• The Korean Journal of Pharmacology
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• v.24 no.1
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• pp.63-70
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• 1988

Alterations in splanchnic circulatory hemodynamics along with reactivities to the alpha adrenoceptor agonists were assessed in association with the preventive effects of propranolol 10 days after portal ligation. Decreases in precapillary resistance (Ra) and postcapillary resistance (Rv) along with increases in mesenteric blood flow (MBF) and capillary pressure (CP) were observed in conjunction with an increment of splenic pulp pressure (SPP). Dose-dependent increase in Rv in response to noradrenaline, increases in Ra and RV to adrenaline, and increases in superior mesenteric arterial pressure (SMAP), Ra and Rv to phenylephrine observed in sham group were significantly attenuated by portal vein stenosis. In PPL-3 group (propranolol 3 mg/kg, i.p. three times daily for 10 days), MBF was significantly decreased in association with decrease in mesenteric venous pressure (MVP) when compared with those of protal ligated (PL) group, and decreased Ra and Rv in PL group were recovered toward the values of sham group. Likewise, in PPL-1 group (propranolol 5 mg/kg, i.p. once daily for 10 days), the pressor response of Rv to adrenaline was recovered up to the level of sham group. Thus, it is suggested that decreases in Ra and Rv in association with increases in MBF and CP may have a close relevance to the increased SPP, and the changes in circulatory hemodynamics and vascular reactivities were effectively reversed by longterm propranolol treatment. Based on these results, it is concluded that these changes observed in portal hypertension are closely related with the altered functions of the adrenoceptors in the splanchnic vascular beds.

• The Journal of Internal Korean Medicine
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• v.29 no.2
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• pp.500-511
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• 2008

The aim of this study was to investigate the inhibitory effect of Saengangeonbitang-gasamchilgn(SGGBTGSCG) on collagen production in rat hepatic stellate cells(HSC) and on the TAA-induced chronic liver injury model in rats. Methods : 1) HSCs were treated with SGGBTGSCG extract powder(50% EtOH SGGBTGSCG, dw SGGBTGSCG). After the treatment, MTT assay, BrdU assay and procollagen assay were done. In addition, gene expressions of collagen type $1{\alpha}2$, ASMA, TIMP1, and TIMP2, all of which are known to be associated with liver fibrosis, were analyzed by RT-PCR. 2) Liver fibrosis was developed in rats by injection of TAA 3 times a week for 5 weeks. After the SGGBTGSCG-treatment, body weight, liver & spleen weight, liver function test, the complete blood cell count and the change of portal pressure were studied. Results : In MTT assay, SGGBTGSCG significantly decreased the viability of HSCs in a dose-dependent manner. In BrdU assay, SGGBTGSCG significantly inhibited the HSC proliferation in a dose-dependant manner. In procollagen assay, SGGBTGSCG decreased procollagen production by HSC. In the change of rats' liver and spleen weight, TAA+SGGBTGSCG groups showed little difference compared with TAA-only group. In the liver function test, SGGBTGSCG decreased the serum level of ALT, AST, and Alp elevated by TAA. In the complete blood cell count, SGGBTGSCG significantly decreased WBC elevated by TAA and increased RBC and Hct lowered by TAA. In the change of portal pressure, SGGBTGSCG decreased portal pressure elevated by TAA. Conclusions : These results suggest that SGGBTGSCG is beneficial in the treatment of cirrhotic patients as well as for patients with chronic hepatitis.

• Journal of Chest Surgery
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• v.5 no.2
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• pp.107-112
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• 1972

