• Membrane Journal
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• v.29 no.6
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• pp.348-354
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• 2019

Recently, the application range of organic solvent nanofiltration (OSN) technology has been expanding, requiring membranes with better performance. In this work, thin film composite (TFC) OSN membrane was fabricated. First, ultrafiltration support membrane was prepared via nonsolvent-induced phase separation (NIPS) technique using polysulfone (PSf) and polyethersulfone (PES). Then, the effect of pore forming additives such as polyvinylpyrrolidone (PVP) and pluronic F-127 were employed to improve the membrane permeance. The well-known interfacial polymerization technique was employed using MPD-TMC chemistry to form a thin film on top of the fabricated support, and its solvent permeance and nanofiltration performance was characterized. It was found that polyethersulfone support exhibited more reliable performance compared to polysulfone, and PVP additive was more effective compared to Pluronic F-127. As for the oSN performance, polar aprotic solvents like acetonitrile show significantly higher flux (986.5 L·m^-2·h^-1·bar^-1) compared to water and EtOH (9.5 L·m^-2·h^-1·bar^-1).

• Proceedings of the Polymer Society of Korea Conference
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• 2006.10a
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• pp.252-252
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• 2006

Utilizing the existence of the induction period in photo-polymerization, we propose a new injection method of photo-polymerizable, thermocrosslinking hydrogels made of di-acrylated Pluronic F127 (DA-PF127). This method can solve the problem of fast dissolution of thermal gelation as a scaffold and the disadvantages of the existing injection method that photo-polymerize di-acrylated Pluronic polymer after injection using optical fiber. Injectable gelation of DA-PF127 by the proposed method was demonstrated both in vitro and in vivo. The enhanced stability by this novel photo-polymerization strategy was confirmed by the more sustained release of loaded protein as well as the prolonged degradation time of the hydrogels.

• Journal of Pharmaceutical Investigation
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• v.20 no.3
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• pp.121-127
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• 1990

Mefenamic acid has been widely used clinically as an anti-inflammatory analgesic. It has poor solubility in water $(41\;{\mu}g/ml)$ and there is the difficulty of dissolution in the mefenamic acid capsules. A study was made to investigate the effect of various surfactants on the dissolution of mefenamic acid capsules. The surfactants used were sodium lauryl sulfate (SLS), Pluronic F-68, F-77, and F-127. Mefenamic acid capsule containing surfactant showed significantly improved dissolution characteristics. The dissolution rate was fast in the order of SLS > F-77 > F-68 > F-127 in mefenamic acid capsules containing 0.2 w/w % surfactant. SLS was selected for further study on the bioavailability in rabbits. The area under the plasma concentration-time curve $(AUC_{0-24})$ of mefenamic acid capsule containing SLS was higher than one of mefenamic acid capsule not containing surfactant.

• Bulletin of the Korean Chemical Society
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• v.33 no.12
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• pp.4261-4264
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• 2012

• Journal of Pharmaceutical Investigation
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• v.39 no.3
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• pp.167-171
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• 2009

Poly(lactic-co-glycolic acid) (PLGA) microspheres have been a useful tool as a controlled drug delivery system for peptides and proteins. Recently, porous microspheres have gained great attention as inhalation drug delivery system due to their low aerodynamic densities. Here, we report highly porous PLGA microspheres, which were prepared by using a single o/w emulsification/solvent evaporation method. Two types of porogen, i.e., (i) extractable Pluronic F127 and (ii) gas foaming salt of ammonium bicarbonate, were used to induce pores on the surface of PLGA microspheres. The respective preparation conditions on dp/cp ratio and porogen concentration were determined by the previous preliminary experiments, and other preparation factors were further optimized on the basis of PLGA Mw and porogen type. The morphological features examined by scanning electron microscope (SEM) show these porous microspheres have highly porous surface structure with a diameter range of 20${\sim}$30 ${\mu}$m. These highly porous PLGA microspheres, which have much lower density, would be a practical aerosol system for pulmonary drug delivery.

