• Journal of the Optical Society of Korea
• /
• v.17 no.3
• /
• pp.237-241
• /
• 2013

This paper presents an efficient evolutionary method to optimize the gain ripple of multi-pumps photonic crystal fiber Raman amplifier using the Fuzzy Adaptive Modified PSO (FAMPSO) algorithm. The original PSO has difficulties in premature convergence, performance and the diversity loss in optimization as well as appropriate tuning of its parameters. The feasibility and effectiveness of the proposed hybrid algorithm is demonstrated and results are compared with the PSO algorithm. It is shown that FAMPSO has a high quality solution, superior convergence characteristics and shorter computation time.

• The Journal of the Korean dental association
• /
• v.50 no.6
• /
• pp.322-328
• /
• 2012

Ectopic eruption of the permanent first molar is defined as the eruption of the tooth in an abnormal position or orientation. It may causes distal root resorption and premature exfoliation of the adjacent primary second molar and uncontrolled space loss is followed. Prolonged partial impaction of the permanent molar may also cause undetected caries or abscess formation of the neighbor teeth. The purpose of this paper is to provide a brief review regarding the etiology, classification, and different management techniques for correcting ectopic eruption of permanent first molar.

• Management Science and Financial Engineering
• /
• v.20 no.2
• /
• pp.33-37
• /
• 2014

A flow shop scheduling problem involves scheduling jobs on multiple machines in series in order to optimize a given criterion. The flow time of a job is the amount of time the job spent before its completion and the stretch of the job is the ratio of its flow time to its processing time. In this paper, a hybrid genetic algorithm (HGA) approach is proposed for minimizing the total stretch in flow shop scheduling. HGA adopts the idea of seed selection and development in order to reduce the chance of premature convergence that may cause the loss of search power. The performance of HGA is compared with that of genetic algorithms (GAs).

• Clinical and Experimental Pediatrics
• /
• v.50 no.3
• /
• pp.230-235
• /
• 2007

In the early neonatal period, the neonate is challenged by the loss of the placental calcium transport and manifests a quick transition, from an environment in which PTHrP plays an important role to a PTH- and 1,25-dihydroxyvitamin D-controlled neonatal milieu. Disturbances in mineral homeostasis are common in the neonatal period, especially in premature infants and infants who are hospitalized in an intensive care unit. In many cases these disturbances are thought to be exaggerated responses to the normal physiological transition from the intrauterine environment to neonatal independence. Some disturbances in calcium and phosphate homeostasis are the result of genetic defects, which in many instances can now be identified at the molecular level. Although fetus develop remarkably normally in the presence of maternal calcium, PTH and vitamin D deficiency, the neonates demonstrate abnormalities that are consequences of the prior abnormal maternal calcium homeostasis. Evaluation and management of hypocalcemia and hypercalcemia in neonate requires specific knowledge of perinatal mineral physiology and the unique clinical and biochemical features of newborn mineral metabolism.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.3 no.1
• /
• pp.7-11
• /
• 1976

The author measured the degree of development and the eruption pattern of first permanent molars with orthopantomography in 553 Korean children(male; 302, female; 251) from 4 to 9 years old. The orthopantomographs were obtained from dept. of pedodontics, college of dentistry, Seoul National University. The results of the studies were as follows: 1. Upper first permanent molars were erupted with distal inclination of about 30 degrees in the early stage and they gradually moved in the mesial direction by bodily movement of the tooth to be in contact with the disto-proximal surface of primary secondary molars in the late stage. 2. Lower first permanent molars were erupted with mesial inclination in the early stage and moved mesially by tipping movement of the tooth to be in contact with the disto proximal surface of the second primary molars in the late stage. 3. The eruptive forces were considered to be main etiologic factors of space closure after the premature loss of primary molars.

• Proceedings of the KIEE Conference
• /
• 2000.07c
• /
• pp.1566-1568
• /
• 2000

This study refers to the crosslinked characteristics of XLPE cables by aging. The cable failure brings about an enormous loss of power supply and the immense expense for cable replacement. These characterization techniques can be used for identifying a cause of failure and for improving a quality of equipments Also, these play an important role in the detection of premature failure. In order to maintain a cable reliability, quality control is needed strictly. It can be possible to estimate a residual lifetime of power cable using characterization techniques.

