• 정신신체의학
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• 제6권2호
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• pp.221-227
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• 1998

Although there has been a considerable research in psychoneuroendocrinology, particularly in relation to the biology of mood disorders, there has been a paucity of research regarding the effects of psychological factors on endocrine diseases. Of the existing literature, the most research is focused on diabetes mellitus, graves' disease. Especially diabetes appears to be the only endocrine disease that has been the focus of recent research studies. Most of the studies had retrospective designs or several methodological flaw. There has been no consistent results demonstrating that psychological factors affect the onset of diabetes mellitus. Several studies have suggested that psychological factors affect the course of diabetes. A small number of studies showed some evidence that psychological stress was associated with changes in glucose regulation in a subset of diabetic patients. There was also evidence to suggest that some temperament and coping skill influence glycemic control in child, adolescent diabetics. Studies of behavioral or psychosocial intervention on diabetic control have been small and have produced mixed results. There was a few controlled study suggested that stressful life events might be a causal role in Cushing's disease and Graves'disease, but there is no presently sufficient evidence to suggest that psychological factors affect the onset and the course of Cushing's disease and Graves' disease. In future, there is need for a well-designed biopsychosocial research with prospective designs, well defined patient population and control groups to study the relationship between psychological factors and endocrine diseases.

• 대한물리치료과학회지
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• 제16권2호
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• pp.19-26
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• 2009

Background: The purpose of this study was to investigate effects of six-week biofeedback training for prevention of falling in elderly persons. Biofeedback training for using the TETRAX system. Methods: Thirty healthy elderly persons(men=17, women=13) who were 79 years of mean age participated in sensory regulation training. They were trained for thirty minutes a day, three times per week. We measured subjects sensory regulated function by TETRAX system, and analyzed mean difference of observed variables by paired t-test between the pre and post test. Results: The first experimental group were significantly difference between pre and post test. The second control group were not significantly between the pre and post test. The third there are significant between group. Conclusion: The results of this study reveal that biofeedback training exercise will improve sensory balance function, and further studies needs to identify which specific factors are related to fall in the elderly population, and it is expected this study may contribute in reducing fall and therapeutic exercise in falling.

• 한국지역지리학회지
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• 제17권3호
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• pp.259-269
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• 2011

전근대사회의 풍수는 마을주민들에게 있어서 오늘날의 문화생태적 환경과 같은 의미로 쓰였다. 마을사람들은 마을의 국지환경에 대해 풍수형국이라는 상징체계로 관계를 맺고 대응하였다. 마을 풍수를 통한 문화생태적 기능은 마을의 공간적 입지 규정, 인구 유입, 마을공동체의 생산 건축 활동 및 토지이용규제, 마을의 환경수용능력 규준, 환경관리, 주민공동체의 집단적 환경 의식 및 태도 형성 등으로 나타났다. 마을 풍수는 자연환경에 대한 주민들의 문화적 적응전략으로서, 마을의 지속가능한 환경시스템을 유지하기 위한 동아시아의 전통적인 문화생태적 방식이자 지식체계라고 평가할 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8599-8604
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• 2016

Ovarian cancer is the main cause of mortality in gynecological malignancy and extensive studies have been conducted to study the underlying molecular mechanisms. The BRCA2 gene is known to be an important tumor suppressor in ovarian cancer, thereby BRCA2 alterations may lead to cancer progression. However, the BRCA2 gene is rarely mutated, and loss of function is suspected to be mediated by epigenetic regulation. In this study we investigated the methylation status and gene expression of BRCA2 in ovarian cancer patients. Ovarian cancer pateints (n=69) were recruited and monitored for 54 months in this prospective cohort study. Clinical specimens were used to study the in situ expression of aberrant BRCA2 proteins and the methylation status of BRCA2. These parameters were then compared with clinical parameters and overall survival rate. We found that BRCA2 methylation was found in the majority of cases (98.7%). However, the methylation status was not associated with protein level expression of BRCA2 (49.3%). Therefore in addition to DNA methylation, other epigenetic mechanisms may regulate BRCA2 expresison. Our findings may become evidence of BRCA2 inactivation mechanism through DNA methylation in the Indonesian population. More importantly, from multivariate analysis, BRCA2 expression was correlated with better overall survival (HR 0.32; p=0.05). High percentage of BRCA2 methylation and correlation of BRCA2 expression with overall survival in epithelial ovarian cancer cases may lead to development of treatment modalities specifically to target methylation of BRCA genes.

• 한국디지털건축인테리어학회논문집
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• 제9권3호
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• pp.25-35
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• 2009

This study is planning improvement of welfare facilities about the hall for the aged in apartment housing. An apartment house, famous residential type in Korea, put an important value on its convenience and economical efficiency of furniture arrangement by maximizing floor space index. In this regard, leisure usage of house was not carefully considered for the aged people. To redefine the efficiency of welfare facilities, research mainly deals with analysis of realistic needs for the aged through the spot survey and interview. The main purpose of this study is to enhance the quality of welfare facilities and propose the improved welfare facilities for the aged people. Through the research, conclusions are as followed First, Facility standard and provisions of the law should be revised for considering population growth of the aged people. Second, there are 4 plan types in the hall for the aged. Contrary to our expectation, diversity of program was not found however various program planning is needed for considering its different types of plan. Third, according to regulation, space restriction is based on the number of households. Therefore, room and space standard does not depend on the number of people. From now on, in order to improve quality of welfare facilities of the aged, revision of laws and overall facility standard should be implemented in advance.

