctant to make Korean's learn the professional knowledge and so the main reference materials of technology not provited. Most of the Libraries put practiced in circulation services were very important circulation in withinder of the reading room rather than in outside of the Library building. On the other hand, their circulation services has above came with many limitations. As stated above, the public Libraries' managements and activitives under the period of Japanese Rule were the way and means to achive the colonial and imperialistic purpose of the Japanese Empire.

• 한국식품위생안전성학회지
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• 제18권3호
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• pp.133-138
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• 2003

우리나라에서 1991년부터 2002년 사이의 복어독 중독 발생상황에 대하여 신문에 보도된 내용을 검색하여 정리하고 특성을 분석하였다. 조사기간 중 우리나라에서는 총 32건의 복어독 중독사고가 발생하여, 111명이 중독되었고 그 중 30명이 사망하여 27.0%의 치사율을 나타내었으며, 연도에 따라 중독건수, 환자수 및 사망자수의 변동이 심하였다. 사망자는 29세 이상의 남성이 대부분을 차지하였다. 식중독 발생건별 환자수를 보면 4인 이하의 소규모 중독사건이 전체 발생건수의 75.0%인 24건을 차지하였고, 식중독 통계 집계기준인 5인 이상의 집단 식중독은 8건에 지나지 않았다. 우리나라에서 복어독 중독 발생건수의 59.4%(19/32)가 11월부터 익년 1월 사이에 발생하였고, 이 시기의 환자수 및 사망자수 또한 각각 65.8%(73/111), 66.7%(20/30)로 나타나 복어중독은 겨울철에 집중되었다. 지역적으로는 발생 건수의 75.0%(24/32)가 부산, 경남, 전남, 제주 등 남해안 지역에서 집중적으로 발생하였다. 섭취장소별로는 총 32건 중 18건(56.3%)이 선박에서 발생하였고, 가정에서 8건(25.0%)이 발생하였으며, 음식점에서 발생한 것은 5건(15.6%)이었다. 복어독 중독의 가장 중요한 원인 음식물은 국(탕 포함)으로 발생건수의 68.8%(22/32), 환자수의 64.0%(71/111), 사망자의 66.7%(20/30)를 차지하였고, 그 외 찜, 회, 내장탕, 알 등도 원인이 된 경우가 있었다.