Recently we experienced a case of the portal hypertension, extrahepatlc origin in the National Medical Center, Seoul. The case was a male aged 19 who was undergone the elective splenorenal shunt with splenectomy 9 years ago and emergency ligation of the coronary vein because of recurred variceal rupture 6 years later and had recurring esophageal varices with bleeding this time.At the age of 10 he had been occasionally suffering from nasal bleeding and visited to our Pediatric department, when there was encountered for the first time the splenomegaly, esophageal varices in the lower third esophagus on the esophagogram, and stenosis and kinking of the portal vein with rich collateral circulation on the splenoportography without hepatic functional impairment.The elective splenorenal shunt with splenectomy was undergone under the diagnosis of portal hypertension due to congenital anomaly of the portal vein and postoperatlvely no troubles had been obtained until postoperative 1st attack of massive hematemesis due to esophagenl variceal rupture recurred about 6 years later which was confirmed by control esophagogram and it was resulted by stenosis of previous anastomotic site of the splenorenal shunt.Then emergency ligation of the coronary vein was only made for bleeding control and no episodes of hematemesis had been encountered thereafter until April 1972 about 3 years after the 2nd operation, when hematemesis recurred again. In this time, recurring esophageal varices were noted in the lower third esophagus on the control esophagogram and he was employed side to end mesocaval shunt as the final step of portal decompression,and following results were obtained. 1] No postoperatlve troubles as leg edema or pain: Postoperatively leg elevation and elastic bandage on the both legs were employed until discharge. 2] During operation the portal pressure was 300 mm $H_2O$ and immediately lowered to 170 mm $H_2O$ after shunt.

• Explosives and Blasting
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• v.26 no.2
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• pp.38-44
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• 2008

Recently, planning road construction in South Korea is focused on upgrading of the existing road by rerouting or restructuring. For this, roads under current construction in Korea go for more straight in its alignments and routing. Straight routing makes it all the more required to construct many mountain tunnels and bridges in Korea where mountains are so widely spread. Some portal of mountain tunnel is not rarely planed at high steep slope of mountain valley where it is not easy to secure working space for tunnel excavation. Reverse excavation is an alternative measure for excavation of tunnel portal at high steep slope. Construction in reverse excavation method has three important points requiring careful consideration: 1)planning of pilot tunnel in proper width, height, and length etc., 2)measure against the effect of one-side earth pressure to the direction of tunnel portal, 3)securing tunnel safety against shallow ground condition at portal zone. This paper intends to suggest applicable range of pilot tunnel for reverse excavation at the portal zone located at high steep slope, and shows result of study on the appropriateness of a reverse excavation by means of 3D numerical analysis. Result of 3D numerical analysis for reverse excavation at high steep slope shows that pilot tunneling will be applicable to start from the point $20{\sim}25m$ before the portal from inside the tunnel.

• Journal of Sasang Constitutional Medicine
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• v.27 no.4
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• pp.388-395
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• 2015

Objectives To grasp the trend of constitution medical industry related to the metabolic disorders by analyzing the web resource.Methods Web search with the search formula ("constitutional" or "spirit") and ("Metabolic" or "diabetes" or "high blood pressure" or "hyperlipidemia" or "obesity") for 20 years (1995.09.10 ~ 2015.09.09.) in the web portal address "Web search with the search formula ("constitutional" or "spirit") and ("Metabolic" or "diabetes" or "high blood pressure" or "hyperlipidemia" or "obesity") for 20 years (1995.09.10 ~ 2015.09.09.) in the web portal address "http://web.search.naver.com".Results In the search area of news, blogs, cafes and knowledge-in, the number of searched pages retrieved by the word "constitution" was about 1.78 million. In the news 9760 cases of "obesity", 4046 cases of "hypertension" and 3253 cases of "diabetes" were searched. In Naver Web search Korean medicine clinics related to "constitution" were 24.3%. If we multiple 25.3% to 1000, the actual number of herbal hospitals, The constitution related to Korean medicine clinics is estimated to be approximately 3160 places. Among metabolic disorders, "Overweight", "Diabetes" and "Hypertension" were most frequently searched.Conclusions Constitutional industry related to metabolic diseases is very actively created on the internet in various areas. Among metabolic diseases, obesity, diabetes, hypertension were found with high frequency.

• Journal of Korean Tunnelling and Underground Space Association
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• v.16 no.2
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• pp.249-260
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• 2014

When a train enters the tunnel at high speed, the pressure wave occurs. When this pressure wave reaches at the exit of tunnel, some are either emitted to the outside or reflected in tunnel by the form of expansion wave. The wave emitted to the outside forms the impulsive pressure wave. This wave is called 'Micro Pressure Wave'. The micro pressure wave generates noise and vibration around a exit portal of tunnel. When it becomes worse, it causes anxiety for residents and damage to windows. Thus, it requires a counterplan and prediction about the micro pressure wave for high speed railway construction. In this paper, the effects of train head nose and tunnel portal shape were investigated by model test, measurement for the micro pressure wave at the operating tunnel as well as numerical analysis for the gradient of pressure wave in the tunnel. As results, a method for predicting the intensity of the micro pressure wave is suggested and then the intensity of the micro pressure wave is analyzed by the tunnel length and the cross-sectional area.