• Journal of the Korean Applied Science and Technology
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• v.31 no.3
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• pp.367-374
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• 2014

In this study, skin permeation enhancement was confirmed by designing it to have a structure and composition similarity to the intercellular lipids that improve miscibility with skin by cross-linked lipids poloxamer. The cross-linked lipids poloxamer was synthesized and analyzed by 1H NMR that structure dose had conjugated pluronic with ceramide3. Active component is released by modification of liquid crystal structure because PPO part, large-scale molecule block of pluronic, has hydrophobic nature at skin temperature of $35^{\circ}C$. Conjugated pluronic with ceramide3 was synthesized using Pluronic F127 and p-NPC (4-nitrophenyl chloroformate) at room temperature yielded 89%. Pluronic(Ceramide 3-conjugated Pluronic) was synthesized by reaction of p-NP-Pluronic with Ceramide3 and DMAP. The yield was 51%. This cross-linked lipids poloxamer was blended and dissolved at isotropic state with skin surface lipids, phospholipid, ceramide, cholesterol and anhydrous additive solvent. Next step was preceded by ${\alpha}$-Transition at low temperature for making the structure of Meso-Phase Lamella, and non-hydrous skin analogue liquid crystal using thermo-sensitivity smart sensor, lamellar liquid crystal structure through aging time. For confirmation of conjugation thermo-sensitivity smart sensor and non-hydrous skin analogue liquid crystal, structural observation and stability test were performed using XRD(Xray Diffraction), DSC(Differential Scanning Calorimetry), PM (Polarized Microscope) And C-SEM (Cryo-Scanning Electron Microscope). Thermo-sensitivity observation by Franz cell revealed that synthesized smart sensor shown skin permeation effect over 75% than normal liquid crystal. Furthermore, normal non-hydrous skin analogue liquid crystal that not applied smart sensor shown similar results below $35^{\circ}C$ of skin temperature, but its effects has increased more than 30% above $35^{\circ}C$.

• Applied Chemistry for Engineering
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• v.32 no.2
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• pp.219-223
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• 2021

Considering the current COVID 19 pandemic, herein, we developed a material that can be used to fabricate a device for checking the body temperature of a person who has been exposed to influenza or corona virus. This material was formed by mixing pluronic F127 (F127) with a polydiacetylene (PDA) vesicle, which was formed with 10,12-pentacosadiynoic acid. The color of the system started to change from blue to light purple at 37 ℃, finally turning reddish at 40 ℃. Thus, the developed material can be used to detect changes in body temperature, and thus, detect signs of fever. The mixing ratio of the PDA vesicle and F127 was an important factor for controlling the temperature at which the color change started. The results showed that the color change accompanied by the separation of the PDA vesicle with F127. We believe that this phenomenon plays an important role in reducing the conjugation length in the double and triple bond of PDA.

• Korean Journal of Microbiology
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• v.28 no.3
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• pp.274-277
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• 1990

The hyphal tip phenoloxidases of Coprinus congregatus were localized by the protoplast-concanavalin A method. Protoplast were generated from cultures grown on a solid medium which was solidified with a new gelling agent, Pluronid Polyol F127, instead of agar. the enzymes were associated with the cell membrane which might work as a transducer in the light recepter complex.

• Macromolecular Research
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• v.17 no.12
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• pp.1025-1031
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• 2009

Several kinds of biodegradable hydrogels were prepared via in situ photopolymerization of Pluronic F127/poly($\varepsilon$-caprolactone) macromer and acrylic acid (AA) comonomer in aqueous medium. The swelling kinetics measurements showed that the resultant hydrogels exhibited both thermo- and pH-sensitive behaviors, and that this stimuli-responsiveness underwent a fast reversible process. With increasing pH of the local buffer solutions, the pH sensitivity of the hydrogels was increased, while the temperature sensitivity was decreased. In vitro hydrolytic degradation in the buffer solution (pH 7.4, $37^{\circ}C$), the degradation rate of the hydrogels was greatly improved due to the introduction of the AA comonomer. The in vitro release profiles of bovine serum albumin (BSA) in-situ embedded into the hydrogels were also investigated: the release mechanism of BSA based on the Peppas equation was followed Case II diffusion. Such biodegradable dual-sensitive hydrogel materials may have more advantages as a potentially interesting platform for smart drug delivery carriers and tissue engineering scaffolds.

• Polymer(Korea)
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• v.36 no.2
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• pp.163-168
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• 2012

Recently, along with technology development of endoscopic equipment, the stent technology has been developed for the convenience of operation, shortening of recovery times, and reduction of patient's pain. In this study, paclitaxel-eluting metal stents for treatment of biliary benign stenosis were developed through an electrospray-coating method. Polyether-based polyurethane (PELLETHANE 2363-80AE$^{(R)}$)) and paclitaxel were coated onto the surface of a metallic stent and Pluronic F127 was used as an additive. As a result, physicochemical characterization of paclitaxel via SEM, FTIR, contact angle and XRD techniques revealed the information of solid state of paclitaxel-loaded PU film. The in vitro release profile showed a slower release rate with a higher content of paclitaxel.