• Earthquakes and Structures
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• 제8권2호
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• pp.443-462
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• 2015

Some model building codes stipulate that the design displacement of a building can be computed using the elastic static analysis results multiplied by the deflection amplification factor, $C_d$. This approach for estimating the design displacement is essential and appealing in structural engineering practice when nonlinear response history analysis (NRHA) is not required. Furthermore, building codes stipulate the consideration of accidental torsion effects using accidental eccentricity, whether the buildings are symmetric-plan, or asymmetric-plan. In some model building codes, the accidental eccentricity is further amplified by the torsional amplification factor $A_x$ in order to minimize the discrepancy between statically and dynamically estimated responses. Therefore, this warrants exploration of the reliability of statically estimated design displacements in accordance with the building code requirements. This study uses the discrepancy curves as a way of assessing the reliability of the design displacement estimates resulting from the factors $C_d$ and $A_x$. The discrepancy curves show the exceedance probabilities of the differences between the statically estimated design displacements and NRHA results. The discrepancy curves of 3-story, 9-story, and 20-story example buildings are investigated in this study. The example buildings are steel special moment frames with frequency ratios equal to 0.7, 1.0, 1.3, and 1.6, as well as existing eccentricity ratios ranging from 0% to 30%.

• 미생물과산업
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• 제19권2호
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• pp.34-41
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• 1993

Industrial strain improvement is concerned with developing or modifying microorganisms used in production of commercially important fermentation products. The aim is to reduce the production cost by improving productivity of a strain and manipulating specific characteristics such as the ability to utilize cheaper raw materials or resist bacteriophages. The traditional empirical approach to strain improvement is mutation combined with selection and breeding techniques. It is still used by us to improve the productivity of organisms in amino acids, organic acids and enzymes production. The breeding of high L-lysine-producing strain Au112 is one of the outstanding examples of this approach. It is a homoserine auxotroph with AEC, TA double metabolic analogue resistant markers. The yield reaches 100 g/l. Besides, the citric acid-producing organism Aspergillus niger, Co827, its productivity reaches the advanced level in the world, is also the result of a series mutations especially with $^60Co{\gamma}$-radiation. The thermostable .alpha.-amylase producing strain A 4041 is the third example. By combining physical and chemical mutations, the strain A 4041 becomes an asporogenous, catabolite derepressed mutant with rifamycin resistant and methionine, arginine auxotroph markers. The .alpha.-amylase activity reaches 200 units/ml. The fourth successful example of mutation in strain improvement is the glucoamylase-producing strain Aspergillus niger SP56, its enzyme activity is 20,000 units/ml, 4 times of that of the parental strain UV-11. Recently, recombinant DNA approach provides a worthwhile alternative strategy to industrial strain improvement. This technique had been used by us to increase the thermostable .alpha.-amylase production and on some genetic researches.

• Journal of Computing Science and Engineering
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• 제2권2호
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• pp.109-136
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• 2008

In this survey paper, we discuss biomedical ontologies and major text mining techniques applied to biomedicine and healthcare. Biomedical ontologies such as UMLS are currently being adopted in text mining approaches because they provide domain knowledge for text mining approaches. In addition, biomedical ontologies enable us to resolve many linguistic problems when text mining approaches handle biomedical literature. As the first example of text mining, document clustering is surveyed. Because a document set is normally multiple topic, text mining approaches use document clustering as a preprocessing step to group similar documents. Additionally, document clustering is able to inform the biomedical literature searches required for the practice of evidence-based medicine. We introduce Swanson's UnDiscovered Public Knowledge (UDPK) model to generate biomedical hypotheses from biomedical literature such as MEDLINE by discovering novel connections among logically-related biomedical concepts. Another important area of text mining is document classification. Document classification is a valuable tool for biomedical tasks that involve large amounts of text. We survey well-known classification techniques in biomedicine. As the last example of text mining in biomedicine and healthcare, we survey information extraction. Information extraction is the process of scanning text for information relevant to some interest, including extracting entities, relations, and events. We also address techniques and issues of evaluating text mining applications in biomedicine and healthcare.