• Molecules and Cells
• /
• v.37 no.1
• /
• pp.1-8
• /
• 2014

Mammalian-cell messenger RNAs (mRNAs) are generated in the nucleus from precursor RNAs (pre-mRNAs, which often contain one or more introns) that are complexed with an array of incompletely inventoried proteins. During their biogenesis, pre-mRNAs and their derivative mRNAs are subject to extensive cis-modifications. These modifications promote the binding of distinct polypeptides that mediate a diverse array of functions needed for mRNA metabolism, including nuclear export, inspection by the nonsense-mediated mRNA decay (NMD) quality-control machinery, and synthesis of the encoded protein product. Ribonucleoprotein complex (RNP) remodeling through the loss and gain of protein constituents before and after pre-mRNA splicing, during mRNA export, and within the cytoplasm facilitates NMD, ensuring integrity of the transcriptome. Here we review the mRNP rearrangements that culminate in detection and elimination of faulty transcripts by mammalian-cell NMD.

• Clinical and Experimental Reproductive Medicine
• /
• v.19 no.1
• /
• pp.49-56
• /
• 1992

Bone mineral density was measured to assess whether the patients with premonopausal hypogonadism, comprised of 19 patients with hypogonadotropic hypogonadism(HH), 55 with premature ovarian failure(POF), 23 with hyperprolactinemia(HPLN), and 8 with Sheehan's syndrome. All aged from 20 to 39, were associated with some decrease in regional bone mass compared with that of 63 normal-associated with some decrease in regional bone mass compared with that of 63 normal-cycling control women matched with age and sex. Measurement of bone mineral density was carried out using Dual photon absorptiometry at four sites; femur neck, ward's triangle, trochanter and spine(L2-L4). Bone mineral density at all four sites were significantly decreased in patients with HH(p<0.01), POF(p<0.01). In hyperprolactinemic patients, the decrease in bone mass was significant at femur neck and Ward's triangle(p<0.05). The patients with POF were noted to be associated with significant bone loss when their duration of amenorrhea exceeded one year. In this study, the degree of loss of bone mass and the affected sites seemed to be different depending on the various types of hypogonadism and POF was noted have caused the appearance of loss of bone mass earlier than other thpes of hypogondism we experienced.

• Clinical and Experimental Pediatrics
• /
• v.46 no.10
• /
• pp.966-971
• /
• 2003

Purpose : It is now well established that infection and inflammation play an important role in the pathogenesis of ischemic brain damage. The loss of neutrophils from systemic circulation is an associated finding in injury mediated by granulocyte. Periventricular leukomalacia(PVL) caused by ischemia is the principal form of brain injury in premature infants. This study was conducted to evaluate whether the low neutrophil count is associated with periventricular leukomalacia(PVL) in premature infants. Methods : Retrospective review of medical records was undertaken. Subjects were premature infants with a birth weight of less than 1,500 gm, admitted to the Neonatal Intensive Care Unit of Kyungpook University Hospital. A complete blood count of peripheral blood was done within the 1st hour of life. Neutropenia was defined as absolute neutrophil count < $1,500/mm^3$, PVL as increased periventricular echodensities followed by cyst formation on ultrasonography or corresponding signs on brain MRI. Results : Thirteen infants out of a total population of 37 revealed neutropenia. Respiratory distress syndrome and requirement for respiratory support were not different between infants with neutropenia( neutropenia group) and infants without neutropenia(control group). Intraventricular hemorrhage (IVH) and grade 3 and 4 IVH were more frequent in neutropenia group(P<0.05). There was no statistically significant increase of PVL in neutropenia group. The neutrophil count was $18,760.0{\pm}10,266.1/mm^3$, $7,272.0{\pm}7,435.0/mm^3$ infants with PVL and $11,131.7{\pm}3,386.5/mm^3$, $2,407.5{\pm}1,933.1/mm^3$ in infants without PVL, respectively. The frequency of mechanical ventilation and artificial surfactant therapy was higher in infants with PVL compared with infants without PVL, but statistical analysis was not performed due to small number of subjects. Conclusion : A low number of neutrophils in the systemic circulation was not associated with an increased risk of PVL in premature infants.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.35 no.1
• /
• pp.1-6
• /
• 2009

DNA double-strand breaks (DSBs) occur commonly in the all living and in cycling cells. They constitute one of the most severe form of DNA damage, because they affect both strand of DNA. DSBs result in cell death or a genetic alterations including deletion, loss of heterozygosity, translocation, and chromosome loss. DSBs arise from endogenous sources like metabolic products and reactive oxygen, and also exogenous factors like ionizing radiation. Defective DNA DSBs can lead to toxicity and large scale sequence rearrangement that can cause cancer and promote premature aging. There are two major pathways for their repair: homologous recombination(HR) and non-homologous end-joining(NHEJ). The HR pathway is a known "error-free" repair mechanism, in which a homologous sister chromatid serves as a template. NHEJ, on the other hand, is a "error-prone" pathway, in which the two termini of the broken DNA molecule are used to form compatible ends that are directly ligated. This review aims to provide a fundamental understanding of how HR and NHEJ pathways operate, cause genome instability, and what kind of genes during the pathways are associated with head and neck cancer.