• Biomolecules & Therapeutics
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• v.29 no.6
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• pp.605-614
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• 2021

Autophagy is an important degradative pathway that eliminates misfolded proteins and damaged organelles from cells. Autophagy is crucial for neuronal homeostasis and function. A lack of or deficiency in autophagy leads to the accumulation of protein aggregates, which are associated with several neurodegenerative diseases. Compared with non-neuronal cells, neurons exhibit rapid autophagic flux because damaged organelles or protein aggregates cannot be diluted in post-mitotic cells; because of this, these cells exhibit characteristic features of autophagy, such as compartment-specific autophagy, which depends on polarized structures and rapid autophagy flux. In addition, neurons exhibit compartment-specific autophagy, which depends on polarized structures. Neuronal autophagy may have additional physiological roles other than amino acid recycling. In this review, we focus on the characteristics and regulatory factors of neuronal autophagy. We also describe intracellular selective autophagy in neurons and its association with neurodegenerative diseases.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.27 no.2
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• pp.9-15
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• 2019

The initial buckling of thin walled structures does not result in immediate failure. This post buckling capability is used to achieve light weight design, and final failure of thin walled structure is called crippling. To predict the failure load, empirical methods are often used for thin walled structures in design stage. But empirical method accuracy depend on geometry. In this study, experimental, empirical and numerical study of the crippling behavior of I-section beam made of carbon-epoxy are performed. The progressive failure analysis model to simulate the crippling failure is evaluated using the test results. In this study, commercial software LS-DYNA is utilized to compute the collapse load of composite specimen. Six kinds of specimens were tested in axial compression where correlation between analytical and experimental results has performed. From the results, we have partially conclude that the flange width-to-thickness ratio is found to influence the accuracy of empirical and numerical method.

• Smart Structures and Systems
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• v.30 no.6
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• pp.649-659
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• 2022

Structural Health Monitoring (SHM) researchers have identified Augmented Reality (AR) as a new technology that can assist inspections. Post-seismic structural inspections are conducted to evaluate the safety level of the damaged structures. Quantification of nearby structural changes over short-term and long-term periods can provide building inspectors with information to improve their safety. This paper proposes a Time Machine Measure (TMM) application based on an Augmented Reality (AR) Head-Mounted-Device (HMD) platform. The primary function of TMM is to restore the saved meshes of a past environment and overlay them onto the real environment so that inspectors can intuitively measure dynamic structural deformation and other environmental movements. The proposed TMM application was verified by demo experiments simulating a real inspection environment.

• Mycobiology
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• v.29 no.2
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• pp.90-95
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• 2001

During the study of microbial structures in root-regions of tomato and red pepper from fields, various soil-inhabiting fungi were isolated with the dilution plate technique. Among them an ascomycete, Emericellopsis mirabilis and three hyphomycetes, Gliocladium solani, Humicola veronae and Verticillium chlamydosporium are presented for the first time in Korea along with Talaromyces trachyspermus, Chaetomium globosum and Doratomyces microsporus.

• Proceedings of the Korea Concrete Institute Conference
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• 2001.11a
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• pp.363-368
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• 2001

Abutments in Kumdang bridge are massive concrete structures of which total height is l0m, length is 30m, and width is 7m. Therefore, there is every probability that early age thermal cracking such as hydration heat occur. We measure heat of hydration, strains of rebar, and stresses of concrete abutment during construction. Using analysis of measuring data, we examine thermal stresses, and make use of results as method which control thermal cracking. Finally, we develope thermal stress analysis program which have pre/post processor to be easy of accessing and the usefulness of that is estimated through comparison of results.

• Proceedings of the Korean Geotechical Society Conference
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• 2009.03a
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• pp.659-662
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• 2009

In this paper described are the performance design guidelines of writing the items of foundation structures for designers. To accept the new performance code instead of existing design code in the construction market, performance design focuses on requirements to guidelines of foundation structure.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1998.10a
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• pp.141-148
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• 1998

An analytical model which can simulate the post-cracking behavior of reinforced concrete structures subjected to in-plane shear and normal stresses is presented. Based on the force equilibriums, compatibility conditions, and bond stress-slip relationship between steel and concrete, a criterion to simulate consider the tension-stiffening effect is proposed. The material behavior of concrete is described by an orthotropic constitutive model, and focused on the tension-compression region with tension-stiffening and compression softening effects defining equivalent uniaxial relations in the axes of orthotropy. Correlation studies between analytical results and available experimental data are conducted with the objective to establish the validity of the proposed model.

• Magazine of the Korean Society of Agricultural Engineers
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• v.42
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• pp.9-16
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• 2000

GPS(Global Positioning System) surveying is an effective method using satellite measurement system and can be applied to construction of digital map of irrigation canal networks. In this study, GPS surveying method for irrigation structures was developed. A selected main canal of an irrigation district were surveyed by GPS. The obtained surveying results were corrected by post-processed DGPS (Differential Global Positioning System) and imported to GIS for the digital map construction.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.20-20
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• 2003

The success of genome project brought us a vast amount of sequence information about whole genes for some species. In order to get functional understanding of un-annotated genes, a number of frontiers in structural biology proposed a new paradigm for structural research on the basis of given information. Structural biologists believe that the whole characters of the living cells come from the protein functions, which could be regulated by three-dimensional protein structures.

• Journal of Korean Institute of Industrial Engineers
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• v.22 no.3
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• pp.365-375
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• 1996

We consider an extension of the multiple choice linear knapsack problem and develop a fast algorithm of order $O(r_{max}n^2)$ by exploiting some new properties, where $r_{max}$ is the largest multiple choice number and n is the total number of variables. The proposed algorithm has convenient structures for the post-optimization in changes of the right-hand-side and multiple choice numbers. A numerical example is presented.