• Journal of Yeungnam Medical Science
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• 제10권2호
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• pp.518-524
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• 1993

저자 등은 만성질환으로 인해 영양결핍 및 면역저하상태로 생각되는 75세 폐결핵환자에서 분선충의 대량의 자가감염을 객담, 분변에서 확인하여 치료하였으나 사망한 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 대한수의학회지
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• 제34권4호
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• pp.787-799
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• 1994

To elucidate morphologic lesion of porcine exudative epidermitis which is occurred sporadically in Korea, Staphylococcus hyicus subsp. hyicus isolated from the naturally affected pigs was inoculated to suckling pigs. The infected piglets were observed grossly and histopathologically. Although affected piglets were taking acute, subacute, or chronic course, some piglets suffered from chronic disease showed poor prognosis and marked growth depression. Affected peglets had erythematous skin on the face, ear, and abdomen and these localized lesions appear as brownish spots of exudative epidermitis and fromed crust in the early stage. But, after this stage, the skin were covered by viscous greasy exudate and formed blackish brown crust and appeared fissures and hypertrophy. Grossly, there has been hemorrhage with the removal of crust-like materials of epidermis and edematous subcutis. The superficial lymph nodes were edematous and swollen or congested and hemorrhagic. Some piglets had swollen ureters, cysts in the renal cortex, or polyarthritis. A few cases had mild edematous swelling of kidney, intestinal catarrh and congestion of brain. Microscopically, skin lesions had detachment of keralinized layer and parakeratosis of epidermis, hydropic degeneration of epidermal cell, and retrogressive degeneration of hair root sheath. Dermis had edema, and infiltration of neutrophils and mononuclear cells. As the disease was proceeded, there was marked perivasculitis with lots of mononuclear inflammatory cells. More chronic lesions formed granuloma-like bodies(nodules) due to more mononuclear, perivascular inflammatory cell infiltration and proliferation of fibroblast. Lots of plasma cells and eosinophils were also present in dermis. Epidermis was hyperplastic by proliferation of basal cells stratum germinativum and epidermal pegs often extended into the dermis. In secondary infection, lots of neutrophils could be seen in epidermis and derms. Kidney had neutrophilic infiltration, necrotic and cystic glomeruli, and dilation of renal tubules and ureters. Purulent arthritis was sometimes observed in joints. Three days old mice administrated Staphylococcus hyicus subsp hyicus subcutaneously before had focal congestion and hemorrhage, necrosis, and subcutaneous edema of the skin. This observation was also seen in the study of mice administrated exfoliatin toxin of Staphylococcus which evoked human staphylococcal scalded skin syndrome.

• 대한물리치료과학회지
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• 제10권1호
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• pp.180-189
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• 2003

The experiments were designated to evaluate the anti-nociceptive effect of low power laser stimulation on acupoint or non-acupoint using arthrogenic solution induced poly arthritis animal model. Evaluation of potential antinociceptive effect of low power laser on arthritis has employed measurements of the foot bending test, the development of either thermal or mechanical hyperalgesia following the arthritis induction. The analysis of thermal hyperalgesia includes Hargreaves's method. Randall-Sellitto test was utilized for evaluating mechanical hyperalgesia. In addition, the antinociceptive effect of low power laser stimulation on arthritis induced spinal Fos expression was analyzed using a computerized image analysis system. The results were summerized as follows: 1. In laser stimulation on acupoint treated animal, laser stimulation dramatically inhibited the development of pain in foot bending test as compared to those of non acupoint treated animal group and non treated animal group. 2. The threshold of thermal stimulation was significantly increased by low power laser stimulation on acupoint as compared to that of non treated control group. 3. Laser stimulation on acupoint dramatically attenuated the development of mechanical hyperalgesia as compared to that of non treated group. 4. Low power laser stimulation on acupoint significantly suppressed arthritis induced Fos expression in the lumbar spinal cord at 3 week post arthritis induction. In conclusion, the results of the present study demonstrated that low power laser stimulation on acupoint has potent anti-nociceptive effect on arthritis. Additional supporting data for an antinociceptive effect of laser stimulation was obtained using Fos immunohistochemical analysis on spinal cord section. Those data indicated that laser stimulation induced antinociception was mediated by suppression of spinal neuron activity in pain sensation.

