• 동아시아식생활학회지
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• 제22권1호
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• pp.25-32
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• 2012

This study was conducted to evaluate the quality characteristics of Sulgidduk prepared with different amounts of Hasuo (Polygoni Multiflori Radix) powder. Proximate composition analysis showed that the moisture content, pH, acidity, and volume of Sulgidduk decreased with a rise in the level of added hasuo powder. The L-value decreased, while a and b values increased, with increasing amounts of hasuo powder. In mechanical evaluation of physical properties, hardness decreased while springiness, chewiness, cohesiveness, and brittleness increased with increasing hasuo powder content. Scanning election microscopy indicated that the number of air cells decreased as the ratio of hasuo powder increased. Sensory evaluation showed that moistness and springiness decreased significantly when the amounts of hasuo powder increased. The sample containing 30 g hasuo powder scored the highest for sweet taste, savory taste, springiness, chewiness, swallowing, and in overall acceptability scores. Next, the sample containing 60 g hasuo powder scored higher than control. The optimum concentration indicate that addition of 30~60 g hasuo powder to Sulgidduk resulted in highest quality.

• 한국한의학연구원논문집
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• 제16권1호
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• pp.19-27
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• 2010

Objectives & Method : We investigated toxicity, poisoning symptoms, poisoning treatment and prevention against poisoning of mind-tranquilizing herbal medicines(安神藥) in order to use herbal medicines accurately. Result : Cinnabaris(朱砂), Zizyphi Spinosae Semen(酸棗仁), Polygalae Radix(遠志), Ganoderma(靈芝) and Polygoni Multiflori Ramulus(夜交藤) may give rise to some side effects or toxic symptoms in mind-tranquilizing herbal medicines(安神藥). The representative methods of poisoning treatment in western medicines are washing out the stomach, promotion of vomiting, causing diarrhea, supplies of grape sugar and symptomatic treatment, etc. The representative methods of poisoning treatment in oriental medicine take advantage of herbs. And Oriental medical doctor should meet symptoms as patients call for attention. In order to prevent against poisoning of mind-tranquilizing herbal medicines(安神藥), the patients should keep usage, dosage and notes and oriental medical doctors should do processing drugs. Conclusion : We should pay attention to clinical using of Cinnabaris(朱砂), Zizyphi Spinosae Semen(酸棗仁), Polygalae Radix(遠志), Ganoderma(靈芝) and Polygoni Multiflori Ramulus(夜交藤) in mind-tranquilizing herbal medicines(安神藥).

• 한국식품저장유통학회지
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• 제18권6호
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• pp.836-843
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• 2011

기능성 소재로서 약리적인 성질과 생리활성을 지닌 하수오를 첨가한 머핀에 건강과 웰빙을 접목하여 설탕 대체 올리고당 종류를 달리한 머핀의 품질특성을 살펴본 결과 무게는 프락토 올리고당 첨가 하수오 머핀이 가장 높게 나타났으며 부피와 비체적은 설탕 첨가 하수오 머핀에 비해 올리고당 첨가 하수오 머핀군이 낮게 나타났다. pH는 설탕첨가 하수오 머핀에 비해 올리고당 첨가 하수오 머핀이 낮게 나타났으며 수분함량은 높게 나타났다. 색도인 $L^*$값은 설탕첨가 하수오 머핀이 가장 낮게 나타났으며 a, b값은 올리고당 첨가 하수오 머핀군이 설탕 첨가 하수오 머핀에 비해 낮게 나타났으나 시료간 유의적인 차이가 없었다. 조직감에서 탄력성과 응집성은 프락토 올리고당 첨가 하수오 머핀이 가장 높게 나타났으며 응집성은 올리고당 첨가 하수오 머핀이 높게 나타났다. 머핀의 항산화활성은 설탕 첨가 하수오 머핀은 38.67, 올리고당 첨가 하수오 머핀은 42.87~65.95로 높게 나타났으며 관능검사에서 삼킨 후 느낌, 향과 맛, 조직감은 프락토 올리고당 첨가 하수오 머핀이 가장 높게 나타났으며, 전반적인 기호도에서 설탕 첨가 하수 머핀에 비해 프락토 올리고당과 이소말토 올리고당 첨가 하수오 머핀이 높게 나타나 설탕 대체 당류 첨가 제조시 적합하리라 사료된다.

