• 제목/요약/키워드: Pregnancy stress

검색결과 181건 처리시간 0.023초

Palmitic acid induces inflammatory cytokines and regulates tRNA-derived stress-induced RNAs in human trophoblasts

  • Changwon Yang;Garam An;Jisoo Song;Gwonhwa Song;Whasun Lim
    • Journal of Animal Reproduction and Biotechnology
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    • 제37권4호
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    • pp.218-225
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    • 2022
  • High levels of proinflammatory cytokines have been observed in obese pregnancies. Obesity during pregnancy may increase the risk of various pregnancyrelated complications, with pathogenesis resulting from excessive inflammation. Palmitic acid (PA) is a saturated fatty acid that circulates in high levels in obese women. In our previous study, we found that PA inhibited the proliferation of trophoblasts developing into the placenta, induced apoptosis, and regulated the number of cleaved halves derived from transfer RNAs (tRNAs). However, it is not known how the expression of tRNA-derived stress-induced RNAs (tiRNAs) changes in response to PA treatment at concentrations that induce inflammation in human trophoblasts. We selected concentrations that did not affect cell viability after dose-dependent treatment of HTR8/SVneo cells, a human trophoblast cell line. PA (200 μM) did not affect the expression of apoptotic proteins in HTR8/SVneo cells. PA significantly increased the expression of inflammatory cytokines including interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α. In addition, 200 μM PA significantly increased the expression of tiRNAs compared to 800 μM PA treatment. These results suggest that PA impairs placental development during early pregnancy by inducing an inflammatory response in human trophoblasts. In addition, this study provides a basis for further research on the association between PA-induced inflammation and tiRNA generation.

Evaluation of Maternal Toxicity in Rats Exposed to Multi-Wall Carbon Nanotubes during Pregnancy

  • Lim, Jeong-Hyeon;Kim, Sung-Hwan;Lee, In-Chul;Moon, Chang-Jong;Kim, Sung-Ho;Shin, Dong-Ho;Kim, Hyoung-Chin;Kim, Jong-Choon
    • Environmental Analysis Health and Toxicology
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    • 제26권
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    • pp.6.1-6.8
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    • 2011
  • Objectives: The present study investigated the potential adverse effects of multi-wall carbon nanotubes (MWCNTs) on pregnant dams and embryonic development following maternal exposure in rats. Methods: MWCNTs were orally administered to pregnant rats from gestational day (GD) 6 through 19 at dose levels of 0, 8, 40, 200, and 1000 mg/kg/day. During the test period, clinical signs, mortality, body weights, food consumption, serum biochemistry, oxidant-antioxidant status, gross findings, organ weights, and Caesarean section findings were examined. Results: All animals survived to the end of the study. A decrease in thymus weight was observed in the highest dose group. However, maternal body weight, food consumption, serum biochemical parameters, and oxidant-antioxidant balance in the kidneys were not affected by treatment with MWCNTs. No treatment-related differences in gestational index, embryo-fetal mortality, or fetal and placental weights were observed between treated and control groups. Conclusions: The results show that 14-day repeated oral dosing of MWCNTs during pregnancy induces minimal maternal toxicity at 1000 mg/kg/day in rats. Under these experimental conditions, the no-observed-adverse-effect level of MWCNTs is considered to be 200 mg/kg/day for dams and 1000 mg/kg/day for embryonic development.

Effects of nonpharmacological interventions on the psychological health of high-risk pregnant women: a systematic review and meta-analysis

