• 대한치과보철학회지
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• 제57권1호
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• pp.8-17
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• 2019

목적: 본 연구의 목적은 최근 5년간 식립된 임플란트 증례를 대상으로 임플란트 주위염의 유병률을 조사하고, 질환 발생에 영향을 미칠 수 있는 요소들을 분석, 평가하는 것이다. 대상 및 방법: 2012년 1월 1일부터 2016년 12월 31일까지 이화여자대학교 의과대학 부속 목동병원 치과진료부 치주과에 내원한 환자 중 본원에서 임플란트를 식립하고 보철수복을 시행한 환자 422명(853개 임플란트)에 대한 의료기록과 방사선 사진을 바탕으로 임플란트 주위염의 유병률을 조사하고 임플란트 주위염에 영향을 미칠 수 있는 요소와의 연관성을 분석하였다. 각 위험요소와 임플란트 주위염의 통계적 연관성을 분석하기 위해 일반화추정방정식(generalized estimation equations, GEE)을 사용하여 각 변수들과 임플란트 주위염의 발생 사이 상관관계를 평가하였다. 또한 관찰 기간 중 임플란트 주위염의 누적 유병률은 Kaplan Meier Method를 사용하였다. 결과: 임플란트 주위염의 유병률은 환자 수준에서 7.3% (422명 중 31명), 임플란트 수준에서 5.5% (853개 중 47개)로 나타났다. 성별, 골유도재생술(guided bone regeneration, GBR)여부, 보철물 부하기간이 임플란트 주위염의 발생과 통계적 상관관계를 갖는 것으로 나타났다. 부하기간에 따른 임플란트 주위염의 누적 유병률을 분석한 결과 보철물 장착 후 19개월째 첫 임플란트 주위염이 발생하였고, 이후로 임계점(critical point) 없이 위험도는 시간에 따라 전반적으로 상승하는 양상을 보였다. 결론: 임플란트 주위염의 유병률은 환자수준에서 7.3%, 임플란트 수준에서 5.5%로 나타났으며, 남성, GBR을 시행한 경우, 보철물 부하기간이 길수록 임플란트 주위염의 발생 위험도가 증가한다.

• Journal of Preventive Medicine and Public Health
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• 제21권1호
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• pp.89-98
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• 1988

While there have been not a few reports on the seroepidemiological characteristics of hepatitis B virus (HBV) infection in Korea, most of them, however, have had several limitations; operational definition of HBV infection, validity of detection methods of HBV serologic markers, size of the study population, and confirmation of the vaccination history against HBV, etc. In order to avoid such limitations, authors randomly selected 1,495 healthy adults among the 217,511 insured (target population) of Korean Medical Insurance Corporation, living in seoul, and tested HBV serologic markers by RIA method and conducted direct interview to them. Although HBV serologic markers (HBsAg, anti-HBs and anti-HBc) of all the subjects were tested, 392(26.2%) of interview failure cases and 361 vaccinee were excluded from the actual population. Finally, the serologic markers tested of 742 nonvaccinee (study population) only were analysed for the seroepidemiologic observation of the natural infection of HBV. The seroepidemiological characteristics of HBV infection in Korea were as follows ; 1. Point prevalence of HBs antigenemia was 11.7(9.1{\sim}14.3)% in male, which was slightly higher than that of female, 9.5($3.7{\sim}15.3$)%. This level was one of the highest among those of Asian-Pacific countries. Decreasing tendency of HBsAg prevalence alter the age of 50 was observed, which seems to be due to selective attrition of HBV chronic carriers among the healthy adults and/or to the limited-lasting duration of the HBs antigenemia, in part. 2. Point prevalence of anti-HBc(78.8% in male,50.9% in female) was higher than that of anti-HBs(65.2% in male,46.6% in female), respectively. And both of them were higher in male than in female. Increasing tendency of the prevalence of both antibodies was observed by age, which seems to be largely due to recurrent infection in adults and to some cumulative effect, in part, of their relatively longer-lasting duration. 3. The level of HBV infection defined by positive for at least one of the 3 serologic markers of HBV by RIA method was 84.7($81.8{\sim}87.6$)% in male and 61.2($51.9{\sim}70.5$)% in female, which was also one of the highest among those of Asian-Pacific countries. The proportion of susceptible population to HBV infection among healthy adults was 15.3% in male and 38.8% in female. 4. The relative frequency of current or past infection and chronic carrier among HBV infected person was estimated. The currently or past infected was estimated 75.7% in male and 71.8% in female, and chronic carrier state, 13.8% in male and 14.1% in female. The analysis of the geometric mean of the antibody titer in anti-HBs positive sera indicated also to be compatible with the above findings, suggesting that active, even though inapparent, infection of HBV occur so frequently among healthy adults in Korea.

• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8281-8285
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• 2016

Background: Helicobacter pylori is a cause of chronic gastritis, peptic ulcer disease, and gastric malignancy, infection being a serious health problem in Thailand. Recently, clarithromycin resistant H. pylori strains represent the main cause of treatment failure. Therefore this study aimed to determine the prevalence and pattern of H. pylori resistance to clarithromycin in Suranaree University of Technology Hospital, Suranree University of Technology, Nakhon Ratchasima, Northeastern Thailand, Nakhon Ratchasima province, northeast of Thailand. Materials and Methods: This hospital-based cross-sectional study was carried out between June 2014 and February 2015 with 300 infected patients interviewed and from whom gastric mucosa specimens were collected and proven positive by histology. The gastric mucosa specimens were tested for H. pylori and clarithromycin resistance by 23S ribosomal RNA point mutations analysis using real-time polymerase chain reactions. Correlation of eradication rates with patterns of mutation were analyzed by chi-square test. Results: Of 300 infected patients, the majority were aged between 47-61 years (31.6%), female (52.3%), with monthly income between 10,000-15,000 Baht (57%), and had a history of alcohol drinking (59.3%). Patient symptoms were abdominal pain (48.6%), followed by iron deficiency anemia (35.3%). Papaya salad consumption (40.3%) was a possible risk factor for H. pylori infection. The prevalence of H. pylori strains resistant to clarithromycin was 76.2%. Among clarithromycin-resistant strains tested, all were due to the A2144G point mutation in the 23S rRNA gene. Among mutations group, wild type genotype, mutant strain mixed wild type and mutant genotype were 23.8%, 35.7% and 40.5% respectively. With the clarithromycin-based triple therapy regimen, the efficacy decreased by 70% for H. pylori eradication (P<0.01). Conclusions: Recent results indicate a high rate of H. pylori resistance to clarithromycin. Mixed of wild type and mutant genotype is the most common mutant genotype in Nakhon Ratchasima province, therefore the use of clarithromycin-based triple therapy an not advisable as an empiric first-line regimen for H. pylori eradication in northeast region of Thailand.

• 농촌의학ㆍ지역보건
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• 제5권1호
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• pp.16-27
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• 1980

Five hundred seventeen farmers(214 males and 303 females), over age 30 and living in Suh San County, Unsan township, were examined to determine the prevalence of peasants syndrome. Using the health interview questionnaire, the farmers were asked whether they had any of eight subjective symptoms during the past one month before the survey, October 1979. Those symptoms reported were scored based on a pre-determined point system. The farmers with high symptom scores(7 points or more) were further examined by the liver function test. In addition, all the sample(517 cases) were subjected to the examination of urinalysis and blood pressure. The liver function test is also undertaken for those farmers with high symptome scores(7 points or more) and those with abnormal findings in urinalysis and blood pressure. The results are summarized below: 1) 156 out of 517 farmers(30.2%) have had seven points or more of the symptom scores. Among the eight major symptoms, 72% of the farmers complained of lumbago. 2) The prevalence of peasant's syndrome were higher among females and the older age group. The symptom scores of this syndrome were slightly higher among women who have had many children (e. g. 4 or more). 3) The prevalence of peasant's syndrome was also related to the level of one's education-the lower education groups were found to have higher symptom scores of this syndrome. This may be due to the fact that the lower education groups are more exposed to manual labor. 4) The points of the peasants syndrome were higher in hypertensive farmers and those with abnormal findings of urinaly sis. 5) It was reported, in Japan, that those with high scores of the syndrome are more likely to have an abnormal findings in the liver function test. However, in this study it was observed that there was no significant difference between those with high scores of the syndrome (7 points or more) and those with low score of the syndrome(6 points or less) in the prevalence of abnormal liver function. As this study indicates that the point system given for the peasant's syndrome is closely related to the high bleod pressure and abnormal urinalysis(and to some extent to the abnormal liver function), there is a need to study peasant's syndrome more extensively. Such an effort will serve to detect varonic disease conditions among farmer's towards better management of farmer's health, which is vitally important for rural development in Korea.

