• Title/Summary/Keyword: Polyethyleneglycol

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Chitosan-Iron casein succinylate nanoparticles as oral delivery systems: increasing the stability and enhancing the absorption of iron nanoparticles.

  • Cho, Jung-Hye;Oungbho Kwunchit;Park, Jeong-Sook;Kim, Chong-Kook
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.249.1-249.1
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    • 2003
  • The objective of the study was to develop an oral delivery system to increase the stability and efficacy of iron casein succinylate. Aqueous nanoparticles were prepared using complex coacervation of the oppositely charged chitosan and iron casein succinylate with polyethyleneglycol (PEG). The physicochemical properties of nanoparticles were investigated using dynamic light scattering, zeta potential and scanning electron microscopy. Chitosan-iron casein succinylate interactions were investigated in solid state by differential scanning calorimetry (DSC) and FT-IR spectrometry. (omitted)

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Hydrophilic Graphite Nanoparticles Synthesized by Liquid Phase Pulsed Laser Ablation and Their Carbon-composite Sensor Application (액상 펄스 레이저 어블레이션에 의한 친수성 그라파이트 나노입자의 제조 및 센서 응용)

  • Choi, Moonyoul;Kim, Yong-Tae
    • Journal of the Korean Electrochemical Society
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    • v.15 no.4
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    • pp.236-241
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    • 2012
  • It is widely recognized that it is hard to prepare hydrophilic graphite nanoparticles because of their high crystallinity and inert characteristics. In this study, we successfully synthesized the hydrophilic graphite nanoparticles by using liquid phase pulsed laser ablation method which has been actively employed for the thin film deposition up to now. The obtained hydrophilic graphite showed an ultra-high dispersion stability in water, because the hydrophilic functional groups like carboxyl and carbonyl group was simultaneously introduced onto the graphite surface with the nanoparticle formation, as confirmed by FT-IR and zeta potential measurements. Finally, a markedly enhanced gas sensing ability for acetone was shown in comparison with the conventional carbon black for the carbon polymer composite sensor with polyethyleneglycol (PEG).

Biological Activity of Multifunctional Oligopeptide Derivatives

  • Kim, Bo Mi
    • Journal of Integrative Natural Science
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    • v.9 no.2
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    • pp.86-93
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    • 2016
  • The peptide sequences, GHK(Gly-His-Lys) and KTTKS(Lys-Thr-Thr-Lys-Ser), using a collagen stimulator recently were manipulated at N-terminal as a multifunctional peptide derivative with PEG(polyethyleneglycol) linker connected to gallic acid which presents anti-inflammatory activity. The multifunctional peptide derivatives were obtained in a normal peptide preparation method through SPPS(solid phase peptide synthesis) using Fmoc chemistry and a carboxyl group insertion reaction of PEG-3,4,5-triacetoxy benzoate by using potassium tert-butoxide and ethyl bromoacetate, which was separated by Sephadex DEAE. It gave a good compromise to a cosmetic application for cell cytotoxicity, anti-wrinkle, and anti-inflammation.

Comparison of Cu(II)-DIPS and Human Recombinant Superoxide Dismutase, an Antioxidant (항산화제인 Cu(II)-DIPS와 재조합 인간 수퍼옥사이드 디스뮤타제의 비교)

  • Yong, Chul-Soon;Nam, Doo-Hyun;Huh, Keun
    • Journal of Pharmaceutical Investigation
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    • v.25 no.2
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    • pp.145-152
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    • 1995
  • The superoxide dismutase (SOD) mimetic activity of copper complex of 3,5-disopropylsalicylic acid (Cu(II)-DIPS) was tested and compared to those of human recombinant SOD (hrSOD) and its conjugate form with polyethyleneglycol (PEG) using fer- ricytochrome c reduction assay. Stability constant of Cu(II)-DIPS was measured po- tentiometrically using SCOGS2 program. In the presence of 10 g/L albumin, Cu(II)-DIPS lost most of its SOD mimetic activity. HrSOD was modified with polyethylene glycol (PEG) of M.W. 5000. These conjugates have markedly prolonged plasma half-lives of enzymatic activity (15.5 hr) compared to native hrSOD (5 min). In summary, efficient SOD mimetics should be stable enough not to dissociate in blood by serum protein. HrSOD could have longer half-life by conjugation with inert PEG for sustained SOD effect.

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Purification and Physical Proerties of Biosurfactant Produced from Rhodotorula muciloginosa (Rhodotorula muciloginosa G-1에서 생산되는 biosurfactant의 정제 및 물리적 성질)

  • 이철수;이병옥;강상모
    • Microbiology and Biotechnology Letters
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    • v.23 no.2
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    • pp.229-235
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    • 1995
  • The surface tension-decreasing biosurfactant was purified from Rhodotorula muciloginosa G-1. The purification procedure was the solvent extraction of culture broth. To ensure complete extraction, the sample was extracted twice with equal volume of ethylacetate. The crude solution was washed with n-hexane to remove unconsumed soybean oil. The crude sample of biosurfactant was applied to Silica gel column chromatography equilibrated with chloroform, and eluted with chloroform : methanol gradient. Serveral solvent system was used to developed the thin layer chromatography (TLC). The purified biosurfactant sample gave one spot (Rf 0.78). It was estimated that biosurfactant was glycolipid about having M.W.1,500 with standard of polyethyleneglycol by Sephadex LH-20 column chromatography.

