• Herbal Formula Science
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• v.16 no.2
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• pp.71-90
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• 2008

東醫寶鑑(DongEuiBoGam) is considered as one of the most valuable medical books for Korean traditional medicine. Since 許浚(Heo Jun), the best physician on his day, wrote 東醫寶鑑(DongEuiBoGam), it has been not only a guidebook for basic medical studies, but also a field manual for clinicians. 東醫寶鑑(DongEuiBoGam) is a medical encyclopedia which integrated more than 81 medial classics. And its contents is well organized according to the symptoms of each disease. So today most clinics refer to 東醫寶鑑(DongEuiBoGam). But if we just read 東醫寶鑑(DongEuiBoGam) and use the prescriptions without understanding, the effect of medicine will be reduced by half. We should totally understand recipes in 東醫寶鑑(DongEuiBoGam) and be able to change the recipes according to the symptoms of each patient's disease. So finding the common traits of the recipes in 東醫寶鑑(DongEuiBoGam) is very important. In this research, the recipes of the fire part(火門) of Various Disease vol. Ⅲ(雜病篇 卷之三) are analyzed according to the traits of each herb in the recipes. And new classification of prescriptions according to the community of their traits is also suggested.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.3
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• pp.367-372
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• 2010

The purpose of this study is to make a basis of in vivo or clinical study about alopecia. We investigated the prescriptions of alopecia by researching oriental medicine literature. We found the prescriptions used for alopecia. And we surveyed the frequency and classification of the herbs used for alopecia. The results of this study were recorded as follows. The most frequently used single herbs in the prescriptions were Angelicae Gigantis Radix(當歸), Glycyrrhizae Radix(甘草), Poria(茯笭), Paeoniae Radix Alba(白芍藥). Herbs specifically frequently used in the prescriptions of alopecia were as follows. Polygoni Multiflori Radix(何首烏), Rehmanniae Radix(生地黃), Cuscutae Semen(菟絲子), Bupleuri Radix(柴胡), Scutellariae Radix(黃芩), Viticis Fructus(蔓荊子), Aconiti Iateralis Preparata Radix(附子). Herbs frequently used were classified by property. The result was as follows. (()-The number of herbs) 補益藥(32), 解表藥(18), 淸熱藥(15) 收澀藥(9), 活血祛瘀藥(8), 利水滲濕藥(8).

• Journal of Korean Medical classics
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• v.36 no.1
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• pp.79-107
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• 2023

Objectives : This study aims to improve the diagnosis and treatment of contemporary insomnia by examining Zhang Jiebin's discussion on treating insomnia. Methods : The classical texts from the 'Insomnia' chapter of the Jingyue Quanshu were examined threefold in terms of symptom, treatment, and prescription analysis, after which the treatment discussion part was examined within the historical context of discussions on insomnia in major medical texts starting from the Huangdineijing. Results : According to Zhang, the cause of insomnia could be divided into two, after which criteria for diagnosis and treatment were set as excess pathogen and vital qi deficiency. He argued that insomnia could be naturally resolved through improvement of various pathogenic situations. Discussions on insomnia from various medical texts since the Huangdineijing suggest that pathology related to psychological function and emotions gradually increased and expanded over time. Conclusions : Zhang's discussion on symptom, treatment and prescriptions of insomnia suggests a new framework that could improve treatment effects through a Korean Medical Mind-Body approach, rather than the contemporary classification of organic insomnia and non-organic insomnia.

• Journal of Korean Ophthalmic Optics Society
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• v.9 no.1
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• pp.181-188
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• 2004

Monovision is defined as correcting one eye for distance vision and the other eye for near vision. Single-vision contact lenses are used for each eye. The patient selectively suppresses one eye while using the other eye. This study was performed to measure binocular function and patient satisfaction with monovision induced by adding +3.00D to spectacle prescription for distance vision in nonpresbyopic students. This study comprised 144 nonpresbyopic students with monovision induced by adding +3.00D to spectacle prescription. Monovision was induced by undercorrecting the nondominant eye by adding 3.00 diopters for near vision and correcting the dominant eye with emmetropia for distance vision. For research of the binocular function on Monovision. This study was tested the obstacle course, water pouring test, catching and throwing, bead classification including the stereopsis test. These tests were comparative to the normal binocular state. As a results, the stereopsis have a significant reductions in Monovision. There was no significantly difference between monovision group and control group in monovision exercise (obstacle course, water pouring test, catching and throwing, and bead sorting) at near and distance. This study indicates that monovision is an effective and reasonable therapeutic modality for correcting presbyopia. By the application of above methods, this study could be used the student for the practical practice and understand on the Monovison.