• 대한수의학회지
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• 제49권2호
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• pp.149-155
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• 2009

The objective of this study was to analyze data from the planned national serological monitoring program for Aujeszky's disease (AD) using a simulation model to evaluate probable outcomes expected in the sample derived from the simulated herds at predefined within-herd prevalence and herd prevalence. Additionally, prevalence at animal- and herd-level estimated by the stochastic simulation model based on the distributions of the proportion of infected herds and test-positive animals was compared with those of data from a national serological survey in 2006, in which 106,762 fattening pigs from 5,325 herds were tested for AD using a commercial ELISA kit. A fixed value of 95% was used for test sensitivity, and the specificity was modeled with a minimum, most likely and maximum of 95, 97 and 99%, respectively. The within-herd prevalence and herd prevalence was modeled using Pert and Triang distributions, respectively with a minimum, most likely and maximum point values. In all calculations, population size of 1,000 was used due to lack of representative information. The mean number of infected herds and true test-positives was estimated to be 27 herds (median = 25; 95% percentile 44) and 214 pigs (median = 196; 95% percentile 423), respectively. When testing 20 pigs (mean of 2006 survey) in each herd, there was a 3.3% probability that the potential for false-positive reactions due to less than 100% specificity of the ELISA test would be detected. It was found that the model showed prevalence of 0.21% (99% percentile 0.50%) and 0.5% (99% percentile 0.99%) at animal- and herd-level, respectively. These rates were much similar to data from the 2006 survey (0.62% versus 0.83%). The overall mean herd-level sensitivity of the 2006 survey for fattening pigs was 99.9%, with only a 0.2% probability of failing to detect at least one infected herd.

• 기술혁신학회지
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• 제6권4호
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• pp.447-461
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• 2003

Over the past 10 years, AIDS has grown to become one of the major health problems in Korea. This paper reviews the current status of the prevalence of AIDS, AIDS law and policy in Korea. This paper also suggests some proposals for policy to reduce HIV transmission from the view point of personal rights and welfare. Korea needs more effective national AIDS prevention and control programs applicable to the current situations of health policy in Korea. The activities of NGOs would be as important as those of government.

• 한국IT서비스학회지
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• 제11권3호
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• pp.227-240
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• 2012

Given the prevalence of internet and web 2.0, SNS(Social Network Service) market is growing rapidly. IT providers which focused marketing point on network hub have become to disseminate SNS mainly now. Many users are using the various functions of SNS to communicate each other or share the information. At this point, identifying the influencing factors to WOM(Word-Of-Mouth) of SNS is very important. In this paper, we aim to examine the effects of perceived variables on the WOM of SNS. In order to analyze the antecedents, we selected perceived factors such as perceived usefulness, perceived easiness, perceived enjoyment and perceived crowd. For statistical analysis, we surveyed real users of SNS. As a result, all antecedents of WOM showed significant influence and among the variables the perceived enjoyment has top standardized coefficient. In addition, perceived crowd has significant on perceived easiness, perceived enjoyment but not on perceived usefulness. The result of this research can be useful guidelines to increase SNS Market.

