• Experimental and Molecular Medicine
• /
• 제50권11호
• /
• pp.10.1-10.11
• /
• 2018

Although early studies suggested that bladder cancer (BCa) is more prevalent in men than in women, muscle-invasive rates are higher in women than in men, suggesting that sex hormones might play important roles in different stages of BCa progression. In this work, we found that estrogen receptor beta ($ER{\beta}$) could increase BCa cell proliferation and invasion via alteration of miR-92a-mediated DAB2IP (DOC-2/DAB2 interacting protein) signals and that blocking miR-92a expression with an inhibitor could partially reverse $ER{\beta}$-enhanced BCa cell growth and invasion. Further mechanism dissection found that $ER{\beta}$ could increase miR-92a expression at the transcriptional level via binding to the estrogen-response-element (ERE) on the 5' promoter region of its host gene C13orf25. The $ER{\beta}$ up-regulated miR-92a could decrease DAB2IP tumor suppressor expression via binding to the miR-92a binding site located on the DAB2IP 3' UTR. Preclinical studies using an in vivo mouse model also confirmed that targeting this newly identified $ER{\beta}$/miR-92a/DAB2IP signal pathway with small molecules could suppress BCa progression. Together, these results might aid in the development of new therapies via targeting of this $ER{\beta}$-mediated signal pathway to better suppress BCa progression.

• Structural Engineering and Mechanics
• /
• 제41권6호
• /
• pp.711-734
• /
• 2012

The foundation of a tall building frame resting on settable soil mass undergoes differential settlements which alter the forces in the structural members significantly. For tall buildings it is essential to consider seismic forces in analysis. The building frame, foundation and soil mass are considered to act as single integral compatible structural unit. The stress-strain characteristics of the supporting soil play a vital role in the interaction analysis. The resulting differential settlements of the soil mass are responsible for the redistribution of forces in the superstructure. In the present work, the nonlinear interaction analysis of a two-bay ten-storey plane building frame- layered soil system under seismic loading has been carried out using the coupled finite-infinite elements. The frame has been considered to act in linear elastic manner while the soil mass to act as nonlinear elastic manner. The subsoil in reality exists in layered formation and consists of various soil layers having different properties. Each individual soil layer in reality can be considered to behave in nonlinear manner. The nonlinear layered system as a whole will undergo differential settlements. Thus, it becomes essential to study the structural behaviour of a structure resting on such nonlinear composite layered soil system. The nonlinear constitutive hyperbolic soil model available in the literature is adopted to model the nonlinear behaviour of the soil mass. The structural behaviour of the interaction system is investigated as the shear forces and bending moments in superstructure get significantly altered due to differential settlements of the soil mass.

• 한국의류산업학회지
• /
• 제23권2호
• /
• pp.247-260
• /
• 2021

While it is an important element of clothing construction, research has so far been very limited on the similarities between virtual and real clothing in terms of the type of neckline. The purpose of this study is to verify the similarity, accuracy of virtualization, and actuality of neckline, which all play an important role in individual impressions and image formation, and require considerable modification when fitting real samples. A total of 5 neckline models were selected through the analysis of dress composition textbooks. The selected designs were then planned and manufactured in muslin. The specimen clothes were then tested on a female model in her 20s. 2 kinds of virtual bodies were created in order to compare the real and the virtual dressing. The first virtual body was made through an Artec 3D Eva scan of the model, and the other was made by entering the model's measurements in a CLO 3D program. A visual image of the front, side, and back image of both the real and virtual dressing were subsequently collected. The collected images were then evaluated by 20 professional fashion workers who checked the similarity between the real and the virtual versions. The current study found that the similarity between the actual and virtual wearing of the five neckline designs with reality appeared higher with the virtual wearing image using the 3D-scanned body. The results of this study could provide further information on the selection of appropriate avatars to clothing companies that check the fit of clothing by utilizing 3D virtualized programs.

