• 제목/요약/키워드: Prediction osteoporosis

검색결과 25건 처리시간 0.146초

Prediction of age-related osteoporosis using fractal analysis on panoramic radiographs

  • Koh, Kwang-Joon;Park, Ha-Na;Kim, Kyoung-A
    • Imaging Science in Dentistry
    • /
    • 제42권4호
    • /
    • pp.231-235
    • /
    • 2012
  • Purpose: This study was performed to evaluate the trabecular pattern on panoramic radiographs to predict age-related osteoporosis in postmenopausal women. Materials and Methods: Thirty-one postmenopausal osteoporotic women and 25 postmenopausal healthy women between the ages of 50 and 88 were enrolled in this study. The bone mineral density (BMD) of the lumbar vertebrae and femur were calculated using dual-energy X-ray absorptiometry (DXA), and panoramic radiographs were obtained. Fractal dimension (FD) was measured using the box counting method from 560 regions of interest ($51{\times}51$ pixels) in 6 sites on the panoramic radiographs. The relationships between age and BMD and between FD and BMD were assessed, and the intraobserver agreement was determined. Results: There was a significant difference in the FD values between the osteoporotic and normal groups (p<0.05). There was a significant difference in the FD values at three sites in the jaws (p<0.05). Age was significantly correlated with the BMD measurements, with an odds ratio of 1.25. However, the FD values were not significantly correlated with the BMD measurements, with an odds ratio of 0.000. The intraobserver agreement showed relatively higher correlation coefficients at the upper premolar, lower premolar, and lower anterior regions than the other sites. Conclusion: Age was an important risk factor for predicting the presence of osteoporosis in postmenopausal women. The lower premolar region was the most appropriate site for evaluating the FD value on panoramic radiographs. However, further investigation might be needed to predict osteoporosis using an FD value on panoramic radiographs.

Prediction of the Dependence of Phase Velocity on Porosity in Cancellous Bone

  • Lee, Kang-Il;Choi, Min-Joo
    • The Journal of the Acoustical Society of Korea
    • /
    • 제27권2E호
    • /
    • pp.45-50
    • /
    • 2008
  • In recent years, quantitative ultrasound (QUS) technologies have played a growing role in the diagnosis of osteoporosis. Most of the commercial bone somometers measure speed of sound (SOS) and/or broadband ultrasonic attenuation (EUA) at peripheral skeletal sites. However, the QUS parameters are purely empirical measures that have not yet been firmly linked to physical parameters such as bone strength or porosity. In the present study, the theoretical models for wave propagation in cancellous bone, such as the Biot model, the stratified model, and the modified Biot-Attenborough (MBA) model, were applied to predict the dependence of phase velocity on porosity in cancellous bone. The optimum values for the input parameters of the three models in cancellous bone were determined by comparing the predictions with the previously published measurements in human cancellous bone in vitro. This modeling effort is relevant to the use of QUS in the diagnosis of osteoporosis because SOS is negatively correlated to the fracture risk of bone, and also advances our understanding of the relationship between phase velocity and porosity in cancellous bone.

3차원 유한요소법을 이용한 골절판에 대한 인체 대퇴골의 골재형성에 관한 연구 (A Study on the Prediction of Bone Remodeling of Plated-Human Femur using 3-Dimensional Finite Element Method)

  • 김현수
    • 대한의용생체공학회:의공학회지
    • /
    • 제13권4호
    • /
    • pp.353-362
    • /
    • 1992
  • The stress distribution of bone is altered by the rigid bone plate, sometimes resulting in unfavorable osteoporosis. The rigidity and the biocompatibility are important factors for the design of prosthesis. However, it is also necessary to consider the effect on the bone remodeling. In this paper, it is attempted to establish an approximate and simple method to predict the trend of the configuration of surface bone remodeling for the case of a bone plate using stress analysis. Thus, three dimensional finite element model of plated-human femur is generated and simulated. In addition. the stress difference method (SDM) is introduced and attempted to demonstrate the configuration of surface bone remodeling of the plated-human femur. The results are compared with those of invivo tests and the feasibility of the stress difference method is discussed.

