• The Journal of Pediatrics of Korean Medicine
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• v.24 no.1
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• pp.65-76
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• 2010

Objectives In the later period of Choseon dynasty, korean pediatrics became a pivot part of medicine. SoAUiBang was the most important book in that era. DongEuiBoGam was the most widely read of all oriental medicine books and published in early days of the Choseon dynasty. Therefore, this comparative study on the prescription and formation of SoAUiBang and DongEuiBoGam could be a useful way to understand SoAUiBang's characteristics. Methods This study was based on SoAUiBang and DongEuiBoGam, two literatures of oriental medicine. Results 1. Formation of SoAUiBang had a similar aspect with that of DongEuiBoGam's and enlarged the area of pediatrics by featuring general medical books. However, its formation did not follow the DongEuiBoGam's, but had its unique formation. It tried to include all diseases of pediatrics in the system of DongEuiBoGam. Plus, smallpox and measles belonged to the epidemic diseases were excluded from the area of pediatrics. 2. Comparing SoAUiBang's prescription of some important diseases with DongEuiBoGam's, it was almost a prescription based on DongEuiBoGam's prescription. However, adjustment of herbs and dosages could not be found in any oriental medicine books including DongEuiBoGam. Conclusions SoAUiBang maintained the traditional Oriental medicine based on author's scholarly creativeness. In addition, it also inherited the lineage of medicine in Korea along with the pedigree of DongEuiBoGam. Therefore, SoAUiBang should be re-evaluated as a medicine book that opened a new field of pediatric and had great academic values.

• Journal of Sasang Constitutional Medicine
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• v.19 no.1
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• pp.29-37
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• 2007

1. Objectives This study is purposed to distinct of Soyangin Hyungbangdojok-san on the ${\ulcorner}$Dongyisusebowon\;{\cdot}\;Shinchukbon${\lrcorner}$ through compare with early medical books prescription and early Dongmu's books prescription 2. Methods This study is research to use of dujok-san in early medical books and Dongmu's books. so the process of Hyungbangdojok-san formation is knowed 3. Result and conclusions 1) Early dojok-san is mostly used in oligouria 2) The use of dojok-san is changed by Dongmu' books 3) Hyungbangdojok-san is used in the superficial disease's pathology

• Korean Journal of Oriental Medicine
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• v.17 no.2
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• pp.73-83
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• 2011

The first medical text in which detailed treatments of diseases by combinations of materia medica are mentioned is the "Shanghanzabinglun(傷寒雜病論)". True meaning of the combinations of materia medica used in this text lies in the fact that the efficacy of a prescription transcends that of the linear sum of each materia medica. This kind of concept regarding the composition of a prescription has come to contribute to the formation of theories in prescriptionology; However, it is difficult to analyze and interpret the meaning of each prescription separately because of differences in interpreting methods, points of view, and terminologies used by members of different academical branches. Therefore, it is desirable that one should understand a prescription as having been modified from a basic prescription, and then bring the interactions of ingredients into the picture, finally understanding the efficacy and chief virtues of the targeted prescription. Nevertheless, with the massive information of prescriptions, which exist in the format of texts, it is impossible to efficiently take advantage of prescription analyzing methods, and therefore the range of analysis extremely restricted. In order to overcomes these weaknesses, this paper suggests that object-oriented prescription database be constructed and that a search program for education and research that could facilitate an efficient access to the database be developed as well.

• Herbal Formula Science
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• v.20 no.2
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• pp.103-116
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• 2012

Objectives : Bangyakhappyeon was classified into three tongs of prescription. When juxtaposed with existing publications on oriental medicine, this composition was considerably original. Due to its ease of searching for diseases and prescription, it has been read by not only doctors and researchers but also among general citizens alike. Based on the fundamentals of Bangyakhappyeon composition, this thesis focused on the thorough research on the prescription of Bupleuri Radix mixture. Methods : 42 prescriptions of Bupleuri Radix mixtures have been divided in to three tongs based on the composition of Bangyakhappyeon. Then, these prescriptions, dosage, and composition were researched and organized. Results : After analyzing the prescription of Bupleuri Radix mixture in the Uibanghwaltu chapter of the Bangyakhappyeon text, the following results were attained. 1. Of the 42 prescriptions of Bupleuri Radix mixtures, jungtong constitutes the most prescription at 30, 8 at hatong, and 4 at sangtong. 2. 42 prescriptions are documented into 18 medical divisions and 44 disease symptoms. 3. After analyzing the prescription dosage of Bupleuri Radix mixture, the dosage of Bupleuri Radix was 3 puns to 4 jeons used in 14 sections. Most use was 1 jeon 14 prescriptions, 33.3% were recorded. 4. Invigorating vital function, catharsis, malaria, mediation method, and clearing away method of Bupleuri Radix have a close relationship with the dosage. 5. The 42 prescriptions formation of using Bupleuri Radix consisted of decoction at 39 prescriptions (92.9%) and the others at 3 prescriptions (7.1%). 6. As a result of researching the component of the prescription of Bupleuri Radix mixture, Sosihotang, Soyosan and Bojungikgitang were used as the basic prescription. Conclusions : prescription of Bupleuri Radix mixture in Uibanghwaltu of Bangyakhappyeon as based on Sosihotang, Soyosan and Bojungikgitang, combined with various oriental medicine was found to treat many kinds of diseases.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.2
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• pp.416-425
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• 2009