• Proceedings of the KSME Conference
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• 2000.04b
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• pp.611-618
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• 2000

The test facility of the 1/60-scale models for the train-tunnel interactions was recently developed to investigate the effects of entry portal shapes, hood shapes and air-shafts for reducing the micro-pressure waves radiating to the surroundings of the tunnel exits by KRRI in Korea. The launching system of train model was chosen as air-gun type. In present test rig, after train model is launched, the blast wave by the driver did not enter to inside of the tunnel model. The train model is guided on the one-wire system from air-gun driver to the brake parts of test facility end. Some cases of the experiments were compared with numerical simulations to prove the test facility.

• Journal of the Korean Society of Safety
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• v.23 no.1
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• pp.28-34
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• 2008

The corrugated steel plate structures is applied to the construction of mountain tunnel portal part with shallow depth, the tunnel on the outskirts of urban areas and ecology move passage. In this study, A finite element method is used for research the behavior of corrugated steel plate structures due to construction position under declinating earth pressure and excavation depth. A finite element method were performed varying construction position(10, 15, 20 and 25m) from slope and excavation depth from surface. The hoop thrust and moment, displacement of corrugated steel plate subjected to construction position and excavation depth is determined from a finite element method. From results of finite element method, it was found that the increase of thrust and the decrease of displacement as the amount of distance increase from slope with construction position. But the thrust and moment, displacement has not different value with excavation depth.

• Proceedings of the KSR Conference
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• 1998.05a
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• pp.604-611
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• 1998

High-speed railway trains entering and leaving tunnels generate finite amplitude pressure wave which propagate back and forth along the tunnels, reflecting at the open ends of the tunnels and at other discontinuities such as ventilation shafts and the train themselves. In present day railways, the magnitudes of the pressure waves are much too small to cause structual damage, but they are a serious potential source of aural discomport for passengers on unsealed trains. Almost always do the pressure waves propagating along the tunnels lead to a hazardous impulse noise near the exit portal of the tunnel. In order to alleviate such undesirable phenomena, some control strategies have been applied to the compression wave propagating inside the tunnel. The objective of the current work is to investigate the effect of tunnel entrance hoods on the entry compression wave at the vicinity of the tunnel entrance. Three types of entrance hoods were tested by the numerical method using the characteristics of method for a wide range of train speeds. The results show that the maximum pressure gradient of compression wave can be considerably reduced by the tunnel entrance hood. Desirable hood shape for reduction of the pressure transients and impulse noise was found to be of abrupt type hood with its cross-sectional area 2.5times the tunnel area.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.4
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• pp.863-870
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• 2008

The aim of this study was to investigate that Injinoryung-san-Ga-Samchilgun(IJORS) has an inhibitory effect on the development of liver fibrosis in rats. The influence of IJORS on liver stellate cell viability in rat was measured by the MTT assay, and proliferation was measured by the BrdU assay. The mRNA expression of procollagen type $1{\alpha}2$, ${\alpha}-SMA$, TIMP1, and TIMP2 all of which are associated with liver fibrosis, were analyzed by RT-PCR. The inhibitory effect of IJORS on procollagen production in hepatic stellate cell was examined using by enzyme immuno assay(procollagen Type 1 C-Peptide EIA). And after IJORS was orally administered to experimental rats with thioacetamide(TAA)-induced liver fibrosis for 4 weeks, the body weight, liver function test, complete blood and the change of portal pressure were measured. IJORS prevented hepatic stellate cell viability and proliferation in a dose-dependent manner. IJORS reduced the mRNA expression of procollagen type $1{\alpha}2$, ${\alpha}-SMA$ and TIMP1 and the production of procollagen protein. IJORS inhibited the increase of AST, ALT, WBC and portal pressure in rats administered by TAA. IJORS is considered to prevent liver fibrosis by inhibiting the activation of stellate cell and production of procollagen and prevent the progress of liver fibrosis by inhibiting the inflammation of liver tissue complicated in many liver disease.