• 제목/요약/키워드: Polyethylene Glycol

검색결과 687건 처리시간 0.032초

Enhancement of Dissolution from Pharmaceutical Preparation of Hydrophobic Drugs ( I ) -Characteristics of Sulpiride-Polyethylene Glycol Coprecipitates-

  • Ku, Young-Soon
    • Journal of Pharmaceutical Investigation
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    • 제12권4호
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    • pp.145-152
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    • 1982
  • Data from IR spectroscopy and X-ray diffractometry were used for the characterization of sulpiride polyethylene glycol coprecipitates related with polymorphism of sulpiride. Sulpiride Form II transformed to Form I during coprecipitating with polyethylene glycol and the transformation rate is increased in proportion to molecular size of polyethylene glycol and the content of polyethylene glycol in coprecipitate.

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실리콘 segment device로부터의 헤파린 방출에 미치는 폴리에틸렌글리콜의 영향 (Effect of Polyethylene Glycol on Release of Heparin from Silicone Segment Devices)

  • 김성호
    • 약학회지
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    • 제29권2호
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    • pp.70-75
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    • 1985
  • The influence of polyethylene glycol derivatives on heparin release from cylindrical monolithic type silicone segment devices was examined in physical saline solution. This water-soluble carrier caused the devices to absorb the water in aqueous media. The release rate of heparin from the devices was increased as molecular weight of polyethylene glycol was increased. Water soluble carrier incorporated into silitone segment devices permits controlled release of heparin that otherwise would be released extremly slowly from the polymer. Heparin released from the silicone segment containing polyethylene glycol showed the first-order kinetics. Without changing the release-pattern, the release rate of heparin could be controlled by varing molecular weight of polyethylene glycol, the water-soluble carrier and depleting polyethylene glycol on the outlayer of devices. The mechanism of release probably showed the creation of pore or microdomine through the devices secondary to the swelling.

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Polyethylene Glycol을 이용한 수침목재의 보존처리

  • 김용한
    • 보존과학연구
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    • 통권5호
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    • pp.179-188
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    • 1984
  • 본문은 Conservation of Water logged Wood(1979, Netherlands National Commission for UNESCO)중의 "The Use of Polyethylene glycol for the Treatment of Waterlogged wood-its Past and Future(Dr.C.Pearson)" 및 "The Conservation of ship wrecks by impregnation with Polyethylene glycol (Dr.J.deJong)"을 역편한 것임.

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ATRP(atom transfer radical polymerization)에 의한 polystyrene과 poly ethylene glycol methyl ether methacrylate(PEGMA)의 블록 공중합체의 합성 (Synthesis of block copolymer of polystyrene and polyethylene glycol methyl ether methacrylate(PEGMA) by ATRP (atom transfer radical polymerization))

  • 김상헌
    • 한국응용과학기술학회지
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    • 제26권3호
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    • pp.306-316
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    • 2009
  • In this study, block copolymer of polystyrene and polyethylene glycol methyl ether methacrylate(PEGMA) by ATRP(atom transfer radical polymerization) method was synthesized. 4 arm-molecule which contained halogen atom was synthesized for an initiator. With 4 arm-molecule monodispered polystyrene were synthesized by ATRP method. The molecular change of synthesized monodispersed polystyrene with respect to time was investigated and living polymer characteristic was confirmed. Block copolymer of polystyrene and polyethylene glycol methyl ether methacrylate(PEGMA) was synthesized by ATRP with macroinitiator which was synthesized from the monodispersed polystyrene(Mn=12000). The molecular weight of obtained PS-b-PEGMA was 22,000.

Polythylene glycol을 이용한 모의적 토양수분 조절방법이 목초의 발아에 미치는 영향과 유효성 (Effects of Drought by Polythylene glycol Solution on Seven Grasses Germination)

  • 윤세형
    • 한국초지조사료학회지
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    • 제10권2호
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    • pp.70-76
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    • 1990
  • The present study elucidates the effect of drught by polyethylene glycol solution on germination of five temperate and two tropical grasses. The results obtained can be summarized as follows: 1. The germination percentage of seven grasses decreased with increasing concentration of polythylene glycol. 2. The germination pattern hi higher concentration of polyethylene glycol showed similar trends to the emergence pattern under drought stress in soil condition. 3. The treatment of 30g is most useful at this study. Therefore, polythlene glycol was the appropriate to creat the drought condition of soil.