Angiogenesis is important for promoting cardiovascular disease, wound healing, and tissue regeneration. We here investigated the pharmacological effects of Korea red ginseng water extract (KRGE) on angiogenesis and its underlying signal mechanism. This study showed that KRGE increased in vitro proliferation, migration, and tube formation of human umbilical endothelial cells, as well as stimulated in vivo angiogenesis. KRGE-induced angiogenesis was accompanied by phosphorylation of ERK1/2, Akt, and endothelial nitric oxide synthase (eNOS) as well as an increase in NO production. Inhibition of PI3K activity by wortmannin completely inhibited KRGE-induced angiogenesis and phosphorylation of Akt, ERK1/2, and eNOS, indicating that PI3K/Akt activation is an upstream event of KRGE-mediated angiogenic pathway. The MEK inhibitor PD98059 completely blocked KRGE-induced angiogenesis and ERK phosphorylation without affecting Akt and eNOS activation. However, the eNOS inhibitor NMA effectively inhibited tube formation, but partially blocked proliferation and migration as well as ERK phosphorylation without altering Akt and eNOS activation, revealing that eNOS/NO pathway is in part involved in ERK1/2 activation. This study first demonstrated the critical involvement of both ERK1/2 and eNOS activation in KRGE-induced angiogenesis, which lie on downstream of PI3K/Akt. Thus, these results indicate that KRGE requires activation of both the PI3K/Akt-dependent ERK1/2 and eNOS signal pathways and their cross-talk for its full angiogenic activity.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.2
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• pp.560-567
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• 2003

Antimetastatic effects of Agaricus mixed prescription (AMP) were studied in the respect of blood-borne metastasis. For this aim, cytotoxicity against various cancer cells and normal cells, Chicken Chorioallantoic membrane (CAM) assay, cancer cell adhesion assay, platelet aggregation assay, pulmonary colonization, life span of S-180 implanted mice, and cytokine release assay were evaluated, respectively. The results were summarized as follows; AMP did not exert any cytotoxicity against all cell lines with IC50 of 25mg/ml on B16BL6. AMP disrupted formation of CAM at 1mg/ml. AMP was suppressive in adhesion assay of B16BL6. AMP also inhibited tumor induced platelet aggregation. In pulmonary colonization assay by B16BL6, the number of colonies in the lungs was significantly decreased in sample group than in control group. In animal study with S-180, the life span of AMP treated group was extended than that of control group. IL-12 was effectively increased in AMP treated group in cytokine release assay. Taken together, AMP can be possibly applied to cancer or metastasis.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.14 no.2
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• pp.89-111
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• 2001

In order to investigate the effects of GamiTakliSodocyum(GTS) on wound healing, migration of epidermis, formation of granulation tissue and number of capillary within the granulation tissue were measured in diabetic mice by local application and NZW rabbits by local application and prescription of medicine in vivo, and proliferation of human epidermal keratinocytes and human dermal fibroblasts and composition of extracellular matrix were measured in vitro. The results were summerized as follows. 1. $2\%,\;10\%$ GTS remarkably increased migration of epidermis in diabetic mice by local application. 2. $2\%,\;10\%$ GTS remarkably increased formation of granulation tissue, number of neovascularization within the granulation tissue in diabetic mice by local application. 3. 5\%,\;10\%$ GTS remarkably increased migration of epidermis in NZW rabbits by local application. 4. $5\%,\;10\%$ GTS remarkably increased fonnation of granulation tissue, number of neovascularization within the granulation tissue in NZW rabbits by local application. 5. $5\%,\;10\%$ GTS increased migration of epidennis in NZW rabbits by prescription of medicine. 6. $5\%,\;10\%$ GTS increased formation of granulation tissue, number of neovascularization within the granulation tissue in NZW rabbits by prescription of medicine. 7. GTS didn't show effect on the proliferation of human epidermal keratinocytes. 8. GTS increased the proliferation of cultured human dermal fibroblasts. 9. GTS increased the expression of procoliagen ${\alpha}1(I) mRNA in cultured human dermal fibroblasts. 10. GTS increased the expression of fibronectin mRNA in cultured human dennal fibroblasts according to dosage of GTS using northern blot hybridization but didn't increase, using RT-PCR. From the above results, it is conclude that GTS might use on wound healing.

