• Archives of Pharmacal Research
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• 제26권4호
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• pp.330-337
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• 2003

The effect of sixteen excipients on the transport of recombinant human epidermal growth factor (rhEGF) across Caco-2 cell monolayers was examined at $37^{\circ}C$. The apparent apical to basolateral (A-B) permeability ($P_{app}$) of 30 $\mu$ M rhEGF was $8.15\times 10^{-7}$ cm/sec, indicative of a poor level of absorption in the GI tract. The Papp was 1.7- and 6.3-fold greater than the $P_{app}$ in the basolateral to apical (B-A) direction and the A-B permeability of mannitol, respectively, and decreased dramatically to a negligible level at $4^{\circ}C$, consistent with a receptor mediated transcytosis of rhEGF. The stability of rhEGF was very poor, undergoing more than 85% degradation in 2 h in the transport medium at $37^{\circ}C$. A significant increase in the $P_{app}$ could be achieved by the addition of certain excipients, as exemplified by 23, 21, 20 and 16-fold increases, in the presence of sodium taurochenodeoxycholate (NaTCDC), sodium taurodeoxycholate (NaTDC), sodium glycodeoxycholate (NaGDC) and sodium laurylsulfate (SLS) (all at a concentration of 1 % w/v), respectively. A significant increase in stability could also be achieved by the addition of some of the excipients, as represented by 1 % SLS, which nearly completely stabilized the rhEGF. Unfortunately, however, an increase in the $P_{app}$ of rhEGF could not be achieved without a simultaneous and extensive decrease in the integrity of the cell membranes. Thus, more efficient excipients, that specifically enhance the permeation of rhEGF and do not alter the membrane integrity, should be pursued in order to safely enhance the permeation of rhEGF.

• 터널과지하공간
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• 제14권3호
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• pp.215-228
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• 2004

지하암반의 변형은 단층, 절리 등의 불연속면을 따라 발생하므로 불연속면의 역학적 특성과 공간적인 분포형태는 구조물의 안정성에 근 영향을 미친다. 한편 연약암반에 높은 응력이 작용하는 경우에는 불연속면뿐만 아니라 무결암에서의 변형이 구조물의 안정성에 영향을 줄 수 있다. 이 연구에서는 암반구조물의 안정성 해석을 위하여 무결암과 절리, 그리고 록볼트를 점소성(visco-plastic) 재료로 가정하고, 연속체 개념을 적용하여 유변학적 모델(Rheological model)에 기초한 2차원 점소성 유한요소 프로그램을 개발하였다. 무결암 모델, 절리암반 모델, 록볼트로 보강된 절리암반 모델의 분석을 통하여 개발된 프로그램을 검증하였고, 각각의 모델에서 무결암의 해석 조건(탄성/점소성)에 따른 변위의 차이를 알아보았다. 연약암반에 높은 응력이 작용할 때, 무결암을 탄성으로 해석한 경우보다 점소성으로 해석한 경우에서 지하구조물의 변위가 더 크게 나타났다. 따라서 연약암반 내 지하구조물의 안정성 해석을 위해서는 절리와 록볼트 뿐만 아니라 무결암에 대해서도 점소성 모델을 적용하는 것이 바람직한 것으로 판단되었다.

• 한국농공학회논문집
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• 제58권3호
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• pp.91-100
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• 2016

Recently, lots of damages have been lost because large magnitude earthquakes were occurred in the world. It has been increased the number of earthquakes in Korea. It needs improvement required for the repair of deteriorated reservoirs, reinforcement and raised reservoir coping with climate change and earthquake. This study aims to investigate the seismic behavior of deterioration reservoir levee using dynamic centrifugal model test. Therefore, two case tests in centrifugal field of 60 g, the result has provided the influence on the acceleration response, displacement, settlement and the pore water pressure of the reservoir with earthquakes. From the results larger displacement and acceleration response at the front side of reservoir embankment with poor-fabricated core in seismic condition may degrade overall stability. Reasonable reinforcement method of the raised reservoir embankment is required for ensuring long-term stability on earthquake.

• Journal of Forest and Environmental Science
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• 제36권2호
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• pp.69-77
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• 2020

Lignocellulosic biomass has recalcitrant characteristics against chemical and biological conversion due to its structural heterogeneity and complexity. The pretreatment process to overcome these recalcitrant properties is essential, especially for the biochemical conversion of lignocellulosic biomass. In recent years, pretreatment methods using ionic liquids (ILs) and deep eutectic solvents (DESs) as the green solvent has attracted great attention because of their advantages such as easy recovery, chemical stability, temperature stability, nonflammability, low vapor pressure, and wide liquids range. However, there are some limitations such as high viscosity, poor economical feasibility, etc. to be solved for practical use. This paper reviewed the research activities on the pretreatment effect of various ILs including DESs and their co-solvents with organic solvents on the enzymatic saccharification efficiency of lignocellulosic biomass and the nanocellulose preparation from the pretreated products.

• Carbon letters
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• 제24권
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• pp.73-81
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• 2017

Interconnected meso/microporous activated carbons were prepared from pumpkin seeds using a simple chemical activation method. The porous carbon materials were prepared at different temperatures (PS-600, PS-700, PS-800, and PS-900) and demonstrated huge surface areas ($645-2029m^2g^{-1}$) with excellent pore volumes ($0.27-1.30cm^3g^{-1}$). The well-condensed graphitic structure of the prepared activated carbon materials was confirmed by Raman and X-ray diffraction analyses. The presence of heteroatoms (O and N) in the carbon materials was confirmed by X-ray photoemission spectroscopy. High resolution transmission electron microscopic images and selected area diffraction patters further revealed the porous structure and amorphous nature of the prepared electrode materials. The resultant porous carbons (PS-600, PS-700, PS-800, and PS-900) were utilized as electrode material for supercapacitors. To our delight, the PS-900 demonstrated a maximum specific capacitance (Cs) of $303F\;g^{-1}$ in 1.0 M $H_2SO_4 $ at a scan rate of 5 mV. The electrochemical impedance spectra confirmed the poor electrical resistance of the electrode materials. Moreover, the stability of the PS-900 was found to be excellent (no significant change in the Cs even after 6000 cycles).