• The Journal of Korean Medical History
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• v.24 no.2
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• pp.25-55
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• 2011

The currently existing "Bonchojeonghwa (本草精華)" is a manuscript without the preface and the epilogue, composed of 2 books in 2 volumes. This book is a quintessence of knowledge on science of medicinal ingredients (medicinal phytology I herbal science) as well as an trial of new development in Chosun medical science. I.e. this book includes surprising change representing medical science in Chosun dynasty as a single publication on science of medicinal ingredients. It holds a value essential to clinician as a specialized book in medicinal ingredients, and Includes richer content on medicinal ingredients than any other books published before. In addition, it is away from boring list-up of superfluous knowledge as seen in "Bonchokangmok(本草綱目)" published in China, and well summarizes essential knowledge which can be used within a range of medicines available in Korea. This book has an outstanding structure that can be even used in today's textbook on science of medicinal ingredients, as it has clear theory, system and classification. Because it handles essential learning points prior to prescription to disease, it is possible to configure new prescription and adjustment of medicinal materials. Moreover, this book can play a good role for linguistic study at the time of publication, because it describes many drugs in Hangul in many parts of the book. "Bonchojeonghwa" includes a variety of animals, plants and mineral resources in Korea, like "Bonchokangmok" which was recently listed in UNESCO. As such, it has a significance in natural history as well as pharmacy in Korean Medicine. It has various academic relationships all in biologic & abiologic aspects. It has importance in sharing future biological resources, building up international potential, setting up the standard for biologic species under IMF system, and becoming a base for resource diplomacy. We should not only see it as a book on medicinal ingredients in terms of Oriental Medicine, but also make an prudent approach to it in terms of study strengthening Korea's national competitiveness. After bibliographical reviewing on the features & characteristics of the only existing copy of "Bonchojeonghwa" housed in Kyujanggak(奎章閣) of Seoul National University, the followings are noted. First, "Bonchojeonghwa" is a specialized book on medicinal ingredients voluntarily made by private hands to distribute knowledge on drugs in the desolate situation after Imjinoeran (Japanese Invasion in 1592), without waiting for governmental help. Second, it raised accessibility and practicality by new editing. Third, it classified 990 different kinds of drugs into plant, animal, and mineral at large, and dassified more in detail into 15 'Bu' and 48 'Ryu' at 258 pages. Fourth, the publication of this book is estimated to be around 1625~1633, at the time of Injo's reign in 17th century. Fifth, it contains the existing & up-to-date knowledge at the time of publication, and it is possible to see the supply-demand situation by Hangul descriptions in 149 places in the book. By the fact that there are many linguistic evidences of 17th century, explains well when the book was published.

• The Journal of Dong Guk Oriental Medicine
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• v.11
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• pp.1-40
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• 2008

The leukemia is caused by with abnormal changes of the hemotopoietic cell and in the various neoplasm group which occurs from lymph organization and the bone marrow occurs disrupts immigrates toward the blood of circumference and a hemotopoiesis and the arm discouragement royal tomb and is a disease which infiltrates with the organization. Western medical diagnosis and classification and presents eastern medicinal demonstration which is confronted in him about the leukemia, eastern medicinal diagnosis and treatment the clinical dissertation against precisely, saw and dissertation precisely tried about leukemia therapeutic effect of the herbal extract, last from conclusion like this dissertation precisely in the base which tries groped the direction of eastern medicinal treatment method research about the leukemia. Eastern medicine approach led about diagnosis and treatment of the leukemia and with leukemia treatment the medical herb which the eastern medicine possesses in development and room sacrifice an eastern medicine theory and the false eye presented the drug which is therapeutic possibility and they presented. The eastern medicine demonstration and therapeutic method is showing the therapeutic ratio which is effective about the leukemia. But according to the patient does a about prescription and therapeutic method differently and the room my composition is complicated and clinical day is consistent decides upon a reproducibility and a therapeutic ratio with difficult point of accumulation, with standardization of therapeutic method has the difficult point of supply. In treatment of the leukemia demonstrates a nature of a disease consequently with theory of eastern medicine and appropriately prescribes endeavors raises a therapeutic ratio and the medical herb and room proposal remedial value, under verifying reveals the clinical trial which is standardized leads and the medical herb and a room sacrifice and the verification and supply of effect and safety are necessary.