• Korean Journal of Pharmacognosy
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• v.37 no.2 s.145
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• pp.103-109
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• 2006

Advanced glycation end products (AGEs) formation plays an important role in the progression of diabetic complications. To develop effective herbal formulations with suppression of diabetic nephropathy, a common complication in diabetic patients, we evaluated inhibitory activities of KIOM-79, a new herbal prescription, on the formation of AGEs using in vitro and in vivo model systems. Effects of KIOM-79 on the expression of AGEs, RAGEs (receptor for Advanced glycation end products), type IV collagen and renal $TGF-{\beta}1$ mRNA was also examined in streptozotocon (STZ)-induced diabetic rats. STZ-induced diabetic rats were treated orally with KIOM-79 (250 and $500\;kg^{-1}$ once a day for 13 weeks). In vitro system KIOM-79 suppressed the formation of AGEs $(18.12\;{\mu}g/ml)$. In STZ-induced diabetic rats showing accumulation of AGE and RAGE, pathological examination revealed that KIOM-79 prevented AGE and RAGE deposition in the kidney. In STZ induced diabetic rats, the expansion of mesangial matrix and the glomerular tufts seemed to be larger than those in normal rats. Howεver, after administration with KIOM-79, mesangial metrix and glomerular volume were decreased, and overexpression of type IV collagen was also decreased. Overexpression of renal $TGF-{\beta}1$ mRNA was inhibited significantly. These results suggest that the KIOM-79 might be an effective herbal prescription to prevent or alleviate the progression of diabetic nephropathy.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.5
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• pp.1278-1284
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• 2007

Solanum Iyratum Thunb (Solanaceae) has multiple applications in korean traditional medicine because of its cytotoxic, immunological and anti-inflammatory activities. However, no study on the anti-arthritic activity of Solanum Iyratum Thunb has been reported in vivo. Rheumatoid arthritis (RA) is a systemic autoimmune disease with chronic inflammation characterized by hyperplasia of synovial cells in affected joints, which ultimately leads to the destruction of cartilage and bone. Cytokine production were assessed during CIA(collagen-induced arthritis) model mice in lymph node (LN), in knee joint and spleen, using ELISA. DBA/1j mice were immunized with bovine type II collagen. After a second collagen immunization, mice were treated with Solanum Iyratum Thunb (SLT) orally at 400, 200 mg/kg once a day for 4 weeks. The severity of arthritis within the knee joints was evaluated by histological assessment of cartilage destruction and pannus formation. SLT significantly suppressed the progression of CIA and inhibited the production of TNF-alpha and IFN-gamma in serum and spleen cell culture supernatant. The erosion of cartilage was dramatically reduced in mouse knees after treatment with SLT. In conclusion, our results demonstrates that SLT significantly suppressed the progression of CIA. This action was characterized by suppression of arthritis index, cartilage erosion and synovial cell infiltration and the decreased production of $TNF-{\alpha}$, $IFN-{\gamma}$, CD4+, CD19+, CD3+/CD69+ cells (in lymph node), CD11b+/Gr-1 + (in knee joint).

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.1
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• pp.93-98
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• 2000

We performed this study to determine the radioprotective effects of Shi-Quan-Dai-Bu-Tang, as a prescription of traditional Oriental medicine, and its major ingredients. The jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells were investigated in mice irradiated with high and low dose of ${\gamma}$-rays. The administration of danggui, baishaoyao, rensan, gancao or baifuling before irradiation protected the jejunal crypts (p<0.005). Shoudehuang, danggui, baishaoyao, rensan and huangqui increased the formation of endogenous spleen colony (p<0.05). Chuanxiong, baishaoyao, rensan and baifuling reduced the frequency of radiation-induced apotosis (p<0.05). The results indicated that the extracts of danggui, baishaoyao, rensan and baifuling may have radoprotective effects in mice irradiated with high and low dose of ${\gamma}$-rays. The radioprotective effect of the prescription, Shi-Qaun-Da-Bu-Tang, was not significant.