• 대한소아치과학회지
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• 제37권1호
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• pp.136-142
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• 2010

이소맹출은 치아가 비정상적인 위치나 방향으로 맹출하는 것으로 정의되며 구치부에서는 근심측으로 맹출하여 인접치아의 치근 흡수나 조기 탈락을 야기하여 공간 상실을 일으킬 수 있고, 부분 맹출된 경우 치은 하방의 치아우식 위험성이 증가하고 농양을 형성할 수도 있다. 구치부의 이소맹출 가운데 66% 정도는 가역적인 경우로 특별한 치료 없이 자연적으로 정상적인 맹출이 일어나며, 비가역적인 이소맹출의 경우에는 치아의 맹출 상태, 인접치에 의해 매복된 양, 인접치의 동요도, 통증이나 감염 여부 등의 여러 요인을 고려하여 본격적인 치료가 필요하다. 본 논문에서는 비가역적으로 이소맹출된 상악 제1대구치와 하악 제2대구치를 치간이개 고무줄, modified Halterman appliance 그리고 외과적 노출 후 modified Halterman appliance를 이용한 방법 등으로 정상적인 맹출을 유도한 증례를 보고 하는 바이다.

• Journal of Ginseng Research
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• 제41권1호
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• pp.69-77
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• 2017

Background: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging. Methods: Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. Results: In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. Conclusion: These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin.

• Journal of Genetic Medicine
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• 제17권1호
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• pp.39-42
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• 2020

The Senior-Loken syndrome was first described in 1961 as an oculo-renal disease consisting of familial juvenile nephronophthisis and Leber congenital amaurosis. It is a rare autosomal recessive disorder with a prevalence of 1:1,000,000 caused by mutations in nine genes (NPHP 1-8 and NPHP 10). Ocular manifestations (e.g., photophobia, nystagmus, and extreme hyperopia) occur within the first few years of life while renal manifestations (e.g., formation of multiple cysts impairing kidney function and end-stage renal disease) appear in late childhood to adolescence. Here, we report a case of a Filipino male presenting with rotatory nystagmus and progressive deterioration of vision since childhood. He had congenital amaurosis and juvenile nephronophthisis that progressed to end stage renal disease by age 19. All laboratory and imaging findings were consistent with chronic kidney disease. Molecular genetic testing of ciliopathy-related genes was performed revealing a homozygous mutation in exon 11 of the IQCB1/NPHP5 gene, c.1090C>T (p.Arg364^⁎). This sequence change created a premature translational stop signal resulting in a truncated protein product, nephrocystin-5 and its consequent loss of function. His symptoms eventually improved with initiation dialysis. The prognosis of Senior-Loken syndrome remains dismal and a high index of suspicion, early diagnosis and timely intervention of renal complications are warranted.

• 보건의료기술평가
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• 제6권2호
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• pp.123-132
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• 2018

Objectives: Maternal morbidity and mortality are important healthcare issues. However there have been few studies on cost of illness (COI) from maternal disorders. This study aimed to estimate the COI due to maternal disorders in Korea. Methods: By reviewing previous studies and consulting expert we determined the scope of maternal disorders. We operationally defined maternal disorders as maternal hemorrhage, maternal sepsis, hypertensive disorders of pregnancy, obstructed labor, and abortion for maternal disorders. The reference period of this study is the year 2015. Main source of data were the National Health Insurance Service claims data, cause of death statistics from the Korea National Statistical Office, and the Korea Health Panel study. We classified the total costs into direct and indirect costs. The direct costs cover healthcare costs and non-healthcare costs. The indirect costs consist of productivity losses due to morbidity and premature death. Results: The cost of maternal disorders in 2015 was 229.7 billion won. The direct and indirect costs of maternal disorders were 165.2 billion won and 64.5 billion won respectively. The largest cost item for maternal disorders was healthcare cost (138.3 billion won, 60.2%). By age groups, the COI in 30-39 years old women were the highest (165.1 billion won, 71.9%). Abortion was the disorder with the highest COI among maternal disorders (71.9 billion won, 31.3%). Conclusion: The COI due to maternal disorders in Korea is quite substantial. Economic burden of maternal disorder increased when being compared with the year 2012 data despite the continued low birth rate in Korea. Therefore, it is necessary to continuously monitor the social costs of the maternal disorders in Korea.

