• 생물정신의학
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• 제17권4호
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• pp.177-193
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• 2010

Significant advances have been made in understanding the biological underpinnings of post-traumatic stress disorder(PTSD), particularly in the field of genetics and neuroimaging. Association studies in candidate genes related with hypothalamic-pituitary-adrenal axis, monoamines including serotonin, dopamine and noradrenaline, and proteins including FK506-binding protein 5 and brain-derived neurotrophic factor have provided important insights with regard to the vulnerability factors in PTSD. Genome-wide association studies and epigenetic studies may provide further information for the role of genes in the pathophysiology of PTSD. Hippocampus, medial prefrontal cortex, anterior cingulated cortex and amygdala have been considered as key structures that underlie PTSD pathophysiology. Future research that combines genetic and neuroimaging information may provide an opportunity for a more comprehensive understanding of PTSD.

• Biomolecules & Therapeutics
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• 제22권3호
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• pp.213-222
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• 2014

Abnormal adaptation of the stress-response system following traumatic stress can lead to alterations in the hypothalamic-pituitaryadrenal (HPA) axis that may contribute to the development of post-traumatic stress disorder (PTSD). The present study used several behavioral tests to investigate the anxiolytic-like and antidepressant activity of L-tetrahydropalmatine (L-THP) in an experimental rat model of anxiety and depression induced by single prolonged stress (SPS), an animal model of PTSD. Male rats were treated intraperitoneally (i.p.) with vehicle or varied doses of THP 30 min prior to SPS for 8 consecutive days. Daily THP (50 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index, increased the risk assessment, and increased the number of head dips over the borders of the open arms after SPS. THP was also associated with increased time spent at the center of the open field, reduced grooming behaviors in the EPM test, and reduced time spent immobile in the forced swimming test (FST). It also blocked the decrease in neuropeptide Y (NPY) and the increase in corticotrophin-releasing factor (CRF) expression in the hypothalamus. This is the first study to determine that THP exerts pronounced anxiolytic-like and antidepressant effects on the development of the behavioral and biochemical symptoms associated with PTSD, indicating its prophylactic potential. Thus, THP reversed several behavioral impairments triggered by the traumatic stress of SPS and is a potential non-invasive therapeutic intervention for PTSD.

• 한국콘텐츠학회논문지
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• 제15권9호
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• pp.134-145
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• 2015

2014년 4월 16일 전남 진도 인근 관매도 해상에서 침몰한 세월호 참사가 발생한 지 1주기가 지났다. 총 304명의 희생자와 실종자를 낳은 세월호 참사는 2010년대 이후 대한민국에서 가장 큰 규모의 참사였다. 그러나 세월호 참사 1주기가 지나도록 유족의 트라우마에 대한 심리적, 커뮤니케이션학적 연구는 전혀 없었다. 본 연구는 국내에서 처음으로 자식을 잃은 부모로서 세월호 참사로 인한 극심한 외상 후 스트레스 장애를 겪고 있는 세월호 유가족의 실태를 조사했다. 연구결과 신체적으로, 심리적으로 세월호 유족의 경우 외상 후 스트레스 장애가 발생하고 있음을 확인할 수 있었고 치료에는 소홀한 것으로 나타났다. 외상 후 스트레스 장애는 일상생활에도 영향을 미쳤다. 세월호 유족은 대인관계, 직장관계, 거주지, 가치관 등 많은 부분에서 일상적인 생활에 문제가 많은 것을 확인할 수 있었다. 본 연구를 통해 참사로 인한 세월호 유족의 외상 후 스트레스 장애가 막대한 것으로 나타난 만큼 학계에서도 더욱 적극적으로 관련된 논의를 함께해 우리 사회에서 방치된 세월호 유가족의 고통을 치료하는데 나서야 할 것이다.

