• Experimental and Molecular Medicine
• /
• 제50권12호
• /
• pp.13.1-13.12
• /
• 2018

We aimed to explore whether changes in circulating levels of miRNAs according to type 2 diabetes mellitus (T2DM) or prediabetes status could be used as biomarkers to evaluate the risk of developing the disease. The study included 462 patients without T2DM at baseline from the CORDIOPREV trial. After a median follow-up of 60 months, 107 of the subjects developed T2DM, 30 developed prediabetes, 223 maintained prediabetes and 78 remained disease-free. Plasma levels of four miRNAs related to insulin signaling and beta-cell function were measured by RT-PCR. We analyzed the relationship between miRNAs levels and insulin signaling and release indexes at baseline and after the follow-up period. The risk of developing disease based on tertiles (T1-T2-T3) of baseline miRNAs levels was evaluated by COX analysis. Thus, we observed higher miR-150 and miR-30a-5p and lower miR-15a and miR-375 baseline levels in subjects with T2DM than in disease-free subjects. Patients with high miR-150 and miR-30a-5p baseline levels had lower disposition index (p = 0.047 and p = 0.007, respectively). The higher risk of disease was associated with high levels (T3) of miR-150 and miR-30a-5p ($HR_{T3-T1}=4.218$ and $HR_{T3-T1}=2.527$, respectively) and low levels (T1) of miR-15a and miR-375 ($HR_{T1-T3}=3.269$ and $HR_{T1-T3}=1.604$, respectively). In conclusion, our study showed that deregulated plasma levels of miR-150, miR-30a-5p, miR-15a, and miR-375 were observed years before the onset of T2DM and pre-DM and could be used to evaluate the risk of developing the disease, which may improve prediction and prevention among individuals at high risk for T2DM.

• 한국산학기술학회논문지
• /
• 제16권1호
• /
• pp.389-396
• /
• 2015

본 연구에서는 공복혈당장애 및 당뇨병과 치주질환의 관련성을 알아보고자 하였다. 본 연구는 국민건강영양조사 제5기(2010년, 2012년) 원시자료를 이용하였으며, 만 19세 이상 성인 총 10,856명을 최종 연구대상자로 선정하였다. 치주질환 유병여부를 종속변수로 한 로지스틱 회귀분석에서는 모든 변수가 보정된 상태에서 성별, 연령, 교육수준, 흡연 및 당뇨병상태가 통계적으로 유의하게 관련이 있는 것으로 나타났다(p<0.001). 본 연구결과 당뇨병의 전단계인 공복혈당장애가 치주질환의 확실한 위험요인으로 보이지는 않지만, 전당뇨병 환자는 당뇨병을 예방하거나 지연시키는 노력을 하지 않으면, 10년 내에 당뇨병으로 발전될 가능성이 높으므로 전당뇨병 단계에서부터 치주질환의 지속적인 검사와 관리가 필요하다고 할 수 있다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권2호
• /
• pp.675-678
• /
• 2015

Background: There are several validated risk factors for breast cancer. However the legitimacy of elevated fasting blood glucose (FBG) is not well established. This study was designed to assess this parameter as a risk factor for breast cancer among pre- and post-menopausal women. Materials and Methods: This case-control study was conducted at Department of Biochemistry, University of Karachi from June 2010 to August 2014. Simple random sampling technique was used to collect data of study subjects comprising 175 diagnosed breast cancer patients with positive histopathology from Breast Clinic, surgical unit-1, Civil Hospital, Karachi and 175 healthy controls from various screening programs. Blood samples were analyzed for FBG and serum insulin. Results: FBG, HOMA-IR, systolic and diastolic blood pressure were significantly raised in breast cancer cases when compared to control subjects. Cases and controls were further categorized in to two groups using cutoff value of 110mg/dl to distinguish subjects into normal fasting glucose (<110mg/dl) and having impaired fasting glucose (${\geq}110-{\leq}125mg/dl$) or diabetes (${\geq}126mg/dl$). Odds ratios were found to be 1.57, 2.15 and 1.17 in overall, pre-menopausal and post-menopausal groups, respectively. (all p < 0.05). Conclusions: A statistically significant risk of breast cancer exists in women having elevated fasting blood glucose levels, corresponding to prediabetes and diabetes, among pre and postmenopausal ages, with comparatively greater effects in the premenopausal group.