  • PDF

Osteoporosis prediction from the mandible using cone-beam computed tomography

  • Barngkgei, Imad;Haffar, Iyad Al;Khattab, Razan
    • Imaging Science in Dentistry
    • /
    • 제44권4호
    • /
    • pp.263-271
    • /
    • 2014
  • Purpose: This study aimed to evaluate the use of dental cone-beam computed tomography (CBCT) in the diagnosis of osteoporosis among menopausal and postmenopausal women by using only a CBCT viewer program. Materials and Methods: Thirty-eight menopausal and postmenopausal women who underwent dual-energy X-ray absorptiometry (DXA) examination for hip and lumbar vertebrae were scanned using CBCT (field of view: $13cm{\times}15cm;$ voxel size: 0.25 mm). Slices from the body of the mandible as well as the ramus were selected and some CBCT-derived variables, such as radiographic density (RD) as gray values, were calculated as gray values. Pearson's correlation, one-way analysis of variance (ANOVA), and accuracy (sensitivity and specificity) evaluation based on linear and logistic regression were performed to choose the variable that best correlated with the lumbar and femoral neck T-scores. Results: RD of the whole bone area of the mandible was the variable that best correlated with and predicted both the femoral neck and the lumbar vertebrae T-scores; further, Pearson's correlation coefficients were 0.5/0.6 (p value=0.037/0.009). The sensitivity, specificity, and accuracy based on the logistic regression were 50%, 88.9%, and 78.4%, respectively, for the femoral neck, and 46.2%, 91.3%, and 75%, respectively, for the lumbar vertebrae. Conclusion: Lumbar vertebrae and femoral neck osteoporosis can be predicted with high accuracy from the RD value of the body of the mandible by using a CBCT viewer program.

Usefulness of Fracture Risk Assessment Tool Using Lumbar Bone Mineral Density in Prediction of Osteoporotic Vertebral Fracture

  • Lee, Heui Seung;Lee, Sang Hyung;Chung, Young Seob;Yang, Hee-Jin;Son, Young-Je;Park, Sung Bae
    • Journal of Korean Neurosurgical Society
    • /
    • 제58권4호
    • /
    • pp.346-349
    • /
    • 2015
  • Objective : To investigate the value of lumbar bone mineral density (BMD) in fracture risk assessment (FRAX) tool. Methods : One hundred and ten patients aged over 60 years were enrolled and divided into 2 groups as non-osteoporotic vertebral fracture (OVF) and OVF groups. The 10-year-risk of major osteoporotic vertebral fracture of each group was calculated by FRAX tool with femoral and lumbar spine BMDs to compare the usefulness of lumbar spine BMD in prediction of OVF. The blood level of osteocalcin and C-terminal telopeptide (CTX) as markers of activities of osteoblast and osteoclast, respectively were analyzed using the institutional database. Results : In the OVF group, the ratio of patients with previous fracture history or use of glucocorticoid was higher than those in non-OVF group (p=0.000 and 0.030, respectively). The levels of T-score of femur neck and lumbar spine in OVF group were significantly lower than those in non-OVF group (p=0.001 and 0.000, respectively). The risk of OVF in FRAX using femur BMD in non-OVF and OVF groups was $6.7{\pm}6.13$ and $11.4{\pm}10.06$, respectively (p=0.007). The risk of using lumbar BMD in the 2 groups was $6.9{\pm}8.91$ and $15.1{\pm}15.08$, respectively (p=0.002). The areas under the receiver operator characteristic curve in the FRAX risk with lumbar and femur neck BMD were 0.726 and 0.684, respectively. The comparison of osteocalcin and CTX was not significant (p=0.162 and 0.369, respectively). Conclusion : In our study, the 10-year risk of major osteoporotic fracture in the OVF group of our study was lower than the recommended threshold of intervention for osteoporosis. Hence, a lower threshold for the treatment of osteoporosis may be set for the Korean population to prevent OVF. In the prediction of symptomatic OVF, FRAX tool using lumbar spine BMD may be more useful than that using femur neck BMD.