  • Yoo, Hyeji;Ahn, Sukhee
    • Women's Health Nursing
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    • 제27권3호
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    • pp.180-195
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    • 2021
  • Purpose: This study aimed to summarize the current evidence on the effects of nonpharmacological interventions on psychological health outcomes for women with high-risk pregnancies due to conditions such as preeclampsia, gestational diabetes, or preterm labor. Methods: The following databases were searched from January 2000 to December 2020: PubMed, Ovid Embase, CINAHL, Web of Science, DBpia, RISS, and KISS. Two investigators independently reviewed and selected articles according to the inclusion/exclusion criteria. RoB 2 and the ROBINS-I checklist were used to evaluate study quality. Results: Twenty-nine studies with a combined total of 1,806 pregnant women were included in the systematic review and meta-analysis. Psychological health improvements were found in women with preeclampsia (Hedges' g=-0.67; 95% confidence interval [CI], -0.91 to -0.44), gestational diabetes (Hedges' g=-0.38; 95% CI, -0.54 to -0.12), and preterm labor (Hedges' g=-0.73; 95% CI, -1.00 to -0.46). The funnel plot was slightly asymmetrical, but the fail-safe N value and the trim-and-fill method showed no publication bias. Conclusion: Nonpharmacological interventions for women with high-risk pregnancies due to conditions such as preeclampsia, gestational diabetes, and preterm labor can improve psychological parameters such as anxiety, stress, and depression. Nurses can play a pivotal role in the nursing management of pregnant women with high-risk conditions and apply various types of nonpharmacological interventions to meet their needs in uncertain and anxious times during pregnancy.

Influence of Marital Intimacy, Family Support, and Fatigue on the Stress of Pregnant Woman (임부 스트레스에 부부친밀도, 가족지지 및 피로가 미치는 영향)

  • Kim, Miok;Yu, Mi
    • Journal of the Korea Academia-Industrial cooperation Society
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    • 제15권4호
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    • pp.2179-2188
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    • 2014
  • During pregnancy, the woman experiences physical and psycho-social changes. Such changes and other factors may become stress for the pregnant woman, making it difficult to maintain healthy and happy pregnant period. In this study, we identify factors for the stress, marital intimacy, family support, and fatigue, in order to provide the foundation for developing intervention programs and improve the quality of nursing. The subjects of there search were 185 pregnant women. Stress had a negative correlation with marital intimacy and family support, and positive correlation with fatigue. Family support, fatigue, adjustment to change due to pregnant, and breastfeeding experience were the influencing factors on the stress of pregnant women. A stress management program for pregnant women needs to be designed to help them with their physical and psychological adjustments. The program will be more effective when accompanied by the family support.

A Correlation Study of Maternal Stress, Anxiety, and Perception of the Newborn in the Early Postpartum Stage (산욕 초기 어머니의 스트레스, 불안 및 신생아 지각 간의 관계)

  • 구현영;문영임
    • Journal of Korean Academy of Nursing
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    • 제28권3호
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    • pp.616-624
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    • 1998
  • The purpose of this study was to contribute to maternal nursing in early postpartum stage and to neonatal nursing. Data were collected through self-report questionnaires which were constructed to include parental role stress scale, state-trait anxiety scale, and perception of the newborn scale. The subjects consisted of 100 mothers in the early postpartum stage at three hospitals in the Kyoung-In area, from November 8 to December 26, 1997. The data were analyzed by an SPSS program. The results are as follows ; 1. The mean of parental role stress of mothers in the early postpartum stage was 10.70$\pm$2.63. The means of state anxiety and trait anxiety of mothers were 36.29$\pm$8.45 and 38.53$\pm$8.36. The mean of perception of the newborn was 2.65$\pm$5.05, and 59% of mothers rated their newborn as better than the average newborn. 2. The level of parental role stress correlated to the level of state anxiety and trait anxiety. The level of state anxiety and trait anxiety were also related. The level of perception of the newborn was related to the level of state anxiety and trait anxiety. 3. Mothers who did not want the pregnancy, whose newborns were girls, and who already had one child had higher state anxiety than those who did not. Mothers who already had one child, and whose newborn had no specific signs had higher trait anxiety than those who did not. Mothers who professed a religions had a higher perception of the newborn than those who did not. The above findings indicate that the levels of parental role stress, state anxiety, trait anxiety and perception of the newborn of mothers in early postpartum stage were correlated. Therefore nursing intervention for reducing stress and anxiety, and improving perception of the newborn should be provided for mothers in early postpartum stage.

