• Korean Journal of Acupuncture
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• v.20 no.3
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• pp.147-162
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• 2003

Objectives : This study was designed to investigate possibilities of herbal acupuncture for obesity. Methods : We researched into 23 kinds of literature and considered acupoints and herbs of herbal acupuncture for obesity. Results : Prescriptions for obesity include Erchentang(二陳湯), Liujunzitang(六君子湯) for phlegm-retention syndrome(痰飮), Wulingsan(五?散), Qianghuoshengshitang(羌活勝濕湯), Shenshitang(渗濕湯), Lingguishugantang(?桂朮甘湯) for Dampness syndrome(濕證) and Pingweisan(平胃散) for activating spleen and stomach(運化脾胃). And Rhizoma atractylodis(蒼朮), Tuber pinelliae(半夏), Rhizoma atractylodis macrocephalae(白朮), Fructus ponciri(枳殼), Fructus immaturus ponciri(枳實), Poria(茯?), Semen coicis(薏苡仁), Rhizoma alismatis(澤瀉) Fructus amomi(砂仁), Polyporus umbellatus(猪?), Medulla tetrapanacis(通草) can be used for both herbal medication and herbal acupuncture. And also there are some important acupoints for treating obesity, which are Sanyinjiao(三陰交), Pishu(脾兪), Gongsun(公孫), Fenglong(豊隆), Yinlingquan(陰陵泉), Zusanli(足三里), Qihai(氣海), Sanjiaoshu(三焦兪), Zhongwan(中脘), Neiguan(內關), Weishu(胃兪), Shenshu(腎兪) and Shangjuxu(上巨虛). Conclusions : We recommend that herbal acupuncture can be used for obesity. This method is a kind of injection using herbal extract, which can apply pharmacognosy theory and meridian system at the same time.

• Journal of Haehwa Medicine
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• v.17 no.1
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• pp.59-65
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• 2008

Objective: The purpose of this study is to find out Herbal medicine effective to the hypertensive patients. Methods: The present study was done over 42 chinese papers about hypertension from 2000 to 2006. We calculated frequency of the herbs used to treatment for hypertension. Result & Conclusion: 1. In 42 herbal medicines, Gamibanhabaekchulcheonmatang and Gamitaeksatang showed high frequency. 2. In 125 herbs, RADIX SALVIAE MILTIORRHIZAE(丹蔘) showed highest frequency. And RAMULUS ETUNCUS UNCARIAE(釣鉤藤), RADIX ACHYRANTHIS BIDENTATAE(牛膝), RADIX PAEONIAE ALBA(白芍藥), RHIZOMA ALISMATIS(澤瀉), RHIZOMA CNIDII(川芎), PORIA(白茯苓), RHIZOMA GASTRODIAE(天麻), SPICA PRUNELLAE(夏枯草), CONCHA HALIOTIDIS(石決明) showed high frequency.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.4
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• pp.1027-1031
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• 2006

In oriental medicine, Geijibokryunghwan(GBH) was used to improvement various symptoms created by the thrombosis. We investigated the effects of an oriental medicinal prescriptions, Geijibokryunghwan (GBH) consisting of herbs of Cinnamomi Ramufus (Geiji; 桂枝), Poria cocos (Bokrung; 茯?), Moutan Cortex Radicis(Modanpi; 牧丹皮), Paeoniae Radix (Jakyak; 芍藥) and Persicae Semen (Doin; 桃仁) on tumor growth-inhibitory activity and cancer chempreventive activity in assays representing three maior stages of carcinogenesis. Cancer chempreventive agents include nonsteroidal anti-inflammatory drugs (NSAIDS) such as indomethacin, aspirin, piroxicam, and sulindac, all of which inhibit cyclooxygenase (COX). Effects of the GBH extracts on carrageenan-induced edema Inflammation using female (C57BL/6XC3H) Fl (B6C3Fl ) mice and tumorigenesis were examined. Finally, cyclooxygenase metabolites were determined after extracts treatment. These data suggest that GBH extracts merits investigation as a potential cancer chempreventive agent in humans.