• 대한간호학회지
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• 제45권1호
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• pp.118-128
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• 2015

Purpose: Evidence suggests that some patients with breast cancer experience cognitive difficulties following chemotherapy. This longitudinal study was done to examine the prevalence of cognitive impairment and trajectory of cognitive function over time in women with breast cancer, who received adjuvant chemotherapy. Methods: Participants were 137 patients with breast cancer. They completed neuropsychological tests and the Functional Assessment of Cancer Therapy-Cognitive Function before adjuvant therapy (pretest), toward the end of adjuvant therapy (posttest), and 6 months after the completion of adjuvant therapy (follow-up test). Of the patients, 91 were treated with adjuvant chemotherapy and 46 patients who did not receive chemotherapy made up the comparison group. A reliable-change index and repeated-measure ANOVA were used for statistical analyses. Results: At the posttest point, over 30% of patients showed complex cognitive impairment and reported greater difficulty in subjective cognitive function. At the follow-up test point, 22.0% of patients exhibited complex cognitive impairment and 30.8% of patients complained of subjective cognitive impairment. Repeated-measure ANOVA showed significant decreases after receiving chemotherapy followed by small improvements 6 months after the completion of chemotherapy in cognitive domains of change for attention and concentration, memory, executive function, and subjective cognitive function. Conclusion: These results suggest that chemotherapy in patients with breast cancer may be associated with objective and subjective cognitive impairments. Further studies are needed to explore the potential risk factors and predictor of chemotherapy-related cognitive changes. Also nursing interventions for prevention and intervention of cognitive impairments should be developed and tested.

• 대한예방한의학회지
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• 제19권3호
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• pp.1-10
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• 2015

Objectives : The purpose of this study was to reveal the prevalence of Mibyeong and its symptoms including fatigue, pain, sleep disturbance, dyspepsia, depression, anxiety and anger by using the national survey. Methods : Questionnaires were collected by Gallup Korea. Participants were chosen through stratified sampling method based on area, gender and age. Questionnaire was designated to confirm the recognition, managing of Mibyeong, investigation of life habit, medical history, basic information, QoL questionnaires (Short Form-12, EuroQol-5D) and understanding of Mibyeong medical service conditions. Generally all questionnaires were used for survey the Mibyeong status in public except QoL questionnaires. Questionnaires were fulfilled by professional surveyor as face to face interview. Descriptives was used for data analysis and the results were expressed as percentage ratios (%) Results : 1,101 of people were acquired in this study. Eighty point two (80.2%) percent of participants did not know the concept of Mibyeong accurately even though 80.6% complained of Mibyeong related symptoms. Among them, fatigue was accounted for the highest response (70.7%)in this study. Sixty point four percent of participants identified non-smoking, stop drinking, eating habits and sleeping habits as a way to manage their Mibyeong related symptoms. In addition, exercising (60.8%), visiting medical institution (58.4%) and taking health functional food (52.7%) were presented. Only 23.1% among people with symptoms Mibyeong visited medical facilities. Moreover, the quality of life was found to be significantly correlated with health status. Conclusions : This study could contribute to express the importance of announcing the concept of Mibyeong and status to Korean public. Moreover, more Mibyeong studies should be conducted in the future to evaluate the Mibyeong status objectively.

• Clinical and Experimental Pediatrics
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• 제57권4호
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• pp.186-192
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• 2014

Purpose: The prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) has increased worldwide. The aim of this study was to estimate the proportion of MRMP in a tertiary hospital in Korea, and to find potential laboratory markers that could be used to predict the efficacy of macrolides in children with MRMP pneumonia. Methods: A total of 95 patients with M. pneumoniae pneumonia were enrolled in this study. Detection of MRMP was based on the results of specific point mutations in domain V of the 23S rRNA gene. The medical records of these patients were reviewed retrospectively and the clinical course and laboratory data were compared. Results: The proportion of patients with MRMP was 51.6% and all MRMP isolates had the A2063G point mutation. The MRMP group had longer hospital stay and febrile period after initiation of macrolides. The levels of serum C-reactive protein (CRP) and interleukin-18 in nasopharyngeal aspirate were significantly higher in patients who did not respond to macrolide treatment. CRP was the only significant factor in predicting the efficacy of macrolides in patients with MRMP pneumonia. The area under the curve for CRP was 0.69 in receiver operating characteristic curve analysis, indicating reasonable discriminative power, and the optimal cutoff value was 40.7 mg/L. Conclusion: The proportion of patients with MRMP was high, suggesting that the prevalence of MRMP is rising rapidly in Korea. Serum CRP could be a useful marker for predicting the efficacy of macrolides and helping clinicians make better clinical decisions in children with MRMP pneumonia.