• Journal of Korean Neurosurgical Society
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• 제50권4호
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• pp.288-292
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• 2011

Objective : Matrix metalloproteinases (MMPs), especially MMP-2 and MMP-9 have been known to play an important role in secondary inflammatory reaction after spinal cord injury (SCI). The aim of this study was to investigate the expression and activity of MMP-2 and MMP-9 and to determine their relationship with disruption of endothelial blood-barrier after photochemically induced SCI in rats. Methods : Female Sprague-Dawley rats, weighing between 250 and 300 g (aged 8 weeks) received focal spinal cord ischemia by photothrombosis using Rose Bengal. Expressions and activities of MMP-2 and MMP-9 were assessed by Western blot and gelatin zymography at various times from 6 h to 7 days. Endothelial blood-barrier integrity was assessed indirectly using spinal cord water content. Results : Zymography and Western blot analysis demonstrated rapid up-regulation of MMP-9 protein levels in spinal cord after ischemic onset. Expressions and activities of MMP-9 showed a significant increased at 6 h after the photothrombotic ischemic event, and reached a maximum level at 24 h after the insult. By contrast, activated MMP-2 was not detected at any time point in either the experimental or the control groups. When compared with the control group, a significant increase in spinal cord water content was detected in rats at 24 h after photothrombotic SCI. Conclusion : Early up-regulation of MMP-9 might be correlated with increased water content in the spinal cord at 24 h after SCI in rats. Results of this study suggest that MMP-9 is the key factor involved in disruption of the endothelial blood-barrier of the spinal cord and subsequent secondary damage after photothrombotic SCI in rats.

• Wind and Structures
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• 제20권6호
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• pp.763-791
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• 2015

"Wind and Ports" is a European project that has been carried out since 2009 to handle wind forecast in port areas through an integrated system made up of an extensive in-situ wind monitoring network, the numerical simulation of wind fields, the statistical analysis of wind climate, and algorithms for medium-term (1-3 days) and short term (0.5-2 hours) wind forecasting. The in-situ wind monitoring network, currently made up of 22 ultrasonic anemometers, provides a unique opportunity for detecting high resolution thunderstorm records and studying their dominant characteristics relevant to wind engineering with special concern for wind actions on structures. In such a framework, the wind velocity of thunderstorms is firstly decomposed into the sum of a slowly-varying mean part plus a residual fluctuation dealt with as a non-stationary random process. The fluctuation, in turn, is expressed as the product of its slowly-varying standard deviation by a reduced turbulence component dealt with as a rapidly-varying stationary Gaussian random process with zero mean and unit standard deviation. The extraction of the mean part of the wind velocity is carried out through a moving average filter, and the effect of the moving average period on the statistical properties of the decomposed signals is evaluated. Among other aspects, special attention is given to the thunderstorm duration, the turbulence intensity, the power spectral density and the integral length scale. Some noteworthy wind velocity ratios that play a crucial role in the thunderstorm loading and response of structures are also analyzed.

• 한국게임학회 논문지
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• 제5권3호
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• pp.17-24
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• 2005

디지털미디어의 상호작용성의 특징은 전통적인 스토리텔링을 변화시켜 디지털 스토리텔링이라는 새로운 개념으로 자리 잡고 있다. 게임 스토리텔링은 영화나 애니메이션의 전개방식과는 달리 개방형스토리 전개방식(open ended design)을 택하고 있으며, 플레이어 캐릭터(player character)의 선택(player's decision)에 따라 무한개의 스토리를 만들어 낼 수 있다. 가장 스토리 중심적인 RPG장르에서 캐릭터를 중심으로 한게임 스토리텔링 구조를 제안하고, 다양한 스토리 밸류(Story value)를 가지고 디자인되어 있는 캐릭터들이 게임 스토리텔링 구조(Game Storytelling Structure) 속에서 플레이어의 흥미와 몰입을 가져오는 배경이야기(Background Story), 판타지적인 게임월드(Game World)과 그 속에서 발생하는 사건(Event)들과 어떻게 상호작용하는지 사례를 통해 분석하였다. 본 연구는 예측 가능한 게임 메카닉(game mechanics)설계와 특별한 목표를 가지고 있는 게임인 경우 게임 플레이를 통제할 수 있는 수단이 되는 필수적인 작업이다.

