• Genomics & Informatics
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• v.7 no.2
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• pp.107-110
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• 2009

In Sasang constitutional medicine, both disease susceptibility and drug response are considered to be related to the characteristics of an individual's physiology and psychology: a theory which is central to traditional Korean medicine. Based on such observable characteristics, Sasang constitutional medicine classifies people into four constitutional types. Genetic studies of Sasang constitution would help reveal the inheritance patterns and models of the typological traits and, moreover, help with traditional medical diagnosis and treatment. To investigate the heritable aspect of Sasang constitution, we collected various pedigrees from South Korea. The study population has 101 pedigrees composed of 593 individuals. The determination of the Sasang constitution type of each individual was performed by doctors who diagnose the Sasang constitutional type of individuals as part of their professional practice. We calculated estimates of familial correlation and heritability. Parent-Offspring pairs showed the strongest familial correlation of Sasang constitutional type, with the correlation values of 0.21 and 0.28, followed by sibling pairs with the value ranging between 0.14 and 0.25. From the heritability analysis conducted with the Variance-Component method, the heritability of TE (Tae-Eum) type, SY (So-Yang) type, and SE (So-Eum) type were 55%, 41%, and 47%, respectively. This pattern of heritability was consistent with different set of analyses, which suggest the robustness of our result. Our result clearly shows that the Sasang constitution type is heritable, and further genetic analysis based on our result will shed light on the biological mechanism of Sasang constitution.

• Tuberculosis and Respiratory Diseases
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• v.81 no.2
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• pp.116-122
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• 2018

Background: Chronic obstructive pulmonary disease (COPD) is a serious chronic condition with a global impact. Symptoms of COPD include progressive dyspnea, breathlessness, cough, and sputum production, which have a considerable impact on the lives of patients. In addition to the human cost of living with COPD and the resulting death, COPD entails a huge economic burden on the Chinese population, with patients spending up to one-third of the average family income on COPD management in some regions is clinically beneficial to adopt preventable measures via prudent COPD care utilization, monetary costs, and hospitalizations. Methods: Toward this end, this study compared the relative effectiveness of six indices in predicting patient healthcare utilization, cost of care, and patient health outcome. The six assessment systems evaluated included the three multidimensional Body mass index, Obstruction, Dyspnea, Exercise capacity index, Dyspnea, Obstruction, Smoking, Exacerbation (DOSE) index, and COPD Assessment Test index, or the unidimensional measures that best predict the future of patient healthcare utilization, cost of care, and patient health outcome among Chinese COPD patients. Results: Multiple linear regression models were created for each healthcare utilization, cost, and outcome including a single COPD index and the same group of demographic variables for each of the outcomes. Conclusion: We conclude that the DOSE index facilitates the prediction of patient healthcare utilization, disease expenditure, and negative clinical outcomes. Our study indicates that the DOSE index has a potential role beyond clinical predictions.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.8
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• pp.1217-1223
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• 2020

Objective: Eggshells with a uniform color and intensity are important for egg production because many consumers assess the quality of an egg according to the shell color. In the present study, we evaluated the influence of dominant effects on the variations in eggshell color after 32 weeks in a crossbred population. Methods: This study was conducted using 7,878 eggshell records from 2,626 hens. Heritability was estimated using a univariate animal model, which included inbreeding coefficients as a fixed effect and animal additive genetic, dominant genetic, and residuals as random effects. Genetic correlations were obtained using a bivariate animal model. The optimal diagnostic criteria identified in this study were: L^🟉 value (lightness) using a dominance model, and a^🟉 (redness), and b^🟉 (yellowness) value using an additive model. Results: The estimated heritabilities were 0.65 for shell lightness, 0.42 for redness, and 0.60 for yellowness. The dominance heritability was 0.23 for lightness. The estimated genetic correlations were 0.61 between lightness and redness, -0.84 between lightness and yellowness, and -0.39 between redness and yellowness. Conclusion: These results indicate that dominant genetic effects could help to explain the phenotypic variance in eggshell color, especially based on data from blue-shelled chickens. Considering the dominant genetic variation identified for shell color, this variation should be employed to produce blue eggs for commercial purposes using a planned mating system.