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제17권4호
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• pp.15-23
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• 2011

Long-term care Insurance system for the Elderly was started to respond to the aged society on July 2008 in Korea. So responsibility of the care for the old is being changed from the family to the society. The introduction of that insurance system has brought the growth of demand for care service. To improve the level of quality for care service providers in long-term care, the role of care worker in providers is recognized as important. But welfare system for the care worker seems to be poor. So the Seoul Metropolitan Council is preparing an ordinance for the care worker and the purpose of this study is for the ordinance as well. Questionnaires, interviews, documentary surveys were used to carry out this study. The results of this study are summarized as follows. The job stability is the most important thing for the care worker, so local government has to make efforts to promote the job stability of care worker. A welfare center for care workers is needed for the health for care workers in the local government. And the local government has to supervise service providers more strictly and evaluate them in treatments of care worker.

• Journal of Pharmaceutical Investigation
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• 제31권3호
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• pp.167-172
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• 2001

All-trans retinoic acid (ATRA), vitamin A acid, has been shown to exert anticancer activity in a number of types of cancers, particularly in acute promyelocytic leukaemia (APL). Due to its highly variable bioavailability and induction of its own metabolism after oral treatment, development of parenteral dosage forms are required. However, its poor aqueous solubility and chemical unstability give major drawbacks in parenteral administration. This study was undertaken to investigate a possibility to develop a parenteral formulation of ATRA by employing solid lipid nanoparticle (SLN) as a carrier. By optimizing the production parameters and the composition of SLNs, SLNs with desired mean particle size (<100 nm) as a parenteral dosage form could be produced from trimyristin (as solid lipid), Egg phosphatidylcholine and Tween 80 (as SLN stabilizer). The mean particle size of SLN formulation of ATRA was not changed during storage, suggesting its physical stability. Thermal analysis confirmed that the inner lipid core of SLNs exist at solid state. The mean particle size of ATRA-loaded SLNs was not significantly changed by the lyophilization process. ATRA could be efficiently loaded in SLNs, while maintaining its anticancer activity against HL-60, a well-known APL cell line. Furthermore, by lyophilization, ATRA loaded in SLN could be retained chemically stable during storage. Taken together, our present study demonstrates that physically and chemically stable ATRA formulation adequate for parenteral administration could be obtained by employing SLN technology.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 추계학술대회 논문집 학회본부 C
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• pp.737-739
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• 1998

Gate insulators using various fluoride films were investigated for thin film transistor applications. Conventional oxide containing materials exhibited high interface states, high $D_{it}$ gives an increased threshold voltage and poor stability of TFT. To improve TFT performances, we must reduce interface trap charge density between Si and gate insulator. In this paper, we investigated gate insulators such as such as $CaF_2$, $SrF_2$, $MgF_2$ and $BaF_2$. These materials exhibited an improvement in lattice mismatch, difference in thermal expansion coefficient, and electrical stability MIM and MIS devices were employed for an electrical characterization and structural property examination. Among the various fluoride materials, $CaF_2$ film showed an excellent lattice mismatch of 0.737%, breakdown electric field higher than 1.7MV/cm and leakage current density of $10^{-6}A/cm^2$. This paper probes a possibility of new gate insulator material for TFT application.

• The Journal of Advanced Prosthodontics
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• 제8권5호
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• pp.411-416
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• 2016

Patients who underwent resection of maxilla due to benign or malignant tumor, or accident will have defect in palatal area. They get retention, support and stability from remaining tissues which are hardly optimal. The advantage of swing-lock attachment design is having multiple contacts on labial and lingual side of the abutment teeth by retentive strut and palatal bracing component. Because the force is distributed equally to abutment teeth, abutment teeth of poor prognosis can be benefited from it. It is also more advantageous to cover soft tissue defects which are hard to reach with conventional prosthesis. A 56-year-old female patient who had undergone a maxillectomy due to malignant melanoma complaining of loose and unstable surgical obturator. Surveyed crowns were placed on #12, 26, and 27. Teeth #11, 21, 22, and 23 had lingual rest seat and #24 had mesial rest seat to improve stability and support of the obturator. This clinical report presents the prosthetic management of a patient treated with obturator on the maxilla using swing-lock attachment to the remaining teeth.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2006년도 춘계 학술발표회 논문집
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• pp.652-661
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• 2006

The cut slopes in Jinju area constitute the Cretaceous Sedimentary rock which is one of the most poor ground conditions. The geological rocks of the cut slopes are correlated with Jinju Formation. Most of the rocks consist of Black Shale layer, but the lower parts consist of Alkorsic White Sandstone. So, It is characteristic of the differential weathering due to the difference of rock species. Moreover, vertical joints which concentrate on the released rock and weak rock fragments are accompanied with minor faults. We make out face mapping about each slopes through the detailed field-study and deduce RMR and SMR from the field data. The strength properties of rocks were obtained from references, indoor tests, and Back Analysis method. And, choosing properties were used in the stability analysis as stereographic projection and limit equilibrium analysis and we establish the countermeasures for the cut slopes.