• Molecules and Cells
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• 제41권1호
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• pp.35-44
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• 2018

Mitochondria are responsible for supplying of most of the cell's energy via oxidative phosphorylation. However, mitochondria also can be deleterious for a cell because they are the primary source of reactive oxygen species, which are generated as a byproduct of respiration. Accumulation of mitochondrial and cellular oxidative damage leads to diverse pathologies. Thus, it is important to maintain a population of healthy and functional mitochondria for normal cellular metabolism. Eukaryotes have developed defense mechanisms to cope with aberrant mitochondria. Mitochondria autophagy (known as mitophagy) is thought to be one such process that selectively sequesters dysfunctional or excess mitochondria within double-membrane autophagosomes and carries them into lysosomes/vacuoles for degradation. The power of genetics and conservation of fundamental cellular processes among eukaryotes make yeast an excellent model for understanding the general mechanisms, regulation, and function of mitophagy. In budding yeast, a mitochondrial surface protein, Atg32, serves as a mitochondrial receptor for selective autophagy that interacts with Atg11, an adaptor protein for selective types of autophagy, and Atg8, a ubiquitin-like protein localized to the isolation membrane. Atg32 is regulated transcriptionally and post-translationally to control mitophagy. Moreover, because Atg32 is a mitophagy-specific protein, analysis of its deficient mutant enables investigation of the physiological roles of mitophagy. Here, we review recent progress in the understanding of the molecular mechanisms and functional importance of mitophagy in yeast at multiple levels.

• Asian-Australasian Journal of Animal Sciences
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• 제15권12호
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• pp.1822-1830
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• 2002

The microsatellites are the short tandem repeats of 1 to 6 bp long monomer sequences that are repeated several times. These short tandem repeats are considered to be generated by the slipped strand mispairing. Based on the unique capability of alternating purine-pyrimidine residues to form Z-DNA, the possible role of the microsatellites in gene regulation has been proposed. The microsatellites are highly polymorphic, follow Mendelian inheritance and are evenly distributed throughout the genomes of eukaryotes. They are easy to isolate and the polymerase chain reaction based typing of the alleles can be readily automated. These properties make them the preferred markers for comparison of the genetic structure of the closely related breeds/populations; very high-resolution genetic mapping and parentage testing etc. The microsatellites have rapidly replaced the restriction fragment length polymorphism (RFLP) and the random amplified polymorphic DNA (RAPD) in most applications in the population genetics studies in most species, including the various farm animals viz. cattle, buffalo, goat, sheep and pigs etc. More and more reports are now available describing the use of microsatellites in pigs ranging from measurement of genetic variation between breeds/populations, developing high resolution genetic maps to identifying and mapping genes of biological and economic importance.

• 생물정신의학
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• 제18권4호
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• pp.181-188
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• 2011

Major depression is a devastating disorder of which lifetime prevalence rate is as high as up to 25% in general population. Although the etiology of the disorder is still poorly understood, it is generally accepted that both genetic and environmental factors are involved in the precipitation of depression. Stressful lifetime events are potent precipitating environmental factors for major depression and early-life stress is in particular an important element that predisposes individuals to major depression later in life. How environmental factors such as stress can make our neural networks susceptible to depression and how those factors leave long-lasting influences have been among the major questions in the field of depression research. Epigenetic regulations can provide a bridging mechanism between environmental factors and genetic factors so that these two factors can additively determine individual predispositions to major depression. Here we introduce epigenetic regulations as candidate mechanisms that mediate the integration of environmental adversaries with genetic predispositions, which may lead to the development of major depression, and summarize basic molecular events that underlie epigenetic regulations as well as experimental evidences that support the active role of epigenetic regulation in major depression.

• 한국식품과학회지
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• 제43권6호
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• pp.659-674
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• 2011

Saccharin was reported to cause urinary bladder cancer in male rats when fed at high doses in a two-generation study, which led to a ban on the use of saccharin in Canada. However, no carcinogenic effect has been observed in other animal experiments conducted with mice, hamsters, or monkeys. Furthermore, numerous epidemiological studies have indicated that there was no relationship between saccharin consumption and the risk of bladder cancer in the human population. Sodium saccharin produces urothelial bladder tumors in rats by the formation of a urinary calcium phosphatecontaining precipitate, which is not relevant to humans because of critical interspecies difference in urine composition. Consequently, in 1999 IARC (International Agency for Research on Cancer) concluded that saccharin and its salts cannot be classified as to their carcinogenicity in humans. In 2010, the EPA (Environmental Protection Agency) of the United States removed saccharin from its list of hazardous substances. It is expected that the use of saccharin in foods might be expanded because saccharin is currently considered safe.

• KIEAE Journal
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• 제4권4호
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• pp.35-44
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• 2004

In Korea, the apartment buildings have been constructed recently in large quantities to provide housing due to the gravitation of population towards large cities. However, because of this trend toward high-rise apartment, a number of problems are occurred such as the deterioration of comfort in the dwelling environment and the lack of solar access right in apartment buildings. In the building law, the sunshine hour and the minimal separated distance between apartment buildings as regulated as the criteria for the site planning. Most of site planners, however, designed the apartment site only following minimum separated distance. As a result, the problem of sunshine hours lack is caused and legal dispute concerning solar access right is also arisen. The purpose of this study is to improve solar access right regulation and to help site design of apartment planning. Accordingly, we execute empirical analysis based on computer simulation in order to find suitable separated distance between typically designed apartment buildings. First, we estimated sunshine hours according to independent building orientation, height, and length. Second, we calculated sunshine hours in various case of apartment arrangement; parallel type, courtyard type, tower type and etc. with various separated distance.