• 한국임상약학회지
• /
• 제29권4호
• /
• pp.278-285
• /
• 2019

Background: Rheumatoid arthritis is highly prevalent in overweight patients with type 2 diabetes mellitus and can be reduced by physical activity via altered proinflammatory parameters. However, the association between the frequency of physical activity and the prevalence of rheumatoid arthritis in prediabetic patients remains unclear and was evaluated in this study. Methods: Utilizing the Korean National Health Insurance Sharing Service database, 58,391 adults, who met the research criteria and underwent a general medical check-up between 2009 and 2013, were selected for this study. To analyze the data, a logistic regression with a proc survey logistic procedure was used. Results: The study revealed that the cumulative rheumatoid arthritis prevalence was lower in prediabetic patients compared to that in the control group (OR, 0.64; 95% CI, 0.483-0.840; p=0.001). More frequent physical activity (≥3 days/week) was significantly associated with a reduced rheumatoid arthritis prevalence in both groups (OR, 0.28; 95% CI, 0.039-0.521; p=0.044 vs. OR, 0.15; 95% CI, 0.063-0.237; p=0.007). Additionally, a 3.8-fold higher risk of rheumatoid arthritis development was observed in prediabetic adults with less frequent baseline physical activity (≤2 days/week). Overall, in prediabetes, the prevalence of rheumatoid arthritis was associated with the frequency of physical activity and not with the fasting plasma glucose levels. Conclusion: More frequent physical activity is associated with a low risk of developing rheumatoid arthritis in prediabetic patients. Thus, further studies are needed to confirm the clinical outcomes of frequent physical activity in rheumatoid arthritis prevention and control.

• 수면정신생리
• /
• 제24권1호
• /
• pp.12-18
• /
• 2017

Adequate amount and quality of sleep are important for metabolic control in patients with type 2 diabetes. Too short or too long sleep time disrupts glycemic control in both prediabetes and type 2 diabetic patients. Circadian misalignment such as shift work is also associated with an increased risk of developing type 2 diabetes. Clinicians should pay attention to the sleep problems and circadian patterns of patients. However, the pathophysiologic mechanism of the association between sleep and diabetes is likely to be complex and bidirectional. The underlying mechanism remains poorly understood, and further research is warranted.

• Clinical and Experimental Pediatrics
• /
• 제64권12호
• /
• pp.619-627
• /
• 2021

Pediatric obesity has become a serious public health issue. The prevalence of obesity in children and adolescents has increased worldwide and in Korea over several decades. Obese children are more likely to be obese adults with an increased cardiovascular risk. Therefore, maintaining a healthy weight and preventing obesity during childhood are of critical importance. Moreover, obese children and adolescents often have endocrine comorbidities such as prediabetes, type 2 diabetes, dyslipidemia, metabolic syndrome, polycystic ovary syndrome, and central precocious puberty. Hence, the early implementation of obesity management using a multidisciplinary team approach and screening for these comorbidities in obese children and adolescents are required with the appropriate management of each comorbidity and/or specialist referral.

• 농촌의학ㆍ지역보건
• /
• 제37권4호
• /
• pp.215-222
• /
• 2012

당화혈색소 5.7%이상에서 6.4%이하인 당뇨전 단계는 당뇨와 심혈관 질환의 위험요소임이 이미 알려져 있다. 최근 미국 당뇨병 학회에서는 당화혈색소를 당뇨의 진단 기준으로 추가하였다. 이러한 배경을 바탕으로 본 연구에서는 농촌 지역 건강한 성인 남녀를 대상으로 당화혈색소와 내장지방과의 관련성을 살펴보았다. 일개 대학병원 건강 검진 수진자 중 건강한 성인 남녀 507명을 연구 대상자로 선정하였다. 연구 대상자에게 설문지를 기입하도록 하고 혈압, BMI, 혈액검사를 측정하였고, 총 복부지방, 내장지방, 피하지방은 CT를 이용하여 측정하였다. 연구 대상자를 남녀로 구분지어 평균값을 비교한 결과 내장지방, 피하지방, 중성지방, 당화혈색소가 유의한 차이를 보였다. 남녀로 구분지어 당화혈색소 5.7%를 기준으로 미만 군과 이상 군으로 분류하고 피하지방과 내장지방 및 혈액검사를 비교해보았다. 이 중 내장지방만이 남녀 모두에서 5.7%이상 군과 미만 군 사이에서 유의한 차이를 보였다. 당화혈색소 5.7%이상 군에서 5.7% 미만 군에 비해 내장지방이 높았다. 전진선택법으로 변수를 선택하여 로지스틱 회귀분석을 한 결과, 비교 위험도 1.007(95% CI1.002~1.012) 으로 복부 지방 중 내장지방이 증가함에 따라 당화혈색소가 약간 증가하는 결과를 관찰하였다. 그러므로 본 연구가 시사하는 바와 같이, 당화혈색소가 5.7% 이상처럼 정상이 아닌 경우에는 당뇨병의 유무와 상관없이 여러 심혈관질환 관련 위험 인자를 조사하여 이에 적절한 치료와 예방이 필요할 것으로 사료된다.