• 동의생리병리학회지
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• 제19권6호
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• pp.1666-1672
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• 2005

Oriental medicinal drugs have a broad spectrum of clinical use for the cure of nervous system diseases including brain ischemic damages or neuropathies. Yet, specific drugs or drug components used in the oriental medicine in relation to none fiber regeneration are not known. In the present study, possible growth promoting effects of oriental medicinal drugs were investigated in the injured sciatic nerve system in the rat. By immunofluorescence staining, we found that Jahageo (JHG, Hominis placenta) increased Induction levels of axonal growth associated protein GAP-43 in the rat sciatic none. Small growth promoting activity was found in Golsebo (GSB, Drynariae rhizoma) and Baikhasuo (BHSO, Polygoni multiflori radix) drugs. JHG also increased cell cycle protein Cdc2 levels in the injured area of the sciatic nerves. Immunofluorescence staining indicated that induced Cdc2 protein was mostly localized in the Schwann cells in the injury area, implying that JHG activity might be related to increased Schwann cell proliferation during axonal regeneration. Moreover, levels of phospho-extracellular signal-regulated (ERK) pathway in the injured neNes were elevated by JHG treatment while levels of total ERK were unaltered. In vivo measurement of axonal regeneration using retrograde tracer showed that JHG, GSB and BHSO significantly enhanced Dil-labeled regenerating motor neurons compared with saline control. The present data suggest that oriental medicinal drugs such as JHG, GSB, and BHSO may be a useful target for developing specific drugs of axonal regeneration.

• 대한한의학회지
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• 제33권1호
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• pp.160-168
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• 2012

Objectives: Cynanchi wilfordii Radix has commonly been used with or instead of Polygoni multiflori Radix in Korea. The purpose of this study was to investigate their history in the traditional Oriental medical literature and quantitative determination of conduritol F from Cynanchi wilfordii Radix according to various harvest times. Methods: We conducted studies of the traditional Oriental medical literature and analysis of the component, conduritol F, simultaneously. Efficacy and origin of Cynanchi wilfordii Radix in literature study, time of harvest in component research. Chromatographic analysis performed using Silica(2) 100A column (Phenomenex 5 um, 250 mm 4.6 mm) with a mixture of acetonitrile and water (98 : 2)(v/v). The analyses detected at UV (210 nm). Results: Conduritol F was detected in Cynanchi wilfordii Radix, but in Cynanchi auriculati Radix was not. We indicate that conduritol F is as a distinguishable indicator with other materia medica. We think the proper harvesting time is October and November. Conclusions: Measures of trunk control were significantly related with values of dynamic balance and gait. Based on these results, trunk control is an essential core component of balance and gait. Trunk control training programs after stroke should be developed and emphasized.

• 동의생리병리학회지
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• 제24권3호
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• pp.367-372
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• 2010

The purpose of this study is to make a basis of in vivo or clinical study about alopecia. We investigated the prescriptions of alopecia by researching oriental medicine literature. We found the prescriptions used for alopecia. And we surveyed the frequency and classification of the herbs used for alopecia. The results of this study were recorded as follows. The most frequently used single herbs in the prescriptions were Angelicae Gigantis Radix(當歸), Glycyrrhizae Radix(甘草), Poria(茯笭), Paeoniae Radix Alba(白芍藥). Herbs specifically frequently used in the prescriptions of alopecia were as follows. Polygoni Multiflori Radix(何首烏), Rehmanniae Radix(生地黃), Cuscutae Semen(菟絲子), Bupleuri Radix(柴胡), Scutellariae Radix(黃芩), Viticis Fructus(蔓荊子), Aconiti Iateralis Preparata Radix(附子). Herbs frequently used were classified by property. The result was as follows. (()-The number of herbs) 補益藥(32), 解表藥(18), 淸熱藥(15) 收澀藥(9), 活血祛瘀藥(8), 利水滲濕藥(8).