• Journal of the Korean Chemical Society
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• v.54 no.4
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• pp.363-373
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• 2010

Computational studies were carried out on the opiates morphine, heroin, codeine, pentazocine, and buprenorphine, under the density functional theory. The geometric parameters of the pharmacophore and substituents were evaluated at the B3LYP/6-31+G(d) level of theory. The electronic structure calculations were performed using the same hybrid functional at the B3LYP/6-311++G (d,p) level of theory. The atomic charges were obtained by Mulliken population analysis. Given the reported biological activity, calculated partition coefficients, and electronic and geometric analysis, pentazocine and buprenorphine were chosen as models for proposed analogues. These analogues were then studied and compared with the model molecules. The study reveals that the geometry and electronic structure of the pharmacophore remains consistent in the presence of different substituents. Because the proposed analogues preserve the studied properties of the model molecules, it is likely that these analogues display biological activity.

• Journal of Korean Society for Geospatial Information Science
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• v.1 no.1 s.1
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• pp.117-125
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• 1993

GSIS is a system that contains spatially referenced data that can be analyzed and converted to information for a specific set of purpose, or application. The key feature of a GSIS is the analysis of data to produce new information. The current emphasis in the transportation is to implement GSIS in conjunction with real time systems Requirements for a transportation GSIS are very different from the traditional GSIS software that has been designed for environmental and natural resource applications. A transportation GSIS may need to include the ability for franc volume, forecasting, pavement management A regional transportation planning model is actually a set of models that are used to inventory and then forecast a region's population, employment, income, housing and the demand of automobile and transit in a region. The data such as adminstration bound, m of landuse, road networks, location of schools, offices with populations are used in this paper. Many of these data are used for analyzing of traffic volume, traffic demand, time of mad construction using GSIS.

• Bulletin of the Korean Space Science Society
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• 2009.10a
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• pp.30.2-30.2
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• 2009

There is a growing body of evidence for the presence of multiple stellar populations in some globular clusters, including NGC 1851. For most of these peculiar globular clusters, however, the evidence for the multiple red giant-branches (RGBs) having different heavy elemental abundances as observed in $\omega$ Centauri is hitherto lacking, although spreads in some lighter elements are reported. It is therefore not clear whether they also share the suggested dwarf galaxy origin of $\omega$ Cen or not. Here we show from the CTIO 4m UVI photometry of the globular cluster NGC 1851 that its RGB is clearly split into two in the U - I color. The two distinct RGB populations are also clearly separated in the abundance of heavy elements as traced by Calcium, suggesting that the type II supernovae enrichment is also responsible, in addition to the pollutions of lighter elements by intermediate mass asymptotic giant branch stars or fast-rotating massive stars. The RGB split, however, is not shown in the V - I color, as indicated by previous observations. Our stellar population models show that this and the presence of bimodal horizontal-branch distribution in NGC 1851 can be naturally reproduced if the metal-rich second generation stars are also enhanced in helium.

• IMMUNE NETWORK
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• v.13 no.6
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• pp.264-274
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• 2013

The unrestricted population of $CD4^+Foxp3^+$ regulatory T (Treg) cells, which have been known to control the expression of autoimmune diseases and protective immunity to inflammatory reactions, has led to greater appreciation of functional plasticity. Detecting and/or isolating Ag-specific $CD4^+Foxp3^+$ Tregs at the single cell level are required to study their function and plasticity. In this study, we established and compared both MHC class II tetramer and intracellular CD154 staining, in order to detect $CD4^+Foxp3^+$ Treg specific for foreign Ag in acute and chronic infections with lymphocytic choriomeningitis virus (LCMV). Our results revealed that MHC class II tetramer staining showed a lower detection rate of LCMV $GP_{66-77}$-specific $CD4^+$ T cells because most of MHC class II tetramers were unbound and unstable when combined staining was performed with intracellular cytokines. In contrast, intracellular CD154 staining was revealed to be easier and simple for detecting LCMV $GP_{66-77}$-specific $CD4^+$ T cells, compared to MHC class II tetramer staining. Subsequently, we employed intracellular CD154 staining to detect LCMV $GP_{66-77}$-specific $CD4^+Foxp3^+$ Tregs using $Foxp3^{GFP}$ knock-in mouse, and found that LCMV $GP_{66-77}$-specific $CD4^+Foxp3^+$ Tregs and polyclonal $CD4^+Foxp3^+$ Tregs showed differential expansion in mice infected with LCMV Arms or Cl13 at acute (8 and 13 days pi) and chronic phases (35 days pi). Therefore, our results provide insight into the valuable use of intracellular CD154 staining to detect and characterize foreign Ag-specific $CD4^+Foxp3^+$ Treg in various models.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.1
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• pp.30.2-30.2
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• 2013