• 한국산학기술학회논문지
• /
• 제17권2호
• /
• pp.104-111
• /
• 2016

본 연구는 중년기 성인의 당뇨병 유병형태에 대한 생리적 지표 및 생활습관 요인을 비교, 조사하기 위해 시행되었다. 대상자는 2010-2012년 국민건강영양조사 자료를 이용한 2차 자료 분석이며, 40-64세의 중년기 성인 5,363명을 표본으로 하였다. 자료는 기술적 통계, 교차분석, ANCOVA, 로지스틱 회귀분석으로 분석하였다. 정상군, 전당뇨병군, 당뇨병군을 비교한 결과는 다음과 같다. 체질량지수는 정상군보다 전당뇨병군과 당뇨병군에서 유의하게 높았다. 고혈압, 복부비만여부, 고콜레스테롤혈증여부, 고중성지방혈증여부, 흡연, 음주, 탄수화물 섭취량은 세 군 간에 유의한 차이가 있었다. 생리적 지표 및 생활습관 요인 중 고혈압(OR:1.64, CI 1.35-2.01), 고콜레스테롤혈증(OR:1.36, CI 1.03-1.79), 고중성지방혈증(OR:1.71, CI 1.34-2.18), 복부비만(남;OR:2.31, CI 1.75-3.05, 여;OR:2.20, CI 1.67-2.91), 체질량지수(OR:1.13, CI 1.10-1.17), 음주(OR:1.44, 1.16-1.79)가 당뇨병전단계에 영향을 주는 요인으로 나타났다. 당뇨병에 영향을 주는 요인은 고혈압(OR:2.27, CI 1.68-3.06), 고콜레스테롤혈증(OR:2.31, CI 1.67-3.20), 고중성지방혈증(OR:1.95, CI 1.39-2.73), 복부비만(남;OR:2.31, CI 1.60-3.32, 여;OR:3.26, CI 2.24-4.73), 체질량지수(OR:1.12, CI 1.07-1.18), 흡연(OR:1.59, CI 1.18-2.13)으로 나타났다. 본 연구 결과를 바탕으로 중년기 성인에서 고혈압, 비만, 이상지질혈증, 음주, 흡연 등의 생활습관을 개선할 수 있는 효과적인 당뇨병 예방을 위한 중재 프로그램의 개발을 제언한다.

• Journal of Preventive Medicine and Public Health
• /
• 제39권4호
• /
• pp.353-358
• /
• 2006

Objectives: An increase in the serum gamma-glutamyltransferase (GGT) concentration has been regarded as a marker of alcohol drinking or liver disease. Some reports, however, have suggested that the serum GGT may be a sensitive and early biomarker for the development of prediabetes and diabetes. In this study we investigated whether serum GGT is a reliable predictor of the incident impaired fasting glucose (IFG), including diabetes. Methods: We performed a prospective study for two years (2002-2004). We analyzed the periodic health examination data from a total of 4,711 men. The examinations were done in the years 2002 and 2004. The analyzed data included a self-questionnaire, a physical examination and the laboratory results. Both IFG and diabetes were defined as a serum fasting glucose concentration of more than 100 mg/dL and 126 mg/dL, respectively. Results: A total of 738 cases (15.7%) of incident IFG and 13 cases (0.3%) of diabetes occurred. The mean serum GGT concentrations were quite different between the normal (38.0 IU) and incident IFG groups (50.3 IU), and the incident diabetes group (66.0 IU) (p<0.001). After multivariable adjustment, the relative risks for incident IFG or diabetes across the baseline GGT categories (<10th, 10th-20th, 30th-40th, 50th-60th, 70th-80th and >90th percentile) were 1.0, 1.172 (0.769-1.785), 1.107 (0.725-1.689), 1.444 (0.934-2.232), 2.061 (1.401-3.031) and 2.545 (1.784-3.631) (p-value for trend: <0.001). The risks significantly increased with increasing levels of GGT for 2 years; when comparing the increased groups (<10%, 10-20%, >20%) versus the decreased over 20% group of GGT, the risks for IFG or diabetes were 1.334 (1.002-1.776), 1.613 (1.183-2.199) and 1.399 (1.092-1.794). Conclusions: Our findings suggest that serum GGT concentrations within its normal range may be an early predictor of the development of IFG and diabetes. As serum GGT is a relatively inexpensive test and a reliable marker, it might have important implications in public health promotion.

• 한방재활의학과학회지
• /
• 제24권1호
• /
• pp.1-12
• /
• 2014

Objectives This study was performed to evaluate the effects of fermented lotus extracts on prediabetes and hyperlipidemia in high fructose diet rats. Methods Extracts of lotus leaf and lotus root were fermented using 4 different probiotics separately, including Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, and Bifidobacterium longum. Expressions of adipogenic transcription factors including Adiponectin, GLUT-4, Leptin, PPAR gamma, Resistin and Visfatin were analyzed by Real time PCR and Western blotting analysis. Results Fermented lotus extracts reduced blood glucose. Fermented lotus extracts inhibited adipogenic transcription factors by inhibiting preadipocytes differentiation. The level of gene expression of Adiponectin, GLUT-4, Leptin, PPAR gamma, Resistin and Visfatin in relation to that of GAPDH were increase or decrease significantly with the Fermented lotus formulation group. Conclusions Fermented lotus extracts showed hypoglycemic and hypolipidemic effects by inhibiting preadipocyte differentiation and controlling insulin sensitivity in high fructose diet rats.