• 한국컴퓨터정보학회논문지
• /
• 제26권11호
• /
• pp.67-74
• /
• 2021

본 논문에서는 스토리텔링에서 세계관 설정의 중요 요소였던 캐릭터의 역할 확장에 대해 분석하고자 한다. 미디어의 발달로 세계관을 설정하는 방식이 변화하기 시작했다. 이러한 변화의 중심에는 최근 조명을 받고 있는 '트랜스미디어'와 '메타버스'가 있다. 미디어의 교차와 융합이 활발하게 시도되는 트랜스미디어의 발달과 함께 캐릭터는 태생적 제약에서 벗어나 다양한 미디어를 넘나들며 새로운 스토리 안에서 다양한 활약을 펼치고 있다. 또한 현실세계의 확장된 개념인 메타버스에서 아바타는 사용자이자 창작자로서 메타버스 세계를 구성하고 확장하는 역할을 맡고 있다. 이러한 변화를 분석해 정통적인 세계관 설정에서 요소로서 활용되던 캐릭터가 세계관을 대체하는 현상에 대해 다뤄보고자 한다.

• 컴퓨터교육학회논문지
• /
• 제22권3호
• /
• pp.123-133
• /
• 2019

본 연구는 스마트교육의 한 요소인 스마트 기기를 활용하여 축적된 데이터를 기초로 유아의 개별 맞춤학습을 위한 스마트교육환경을 구축하는데 목적을 두고 있다. 이를 위해 유치원 만5세 학급에서 자유선택활동 운영을 위한 개선 방안을 제안하고, 유아 스스로 놀이 계획을 세우고 평가하는 자유선택활동 운영시스템을 구현하였다. 본 연구 참여한 유아들은 놀이계획, 놀이수행 및 수행평가등 전체 활동시간을 스스로가 적극적이며 즐겁게 참여하였다. 그 결과 유아는 스마트기기를 통한 자신의 흥미영역에 대한 활동선택에 기존교육환경보다 적극적으로 참여하는 것을 확인할 수 있었다. 본 연구에서 제안된 자유선택활동 운영시스템을 이용한 교사는 분석된 자료를 활용하여 스마트기기를 이용한 개별유아의 흥미분야와 학습수준 및 교실의 각 영역별 이용형태를 혼자서 쉽게 파악할 수 있었다.

• 한국산업정보학회논문지
• /
• 제24권2호
• /
• pp.65-80
• /
• 2019

ICT 기반의 제4차 산업혁명의 도래는 제조업과 ICT 융합이 새로운 경쟁력이 되고, 생산 방식의 혁명을 일으키며 제조업 위기의 돌파구로 주목을 받으면서 제조업 부활에 날개를 달아주는 요소로 부상하고 있다. 스마트 팩토리가 구현되면 각 공장에서 수집된 수많은 데이터를 기반으로 분석 및 의사결정을 하는 공장 운영체계(Data Driven Operation)를 갖춤으로써 생산현장에서 발생하는 현상과 문제들의 상관관계를 찾아낼 수 있다. 고객의 니즈가 다양해짐에 따라 다품종 대량생산에서 맞춤형 유연생산 체제로의 전환이 요구되며, 기업은 이를 위해 스마트 팩토리의 도입이 필수적이다. 본 연구는 국내 스마트 팩토리 도입 기업들을 대상으로 스마트 팩토리 지속사용의도와 전환의도에 영향을 미치는 요인들을 기술수용모형( Technology acceptance model: TAM)을 토대로 실증 분석한다. 이를 위해 본 연구는 스마트 팩토리를 운영 중인 기업들을 대상으로 온라인과 오프라인을 통해 설문조사를 실시하였으며, 최종적으로 122개의 표본을 분석에 사용하였다. 본 연구의 결과는 스마트 팩토리에 관심 있는 연구자들과 실무자들에게 많은 시사점을 제공할 것이다.