The mean color of globular cluster (GCs) systems in early-type galaxies (ETGs) is, in general, bluer than the integrated color of field stars in their host galaxies. Recently, Goudfrooij & Kruijssen (2013) reported that even red GCs in the ETGs show bluer colors than their host field stars and suggested the different initial mass function (IMF) for red GCs and field stars to explain the observed offset in color. Here we suggest an alternative scenario that explains the observed color offsets between red GCs in ETGs and the field stars in the parent galaxies without invoking to the variation of the IMF. We find that the inclusion of second-generation (SG) helium-enhanced populations in the model fully explains the observed color offset between red GCs and field stars in the host galaxies. We have also tested the effect of the IMF slope on our models, but the effect is relatively small compared to the effect of the SG population. Our new model suggests that, in order to explain far-UV strong metal-rich GCs in M87 and the observed color offset between metal-rich GCs and the field stars in ETGs simultaneously, the inclusion of the SG populations with enhanced helium abundance is a more natural solution than the model that only adopted variations in the IMF.

• Journal of Ecology and Environment
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• v.43 no.4
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• pp.427-437
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• 2019

Background: Climate change is believed to be continuously affecting ticks by influencing their habitat suitability. However, we attempted to model the climate change-induced impacts on future genus Rhipicephalus distribution considering the major environmental factors that would influence the tick. Therefore, 50 tick occuance points were taken to model the potential distribution using maximum entropy (MaxEnt) software and 19 climatic variables, taking into account the ability for future climatic change under representative concentration pathways (RCPs) 4.5 and 8.5, were used. Results: MaxEnt model performance was tested and found with the AUC value of 0.99 which indicates excellent goodness-of-fit and predictive accuracy. Current models predict increased temperatures, both in the mid and end terms together with possible changes of other climatic factors like precipitation which may lead to higher tick-borne disease risks associated with expansion of the range of the targeted tick distribution. Distribution maps were constructed for the current, 2050, and 2070 for the two greenhouse gas scenarios and the most dramatic scenario; RCP 8.5 produced the highest increase probable distribution range. Conclusions: The future potential distribution of the genus Rhipicephalus show potential expansion to the new areas due to the future climatic suitability increase. These results indicate that the genus population of the targeted tick could emerge in areas in which they are currently lacking; increased incidence of tick-borne diseases poses further risk which can affect cattle production and productivity, thereby affecting the livelihood of smallholding farmers. Therefore, it is recommended to implement climate change adaptation practices to minimize the impacts.

• The korean journal of orthodontics
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• v.15 no.2
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• pp.341-352
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• 1985

The primary objective of this study is to estimate of the mesiodistal crown diameters of the unerupted permanent successors derived from the mesiodistal crown diameters of the deciduous teeth in Korean population. The subjects were 54 individuals (twenty nine boys and twenty five girls) with normal occlusion aged 6 to 13 years. The mesiodistal crown diameters of the deciduous and the successional permanent teeth were measured from the longitudinal dental cast models using the sliding calipers (Mitutoyo Co.). From the study, the results are as follows; 1. Sex differences of mesiodistal won diameters were less in the deciduous teeth, but male were more than that of female in the successional permanent teeth. 2. The mesiodistal crown diameters of the deciduous central incisors, lateral incisors, canines were smaller than that of the successional permanent teeth and the deciduous 1st molars, and 2nd molars were more larger than that of the successional permanent teeth. 3. Size differences between sum of the mesiodistal crown diameters of central incisors and lateral incisors in the decidous teeth and the successional permanent teeth were $7.20{\pm}1.79mm$ in upper, $5.38{\pm}1.64mm$ in lower and that of canine,1st molar and 2nd molar in the deciduous teeth and the successional permanent teeth were $0.56{\pm}1.19mm$ in upper, $2.22{\pm}1.19mm$ in lower. 4. In male, the correlation coefficients between the upper deciduous central incisor and the successional permanent tooth (r = 0.57) and in female, the correlation coefficients between the upper deciduous 1st molar and the successional permanent tooth (r=0.67) appeared the highest. 5. The regression constants were determined to estimate the mesiodistal crown diameters of the unerupted successional permanent teeth.