• 대한한방소아과학회지
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• 제13권2호
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• pp.79-92
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• 1999

Background/Aims: Aplastic anemia is defined as pancytopenia (anaemia, leucopenia, and thrombocytopenia) result from aplasia of the bone marrow. Many studies have shown that survival rate of aplastic anemia is 50-60% with immunomodulation therapy. In Korea, there is a lack of research considering oriental herbal medicine with aplastic anemia. Methods: It was compared and analyzed that recently several experimental or clinical reports of oriental herbal medicine on aplastic anemia. Results and Conclusion: The oriental herb of Panax ginseng radix, Cprdonopsis pilosula radix, Astragalus membranaceus radix, Atractylodes marcrocephala. Cervi Cornu Parvum, Epimedii Herba, Boshniakiae Herba, Morindae Radix, Angelicae gigantis Radix, Cascutae Semen, Lycii Fructus, Polygoni Multiflori Radix potently stimulated hematopoietic stem cell activity, Response rate to oriental herbal medicine of aplastic anemia was 30-60% and effect rate of aplastic anemia was 73-93%, Bian zheng Lun zhi(辨證論治 treatment according to syndrome differentiation) which based on Shen xu(腎虛) is presumed to approach highest degree effect in response rate.

• 한국식품영양과학회지
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• 제40권8호
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• pp.1086-1091
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• 2011

멜라닌 색소는 피부를 보호하는 긍정적인 면을 갖고 있으나 이의 과잉생성은 기미, 주근깨, 피부 반점 등을 유발하며 멜라닌 전구물질의 독성으로 인한 세포의 사멸 및 피부암 생성이 촉진되기도 한다. 이에 적하수오와 백하수오가 멜라닌 세포의 멜라닌화에 관여하는지를 알아보기 위하여 각각의 에탄올 추출물이 tyrosinase 효소활성 및 멜라닌 생성에 미치는 영향을 조사하였다. 하수오와 백하수오의 총 폴리페놀 함량은 각각 17.31${\pm}$0.54 mg GA eq/g, 2.75${\pm}$0.22 mg GA eq/g로 나타났으며, 하수오와 백하수오의 총 플라보노이드 함량은 각각 6.38${\pm}$0.39 mg naringine eq/g, 1.34${\pm}$0.09 mg naringine eq/g로 폴리페놀과 플라보노이드 함량은 백하수오보다 하수오에서 많은 것으로 나타났다. 하수오와 백하수오의 각각 농도별에 따른 ABTS radical 소거활성은 하수오 1 mg/mL 농도에서 96.89${\pm}$0.22%로 나타났으나, 백하수오는 1 mg/mL 농도에서 6.24${\pm}$0.33%로 하수오에 비하여 소거활성이 낮게 나타났다. 에탄올 추출물에 의한 세포 생존율은 최고 100 ${\mu}g/mL$ 처리 시 하수오와 백하수오 각각에서 93.2${\pm}$1.95%, 91.07${\pm}$4.05%로 두 가지 추출물에서 유의할 만한 변화를 나타내지 않았다. 멜라닌 생성에 미치는 영향에 대하여 10 ${\mu}g/mL$ 농도에서는 각각 75.9${\pm}$2.23%, 60.77${\pm}$3.07%로 나타났으며, 100 ${\mu}g/mL$ 농도에서는 각각 42.93${\pm}$ 2.26%, 28.37${\pm}$3.05%로 처리농도가 증가함에 따라 멜라닌 생성이 점점 감소되는 경향을 보였으며 통계학적으로도 유의성이 관찰되었다. 이 결과는 하수오와 백하수오의 에탄올 추출물이 세포에 독성을 미치지 않으며 멜라닌 생성 저해에 효과적인 미백제로서의 가능성을 제시하였다.

• 한국조리학회지
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• 제22권4호
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• pp.128-142
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• 2016