• 대한소아치과학회지
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• 제49권3호
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• pp.340-347
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• 2022

하악 제2소구치 치배의 원심 변위는 해당 치아의 매복 뿐만 아니라 하악 제1대구치의 맹출 경로를 방해하여 추가적인 맹출 지연을 야기할 수 있다. 이 증례 보고는 원심으로 변위된 하악 제2소구치로 인해 하악 제1대구치의 맹출 지연이 나타난 두 증례를 소개하고 있다. 원심으로 변위된 하악 제2소구치 치배의 근심 이동을 위해 선행 유치의 의도적 발거술을 시행할 수 있다. 하지만 제2유구치의 조기 상실 시 바람직하지 않은 하악 제1소구치의 원심 이소맹출이 나타날 수 있다. 하악 제1소구치의 바람직하지 않은 원심 이소맹출을 방지하면서 원심으로 변위된 하악 제2소구치 치배를 근심으로 이동시키기 위해 하악 제2유구치의 편측치아절제술 및 순차적 발거를 수행하였다.

• 한국임상약학회지
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• 제32권3호
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• pp.191-203
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• 2022

Background: Direct-acting antivirals are recommended for the treatment of chronic hepatitis C virus in Korea. However, evaluation of direct-acting antiviral regimens in a real-world setting is limited. The aims of this study were to investigate the effectiveness and safety of direct-acting antiviral treatment in Korean patients infected with chronic hepatitis C virus genotype 1b or 2 at a tertiary care hospital. Methods: This was a retrospective study conducted with patient data obtained between August 2015 and August 2019 at Jeonbuk National University Hospital. The primary effectiveness endpoint was sustained virological response 12 weeks post-treatment (SVR12) via intention-to-treat (ITT) and modified intention-to-treat (mITT) analyses. Results: Of the 270 patients, 47.0% were infected with genotype 1b and 53.0% with genotype 2. ITT analysis revealed that SVR12 was achieved in 78.9% of all patients, 77.2% in genotype 1b patients, and 80.4% in genotype 2 patients. Of the 21.1% of all patients who did not achieve SVR12, the majority of treatment failures were non-virologic failures (19.7%). mITT analysis revealed that SVR12 was achieved in 98.2% of all patients, 98.0% in genotype 1b patients, and 98.3% in genotype 2 patients. Almost half of all patients experienced one or more adverse events (43.3%), leading to 2.6% discontinuing scheduled treatment. The most common adverse event was anemia. Conclusions: Direct-acting antiviral-based treatment regimens showed high effectiveness and safety. Non-virological factors, such as premature treatment discontinuation due to adverse events or loss of follow-up, were the major disruptors in achieving SVR12.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권7호
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• pp.1873-1893
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• 2023

The development of lightweight, low energy and small-sized sensors incorporated with the wireless networks has brought about a phenomenal growth of Wireless Sensor Networks (WSNs) in its different fields of applications. Moreover, the routing of data is crucial in a wide number of critical applications that includes ecosystem monitoring, military and disaster management. However, the time-delay, energy imbalance and minimized network lifetime are considered as the key problems faced during the process of data transmission. Furthermore, only when the functionality of cluster head selection is available in WSNs, it is possible to improve energy and network lifetime. Besides that, the task of cluster head selection is regarded as an NP-hard optimization problem that can be effectively modelled using hybrid metaheuristic approaches. Due to this reason, an Improved Coyote Optimization Algorithm-based Clustering Technique (ICOACT) is proposed for extending the lifetime for making efficient choices for cluster heads while maintaining a consistent balance between exploitation and exploration. The issue of premature convergence and its tendency of being trapped into the local optima in the Improved Coyote Optimization Algorithm (ICOA) through the selection of center solution is used for replacing the best solution in the search space during the clustering functionality. The simulation results of the proposed ICOACT confirmed its efficiency by increasing the number of alive nodes, the total number of clusters formed with the least amount of end-to-end delay and mean packet loss rate.

• BMB Reports
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• 제57권5호
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• pp.256-261
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• 2024

In the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of immunosenescence, given the complexity of aging as a physiological process in living organisms. Our investigation focuses on Cisd2, a causative gene for Wolfram syndrome, to elucidate on immunosenescence. Cisd2 knockout (KO) mice, serving as a model for premature aging, exhibit a shortened lifespan with early onset of aging-related features, such as decreased bone density, hair loss, depigmentation, and optic nerve degeneration. Intriguingly, we found that the Cisd2 KO mice present a higher number of neutrophils in the blood; however, isolated neutrophils from these mice display functional defects. Through mass spectrometry analysis, we identified an interaction between Cisd2 and Calnexin, a protein known for its role in protein quality control. Beyond this function, Calnexin also regulates calcium homeostasis through interaction with sarcoendoplasmic reticulum calcium transport ATPase (SERCA). Our study proposes that Cisd2 modulates calcium homeostasis via its interaction with Calnexin and SERCA, consequently influencing neutrophil functions.

