• Anatomy and Cell Biology
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• v.49 no.4
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• pp.223-230
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• 2016

Stroke leads to a variety of pathophysiological conditions such as ischemic infarct, cerebral inflammation, neuronal damage, cognitive decline, and depression. Many endeavors have been tried to find the therapeutic solutions to attenuate severe neuropathogenesis after stroke. Several studies have reported that a decrease in the neuropeptide regulator 'galanin' is associated with neuronal loss, learning and memory dysfunctions, and depression following a stroke. The present review summarized recent evidences on the function and the therapeutic potential of galanin in post-ischemic stroke to provide a further understanding of galanin's role. Hence, we suggest that galanin needs to be considered as a therapeutic factor in the alleviation of post-stroke pathologies.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.3
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• pp.273-276
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• 2006

RNA interference (RNAi), a process of sequence-specific gene suppression, has been known as a natural gene regulatory mechanism in a wide range of lower organisms. Recently, we have reported that a transfection of human U6 promoter (hU6) driven hairpin small-interference RNA (siRNA) plasmid specifically knocks down the target gene by post-transcriptional gene silencing in mammalian cells. Here we report that transfection of polymerase chain reaction (PCR) products, containing human U6 promoter with hairpin siRNA, knocks down the target gene expression in human teratocarcinoma NT-2/D1 cells. Moreover, we showed 3' end termination sequence, 5 Ts, is not critical elements for knocking down in PCR-based siRNA system. Therefore, the PCR-based siRNA system is a promising tool not only for the screening but also to temporally regulate gene expression in the human progenitor cells.

• The Journal of Korean Academy of Prosthodontics
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• v.32 no.2
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• pp.225-233
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• 1994

The restorations of the severely damaged teeth by post core have been increased with the developement of endodontic procedures. But high failure rates of these procedures being reported, various restorative modifications were induced for successful treatments. Cast post-core and prefabricated post with core buildups are choice of treatment. The main causes of failure of the restorations are the fracture of post and core, root fracture, and recurrent caries due to microleakage. Recently, the acid etching technique and the use of dentin bonding agent at tooth surface to reduce the possible microleakage at the tooth-restoration interfaces were introduced. The object of this study was to measure and compare the microleakage by the types and cementation methods of post-core. For this study, forty extracted human anterior teeth were selected for specimen. After cleansing and routine endodontic procedures, anatomic crowns of each specimen were removed at the level of 2mm above the cementoenamel junction. Canals were preparated for post insertion and specimens were divided into four groups randomly. Post-cores were fabricated according to method for each group. Microleakage was measured by length of dye penetration at the tooth-restoration interfaces with measuring microscope at 50 magnification. Oneway ANOVA and t-test were performed for statistical analysis of resulting data. The following results were obtained from this study. 1. There wert significant statistical differences in degree of microleakage between each group (p<0.01). 2. Cast post-core cemented with ZPC (Group I) showed the most severe microleakage pattern$(1.5547{\pm}0.0872mm)$, and cast post-core cemented with adhesive resin cement after tooth surface treatment with dentin bonding agent (Group II) showed the least microleakage $(0.1497{\pm}0.0872mm)$. 3. Group IV revealed less dye penetrations than group III, but no statistical significance was seen between two groups.

• The Journal of Advanced Prosthodontics
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• v.4 no.1
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• pp.37-42
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• 2012

PURPOSE. The influence of the modified process in the fiber-reinforced post and resin core foundation treatment on the fracture resistance and failure pattern of premolar was tested in this study. MATERIALS AND METHODS. Thirty-six human mandibular premolars were divided into 4 groups (n = 9). In group DCT, the quartz fibre post (D.T. Light-post) was cemented with resin cement (DUO-LINK) and a core foundation was formed with composite resin (LIGHT-CORE). In group DMO and DMT, resin cement (DUO-LINK) was used for post (D.T. Lightpost) cementation and core foundation; in group DMO, these procedures were performed simultaneously in one step, while DMT group was accomplished in separated two steps. In group LCT, the glass fiber post (LuxaPost) cementation and core foundation was accomplished with composite resin (LuxaCore-Dual) in separated procedures. Tooth were prepared with 2 mm ferrule and restored with nickel-chromium crowns. A static loading test was carried out and loads were applied to the buccal surface of the buccal cusp at a 45 degree inclination to the long axis of the tooth until failure occurred. The data were analyzed with MANOVA (${\alpha}$= .05). The failure pattern was observed and classified as either favorable (allowing repair) or unfavorable (not allowing repair). RESULTS. The mean fracture strength was highest in group DCT followed in descending order by groups DMO, DMT, and LCT. However, there were no significant differences in fracture strength between the groups. A higher prevalence of favorable fractures was detected in group DMT but there were no significant differences between the groups. CONCLUSION. The change of post or core foundation method does not appear to influence the fracture strength and failure patterns.

• Korean Journal of Human Ecology
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• v.13 no.2
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• pp.215-224
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• 2004

The purpose of this article was to describe the effectiveness of group filial therapy program for undergraduate students in the period of their pre-parenthood. The goal was to enhance empathy in adult-child interaction, to facilitate students' sensitivity to the child, and to reduce children's behavioral problems. The program was implemented once a week for 8 weeks. Each session was implemented for 120 minutes. The subjects were 13 undergraduate students(22-24 years old) and 13 children(4-10 years old). Pre and post-tests were implemented. After 8 week intervention program, there were significant differences between pre and post-tests. The undergraduate students improved in their empathy in adult-child interaction and enhanced sensitivity to child.