• Korean Journal of Clinical Pharmacy
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• v.25 no.4
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• pp.246-253
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• 2015

Background & Object: Ankylosing spondylitis (AS) is a chronic inflammatory disease that causes ankylosis and deformation of axial joints. Since current medicine cannot cure the disease yet, alleviating pain and preventing deformation with medications are the main therapy for patients with AS. The key medications for these purposes include nonsteroidal anti-inflammatory drugs (NSAIDs), and tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) inhibitors. This study aims to analyze prescribing patterns of AS patients in South Korea. Method: National Patients Sample data compiled by the Health Insurance Review and Assessment Service from 2013 was analyzed. Patients with AS were identified with Korean Standard Classification of Diseases code-6, which was M45. The rates of prescription, discontinuation, and switching ingredients were calculated for each medication during 2013. Results: Total number of patients was 655, and most of them were male (n = 514, 78.5%). Of all age groups, the proportion of 30-40 year old patients was the greatest (35.1%). The most utilized drug class was NSAIDs (82.4%). Less than half of patients were prescribed $TNF-{\alpha}$ inhibitors (n = 212, 32.4%). Meloxicam, aceclofenac, and celecoxib were the most frequently prescribed NSAIDs. In case of $TNF-{\alpha}$ inhibitors, adalimumab, etanercept and infliximab were the top three most prescribed drugs. Although not recommended by the current practice guideline, significant proportions of patients were identified using disease modifying anti-rheumatic drugs (DMARDs). Conclusion: Considering the current practice guideline and previous studies about the efficacy, the use of DMARDs should be reduced and medical insurance term in South Korea should be re-examined.

• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.1
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• pp.8-19
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• 2017

This study on "Wenbingtiaobian" covers identifying pattern of prescription, understanding system of multiple syndrome differentiations, characteristics of treatment and medicinal substances. The source books are "Korean translation of Wenbingtiaobian", "Modern Shanghanlun", "Jinkuiyaolueyishi", "Chinese Medicine Formulas". "Wenbingtiaobian" has system of multiple patterns including three energizer syndrome differentiation, classification of disease, six meridian syndrome differentiation and wei-qi-ying-xue syndrome differentiation. That describes cause, location, nature, power and transmutation of disease. Wei-qi-ying-xue pattern is meaningful to warm-heat disease and three energizer pattern is relevant to dampness-heat disease. The warm disease shows mostly yang brightness bowel syndrome and patterns of three yin viscera. In aspect of the heat disease, qi aspect pattern makes up the largest number of syndrome differentiation and have sometimes with bowel excess or fluid deficiency. And treatment for wei aspect pattern is primarily 'outthrust the pathogen with pungent-cool'. Deficiency cold pattern and cold pattern with dampness occupy most of cold patterns. And many dampness patterns are dampness-heat pattern in middle energizer and 'inhibited lung qi transforming' is major mechanism. Patterns with fluid deficiency in qi aspect syndrome appear mostly in upper or middle energizer and in xue aspect syndrome appear mostly in lower energizer and they form 20% of all syndrome differentiations. The treatment of clearing heat uses pungent-cool(cold) for upper energizer, sweet-cold for middle energizer, sweet(salty)-cold for lower energizer. The treatment of tonifying yin uses mostly salty-cold for middle or lower energizer. The treatment of outthrusting pathogen is applied to all the wei-qi-ying-xue aspect combined with other treatments by using pungent-cool(cold) and light herbs. Understanding diseases in the respect of syndrome differentiation can enhance understanding of modern diseases from a perspective of Korean Traditional Medicinal(KTM) and can make clinical application of KTM treatments easy. Data from this study are expected to be basic for standardization and systemization of KTM.