• 농촌의학ㆍ지역보건
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• 제30권1호
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• pp.51-62
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• 2005

농촌 주민들의 소 사육 실태 및 브루셀라증에 대한 인지도 등을 파악하여 사람 및 소 브루셀라증 관리방안을 수립하는데 기초 자료로 활용하고자 본 조사를 실시하였다. 설문은 울진군 북면 및 포항시 기계면 주민 1,028명을 대상으로 성별 및 연령 등 일반적 사항과 브루셀라증에 대한 인지도, 소 사육 실태, 브루셀라증 보상에 관한 내용 등이 포함된 설문지를 이용하였다. '소 브루셀라증에 대하여 들어본 적이 있거나 아십니까?' 에 관한 설문에서 '예' 라고 응답한 경우는 283명으로 27.5%가 알고 있었다. '소 브루셀라증이 사람에게도 감염된다는 사실을 알고 있습니까?' 에 관한 설문에서 '예' 라고 응답한 경우는 215명으로 77.6%가 알고 있었다. '여자에서 브루셀라증 감염 시 유산될 수 있다는 사실을 알고 있습니까?' 에 관한 설문에서 '예' 라고 응답한 경우는 98명으로 35.1%가 알고 있었다. '소 브루셀라 예방에 대한 교육이나 홍보 책자를 받은 적이 있습니까?' 에 관한 설문에서 '예' 라고 응답한 경우는 69명으로 24.7%가 받았다고 하였다. '최근 축산가에서 발생하는 소 브루셀라증 어떤 상태라고 생각하십니까?' 에 관한 설문에서 '심각하다' 라고 응답한 경우는 189명(68.5%)이었다. '최근 우리나라에서 발생하는 사람 브루셀라증은 어떤 상태라고 생각하십니까?' 에 관한 설문에서 '심각하다' 라고 응답한 경우는 185명(67.3%) 이었다. '키우는 암소에서 유산되거나 미숙한 송아지로 태어난 적이 있습니까?' 에 관한 설문에서 '예' 라고 응답한 경우는 28명(14.9%)이었다. '암소의 유산물이나 미숙 송아지를 맨손으로 직접 만졌습니까?' 에 관한 설문에서 '예' 라고 응답한 경우는 10명(5.3%)이었다. '소 브루셀라증이 발생하면 나라에서 보상해 준다는 것을 알고 있습니까?' 에 관한 설문에서 '예' 라고 응답한 경우는 46명(25.0%)이었다. '자신의 소가 유산한다면 가축위생시험소에 브루셀라 검사 신고를 하겠습니까?' 에 관한 설문에서 '예' 라고 응답한 경우는 114명(67.9%)이었고, 안하겠다는 이유로는 '신고하는 것인지 몰라서' 라고 응답한 경우가 36명(66.7%)으로 가장 많았다.

• Journal of Preventive Medicine and Public Health
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• 제42권4호
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• pp.251-260
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• 2009

Objectives : To estimate the annual socioeconomic costs of stroke in Korea in 2005 from a societal perspective. Methods : We identified those 20 years or older who had at least one national health insurance (NHI) claims record with a primary or a secondary diagnosis of stroke (ICD-10 codes: I60-I69, G45) in 2005. Direct medical costs of the stroke were measured from the NHI claims records. Direct non-medical costs were estimated as transportation costs incurred when visiting the hospitals. Indirect costs were defined as patients and caregivers productivity loss associated with office visits or hospitalization. Also, the costs of productivity loss due to premature death from stroke were calculated. Results : A total of 882,143 stroke patients were identified with prevalence for treatment of stroke at 2.44%. The total cost for the treatment of stroke in the nation was estimated to be 3,737 billion Korean won (KRW) which included direct costs at 1,130 billion KRW and indirect costs at 2,606 billion KRW. The per-capita cost of stroke was 3 million KRW for men and 2 million KRW for women. The total national spending for hemorrhagic and ischemic stroke was 1,323 billion KRW and 1,553 billion KRW, respectively, which together consisted of 77.0% of the total cost for stroke. Costs per patient for hemorrhagic and ischemic stroke were estimated at 6 million KRW and 2 million KRW, respectively. Conclusions : Stroke is a leading public health problem in Korea in terms of the economic burden. The indirect costs were identified as the largest component of the overall cost.