• Biomolecules & Therapeutics
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• 제24권2호
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• pp.199-205
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• 2016

This study aimed to investigate the in vivo relevance of P-glycoprotein (P-gp) in the pharmacokinetics and adverse effect of phenformin. To investigate the involvement of P-gp in the transport of phenformin, a bi-directional transport of phenformin was carried out in LLC-PK1 cells overexpressing P-gp, LLC-PK1-Pgp. Basal to apical transport of phenformin was 3.9-fold greater than apical to basal transport and became saturated with increasing phenformin concentration ($2-75{\mu}M$) in LLC-PK1-Pgp, suggesting the involvement of P-gp in phenformin transport. Intrinsic clearance mediated by P-gp was $1.9{\mu}L/min$ while passive diffusion clearance was $0.31{\mu}L/min$. Thus, P-gp contributed more to phenformin transport than passive diffusion. To investigate the contribution of P-gp on the pharmacokinetics and adverse effect of phenformin, the effects of verapamil, a P-gp inhibitor, on the pharmacokinetics of phenformin were also examined in rats. The plasma concentrations of phenformin were increased following oral administration of phenformin and intravenous verapamil infusion compared with those administerd phenformin alone. Pharmacokinetic parameters such as $C_{max}$ and AUC of phenformin increased and CL/F and Vss/F decreased as a consequence of verapamil treatment. These results suggested that P-gp blockade by verapamil may decrease the phenformin disposition and increase plasma phenformin concentrations. P-gp inhibition by verapamil treatment also increased plasma lactate concentration, which is a crucial adverse event of phenformin. In conclusion, P-gp may play an important role in phenformin transport process and, therefore, contribute to the modulation of pharmacokinetics of phenformin and onset of plasma lactate level.

• 대기
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• 제30권3호
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• pp.221-236
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• 2020

The Gangneung region has the complicated geographical characteristics being adjacent to East Sea and Taeback mountains, and thus sea breeze could play an important role in local weather in various aspects. This study aims to understand overall characteristics of sea breeze largely based on long-term (2009~2018) ground-based observation data. We also propose a selection criteria of sea breeze occurrence day; 1) daily precipitation is less than 10 mm, 2) surface wind direction is 0~110° (northerly to easterly) for more than 3 hours during the daytime, 3) wind direction is 110~360° for more than 3 hours during the nighttime, and 4) land and sea temperature difference is positive during the daytime, 5) sea and land sea-level pressure difference is more than 0.5 hPa. As a result, a total of 595 days was selected for the past 10 years. The occurrence of sea breeze is the highest in late Spring to early Summer (May to June). The passage time of sea breeze at the inland station (1.6 km farther inland) is one hour later than the coastal station. On the typical sea breeze event of April 12, 2019, the passage speed and duration of sea breeze was 15 km hr^-1 and about 9 hours, respectively, with its depth of about 500 m and its head swelling. The current results emphasize the critical role of sea breeze in forecasting surface temperature and wind, and contribute to relieve heat wave especially in summer in the Yeongdong region.

• 한국식품영양과학회지
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• 제44권7호
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• pp.1079-1083
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• 2015

본 연구는 양조과정의 부산물인 주박으로부터 분리한 다당류(JPS)가 초기 면역반응에 중추적인 역할을 수행하는 대식세포에서 활성화를 유도하는지에 관한 여부를 알아보기 위해서 수행되었다. 주박에서 분리한 다당류를 마우스 유래 대식세포인 RAW264.7 cell에 처리하였을 때 대식세포의 활성화의 지표인 NO와 cytokine(IL-6, TNF-${\alpha}$)의 분비가 증가되었다. 또한 이러한 NO와 cytokine의 증가의 원인에 관한 면역기전에 관하여 알아본 결과 JPS의 처리는 MAPKs(ERK, JNK, p-38)의 인산화를 촉진시켜 NF-${\kappa}B$의 활성을 유도하여 면역세포의 활성인자들의 분비를 촉진시킨 것으로 관찰되었다.