• Proceedings of the KIEE Conference
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• 2005.10c
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• pp.291-295
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• 2005

This paper presents the modeling of grounding system on Korean electric railway system. The system model is composed of the catenary system, the grounding-system, the sub-sectioning post, the fault point, the sectioning post, the autotransformer in the substation, and the electric vehicle. The increment of rail-ground voltage may be thought as an amplifier of danger on human body of equipment insulation. The rail-ground voltage on steady state and on fault condition should be under standard limit voltage. To analyze grounding system for steady state and fault condition on Korean railway, modeling for each railway system is performed by 10-port network model. Modeling and analysis of present grounding-system are important to protect human and electronic equipments. The examinations for systematic grounding-system are investigated.

• Biomolecules & Therapeutics
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• v.8 no.3
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• pp.213-216
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• 2000

In vivo administration of Leucostim, a human recombinant granulocyte colony-stimulating factor (G-CSF), was evaluated for the effects on survival, hematologic recovery, and colony forming unit- spleen (CFU-5) in murine bone marrow transplantation (BMT) model. Sublethally irradiated (9 Gy) mice received bone marrow cells from untreated mice, and then were treated with G-CSF subcutaneously at doses of 2.5,5, or $10\mu\textrm{g}$/kg or vehicle solution (control) for 14 days from one day after BMT. There was no effect of irradiation and BMT on mortality. The repeated subcutaneous injections of Leucostim for 14 days post- BMT significantly facilitated hematologic recovery compared with vehicle control in a dose-dependent manner. Moreover, mice treated with Leucostim had significantly increased numbers of CFU-s colonies on day 10 post-BMT. These results suggest that Leucostim, a new G-CSF, has beneficial effects on hematologic reconstitution after BMT.

• Archives of Craniofacial Surgery
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• v.23 no.5
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• pp.232-236
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• 2022

Post-traumatic enophthalmos and hypoglobus are common sequelae of facial bone fractures, even after reduction surgery. They are associated with functional and esthetic issues, which may lower the quality of life. These deformities frequently present late, and adequate correction is difficult. We report three cases of late inferior orbital rim reconstructions with three-dimensional printed implants to help resolve these problems. The average duration between the traumatic event and surgery was 3 years and 4 months. One patient was treated with a completely absorbable implant and exhibited satisfactory results until the implant started to biodegrade at 1 year and 9 months after surgery. Two patients were treated with a permanent implant and demonstrated satisfactory results. However, longer follow-up periods were needed. There were no complications such as infection, diplopia, or restriction of ocular motion and the patients were satisfied with the esthetic results.

• Restorative Dentistry and Endodontics
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• v.13 no.1
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• pp.151-158
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• 1988

The purpose of this study was to evaluate the effect of canal filling methods and post-space preparation time on the apical seal of endodontically treated teeth. Seventy-six single-rooted human teeth were divided into 6 groups and each tooth was obturated and prepared post-space according to the purpose of this study. After all specimens were immersed in Indian ink, decalcified and cleared, the degree of dye penetration into the root canals observed by magnifying glass (X20) and measured by caliper. The results were as follows: 1. In the thermatic condensation, no significant difference in ink penetration occured when the post-spaces were created immediately after obturation or when they were made a week later. 2. In the lateral condensation, no significant difference in ink penetration existed between teeth whose post-space were prepared immediately or delayed. 3. In comparison of experimental groups and control groups, no significant difference showed when the groups were obturated with McSpadden compactor but when the teeth were laterally condensed, the experimental groups showed less ink penetration than controls. 4. Thermatic condensed teeth with McSpadden compactor were less ink penetration thn laterally condensed teeth.

• Journal of the Korean Society of Costume
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• v.52 no.8
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• pp.55-71
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• 2002

The purpose of this study was to identify a basic meaning of humor from the costume expressing cartoon image, to grasp the status of contemporary costume, and also to supply people with a database related to the sphere of costume design. This was done by analyzing and examining humor of the costume expressing cartoon image in post-industrial society. Consequently, the result of this study was summarized as follows; First, humor by parody of Pop Art is recognized as humorous expression that repulsed the main current culture and post-industrial society phenomenon. Second, humor by quotation tends to appear through cartoon character. Costume which quote cartoon character is against Kidult tastes and the pre-existing authoritative prejudices in post-industrial society. Third, humor by bricolage, making bricolage with silhouette, color, pattern item, is recognized as new creation of humor In other words, it is regarded as enlargement of new esthetic consciousness and humor about instrumented gender in post-industrial society. Lastly, humor by deformation expressed itself in deformation of body image of character and cloth silhouette by cartoon image. Deformation of cloth silhouette by cartoon image, being not conscious pre-existing concept of harmony of human and costume, is recognized as humor which have characteristic of play with introduction of new silhouette. In addition to, the result of this study showed that humor expressed in cartoon image of costume has been limited to the works of few designers because of characteristics of fashion designers who made use of popularity as subjects of the works and internal meanings which were related to the characteristics of post-industrial society.