대퇴 근위부의 골소주 패턴에 대한 복합적인 분석을 통한 골다공증 예측 연구 (Prediction of Osteoporosis using Compositive Analysis of Trabecular Patterns on Proximal Femur)

  • 이주환;박성윤;정재훈;김성민
    • 정보처리학회논문지B
    • /
    • 제19B권2호
    • /
    • pp.99-106
    • /
    • 2012
  • 본 연구에서는 각기 다른 측정 부위에서 도출된 골밀도와 골소주 패턴 간의 상관관계를 복합적으로 분석하여 측정부위에 따른 평가변수의 골다공증 예측 가능성을 평가하고자 하였다. 실험대상은 40대 이상의 폐경기 이후 여성 40명을 선정하였고, T-Score 분류법에 따라 각각 20명의 정상군 및 골다공증군으로 분류하였다. 실험대상의 골밀도는 이중 에너지 X선 흡수 계측법을 통해 대퇴경부(Femoral Neck), 전자부(Trochanter) 및 워드 삼각부(Ward's Triangle)에서 측정하였다. 또한 각 측정부위에 $50{\times}50$ 픽셀 크기의 관심영역을 지정하고, 기존 연구에서 제안된 영상처리기법을 적용하여 각 영역의 골소주 패턴을 추출하였다. 골다공증을 예측하기 위한 평가변수는 구조적 변수(평균 회색조, 골면적, 골둘레, 골두께, 말단거리), 골격화 변수(골개수, 골길이) 및 프랙탈 차원(fractal dimension)으로 구분되는 총 8가지를 선정하였다. 실험결과, 골면적, 골둘레, 골두께, 말단거리, 골개수, 골길이 및 프랙탈 차원이 골밀도를 유의하게 반영하였고(p<0.003), 평가변수의 분석을 통한 골다공증의 높은 예측 가능성을 확인하였다.

응력해석에 의한 골절판이 부착된 인체 대퇴골의 골재형성 예측에 관한 연구 (A Study on the Prediction of Bone Remodeling of Plated-Human Femur using Stress Analysis)

  • Kim, Hyun-Su
    • 한국의학물리학회지:의학물리
    • /
    • 제6권2호
    • /
    • pp.111-125
    • /
    • 1995
  • 뼈는 주변 여건에 따라 뼈의 재질 및 형상이 변하는 일종의 동적 구조물로서, 보철물이 부착되면 뼈의 응력상태가 다라져 새로이 골재형성을 하게 된다. 특히, 골절판 부착시 뼈의 접촉은 촉진되나, 그 부위의 응력 변화에 의하여 골절판과 부착된 부분의 뼈는 오히려 약화되는 골다공증 현상을 야기하기도 한다. 본 연구에서는 뼈의 응력변화와 골재형성의 관계를 3차원 유한 요소법을 이용하여 관련시키고자 한다. 이는, 새로이 설계된 골절판 또는 어떤 보철물이, 비록 그 자체의 생체 적합성 및 충분한 강도를 갖게 되더라도 골재형성에 미치는 영향을 판단할 근거가 요구된다고 사료되기 때문이다. 그래서, 현 사용되는 골절판을 인체 대퇴골에 부착된 3차원 유한 요소 모델을 제작하여, 응력 차이법에 의한 골재형성의 경향을 조사하고, 그 경향을 기존 동물 실험결과와 비교 검토하여, 본 연구의 타당성을 평가하여 보철설계의 역학적 기초를 확립하고자 한다.

  • PDF

한국여성의 연령별 골밀도와 그에 미치는 영향인자에 관한 연구(II) :골밀도와 신체 측정치 및 체조성의 관계 (The Effect of Anthropometric Measurement and Body Composition on Bone Mineral Density of Korean Women in Taegu)

  • 이희자
    • Journal of Nutrition and Health
    • /
    • 제29권7호
    • /
    • pp.778-787
    • /
    • 1996
  • The purpose of present study was to assess the change of bone mineral density(BMD) and the influences of anthroopometric indices and body composition on BMD in Korean women in Taegu. Subjects were 242 healthy female in the range of 7-67 years old, were divided into 4 age groups in order to assess the influence o factors on BMD according to age. Body composition and BMD measurements of lumbar spine, femur(neck, ward's triangle, trochanter) and total body were performed by dual energy X-ray absorptiometry. The analysis indicated that BMD of most region was positively related to body weight, BMI in all groups 4(50-67years), and closely related to femurs than lumbar spine. This study found correlations between BMD and both total fat body mass and total lean body mass in group 1, 2, 3, and correlations between BMD and only total fat body mass and in group 4. But on regression models the most significant prediction of BMD throughout the skeleton was total lean body mass in group 1(7-16years)and 2(17-34years, and total fat body mass in group 3 and 4. It is concluded that the our data can be used to screen early women of low bone mass. This study confirms that one of the most effective way to prevent osteoporosis and the fractures is to maximize peak bone mass in early life and to minimize bone loss through maintaining adequate weight.