• The Korean Journal of Physiology and Pharmacology
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• 제20권4호
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• pp.357-366
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• 2016

Pro-inflammatory cytokine and brain-derived neurotrophic factor (BDNF) are modulated in post-traumatic stress disorder (PTSD). This study investigated the effects of ibuprofen (IBU) on enhanced anxiety in a rat model of PTSD induced by a single prolonged stress (SPS) procedure. The effects of IBU on inflammation and BDNF modulation in the hippocampus and the mechanisms underlying for anxiolytic action of IBU were also investigated. Male Sprague-Dawley rats were given IBU (20 or 40 mg/kg, i.p., once daily) for 14 days. Daily IBU (40 mg/kg) administration significantly increased the number and duration of open arm visits in the elevated plus maze (EPM) test, reduced the anxiety index in the EPM test, and increased the time spent in the center of an open field after SPS. IBU administration significantly decreased the expression of pro-inflammatory mediators, such as tumor necrosis $factor-{\alpha}$, $interleukin-1{\beta}$, and BDNF, in the hippocampus, as assessed by reverse transcription-polymerase chain reaction analysis and immunohistochemistry. These findings suggest that IBU exerts a therapeutic effect on PTSD that might be at least partially mediated by alleviation of anxiety symptoms due to its anti-inflammatory activity and BDNF expression in the rat brain.

• 한국보건간호학회지
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• 제33권2호
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• pp.214-227
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• 2019

Purpose: This study examined the socio-demographic factors, the disaster related factors, the physical health related factors and the psychological factors of older adults exposed to natural disaster and these factors may possibly cause the occurrence of PTSD. Methods: A cross-sectional study was designed using the secondary data from the 3rd Disaster Victims Panel Survey (2012-2017). The data from 1,397 disaster victims were analyzed using descriptive statistics and logistic regression analysis. Results: Compared with the younger adult disaster victims, the elderly were more likely to have symptoms of PTSD (15.0% vs. 12.1%). Factors such as the number of years since being exposed to the disaster, anxiety, depression and social adjustment were significantly associated with occurrence of PTSD for both older and younger adults. Female gender was the additional risk factors for the older adults, while marital status, income, having witnessed another person's injury or death, and having lost a home were associated with the occurrence of PTSD. Conclusion: The elderly were more likely to develop PTSD as compared with younger adults. More targeted post-disaster mental health services to the elderly with the symptoms of depressive, anxiety and impaired social adjustments, should be provided to improve their mental health.

• Child Health Nursing Research
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• 제16권4호
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• pp.360-368
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• 2010

Purpose: The purpose of this study was to investigate the relationships between parenting behavior, parenting efficacy, adaptation stress and PTSD (Post Traumatic Stress Disorder) among mothers who have defected from North Korean. Methods: A descriptive study was conducted to illustrate the parenting behavior, parenting efficacy, adaptation stress and PTSD and report the relationships among them. Data were collected between August and November of 2009 in Hanawon and 105 mothers who met eligibility criteria participated in the study. Results: Ignorant/controlling parenting behavior of parenting showed the highest score in our study. The level of parenting efficacy was $2.72{\pm}0.36$ and adaptation stress level was $3.35{\pm}0.47$ showing perceived hostility the highest and homesickness the lowest. Participants with moderate to severe PTSD accounted for 79.5% of the mothers, and 75% of them reported symptoms for 3 months or more. Authoritative parenting behavior showed negative relationships with parenting efficacy, cultural crisis and fear, adaptation stress and PTSD. Conclusion: Mothers who have defected from showed negative parenting behaviors and high adaptation stress level and PTSD while parenting efficacy was high. These findings indicate that parenting intervention programs which can guide these mothers towards positive parenting behaviors need to be developed.

• 대한불안의학회지
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• 제5권2호
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• pp.80-88
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• 2009

Disorder of Extreme Stress, Not Otherwise Specified (DESNOS) is the proposed diagnosis that meets the severe, complex, and prolonged psychological sequela of victims with chronic traumatization (e.g., family violence, incest, and childhood sexual or physical abuse). The hallmarks of DESNOS are a multiplicity of symptoms (e.g., somatization, dissociation, and depression), pathological changes in relationships, identity disturbances, and a propensity to experience repeated harm and injury at the hands of oneself and others. DESNOS can be directly assessed by Structured Interview of Disorder of Extreme Stress (SIDES) and Self- Report Inventory of Disorder of Extreme Stress (SIDES-SR). The treatment of DESNOS should be phaseoriented and involve movement back and forth among three basic stages : 1) stabilization ; 2) trauma processing ; 3) reintegration.