• 대한두경부종양학회지
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• 제38권2호
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• pp.23-27
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• 2022

Systemic lupus erythematosus(SLE) is a multisystemic disorder of autoimmune etiology. SLE can occur commonly in young women, and the early symptoms include fever, myalgia, arthralgia, weight loss, lymphadenopathy and these nonspecific symptoms develop into skin rash, splenomegaly, serositis and encephalopathy. Diagnosis of SLE requires clinical and serologic criteria, and treatment choices are hydroxyquinolone and NSAIDs for mild disease, corticosteroids and immunosuppressant for severe disease. In lupus patient, the prevalence of lymphadenopathy is 12~59%. Although lymphadenopathy is common finding in SLE, it is hard to distinguish in early phase of SLE. A 38-year-old woman visited our hospital for cervical lymphadenopathy with polyarthritis and malaise. Multiple cervical lymph nodes enlargement was found on Neck CT, and serologic laboratory test including ANA, antiphospholipid antibody, and anti-dsDNA was positive. For excluding lymphoma, PET-CT and excisional biopsy were performed. The patient finally diagnosed with SLE, and got regular follow-up without complication.

• 대한약침학회지
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• 제5권1호
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• pp.91-103
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• 2002

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. characterized by leukocyte infiltration, a chronic inflammation of the joint, a pannus formation and the extensive destruction of the 3Iticular caJ1ilage and bone. Several proinflammatory cytokines such as tumor necrosis factor-${\alpa}$(TNF-${\alpa}$), interleukin-1${\beta}$ (IL-1${\beta}$) and interleukin 6 (IL-6) have been implicated in the pathological mechanisms of synovial tissue proliferation, joint destruction and programmed cell death in rheumatoid joint. In the Korean traditional medicine, Hominis placenta (HP) as an herbal solution of herb-acupuncture has been widely used to treat the inflammatory diseases including RA. In order to study the medicinal effect of HP herb-acupuncture on rheumatoid joint, an adjuvant-induced arthritis (AlA) was generated by the injection of 1.5 mg uf Mycobactelium tuberculusis. emulsified in squalene, 10 the base of the tail of Sprague-Dawley(SD) rats. After onset stage of polyarthritis, HP was daily injected to the Zusanti (ST36) acupuncture points in both of rat lags and the expression pattems of cytokines such as TNF-{\alpa}$, IL-1${\beta}$, and 1L-6 at the knee joint were analyzed using immunostaining and RT-PCR. The HP herb-acupuncture was found to be effective to alleviate the arthritic symptums in adjuvant-induced arthritic rats as regards the joint appearance and the expression profiles of inflammatory cytokines. In conclusion, therapeutic effects of HP herb-acupuncture on the rat with AlA might be related to anti inflammatory activities of the hurb-acupuncture.

• 동의생리병리학회지
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• 제17권2호
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• pp.346-351
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• 2003

The current studies investigated the therapeutic effects of Ephedra sinica Stapf (ES) herb-acupuncture on the inflammatory responses of rat arthritic joint, which was induced by the intradermal injection of heat-killed Mycobacterium tuberculosis emulsified in squalene to the base of the tail. The measurements of body weight and articular index were exploited as the assessment methods addressing arthritic symptoms, and the expression profiles of cytokines such as TNF-α, IL-1β and IL-6 in the rat joint were analyzed using RT-PCR. The articular indexes of arthritic rats were significantly restored after the treatment with ES herb-acupuncture. Although the clinical symptoms of arthritic rats were apparently alleviated by the ES treatments, their body weights were not recovered. It maybe due to the weight-loss and energy enhancement effects of ES extracts. The expression of TNF-α, IL-1β and IL-6 genes, which were highly stimulated in the knee joints of arthritic rats, were restored to the levels of normal rats after the ES treatment. The therapeutic effect of ES herb-acupuncture was not observed in ES-treated, non-acupoint arthritic group as a sham control. The ES herb-acupuncture into an acupoint ST36 was found to be effective in alleviating the arthritic symptoms in adjuvant-induced arthritis rats as regards the body weight, joint appearance and the expression profiles of inflammatory cytokines.

• 대한핵의학회지
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• 제36권4호
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• pp.255-260
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• 2002