• 대한불안의학회지
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• 제8권2호
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• pp.127-132
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• 2012

Objective : This study aims to investigate the relationship between addictive mobile phone use and post-traumatic stress disorder (PTSD) symptoms in bullies who experienced school violence. Methods : The study subjects consisted of 97 adolescents in The Foundation for Preventing Youth Violence after school violence. The participants conducted self-report questionnaire for addictive mobile phone use and Impacted Event Scale-revised-Korean version (IES-R-K). Partial correlation and multiple logistic regressions were performed. Results : The scores related to addictive mobile phone use were correlated with total score (r=0.21, p=0.04), avoidance score (r=0.21, p=0.04) and intrusive score (r=0.26, p=0.01) related to PTSD symptoms on the IES-R-K. Intrusive score related to PTSD symptoms on the IES-R-K were significant risk factor for addictive mobile phone use (O.R=1.25, 95% CI=1.12-1.39). Conclusion : This data supports that PTSD intrusive symptoms could be predictable factor of addictive mobile phone use. An appropriate intervention about PTSD symptoms might play a useful role in preventing addictive mobile phone use in bullies of school violence.

• 한국컴퓨터정보학회논문지
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• 제12권4호
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• pp.1-10
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• 2007

본 논문은 열차 내에서 승객의 편의를 제공하고 긴급 상황에 대한 대피 안내 방송 및 자막 서비스와 광고 등의 효과를 극대화하기 위한 네트워크 기반의 승객 안내 시스템 개발에 대하여 기술한다. 기존 시스템은 영상 및 자막 그리고 음성 안내 등의 정보를 방송하기 위해 VGA 신호 분배기를 이용하고 있다. UDP와 TCP/IP 프로토콜을 적용하여 기존 시스템을 개선하고, 이 경우 발생하는 데이터 손실 및 차량 간의 동기화 문제를 해결하기 위하여 레퍼런스 클럭을 이용한다. 열차의 운행 스케줄에 따른 자동 안내 방송과 광고 효과의 향상을 위하여 다양한 3D 효과로 자막을 재생 하도록 XML 기반의 자막 편집기를 개발하였고, 시뮬레이션을 통해 성능을 평가 한다.

• Clinical and Experimental Reproductive Medicine
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• 제26권3호
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• pp.345-353
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• 1999

In the studies on the hatching mechanisms in mammals, many investigators focused on the embryonic intrinsic factor(s) in in vitro culture, but the uterine environment as the extrinsic factor(s) is thought to play an important role in hatching mechanism. Therefore, to evaluate the effect of uterine environment on the hatching event in vivo, the immature(GV) and ovulated(MII) oocytes, and the late 2-cell embryos of mouse were transferred to pseudopregnant foster mother's uterus during peri-implantation period. So it was verified whether there would happen hatching by only uterine environment independently on embryonic stage. The ultrastructural changes of the zona surface of transferred group were compared with those 01 in vivo and vitro group by SEM. 36 hrs after transfer, the immature and ovulated oocytes almost degenerated, and the late 2-cell embryos developed to various embryonic stages. However, the embryos which didn't develop to blastula stage did not hatch. The ultrastructural network of ZP in transferred group seemed to be smoothed uniformly, which was different from in vitro group. In conclusion, it is suggested that the uterine environment during peri-implantation period enhances the embryo hatching by provoking the structural change of ZP.

• 한국식생활문화학회지
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• 제32권6호
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• pp.498-512
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• 2017

The aim of this study was to introduce the foods recorded in "Bongjeopyoram", a cookbook, of which the date of production and author are unknown. This was described in an old document belonging to the Hansan Lee family clan from Chungcheongnam-do and revealed its content and significance in the food culture history of Korea to academia for the first time, A close examination of "Bongjeopyoram" showed that, as with other cookbooks from the Joseon Dynasty, it started with methods of making alcoholic beverages. This was followed by recipes for different types of food in the following order: rice cakes and confectioneries, jeol-sik (seasonal foods), daily meals, foods made for jesa (ancestral rites) or a feast, food for weddings, and food for sijeol-jesa (seasonal ancestral rites). The book contained a total of 18 types of alcoholic beverages, 11 types of rice cakes and confectioneries, 20 types of daily meals, 28 types of jeol-sik and food for sijeol-jesa, 12 types of food for jesa and feasts, and 37 types of food for weddings, for a total of 126 types of food and beverages. "Bongjeopyoram" was an ancient cookbook with detailed records on how to carry out jesa, which was an important event hosted by jonggas, or the head family of a family clan, and how to receive and serve guests in the Joseon period. This book is expected to play a valuable role as a guidance with significance as a cookbook of a jongga from the Joseon Dynasty, a time when bongjesajeopbingaek (hosting jesa for one's ancestors and serving one's guest) was considered important.