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소아의 만성 기능성 변비 치료에 polyethylene clycol 4000과 락툴로스의 효과 비교 (Comparison of polyethylene glycol 4000 and lactulose for treatment of chronic functional constipation in children)

  • 엄지현
    • Clinical and Experimental Pediatrics
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    • 제50권8호
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    • pp.752-756
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    • 2007
  • 목 적 : 만성 기능성 변비 환아의 치료에서 PEG 4000과 락툴로스의 임상적 효용성에 대해 비교 분석 하였다. 방 법 : 2004년 9월부터 2007년 2월까지 노원 을지병원 소아과에 만성 반복성 복통이나 배변 장애를 주소로 내원하여 만성 기능성 변비로 치료받고 1년간 외래 추적이 가능했던 환아 56명을 대상으로 하였다. 전해질이 함유되지 않은 PEG 4000을 투여한 24명의 환아와 락툴로스를 투여한 32명의 환아들을 대상으로 치료 시작시와 치료 1개월, 3개월, 6개월, 1년 후에 각 약물의 효과와 부작용에 대해 비교 분석하였다. 결 과 : 두 군 모두 배변 횟수가 치료전에 비해 유의하게 증가하였고(P<0.05), 복통 또한 치료 전에 비해 유의한 감소가 있었다(P<0.05). 치료를 시작한 시점에서 12개월이 되었을 때 변비와 유분증으로부터의 회복은 PEG 투여군에서는 12례(60%)에서, 락툴로스 투여군에서는 15례(57.7%)에서 있었으며 두 군 간에 유의한 차이는 없었다. 결 론 : 유소아 만성 변비에서 PEG 4000과 락툴로스는 장기적 유지 요법으로 안전하고 효과적인 약물이며 변비와 유분증으로부터의 회복에 두 군간에 유의한 차이는 없었다.

Polyethylene glycol이 3가크롬 전기도금에 미치는 효과 (The Effect of Polyethylene Glycol on the Trivalent Chromium Electroplating)

  • 이주열;;임성환;한승전;권식철
    • 한국표면공학회지
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    • 제44권1호
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    • pp.7-12
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    • 2011
  • The effect of organic additives, polyethylene glycol (PEG), on the trivalent chromium electroplating was analysed in the view point of current efficiency, solution stability and metallurgical structure. It was measured that PEG-containing trivalent chromium solution had about 10% higher current efficiency than pure solution and controlled the micro-crack density of electrodeposits. PEG exhibited profound effect on the solution stability by reducing the consumption rate of formic acid which acts as a complexant to lower the activation energy required for electrochemical reduction of trivalent chromium ions. It was also revealed that the formation of chromium carbide layer was facilitated in the presence of polyethylene glycol, which meant easier electrochemical codeposition of chromium and carbon, not single chromium deposition. Trivalent chromium layer formed from PEG-containing solution was amorphous with local nano-crystalline particles, which were prominently developed on the entire surface after non-oxidative heat treatment.

수성 2상계를 이용한 알파-아밀라제의 생산 (Production of $\alpha$-Amylase using Aqueous Two-Phase System)

  • 최준수;유영제
    • 한국미생물·생명공학회지
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    • 제16권5호
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    • pp.358-362
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    • 1988
  • 세포외 효소를 효율적으로 생산하기 위한 새로운 발효시스템으로서 수성 2상계를 시험하였다. 실험대상으로는 Bacillus amyloliquefaciens 균주에 의하여 $\alpha$-amylase를 생산하는 시스템을 선정하였다. Polyethylene glycol 5%, dextran 7%, 그리고 발효액이 88% 포함된 수성 2상계 발효시스템에 의하여 $\alpha$-amylase의 생합성은 25% 정도 증가하였으며 효소의 비활성화는 관찰되지 않았다. 또한 Polyethylene glycol 이 효소의 생합성을 증진시키는 것으로 관찰되었다. 효소의 생합성을 증가시키며 동시에 효소를 발효액으로부터 분리하기 위하여는 polyethylene glycol을 성장도중에, dextran은 효소의 활성이 최고에 달한 후에 발효액에 가하는 발효방법이 바람직하다.

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Sulpiride-Polyethylene Glycol Coprecipitates의 용출속도(溶出速度)에 관한 연구(硏究) (Enhancement of Dissolution from Pharmaceutical Preparation of Hydrophobic Drugs ( II ) -Dissolution Rates of Sulpiride-Polyethylene Glycol Coprecipitates-)

  • 구영순
    • Journal of Pharmaceutical Investigation
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    • 제13권3호
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    • pp.100-103
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    • 1983
  • Coprecipitates of sulpiride and polyethylene glycol (PEG) decrease the dissolution rate of sulpiride and the degree of decrease is reversely proportional to molecular size of PEG and proportional to increase of PEG ratios in coprecipitates. The physical mixtures of sulpiride and PEG increase the dissolution rate of sulpiride.

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Polyethylene과 Glycol-modified Polyethylene Terephthalate 용기내에서의 Chlorobutanol용액의 안정성 (The Stability of Chlorobutanol Solution in Polyethylene and Glycol-modified Polyethylene Terephthalate Containers)

  • 민신홍;권종원;정구충
    • Journal of Pharmaceutical Investigation
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    • 제16권1호
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    • pp.8-11
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    • 1986
  • There have been many difficulties in utilization of polyethylene (PE) container for volatile ingredients because of its high permeability. We selected glycol-modified polyethylene terephthalate (PETG) lately being used and evaluated the stability of 0.5% chlorobutanol solution for PETG. We used PE bottle, glass flask and rubber stoppered vial for comparison and assayed chlorobutanol contents of the samples stored at various temperatures for nine weeks by HPLC method. The results indicated that the stability of chlorobutanol in PETG container was almost similar to that in glass flask, and was superior to that in PE bottle and rubber stoppered vial.

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