목적: SAPHO 증후군은 전흉벽의 골관절에 주로 위치하는 혈청학적 검사상 음성을 보이면서 다양한 피부증상을 동반하는 골관절 질환으로 질병의 특성에 대한 폭넓은 이해를 통하여 조기진단을 함으로써 불필요한 수술이나 장기간의 비효율적인 항생제 치료를 피하는 것이 임상적으로 중요점이라 할 수가 있겠다. 이에 저자들은 SAPHO 증후군으로 진단받은 환자에서 골신티그라피의 소견의 특징을 알아보고 유용성을 알아보고자 하였다. 대상 및 방법: 다발성 관절통과 반복적으로 재발되는 피부증상이 있어 임상적으로 SAPHO 증후군으로 진단 받은 5명의 환자(모두 남자, $22.8{\pm}4.75$세)를 대상으로 하였다. 모든 환자에서 저에너지 고해상도 조준기가 장착된 이중헤드 감마카메라(ECAM, Siemens, Germany)를 이용하여 전신영상을 얻었고, 2명의 환자에서는 척추 관절의 이상 유무를 확인하기 위하여 SPECT 영상을 얻었다. 골신티그라피상 섭취증가를 보이는 관절을 알아보고 호발빈도와 단순 X선과 관절 침범 유무를 진단하는 성능을 비교하였다. 결과: 골신티그라피상 모든 환자에서 이상소견을 보인 관절은 흉쇄골 관절, 천장골 관절, 수부의 소관절이었다. 흉쇄골 관절이상은 양측성이 3/5 (60%)이고 일측성이 2/5 (40%)로 관찰되었다. 천장골 관절에서는 양측성이 4/5 (80%) 이고 일측성이 1/5 (20%)로 관찰되었다. 척추 관절의 이상은 4/5 (80%)에서 관찰되었는데 이 가운데 요추 이상은 4명 모두에서 볼수가 있었고 흉추의 이상은 3명, 경추의 이상은 1명에서 보여 척추에서는 요추의 침범이 가장 많았다. 척추골 SPECT는 2명에서 시행되었는데 추체나 척추경 보다는 후관절에 이상을 초래함을 평면영상에 비하여 보다 상세히 알 수가 있었다. 결론: SAPHO 증후군은 피부증상과 함께 다양한 골관절을 침범하는 질환으로 골신티그라피를 시행함으로써 관절의 이상을 조기에 진단하여 불필요한 수술이나 장기간의 비효율적인 항생제 치료를 피하는데 도움이 될 것으로 사료된다.

• Journal of Oral Medicine and Pain
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• 제30권1호
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• pp.107-119
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• 2005

측두하악관절 관절염은 골관절염, 골관절증, 다발성 관절염으로 나뉜다 골관절염과 골관절증은 관절통을 제외하면 그 증상, 징후, 방사선적 특징이 비슷하기 때문에 감별진단이 어렵다. 또한 초기 골관절염의 경우 방사선적 변화가 나타나지 않아서 오진을 할 수가 있다. 골스캔과 단광자방출 전산화 단층촬영은 골의 변화를 초기에 감지하는데 유용하다. 이 연구는 골스캔과 단광자방출 전산화 단층촬영을 이용하여 진단학적인 기준을 제시하기 위하여 시도되었다. 임상검사, 전산화단층 촬영, 골스캔, 단광자방출전산화 단층촬영을 실시한 304개의 측두하악관절을 대상으로 연구하였다. 연구결과 다음과 같은 결론이 도출되었다. 1. 골스캔을 이용하여 측두하악관절을 진단하는데 있어서 20대 환자의 단순섭취율이 1.397% 이상인 경우, 30$\sim$40대 환자의 단순섭취율이 1.332% 이상인 경우에는 골관절염으로 추정해 볼 필요가 있다. 2. 단광자방출 전산화단층 촬영을 이용하여 측두하악관절을 진단하는데 있어서 온점이 관찰되는 관상단면, 횡단면이 4개 이상일 경우에는 골관절염으로 추정해 볼 필요가 있다. 3. 골스캔을 이용하여 측두하악관절을 진단하는데 있어서 20대 환자의 단순섭취율이 1.370% 이상인 경우, 30-40환자의 단순 섭취율이 1.104% 이상인 경우에는 골파괴 과정이 진행중인 것으로 생각해 볼 필요가 있다. 4. 단광자방출 전산화단층 촬영을 이용하여 측두하악관절을 진단하는데 있어서 20대와 30-40대에서 온점이 관찰되는 관상단면이 4개 이상일 경우에는 골파괴 과정이 진행중인 것으로, 모든 연령에서 온점이 관찰되는 횡단면이 3개 이상일 경우에는 골파괴 과정이 진행 중인 것으로 생각해 볼 필요가 있다. 5. 임상적으로 주관적 관절통과 촉진통이 모두 나타난 경우에 골변화가 더욱 활발할 가능성이 높다. 6. 관절음, 관절통, 개구제한의 병력이 4.5개월까지 점차 길어질 수록 측두하악관절은 골관절염으로 점차 악화되고, 그 이후에는 골관절증으로 점차 안정화되는 경향을 보였다.