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Synthetic Maternal Stress Hormone Can Modulate the Expression of Hox Genes

  • Yu, Sook-Jin;Lee, Ji-Yeon;Kim, Sang-Hoon;Deocaris, Custer C.;Kim, Myoung-Hee
    • Biomedical Science Letters
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    • 제15권3호
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    • pp.249-255
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    • 2009
  • All living things have been developed efficient strategies to cope with external and internal environmental changes via a process termed 'homeostasis'. However, chronic prenatal maternal stress may significantly contributes to pregnancy complications by disturbing hypothalamic-pituitary-adrenal (HPA) axis and the automatic nervous system (ANS), and results in unfavorable development of the fetus. Dysregulation of these two major stress response systems lead to the increased secretion of the glucocorticoids (GCs) which are known to be essential for normal development and the maturation of the central nervous system. As Hox genes are master key regulators of the embryonic morphogenesis and cell differentiation, we aimed to determine the effects of dexamethasone, a potent synthetic glucocorticoid, on gene expression in mesenchymal stem cell C3H10T1/2. Analysis of 39 Hox genes based on reverse transcription PCR (RT-PCR) method revealed that the expression patterns of Hox genes were overall upregulated by long dexametasone treatment. These results indicate that maternal stress may have a deleterious effect on early developing embryo through the stress hormone, glucocorticoid.

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Development of a Prediction Model for Postpartum Depression: Based on the Mediation Effect of Antepartum Depression (산후우울 예측모형 개발: 산전우울의 매개효과 검증을 중심으로)

  • Lee, Eun Joo;Park, Jeong Sook
    • Journal of Korean Academy of Nursing
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    • 제45권2호
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    • pp.211-220
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    • 2015
  • Purpose: This study was done to develop a prediction model for postpartum depression by verifying the mediation effect of antepartum depression. A hypothesized model was developed based on literature reviews and predictors of postpartum depression by Beck. Methods: Data were collected from 186 pregnant women who had a gestation period of more than 32 weeks and were patients at a maternity hospital, two obstetrics and gynecology specialized hospitals, or the outpatient clinic of K medical center. Data were analysed with descriptive statistics, correlation and exploratory factor analysis using the SPSS/WIN 18.0 and AMOS 18.0 programs. Results: The final modified model had good fit indices. Parenting stress, antepartum depression and postpartum family support had statistically significant effects on postpartum depression, and defined 74.7% of total explained variance of postpartum depression. Antepartum depression had significant mediation effects on postpartum depression from stress in pregnancy and self-esteem. Conclusion: The results of this study suggest that it is important to develop nursing interventions including strategies to reduce parenting stress and improve postpartum family support in order to prevent postpartum depression. Especially, it is necessary to detect and treat antepartum depression early to prevent postpartum depression as antepartum depression can affect postpartum depression by mediating antepartum factors.

The Experience of Parents Whose Child is Dying with Cancer (암 환아 부모의 경험에 대한 질적 연구)