• 대한안전경영과학회지
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• 제10권3호
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• pp.43-53
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• 2008

This study is carried out for the fire safety of the factory building, the fire risk reduction measure in compliance with an example approached in fire risk reduction systematically, contribute to reduce the fire risk. The analytical fire risk process of discovering, identifying, estimating and evaluating risk and control measure as risk reduction measures are core concept, applies loss prevention with loss control techniques. The painting process in the workplace where the fire hazard and death accident accompanies coexists. Loss prevention problem of creation prevention of dangerous atmosphere at workplace is health and human services problem of normal circumstances, must be inspected with problem of combustible gases at the time of fire explosion. Static electricity measure accomplished the risk control process thoroughly as the fire risk reduction process model with the ignition sources measure which is presented. Fire risk from within organizing will be able to classify with each field by detailedly but risk treatment process will be able to apply basically all the same concept. Consequently about risk management example from before, this study is proposed risk management techniques that standardized rightly in the actual condition of organization with one plan, with discovery of fire risk, the feedback process in compliance with a fire risk reduction and the review which control the result is joint responsibility of engineer, technical expert and manager as part of safety management to practice with the fact must be supervised.

• 한국환경과학회지
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• 제10권3호
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• pp.217-223
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• 2001

Where no records are available at a site, a preliminary estimate may be made from relations between floods and catchment chatacteristics. A number of these chatacteristics were chosen for testing and were measured for those catchments where mean annual flood estimates were available. Although the improvement using extended data in regression of flood estimates on catchment characteristics was small, this may be due to the limitations of the regression model. When an individual short term record is to be extended, more detailed attention can be given; an example is presented of the technique which should be adopted in practice, particularly when a short term record covers a period which is known to be biassed. A method of extending the peaks over a threshold series is presented with a numerical example. The extension of records directly from rainfall by means of a conceptual model is discussed, although the application of such methods is likely to be limited by lack of recording raingauge information. Methods of combining information from various sources are discussed in terms of information from catchment characteristics supplemented by records. but are generally applicable to different sources of information. The application of this technique to estimating the probable maximum flood requires more conservative assumptions about the antecedent condition, storm profile and unit hydrograph. It is suggested that the profile and catchment wetness index at the start of the design duration should be based on the assumption that the estimated maximum rainfall occurs in all durations centered on the storm peak.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2002년도 춘계학술대회논문집
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• pp.651-659
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• 2002

Component Mode Synthesis (CMS) is a dynamic substructuring technique to get an approximate eigensolutions of large degree-of-freedom structures divisible into several components. But, In practice. most of large structures are modeled by different teams of engineers. and their respective finite element models often require different mesh resolutions. As a result, the finite element substructure models can be non-conforming and/or incompatible. In this work, A hybrid version of component mode synthesis using a localized lagrange multiplier to treat the non-conforming mesh problem was derived. Evolution Strategies (ESs) is a stochastic numerical optimization technique and has shown a robust performance for solving deterministic problems. An ESs conducts its search by processing a population of solutions for an optimization problem based on principles from natural evolution. An optimization example for raising the first natural frequency of a plate structure using beam stiffeners was presented using hybrid component mode synthesis and robust evolution strategies (RES) optimization technique. In the example. the design variables are the positions and lengths of beam stiffeners.

• Journal of Gastric Cancer
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• 제4권2호
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• pp.59-74
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• 2004

This report attempts to explain the (i) implications of comorbidity for research and practice in the fieldo of oncology, (ii) the approach for dosing of anti-cancer drugs in the presence of comorbidity, as an example of its clinical application, and finally (iii) the dosing guidelines for the anticancer drugs clinically active in gastric cancer in the presence of renal or liver dysfunction. This has resulted from the idea of approaching comorbidity in a systematic way and of integrating it with oncologic decisions. Various methods have been used to assess comorbidity. However, significant work remains to be done to analyze how various diseases combine to influence the oncologic outcome. The main end-point explored so far has been mortality, but a largely open challenge remains to correlate comorbidity with treatment tolerance and functional and quality of life, as well as to integrate it in clinical decision-making. Cancer chemotherapy in comorbidity should be considered as an example of the need for dose optimization in individual patients, and it should be determined by considering the basic principles of the pharmacokinetics and the pharmacodynamics of the agents. This review analyzes the available data on the pharmacokinetics and the toxicities of anti-cancer agents in the comorbidity population.