• Korean Journal of Pharmacognosy
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• v.31 no.4
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• pp.383-389
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• 2000

GRF (Korean Red Ginseng mixed formula) consists of six herbs such as Ginseng Radix rubra Koreana, Lycii Fructus, Artemisiae Capillaris Herba, Poria, and Glycyrrhizae Radix and Hoveniae Fructus. For the evaluation of hepatoprotective effect of GRF, the study was performed on protective effect against hepatic damage induced by galactosamine in vitro and ccl4 in vivo and also elucidate antioxidant activity. In vitro assay with 1.1 mM galactosamine, protection (%) was 44% (GR), and 58% (GRF-A) at 50 ug/ml. GRF effectively protected fatty degenertion and necrosis in murine hepatic damage induced by ccl4. For the -antioxidant study, GRF inhibited hemolysis of erythrocyte and decolored DPPH (2,2-diphenyl-l-picrylhydrazyl) free radical in a dose dependent manner more effetively than GR alone in vitro. GRF and GR significantly suppressed the time course $(1\;hr{\sim}6\;hr)-level$ of MDA (malondialdehyde) following AAPH (2,2'-azo-bis-(2-amidino -propane) dihydrochloride) treatment in vivo as compared with control data. From the results it can be concluded GR and GRF exerted the hepatoprotective effect by dint of antioxidant activity.

• Journal of Korean Medical classics
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• v.20 no.1
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• pp.151-164
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• 2007

In "Sanghanlon(傷寒論)", there are several articles to explain about Oryeongsan's syndrome. Most important articles of them are No. 72 and No. 75. Oryeongsan is explained by many doctors as a prescription to control exterior and interior, because they considered that symptoms of 72 and 75 articles were caused by exterior and interior's syndrome. Accordingly, they explained that RAMULUS CINNAMOMI(桂枝) and warm water remove exterior pathogens, and PORIA(茯笭) and others remove interior fluid retention. But considering the origin of a fluid retention, RAMULUS CINNAMOMI's effects are rather activating Yang(通陽) and warming Yang(溫陽) than removing exterior pathogens. The fluid retention is cauesd by insufficiency of Yang energy, because body fluid's spreading depends on Ynag energy. RAMULUS CINNAMOMI's effects of activating Yang and warming Yang improve the fluid retention and spread body fluid to the whole body. Some doctors use CORTEX CINNAMOMI(肉桂) instead of RAMULUS CINNAMOMI, because CORTEX CINNAMOMI's effects of activating Yang and warming Yang are better than RAMULUS CINNAMOMI's. There are many opinions about what is the main symptom of Oryeongsan's syndrome, but the difficulty in urination is understood by most doctors as the main symptom of Oryeongsan's syndrome. From the viewpoint of that, they understand that Oryeongsan's main effect is the induce diuresis. But the induce diuresis does not only mean a urination. The induce diuresis must be understood as the removing fluid retention by sweat and urine through the spreading body fluid.

• The Journal of Pediatrics of Korean Medicine
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• v.33 no.3
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• pp.56-68
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• 2019

Objectives The purpose of this study to analyze the effect of Korean medicine therapy of Attention deficit hyperactivity disorders. Methods Electronic research articles were selected by using NDSL, OASIS, KISS, KMBASE, K-portal, Pubmed, Cochrane, and Ebscohost. Results We analyzed fifteen studies about Korean medicine treatment of Attention deficit hyperactivity disorders. There are eleven studies on the acupuncture treatment, and the most commonly used acupoints were GV20 and EX-HN1. There are eight studies on the herb medicine treatment. The most commonly used herbal materials are Root of Rehmanniae Radix et Rhizoma Preparata, Root of Rehmanniae Radix et Rhizoma Preparata, Sclerotium of Poria cocos Wolf, and Rhizome of Acori Gramineri Rhizoma. Syncope and hematomas were common side effects of the acupuncture treatment. Also, the acupuncture needle can be stuck or bent during the treatment. In most studies, Attention deficit hyperactivity disorders was improved when treated with Korean medicine. Conclusions More studies are needed to demonstrate the effectiveness of Korean medicine in Attention deficit hyperactivity disorders. This study can be used for various studies of Attention deficit hyperactivity disorders.

• The Journal of Pediatrics of Korean Medicine
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• v.36 no.2
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• pp.40-51
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• 2022

Objective This study identified useful herbal medicines and prescriptions for obesity treatment by analyzing herbal medicines and prescriptions that showed meaningful results in weight loss by changing the gut microbiota. Methods Using PubMed, we selected and studied 23 papers showing meaningful results on weight loss through changes in the gut microbiota using herbal medicines. Result Of the 23 selected papers, 17 were of studies using herbal medicines, and 6 of studies using prescriptions. Pomegranate peel, Flos Lonicera, Rehmannia glutinosa, Rhein, Coix seed, Platycodon grandiflorus, mulberry leaves, Poria cocos, asperuloside, Bupleuri radix, Astragalus polysaccharides, Ephedra sinica, Ganoderma lucidum, Hirsutella sinensis, Caulis spatholobi, aconite, and Bletilla striata were used as herbal medicine. Linggui zhugan-tang, Bofutsushosan, Shenling baizhu powder, Chowiseungcheng-tang, Daesiho-tang, and Yijin-tang were used as prescription. Conclusion Seventeen herbal medicines and six prescriptions associated with meaningful results in weight loss through changes in the gut microbiota, suggest the possibility of treatment and prevention of obesity through herbal medicine.