  • ;;Ida Martinson
    • Journal of Korean Academy of Nursing
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    • 제22권4호
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    • pp.491-505
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    • 1992
  • The purpose of this research was to understand the structure of the lived experience of parents of a child terminally ill with cancer The research question was “What is the structure of the experience of parents of a child terminally ill with cancer\ulcorner” The sample consisted of 17 parents of children admitted to the cancer units of two university hospitals in Seoul. The unstructured interviews were carried out from October 10, 1991 through January 10, 1992. They were audio-recorded and analysed using Van Kaam's method. Parents ascribed the cause of the cancer to the mother's emotional imbalance during pregnancy, the mother's stress, failure to observe religious rites, food, the parent's sin, misfortune and pollution. The theme clusters were tension, fear and depression experienced during pregnancy, stress that children suffer from abusive parents, failure to observe religious activites, bad luck, and sins committed during a previous life. When the child suffered a recurrence of cancer, the parents experienced negative emotions, nervousness, sorrow. depression and death. The theme clusters were feelings of despair, helplessness, regret, guilt, insecurity, emptyness and apathy. The long struggle with cancer resulted in the loss of economic security, loss of psychological and physical well being, and social withdrawal. The theme clusters were the economic burden of medical cost, giving up treatment, debt, limited medical insurance coverage and blood transfusion. The loss of psychological well being included stress, lack of support systems, inability to carry out responsibilities, lack of trust of the medical ten family breakdown, inappropriate expression of emotion and not disclosing the diagnosis to the child. Physically the parents suffered fatigue, insomnia, loss of appetite, loss of weight, dizzness, headache, psychosomatic symptoms, and increased consumption of liquor and cigarettes. Social withdrawal was manifested by taking time off from work to look after the child, decrease of outside social activities and feelings of isolation. Influences on family life were spousal conflicts, negative response of siblings, separation of the family members and economic hardship. The theme clusters were blaming a spouse for the cause of the illness and disagreements, maladjustment, lonliness, hostility and depression of siblings. The high price of medical care over the long period was a major factor influencing the life of the family. Positive experiences during the child's long illness were the strengthening of support systems and religious beliefs and financial help from social organizations. The support of one's spouse primarily helped to overcome the stress of the long illness. In addition, support was received from parents of other children with cancer and from nurses and religious leaders. The nurse, by providing empathetic support, should be a person with whom parents can express their feelings and share their experiences.

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Prevalence Study of Mothers' Perception on Pregnancy, Childbirth, and Childcare: Comparison Between Years 2002 and 2007 (영아기 첫 자녀를 둔 어머니의 임신 및 출산, 양육 변인에 관한 연구: 2002년과 2007년 실태 비교를 중심으로)

  • Kim, Yang Eun;Cho, Bok Hee;Jung, Min Ja
    • Korean Journal of Childcare and Education
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    • 제3권2호
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    • pp.68-85
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    • 2007
  • The purpose of this study is to investigate the changes of mothers' condition including the level of knowledge and parenting stress that mothers have on infant development. The subjects of this study are 270 mothers whose infants range in age from birth to 36 months. The instruments used are: 1)KCDI(Knowledge of Child Development Inventory, Larsen & Juhasz, 1985) 2)Parenting Stress Scale(Kim & Kang, 1997), and a demographic questionnaire. The data analyses use SPSS 12.0 which employs basic statistics, reliability test, and t-test. This study is time-lag design covering five years. Therefore, the data collected originates from 2002 and 2007 to constitute input from two times. The results of this study indicate that the average pregnancy from the 2007 statistics occurred 0.46 months earlier, after marriage, as compared to pregnancies in 2002. Mothers who gave birth by natural birth increased from 59.9 % to 75.3 % over the five year period. Regarding knowledge of infant development, the level of mothers' knowledge was lower in 2007 than in 2002 according to study results. The level of parenting stress of mothers increased for the 2007 statistics as compared to the 2002 survey.

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A study on the mediating effect of self-esteem in caring stress and parenting efficacy for children with disabilities during the COVID-19 period (코로나19 시기 장애자녀 돌봄스트레스와 양육효능감에서 자아존중감의 매개효과에 관한 연구)

  • Seo, Bo-seok;Choi, Jong-soon;Kim, hyun-hwa
    • The Journal of the Convergence on Culture Technology
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    • 제9권1호
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    • pp.175-181
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    • 2023
  • This study verified the mediating effect of self-esteem in the interrelationship between caring stress perceived by parents raising children with disabilities during the COVID-19 period and parenting efficacy. This survey study conducted a regression analysis using survey data conducted on 140 parents of disabled children in Y, Jeollanam-do. The main results of the study are as follows. First, it was found that the higher the caring stress of parents of disabled children during the COVID-19 period, the lower the self-esteem. Second, it was found that self-esteem had an mediating effect on the effect of care stress on the parenting efficacy of parents of disabled children. Based on these findings, a convergence practice strategy has been proposed to reduce and improve the care stress of parents of disabled children, and parenthood efficacy at embraces them as part of a new family without discrimination in pregnancy, childbirth, and childcare.