• 한국지진공학회논문집
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• 제27권3호
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• pp.157-162
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• 2023

As a result of active geological investigation of faults in Korea, many Quaternary faults have been identified and some of them were judged to have potential to generate earthquakes. Those faults need to be considered as additional seismic sources in the seismic hazard analysis. When a fault is introduced as a new source, the earthquakes generated by the fault should be removed from the area sources that include any part of the fault, to avoid double counting. In practice, however, double counting cannot completely be avoided as the complete separation of the fault-generated earthquakes from the area sources is impossible due to uncertainties related to the earthquake location, subsurface structures of faults, etc. When a new fault source is introduced, the only constraint is the invariance of earthquake frequency. The maximum earthquake and the Richter-b value should also be subject to change, but there are no competent approaches to estimate the change due to incomplete separation of earthquakes. To gain insight into the effect of a new fault source, an example calculation of the seismic hazard were carried out. The example calculation shows that addition of a new fault source centers seismic hazard around the fault source.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제37권3호
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• pp.329-348
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• 2023

본 연구는 2022년 12월에 고시된 2022 개정 중학교 수학과 교육과정에서 제시한 통계 내용의 안정적인 현장 정착이라는 현실적인 필요성에 의해 수행된 문헌 연구이다. 2022 개정 수학과 교육과정 개정 방향 중의 하나인 통계교육의 변화 요구를 고려하였다. 특별히 본 연구에서는 중국 중학교 수학과 교육과정의 통계 내용을 면밀히 분석하였다. 왜냐하면 10년마다 수학과 교육과정을 개정하는 중국이 우리나라와 동일한 2022년에 새로운 수학과 교육과정을 고시하였기 때문이다. 이에 본 연구는 대한민국의 2022 개정 중학교 수학과 교육과정 통계 내용 및 2022년판 중국 중학교 수학과 교육과정 및 현재 사용 중인 수학교과서 통계 내용에 대한 상호 분석을 통하여, 우리나라의 새로운 교육과정의 방향에 부합된 통계교육 실현을 위한 기초 자료를 제공하는 것을 연구 목적으로 설정하였다. 이러한 목적을 달성하기 위해 다음과 같은 연구를 수행하였다. 첫째, 중국 중학교 수학과 교육과정의 '통계와 확률' 영역 분석을 통해 우리나라 통계교육에 유의미한 시사점을 제공할 수 있는 요소 5가지를 추출하였다. 둘째, 추출된 요소가 반영된 중국의 수학교과서 및 교육과정 부록에 제시된 예시 내용을 분석하였다. 셋째, 분석 결과를 바탕으로 2022 개정 중학과 수학과 교육과정에 따른 통계교육의 이상을 실현하기 위한 교과서 개발, 교실의 교수·학습 방안 및 추후 새로운 수학과 교육과정에 대한 시사점을 도출하였다. 본 연구를 통해 2022 개정 중학교 수학과 교육과정에서 표방하는 방향에 부합된 현장 통계교육의 안착을 기대한다.

• 기본간호학회지
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• 제14권3호
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• pp.351-360
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• 2007

Purpose: The purpose of this study was to develop a Problem-Based Learning (PBL) package, test its application and evaluate students' recognition of the effectiveness of PBL in nursing colleges. Method: Thirteen steps were used in the process developing the PBL package. After its application, the first questionnaire for self-evaluation and satisfaction with PBL class was given to 94 nursing students in December, 2005. To further evaluate the students' recognition of the effectiveness of PBL, a second questionnaire was given to 83 nursing students out of the 96 in May, 2007 after clinical practice. Data analysis was conducted using means with standard deviation. Results: The results of students' self-evaluation showed high achievement in learning outcome and process using the PBL method. Also, they expressed satisfaction with the subject management, the lecturer and their peers after the PBL class. Students recognized that the PBL class had positive effectiveness in clinical practice and wanted more PBL classes and the inclusion of complex cases from well designed packages. Conclusion: PBL class could be considered as an opportunity to fortify student nurses' abilities to adjust to the real clinical situation.