• Journal of Ginseng Research
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• v.45 no.6
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• pp.734-743
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• 2021

Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer. This study explored the regulatory effect of ginsenoside Rh2 on m6A RNA methylation in cancer. Methods: m6A RNA quantification and gene-specific m6A RIP-qPCR assays were applied to assess total and gene-specific m6A RNA levels. Co-immunoprecipitation, fractionation western blotting, and immunofluorescence staining were performed to detect protein interactions and distribution. QRT-PCR, dual-luciferase, and ChIP-qPCR assays were conducted to check the transcriptional regulation. Results: Ginsenoside Rh2 reduces m6A RNA methylation and KIF26B expression in a dose-dependent manner in some cancers. KIF26B interacts with ZC3H13 and CBLL1 in the cytoplasm of cancer cells and enhances their nuclear distribution. KIF26B inhibition reduces m6A RNA methylation level in cancer cells. SRF bound to the KIF26B promoter and activated its transcription. SRF mRNA m6A abundance significantly decreased upon KIF26B silencing. SRF knockdown suppressed cancer cell proliferation and growth both in vitro and in vivo, the effect of which was partly rescued by KIF26B overexpression. Conclusion: ginsenoside Rh2 reduces m6A RNA methylation via downregulating KIF26B expression in some cancer cells. KIF26B elevates m6A RNA methylation via enhancing ZC3H13/CBLL1 nuclear localization. KIF26B-SRF forms a positive feedback loop facilitating tumor growth.

• International Journal of Human Ecology
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• v.1 no.1
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• pp.59-77
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• 2000

The purpose of this study was to extend our understanding of the developmental antecedents of delay of gratification in infancy. The first goal was to examine direct effects of one feature of an infants’ temperament and of positive and negative parenting assumed at age one on children’s delay of gratification six months later. The second goal of the study was to test the interactive effect of early infant temperament and parenting on children’s delay of gratification. It was hypothesized that 1) less negative infants at 12 months would delay gratification longer six months later, 2) children of parents who provided more positive and sensitive feedback would delay gratification longer than children with parents who were more negative and less sensitive, and 3) there would be differential prediction of parenting for children who scored high and low in negative emotionality as infants. Toward this end, 81 infants were observed interacting at one year of age with their mothers and fathers during laboratory assessments to obtain measures of parenting and infant negative emotionality. At 18 months of age, the child’s capacity to delay touching attractive objects was measured. The main effects of infant negative emotionality and of mothering on children’s delay of gratification were not detected at standard levels of significance. Differential effects of parenting on children’s delay of gratification for infants with low or high negative emotionality, too, were not detected. However, the anticipated effect of fathering on delay of gratification was found in some analyses, indicating that the more positive fathering children received, the longer they could delay gratification in the laboratory six months later.

• Management & Information Systems Review
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• v.21
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• pp.49-76
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• 2007

The main purpose of this study is to assess the relationship between communication satisfaction and group creativity. To achieve this purpose, this study has two objectives. First, I will identify the relationship between the satisfaction of communication and idea creation. Second, the relationship between communication satisfaction and problem solving activity will be statistically tested. The major findings of the study can be summarized as follows: First, Statistically significant positive relations were found between the communication satisfaction and idea creation. Especially, sub-construct for supervisor communication$({\beta}=0.14,\;p<.05)$, quality of media$({\beta}=0.13,\;p<.05)$, individual feedback$({\beta}=0.36,\;p<.001)$, organizational prospect$({\beta}0.31,\;p<.001)$ showed the statistically significant positive(+) relationship with construct in idea creation. Second, the measurement of communication satisfaction had showed statistically significant relationship with the problem solving activity. Especially, communication with supervisor$({\beta}=0.21,\;p<.05)$, quality of media$({\beta}=0.21,\;p<.001)$, organizational prospects$({\beta}=0.22,\;p<.001)$, and communication with subordinate$({\beta}=0.37,\;p<.001)$ showed the significant positive(+) relationship with problem solving activity construct. These consequences suggest that communication satisfaction of employee is effective in the improving the group creativity in organization. In the conclusion, this study present the satisfaction factor of employee communication as a incremental factor of group creativity.

• Journal of Korean language education
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• v.29 no.1
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• pp.85-108
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• 2018

This study pointed out the reality that many novice Korean language teachers who lack rater training are scoring the learners' writing skill. The study performed and analyzed a case where pre-service teachers were educated in order to explore the possibility of promoting rater training in a Korean language teacher training course. The pre-service teachers majoring in Korean language education at the graduate school scored TOPIK compositions and were provided feedback by the FACETS program, which were further discussed at the rater meeting. In three scoring processes, the raters scored with conscious of own rating patterns and showed positive change or over correction due to excessive consciousness. Consequentially, ongoing training can improve rating ability, and considering the fact that professional rater training is hard to progress, the method composed of FACETS analysis and rater training revealed positive effects. On the other hand, the rater training including native Korean and non-native(Chinese) speakers together showed no significant difference by mother tongue but by individual difference. This can be interpreted as a positive implication to the rating reliability of non-native speakers possessing advanced Korean language abilities. However, this must be supplemented through extended research.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.3
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• pp.139-154
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• 2021

This study's impetus is to explore fresh evidence to answer the question, i.e., whether remittances asymmetrically influence financial development in Bangladesh from 1975 to 2019. The study employs several tests, i.e., nonlinear unit root test, Autoregressive Distributed Lagged (ARDL), NARDL, and asymmetric causality test for establishing the pattern of association. Nonlinear unit root tests confirm that variables follow a nonlinear system of being stationary after the first difference. nonlinearity among variables is investigated by performing the BDS test and nonlinear OLS. Directional causality is investigated through both linear and nonlinear effects of remittance inflows by following the non-granger casualty test. The test statistics of Fpass and tBDM showed the Long-run cointegration in the empirical model and positive effect running from remittances inflow to financial development both in the long-run and short-run. Furthermore, the results of a standard Wald test divulge the presence of long-run and short-run asymmetry. Asymmetry causality test established unidirectional causality due to positive and negative shocks in remittances inflows to Bank-based financial development and feedback hypothesis hold for explaining causality between positive and negative shocks in remittance inflows and Stock-based financial development.