• 정신신체의학
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• 제28권2호
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• pp.155-160
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• 2020

연구목적 본 연구는 외상후 스트레스장애(Posttraumatic Stress Disorder, PTSD)를 비롯한 정신질환자의 기질과 성격의 변화 양상을 확인하고 한다 방 법 PTSD 환자 33명과 비PTSD 환자 69명을 대상으로 Temperament and Character Inventory (TCI)를 1, 2차에 걸쳐 측정하였고, 그 결과값에 대해 반복측정 ANOVA와 단순 주효과분석을 시행하였다. 결 과 비PTSD 집단에서는 1차와 2차 검사 결과의 차이가 나타나지 않았다. 반면, PTSD 집단에서는 위험회피, 사회적 민감성, 자율성, 연대감에서 유의미한 차이가 있었다. 또한 위험회피, 사회적 민감성, 자율성, 연대감에서 시간과 그룹 간의 상호작용과 시간에 따른 주효과가 유의하게 나타났다. 결 론 본 연구는 외상적 사건이 자율성, 연대감과 같은 성격적 특성은 물론, 위험회피와 사회적 민감성과 같은 기질적 특성의 변화에 영향을 미칠 수 있음을 확인하였다는 점에서 의의가 있다.

• Journal of Hospice and Palliative Care
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• 제18권1호
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• pp.35-41
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• 2015

목적: 본 연구는 항암치료 단계 유방암 환자의 PTSD, 대처방식, 사회적 지지의 관계를 파악하여 암환자의 PTSD에 관한 효과적인 간호중재의 기초자료를 제시하기 위함이다. 방법: J시 소재 G지역암센터 외과 외래를 방문한 만 30세 이상이며, 항암치료단계인 유방암 환자134명을 대상으로 조사하였다. 수집된 자료는 SPSS WIN 18.0프로그램을 이용하여 서술통계, ANOVA, Pearson correlation coefficients 등을 실시하였다. 결과: 항암치료 단계 유방암 환자의 외상 후 스트레스 장애는 26.9%가 PTSD 고위험군, 17.9%가 PTSD 위험군에 속하는 것으로 나타났다. 대상자의 PTSD 그룹(고위험군, 위험군, 정상)의 대처방식(적극적 대처, 소극적 대처), 사회적 지지의 상관관계는 PTSD 고위험군인 경우 적극적 대처와 소극적 대처가 유의미한 정적 상관관계를 가지는 것으로 나타났으며, PTSD 고위험군에서 사회적 지지와 적극적 대처는 유의미한 정적 상관관계를 가지고 있는 것으로 나타났다. 결론: 항암치료 단계 유방암 환자 중 26.9%가 PTSD 증상을 보이는 것으로 나타났으며, PTSD 고위험군에서 사회적 지지가 증가할수록 적극적 대처가 증가하는 것으로 나타났다. 암은 평생 자기관리가 필요한 질병임을 고려할 때 높은 사회적 지지는 자신의 건강관리 능력을 증진시킬 수 있는 계기가 될 수 있을 것이며, 더 나아가 PTSD 고위험군에게 있어 높은 사회적 지지는 환자의 스트레스를 줄이고 삶의 질을 높이는데 효과적인 역할을 할 것이라 여겨진다.

• 동의신경정신과학회지
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• 제22권4호
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• pp.77-86
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• 2011

Objectives : These days assaults and other natural and human disasters are increasing. But oriental medical treatment researches in Korea are limited in car accident PTSD patients only. Our object is to explore an oriental medical intervention model for the evidence-based approach to PTSD after diverse trauma including disasters. Methods : Domestic papers for Korean researches are obtained from oriental medical related journals by internet searching. International materials are obtained from PubMed searching and a publication from Department of Veterans' Affairs. After assorting searched articles into RCTs and non-RCTs, we analyzed the articles according to the elapsed time from trauma. Results : We confirmed that acupuncture, CBT, and PMR were effective in acute stage after traumatic event. And EMDR, EFT, and relaxation therapy were effective in chronic stage after traumatic event. Building on the findings, we proposed a model of oriental medicine for Disaster Mental Health. Conclusions : Analyzing previous researches about oriental medicine on PTSD, several interventions were confirmed the effectiveness on specific treatment stage. We could find the possibility of Oriental Medicine as a Disaster Mental Heath and proposed a model of Oriental medicine for Disaster Mental Health.