• Herbal Formula Science
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• v.28 no.4
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• pp.351-363
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• 2020

Objectives : The purpose of this paper is to describe how Wu Kun(吳昆) understood Huangdineijing 『黃帝內經』 and implemented his understanding when writting Yifangkao 『醫方考』. Methods : From Yifangkao 『醫方考』, we collected all paragraphs including "經曰", "內經曰" while excluding the ones with "論曰" to filter out Sanghanlun 『傷寒論』's perspective. The contents of Huangdineijing·Suwen 『黃帝內經·素問』 and Huangdineijing·Lingshu 『黃帝內經·靈樞』, cited in Wu Kun's Yifangkao 『醫方考』 were extracted, identified from which part it comes and sorted into headings under RyuPyeon Huangjenaegyung 『類編黃帝內經』. Results : The most cited traditional chinese medical classic in Yifangkao 『醫方考』 was Huangdineijing·Suwen 『黃帝內經·素問』 Yinyangyingxiangdalun 「陰陽應象大論篇」 which was cited 41 times. Zhizhenyaodalun 「至眞要大論篇」 had a total of 39 citations followed by Shengqitongtianlun 「生氣通天論篇」 and Liuyuanzhengjidalun 「六元正紀大論篇」 which were cited 13 times and 11 times each. In addition, it was confirmed that other 28 chapters from Huangdineijing·Suwen 『黃帝內經· 素問』, 3 chapters from Huangdineijing·Lingshu 『黃帝內經·靈樞』, 3 chapters from Nanjing 『難經』 and one chapter from Zhenjiujiayijing 『鍼灸甲乙經』 were also cited. Also the analysis of the classification of the Huangdineijing·Suwen 『黃帝內 經·素問』 showed that 57 citations were classified as 'treatment', 41 citations were classified as 'Yin and Yang and Five phases', 39 citations were calssified as 'Cause and Mechanism of Disease'. Conclusion : 1. Yifangkao 『醫方考』 have explained prescriptions by implementing principles from 5 kinds of traditional chinese medical classic including Huangdineijing·Suwen 『黃帝內經·素問』, Huangdineijing·Lingshu 『黃帝內經·靈樞』 etc. 2. According to table 3, Yifangkao 『醫方考』 have cited Huangdineijing·Suwen 『』 to explain how each compounds were used and how the Korean medical principle of Yin and Yang was applied in the prescriptions. 3. It can be suggested in formula study there is utility to understand principles of traditional chinese medical classic to comprehend prescriptions.

• Korean Journal of Clinical Pharmacy
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• v.26 no.3
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• pp.220-229
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• 2016

Background: The treatment goal for patients with chronic hepatitis B infection is to prevent progression of the disease to cirrhosis and hepatocellular carcinoma. Current therapies include standard and pegylated interferon-alfa and nucleoside/nucleotide analogues: lamivudine, adefovir, entecavir, telbivudine, clevudine, and tenofovir. This study aims to analyze changes in the prescribing patterns of chronic hepatitis B (CHB) medications in South Korea between 2013 and 2014. Methods: A cross-sectional study was conducted using National Patients Sample data compiled by the Health Insurance Review and Assessment Service from 2013 and 2014. Patients with CHB were identified with Korean Standard Classification of Diseases code-6 (B18.0 and B18.1) and those who were maintaining active prescriptions with CHB medications covering the index date (December $1^{st}$, each year) were included. The utilization of antiviral therapy was investigated during 2013 and 2014. Results: A total of 4,204 and 4,552 patients in 2013 and 2014 respectively, were included in the analysis. The proportion of male patients was two of third and the patients 41-60 years old accounted for 60% of all analyzed patients. The most utilized drug was entecavir (55.1% in 2013 and 44.8% in 2014) and the second most utilized drug was tenofovir in both years (18.8% in 2013 and 29.0% in 2014). The percentage of combination therapy was 13.6% and 13.1% in 2013 and 2014, respectively. The proportion of tenofovir prescriptions was increased in 2014 compared with 2013. Conclusion: With the development of new drugs and the changes in clinical practice guidelines, the prescription pattern of the antiviral agents for patients with CHB has changed. The rate of utilization of tenofovir has increased.