  • PDF

여성의 개인적 특성과 생활양식요인을 이용한 골량감소 예측모형 (Prediction Model for Reduced Bone mass in Women using Individual Characteristics & Life Style Factors)

  • 이은남;이은옥
    • 근관절건강학회지
    • /
    • 제5권1호
    • /
    • pp.83-109
    • /
    • 1998
  • This study was carried out to identify the Important modifiable risk factors for reduced bone mass and to construct prediction model which can classify women with either low or high bone mass. Through the literature review, individual characteristics such as age, body weight, height, education level, family history, age of menarche, postmenopausal period, gravity, parity, menopausal status, and breast feeding period were identified and factors of life style such as past milk consumption, past physical activity, present daily activity, present calcium intake, alcohol intake, cigarette smoking, coffee consumption were identified as influencing factors of reduced bone mass in women. Four hundred and eighty women aged between 28 and 76 who had given measurement bone mineral density by dual energy x-ray absortiometry in lumbar vertebrae and femur from July to October, 1997 at 4 general hospitals in Seoul and Pusan were selected for this study. Women were excluded if they had a history of any chronic illness such as rheumatoid arthritis, diabetes mellitus, hyperthroidism, & gastrointestinal disorder and any medication such as calcium supplements, calcitonin, estrogen, thyroxine, antacids, & corticosteroids known affect bone. As a result of these exclusion criteria, four hundred and seventeen women were used for analysis. Multiple logistic regression model was developed for estimating the likelihood of the presence or absence of reduced bone mass. A SAS procedure was used to estimate risk factor coefficient. The results are as follows For lumbar spine, the variables significant were age, body weight, menopause status, daily activity, past milk consumption, and past physical activity(p<0.01), while for femoral Ward's triangle, age, body weight, level of education, past milk consumption, past physical activity(p<0.001). Past physical activity, present daily activity and past milk consumption are the most powerful modifiable predictors in vertebrae and femur among the predictors. When the model performance was evaluated by comparing the observed outcome with predicted outcome, the model correctly identified 74.1% of persons with reduced bone mass and 84.5% of persons with normal bone mass in the lumbar vertebrae and 82.9% of persons with reduced bone mass and 75.0% of persons with normal bone mass in the femoral Ward's triangle. On the basis of these results, a number of recommendations for the management of reduced bone mass may be made : First, those woman who are classified as high risk group of the reduced bone mass in the prediction model should examine the bone mineral density to further examine the usefulness of this model. Second, the optimal amount of milk consumption and a regular weight bearing exercise in childhood, adolescence, and early adult should be ensured.

  • PDF

골다공증 진단을 위한 초음파 영상화 진단 기법 연구 (Study of Ultrasound Imaging Technique for Diagnosing Osteoporosis)

  • 김형준;한승무;이준현;이민래
    • 비파괴검사학회지
    • /
    • 제22권4호
    • /
    • pp.386-392
    • /
    • 2002
  • 골다공골증은 해면골의 골소주 두께 감소 및 파단에 기인한 전체적인 골질이 저하되는 질병이다. 골다공증의 진단은 X-ray 및 초음파를 이용하는 방법이 있다. 그러나 X-ray 방법은 인체에 해로우며 단지 골밀도만을 평가한다. 대부분 골다공증 진단 초음파 시스템은 heel뼈를 통과하는 초음파 속도 및 감쇠 파라미터를 측정하고 있다. 한편, 기존의 초음파 시스템들은 heel뼈의 한 점에서만 측정을 실행하므로 측정 위치에 따른 오차로 인하여 골다공증의 진단 예측성이 매우 낮다. 본 연구에서는 두 개의 초음파 탐촉자를 이용하여 선형 스캐닝 방식에 의한 heel뼈 전체 영역에 대한 초음파 파라미터 값들은 2차원 영상처리기법을 통하여 골다공증을 진단하는 기법을 수행하였다.