본 연구는 하수오 침출약용주의 만성 섭취에 의한 뇌의 기억력 감퇴에 미치는 영향을 알아보고자 전체 섭취 열량의 12%를 설탕으로 공급한 정상 액체식이군, 담금 소주 액체식이군, 백하수오 침출약용주 액체식이군 및 적하수오 침출약용주 액체식이군으로 나누어 6주 동안 액체식이를 공급시킨 다음 시료를 채취하여 생화학 분석을 실시하였다. 혈청과 뇌 조직을 이용한 생화학 분석으로 알코올의 분해 능력을 알아보기 위하여 ADH와 ALDH 활성 및 acetaldehyde 농도, 그리고 뇌의 기억력 측정하기 위하여 총 choline 및 acethycholine 농도와 AChE 활성을 측정하였다. 뇌 조직에서 ADH는 정상식이군에 비해 담금 소주 알코올 섭취군에서 유의적으로 활성이 낮았으나, 담금 소주 대신에 백하수오 및 적하수오 침출 약용주를 섭취했을 때 p<0.05 수준에서 높은 활성을 보였다. ADLH 활성은 모든 군 중에서 백하수오 침출약용주를 섭취한 군에서 가장 높았으며, 알코올의 대사산물로 독성이 강한 acetaldehyde는 담금 소주 섭취군에서 높은 농도를 보였다(p<0.05). 그러나 백하수오 침출약용주를 섭취한 군에서는 낮은 acetaldehyde 농도를 보임으로써 담금 소주에 비해 백하수오 침출약용주에서 알코올 분해능력은 높고, 독성은 낮은 것으로 나타났다. 기억력 감퇴와 상관성이 높은 acetylcholine 농도는 모든 실험군 중에서 담금 소주 섭취군에서 유의적으로 가장 낮았으며(p<0.05), 이러한 결과는 담금 소주군에서 기억력의 손상을 가장 많이 받은 것으로 해석된다. 그러나 담금 소주 대신에 백하수오와 적하수오 침출약용주를 섭취한 군에서의 acetylcholine 농도는 정상식이 섭취군보다 유의적으로 더 높은 함량을 보였다(p<0.05). Acetylcholine 가수분해 효소인 혈청과 뇌 조직에서의 AChE는 정상식이군과 하수오 침출약용주에 비해 p<0.05 수분에서 높은 활성을 보였다.

• 대한한방내과학회지
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• 제16권1호
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• pp.40-61
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• 1995

This study was performed to investigate concept, systoms, causes of disease, pathogenic mechanisms, therapies and precriptions about senile constipation through the successive medical literature, recent chinese medical literature and chinese medical joumals. Senile constipation seems to be applicable to dryness syndrom and constipation of insufficiency type, have something to do with kidney(the most), lung, spleen and large intestine. The most principal cause of disease is yin-fluid, the rest deficiency of qi, insufficiency of yang, stagnation of qi and retention of fever etc. There are enriching the blood and moistening dryness in principal therapy, the rest are invigorating qi and loosing the bowel, warming and invigorating the spleen and kidney, regulating the flow of qi and promoting the stagnancy of qi and expelling the pathogenic heat etc. In prescriptions there are Yunjangtang, Jengaektang, Hwanggitang, Jechunjeon, Yukmatang and Majainhwan as the causes of disease, meanwhile are Yungjang-tang, Jechunjeon and Majainhwan in the vulgaris prescriptions. And in medical herbs there are nourishing yin medicines as Rhizoma rehmanniac, Radix ophiopogonis and Radix scrophulariae etc., invigorating qi medicines as Radix astragali, Radix codonopsitis and Radix polygoni multiflori etc, invigorating yang medicines as Caulis cistanchis and Semen psoraleae etc., promoting qi circulating medicines as Radix saussurea, Lignum aquilariae and Radix linderae etc., and reducing fever and therapeutic method to keep the adverse qi flowing downward medicines as Semen cannabis, Rhizoma rhei, Fructus immaturus ponciri, and Cortex magnoliae etc.. Meantime Rhizoma rehmanniae, Radix ophiopogonis, Caulis cistanchis, Radix angelicae gigantis, Semen cannabis, Semen biotae, Semen pruni japonicae and Semen persicae in principal herb-medicines. In clinical reports the process of disease was between 10 to 20 years, the evacuation cycle between 4 to 7 days, generally possessed chronic diseases as hypertension, diabetes, arteriosclerosis and cerebro- vascular disorders etc. and the efficiency rate was more than 90%. The senile constipation is occured in succession or promoted by chronic diseases as obesity, hypertension, diabetes, arteriosclerosis. hrperlipemia, cerebro- vascular disorders etc., so diet-regulating, adequate exercise, proper evacuation-habit and psychologic rest etc. are important more than medicine-treatments.