• Educational Technology International
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• v.20 no.2
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• pp.195-221
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• 2019

This study explored middle and high school students' learning experiences using e-textbooks in online learning courses. Data were collected from in-depth interviews. The interviewees for this study were 19 students who enrolled voluntarily in an online mathematics and science inquiry program, actively participated in the online learning. The students generally have high academic achievement and motivation for learning in science and mathematics. Data were analyzed based on a grounded theory approach. As a result, the characteristics of the online learning environment using e-textbooks were conceptualized via three different categories including temporal, spatial, and technical. Such characteristics of the learning environment were able to provoke self-directed learning, extended learning, interactive learning, in-depth learning, improved ICT literacy, and formation of positive emotions and learning habits. Most of the learners showed positive feedback towards the use of e-textbooks, while some mentioned the technical limitations compared to conventional paper-based learning. This study suggested that e-textbooks are likely to induce positive experiences for learners in the context of online learning, so it is necessary to design contents that utilize various functions and advantages of electronic teaching materials in order to use e-textbooks effectively.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2010.10a
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• pp.324-329
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• 2010

Vibrations caused by automobile engine are absorbed mostly by a passive-type engine mount. However, user specifications for automobile vibrations require more stringent conditions and higher standard. Hence, active-type engine mount have been developed to cope with such specifications. The active-type engine mount consists of sensor, actuator and controller where a control algorithm is implemented. The performance of the active engine mount depends on the control algorithm if the sensor and actuator satisfies the specification. The control algorithm should be able to suppress persistent vibrations caused by the engine which are related to engine revolution. In this study, three control algorithms are considered for suppressing persistent vibrations, which are the positive position feedback control algorithm, the strain-rate feedback control algorithm, and the modified higher harmonic control algorithm. Experimental results show that all the control algorithms considered in this study are effective in suppressing resonant vibrations but the modified higher harmonic controller is the most effective controller for non-resonant vibrations.

• English Language & Literature Teaching
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• v.9 no.2
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• pp.17-33
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• 2003

College going students who are non-native speakers of English enrolled in English language programmes are not acquiring the needed academic writing skills. Many of these students do not have positive attitudes towards writing, thus forcing language instructors to look for ways of motivating students to write in order to improve writing skills. This action research project investigates the use of portfolio writing to improve writing ability among pre-university students. Research on the use of portfolio writing suggests that it is a useful way for developing interest in writing and for developing effective writing skills over a period of time. Portfolios support the best thinking in composition pedagogy in that it encourages process writing. Although the portfolio is considered a writing product, as a whole it is evidence of the students writing process. An important feature in using portfolios is that students are able to focus on their writing without constantly worrying about grades. Instructors have noticed that students make greater improvement in their writing when their focus is shifted from punitive feedback through letter grades to constructive feedback in the form of suggestions for further revision. This paper describes the use of writing portfolios as an effective means of teaching writing. The findings revealed that writing portfolios helped develop confidence in writing and decreased anxiety towards writing. (217 words)

• Journal of Power Electronics
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• v.18 no.5
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• pp.1555-1566
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• 2018

Proportional capacitor-current-feedback active damping (AD) is a common damping method for the resonance of LCL-type grid-connected inverters. Proportional capacitor-current-feedback AD behaves as a virtual resistor in parallel with the capacitor. However, the existence of delay in the actual control system causes impedance in the virtual resistor. Impedance is manifested as negative resistance when the resonance frequency exceeds one-sixth of the sampling frequency ($f_s/6$). As a result, the damping effect disappears. To extend the system damping region, this study proposes a virtual resistor-inductor-capacitor (RLC) AD method. The method is implemented by feeding the filter capacitor current passing through a band-pass filter, which functions as a virtual RLC in parallel with the filter capacitor to achieve positive resistance in a wide resonance frequency range. A combination of Nyquist theory and system close-loop pole-zero diagrams is used for damping parameter design to obtain optimal damping parameters. An experiment is performed with a 10 kW grid-connected inverter. The effectiveness of the proposed AD method and the system's robustness against grid impedance variation are demonstrated.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.14 no.3
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• pp.253-263
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• 2004

The problem considered in this paper is about the collocation of sensor and actuator for the active control of sound and vibration. It is well-known that a point collocated sensor-actuator pair offers an unconditional stability with very high performance when it is used with a direct velocity feedback (DVFB) control, because the pair has strictly positive real (SPR) property. In order to utilize this SPR characteristics, a matched piezoelectric sensor and actuator pair is considered. but this pair suffers from the in-plane motion coupling problem with the out-of-plane motion due to the piezo sensor and actuator interaction. This coupling phnomenon limits the stability and performance of the matched pair with DVFBcontrol. As a new alternative, a point sensor and distributed piezoelectric actuator pair is also considered, which provides SPR property in all frequency range when the pair is implemented on a clamped-clapmed beam. The use of this sensor-actuator pair is highly expected for the applications to more practical active control of sound and vibration systems with the DVFB control strategy.