• The Journal of Pediatrics of Korean Medicine
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• v.36 no.3
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• pp.35-48
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• 2022

Objectives The purpose of this study is to review relevant clinical studies to investigate the effectiveness of herbal medicines for IgA (Immunoglobulin A) nephropathy in children. Methods Studies on herbal treatment for IgA nephropathy were searched and analyzed through electronic databases such as PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang, CiNii, J-STAGE, Oriental Medicine Advanced Searching Integrated System and Science ON. Studies included Randomized controlled trials and case series. Results We selected nine studies and analyzed the findings. In most studies, improvement of IgA nephropathy was observed after treatment, and was evaluated using factors as 24 hour urine protein, hematuria, Scr (serum creatinine) and BUN (blood urea nitrogen). The most commonly used herbs for IgA nephropathy were Poria cocos (茯苓), Astragalus membranaceus (黃芪), and Rehmannia glutinosa (生地黃). Conclusions Based on the results of the clinical studies, we identified that herbal medicine is an effective treatment for IgA nephropathy. However, additional systematic clinical studies are necessary to prove its effect and safety.

• Herbal Formula Science
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• v.20 no.1
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• pp.13-24
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• 2012

Objectives : Yukmijihwang-tang(Wan), a well-known formula for invigorating yin-particular kidney yin, was first recorded in "Xiao er Yao Zheng Zhi Jue", consisting of Radix Rehmanniae Preparata, Fructus Macrocarpii, Rhizoma Dioscoreae Oppositae, Poria, Rhizoma Alismatis and Cortex Moutan Radicis with dose proportion of 8:4:4:3:3:3. Although clinical trials have been lacking, various pharmacological actions for Yukmijihwang-tang has been identified newly using animal models. In addition, it was reported that Yukmijihwang-tang increases structural chromosome aberrations significantly in Chinese hamster lung cells. In this article, it is purposed that new studies for pharmacology and toxicology of Yukmijihwang-tang are reviewed. Insight into new studies of Yukmijihwang-tang at the cellular and animal levels will enhance our understanding of Yukmijihwang-tang against various diseases will provide new tools to diagnose and treat patients. Methods : Recent researches for Yukmijihwang-tang were reviewed and summarized in terms of pharmacological action and toxicity. All sources for review were based on recent studies loaded on data base of web sites such as Science Direct and National Center for Biotechnology Information. Results and Conclusions : Recently, reports showed that YMJ had antiaging effects, antioxidant and free radical scavenging activities, anti-renal hypertension and prevented tumors, and diabetes mellitus. However, there is little information on its safety except general toxicity, acute and sub-chronic oral toxicity, or genotoxicity. In addition, clinical trial for Yukmijihwang-tang was limited even though Yukmijihwang-tang has been used extensively in Korean traditional medicine. Thus, further studies are necessary to focus on safety evaluation and clinical trial for Yukmijihwang-tang.

• The Journal of Pediatrics of Korean Medicine
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• v.32 no.3
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• pp.26-43
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• 2018

Objectives The purpose of this study was to analyze recent traditional Chinese medicine clinical studies for treatment of childhood obesity. Methods We analyzed 11 clinical studies from January, 2000 to March, 2018 about childhood obesity from the China Academic Journal (CAJ) and China National Knowledge Infrastructure (CNKI). All selected studies were Randomized Controlled Trials and analyzed in order of publication year, demographic information, treatment method, evaluation methods, results, adverse reactions and relapse after treatment discontinuation. Results The main Traditional Chinese Medicine (TCM) treatment was the herbal decoctions, granules and pills. In most studies, the total efficacy of the treatment group was reported to be higher than that of the control group. Adverse reactions were found in small number of studies. Frequently used medical herbs were Crataegi Fructus (山?), Atractylodis Rhizoma (蒼朮), Citri Pericarpium (陳皮), Poria (茯?), and Nelumbinis Folium (荷葉). Also, Water-draining and swelling-dispersing medicinal (利水退腫藥), Qi-regulating medicinal (理氣藥), Resolving dampness with aroma medicinal (芳香化濕藥), Blood-activating and stasis-dispelling medicinal (活血祛瘀藥), Qi-tonifying medicinal (補氣藥), and Digestant medicinal (消食藥) were commonly used. Conclusions This study showed that traditional Chinese medicine, especially herbal medicine treatment can be effective and safe option for treating childhood obesity. These research results can be utilized in other clinical studies as well as in treatment of childhood obesity. Additional well-designed randomized controlled trials and systematic reviews are need to confirm the conclusion.