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Synthesis of High-Performance Polycarboxylate(PC)-Type Superplasticizer, and Its Fluidity and Hydration Behavior in Cement Based-System (폴리카복실레이트계 고성능 유동화제의 합성과 시멘트계 내의 유동 및 수화 반응 거동)

  • Shin, Jin-Yong;Chae, Eun-Jin;Hong, Ji-Sook;Suh, Jeong-Kwon;Hwang, Eui-Hwan
    • Proceedings of the Korea Concrete Institute Conference
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    • 2006.05b
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    • pp.77-80
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    • 2006
  • Graft copolymerized polycarboxylate(PC)-type superplasticizers(PCs) which have carboxylic acid with $\pi$ bond among the molecular structure and polyethyleneglycol methyl ether methacrylate(PMEM) were synthesized by free radical reaction and investigated the chemical structure, polymerization condition, and physical and chemical properties. Also, the effects of PCs in the dispersion, adsorption and hydration of cement were evaluated. As the molecular weight of graft chain decreases, the adsorption amount on cement particles increased. It was advantageous for the flow to reduce molar ratio, the lower the side bone molecular weight, and increase the molar ratio, the larger the side bone molecular weight. The hydration reaction speed was highly delayed at day 1, due to increase in molar ratio and reduction in side bone molecular weight, but it was recovered in the days after.

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A Study for the Armor of General Jung, Gong-chung (정 공청 장군 유품에 대한 연구)

  • 배상경
    • Journal of the Korean Home Economics Association
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    • v.35 no.2
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    • pp.111-122
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    • 1997
  • This thesis researched for the conservation of a suit of armor, one glove, one belt, and on knife case that General Jung, Gong-chung had been worn in the early 17 th centuries. The armor was Doojung-kab for the battle. It was made of two kinds of fabrics, one of them was silk satin's outer fabrics, the other was quilt4d cotton's lining. as the armor was made of silk and cotton, it was treated by dry solvents and dry soap. In the dry cleaning method, used solvents were n-hexane, cyclohexane, benzene, and n-decane. the volume ratio of dry soap was 120: 1. The reaction temperature was 30℃, and reaction time was 10 to 30 minutes per one turn. The glove, belt and knife case were made with leather. They were dipped on the polyethyleneglycol 150 saturated solution during 24hours at 50℃ and then dried naturally. They were washed by toluene to remove the untreated pp.E.G. on the surfaces. It was sterilized by two gases of methylenebromide and ethyleneoxied. For the conservation, it was packed thoroughly by ? polyethylene film sheet without air.

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Durable Press Finish of Cotton via Dual Curing Using UV Light and Heat

  • Jang, Jinho;Yoon, Ki-Cheol;Ko, Sohk-Won
    • Fibers and Polymers
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    • v.2 no.4
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    • pp.184-189
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    • 2001
  • Continuous photografting/crosslinking of polyethyleneglycol dimethacrylate oligomers onto cotton using a water-soluble benzophenone photoinitiator was investigated. Photografting increased with increasing irradiation dose, oligomer concentration and photoinitiator concentration. Maximum grafting efficiency of DM 400 and 600 were 83% and 79%, respectively. the photografting increased the wrinkle resistance of cotton implying surface crosslinking of cotton. bothsurface crosslinking and bulk crosslinking of cotton were accomplished via dual curing of a mixed formulation containing both a thermally curable component (BTCCA/SHP) and a UV-curable component. The wrinkle resistance of the crosslinked cotton was found to be higher when cured by thermal curing due to the facile post-polymerization of the UV active component. The presence of crosslinks in the dually crosslinked cotton was verified with FT-IR and thermogravimetric analysis.

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Breathable Waterproof Finish of PET Fabrics via Microporous UV Coating of Polyurethane Diacrylate (폴리우레탄 디아크릴레이트의 미세다공성 UV코팅에 의한 PET 직물의 투습방수가공)

  • Koo, Gwang-Hoe;Jang, Jin-Ho
    • Textile Coloration and Finishing
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    • v.22 no.3
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    • pp.239-245
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    • 2010
  • Breathable waterproof PET fabrics were prepared by the UV coating of UV-curable polyurethaneacrylate(PUA) formulation mixed with polyethyleneglycol(PEG) as a water soluble pore former. The dispersed PEG in the UV-cured coating was extracted by warm water, which can generate individual circular pores uniformly distributed all over the coating instead of pore channels. Accordingly the moisture permeability of the microporously coated fabrics increased substantially with increasing PEG addition without significant reduction of hydrostatic pressure. Also the silicone diacrylate addition in the formulation was beneficial in increasing the hydrostatic pressure. The UV-based microporous coating can be an alternative to conventional thermal curing of solventborne polyurethane coating owing to the enhanced environment friendliness and energy saving.

Studies on Setting up of Radioimmunoassay System of Thyroid Stimulating Hormone (갑상선자극(甲狀腺刺戟)호르몬의 방사면역측정법(放射免疫測定法) 확립(確立)에 관한 연구(硏究))

  • Kim, Jae-Rok;Park, Kyung-Bae;Awh, Ok-Doo
    • The Korean Journal of Nuclear Medicine
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    • v.20 no.1
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    • pp.75-83
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    • 1986
  • Various TSH RIA kit components were prepared. Conditions for $^{125}I$ labelling of h-TSH were optimized by diminishing the amount of chloramine-T, ertending reaction time and lowering reaction temperature. Yield, specific activity, and immunological activity could be maintained moderately under such mild reaction conditions. The mixture of polyethyleneglycol(PEG) and second antibody worked effectively as a B/F separation agent. Even though the mixture was made with more diluted PEG and second antibody than those of using the sole component separately, the tine required for the B/F separation was shorter in case of using the mixture. The sequential saturation technique was efficient than those of applying ordinary equilibrium saturation technique in assay sensitivity and assay precision points of view.

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