• Ocean Systems Engineering
• /
• 제10권4호
• /
• pp.399-414
• /
• 2020

A floating bridge is an innovative solution for deep-water and long-distance crossing. This paper presents a curved floating bridge's dynamic behaviors under the wind, wave, and current loads. Since the present curved bridge need not have mooring lines, its deep-water application can be more straightforward than conventional straight floating bridges with mooring lines. We solve the coupled interaction among the bridge girders, pontoons, and columns in the time-domain and to consider various load combinations to evaluate each force's contribution to overall dynamic responses. Discrete pontoons are uniformly spaced, and the pontoon's hydrodynamic coefficients and excitation forces are computed in the frequency domain by using the potential-theory-based 3D diffraction/radiation program. In the successive time-domain simulation, the Cummins equation is used for solving the pontoon's dynamics, and the bridge girders and columns are modeled by the beam theory and finite element formulation. Then, all the components are fully coupled to solve the fully-coupled equation of motion. Subsequently, the wet natural frequencies for various bending modes are identified. Then, the time histories and spectra of the girder's dynamic responses are presented and systematically analyzed. The second-order difference-frequency wave force and slowly-varying wind force may significantly affect the girder's lateral responses through resonance if the bridge's lateral bending stiffness is not sufficient. On the other hand, the first-order wave-frequency forces play a crucial role in the vertical responses.

• 디지털융복합연구
• /
• 제19권6호
• /
• pp.285-292
• /
• 2021

최근 코로나19 사태로 캠핑 문화가 급속하게 많은 사람들에게 관심을 받고 있다. 많은 캠퍼들이 겨울철 사용하는 대류난방기구는 온도 성층화 문제를 가지고 있다. 이를 해결하기 위해 다양한 동력 서큘레이터가 활용되고 있다. 몇 가지 무동력 서큘레이터도 판매가 되고 있으나, 서큘레이터의 방향이 대류난방기구와 직각으로 디자인되어 있어 실제 공기 순환의 역할을 제대로 하지 못하고 있다. 이러한 문제점을 해결하고자 3D 프린터를 이용하여 대류난방기구의 방향과 같은 무동력 서큘레이터를 디자인하였다. 펠티어소자와, 세라믹페이퍼 등을 이용하여 무동력으로 전기를 만들어 냈으며, HTPLA-CF 필라멘트를 이용하여 열에 강하게 제작하였다. 3D 프린터를 이용하여 원가를 절감할 수 있었으며, 다양한 대류난방기구의 크기에 맞게 제작 할 수 있는 장점이 있다. 본 연구는 효율적인 대류순환을 통해 온도 성층화 문제를 해결할 수 있는 하나의 방법을 제시한다. 또한 3D 프린터를 이용하여 보다 저렴하게 제품을 제작하는 것이 본 연구의 목적이다.

• Smart Structures and Systems
• /
• 제30권3호
• /
• pp.327-332
• /
• 2022

In building envelope, transparent components play an important role. The structural glazing systems are the weak element of the casing in terms of mechanical resistance, thermal and acoustic insulation. In the present work, new structural glass panels with granular aerogel in interspace were investigated from different points of view. In particular, the mechanical characterization was carried out in order to assess the resistance to bending of the single glazing pane. To this end, a special instrument system was built to define an alternative configuration of the coaxial double ring test, able to predict the fracture strength of glass large samples (400 × 400 mm) without overpressure. The thermal and lighting performance of an innovative double-glazing façade with granular aerogel was evaluated. An experimental campaign at pilot scale was developed: it is composed of two boxes of about 1.60 × 2 m² and 2 m high together with an external weather station. The rooms, identical in terms of size, construction materials, and orientation, are equipped with a two-wing window in the south wall surface: the first one has a standard glazing solution (double glazing with air in interspace), the second room is equipped with the innovative double-glazing system with aerogel. The indoor mean air temperature and the surface temperature of the glass panes were monitored together with the illuminance data for the lighting characterization. Finally, a brief energy characterization of the performance of the material was carried out by means of dynamic simulation models when the proposed solution is applied to real case studies.

• Steel and Composite Structures
• /
• 제44권3호
• /
• pp.437-450
• /
• 2022

When the vertical load-bearing members in high-rise structures fail locally, the beam-column joints play an important role in the redistribution of the internal forces. In this paper, a static laboratory test of three full-scale flush flange beam-reinforced connections with side and cover plates (CP-FBSP connection) with double half-span steel beams and single L-shaped columns composed of concrete-filled steel tubes (L-CFST columns) was conducted. The influence of the side plate width and cover plate thickness on the progressive collapse resistance of the substructure was thoroughly analyzed. The failure mode, vertical force-displacement curves, strain variation, reaction force of the pin support and development of internal force in the section with the assumed plastic hinge were discussed. Then, through the verified finite element model, the corresponding analyses of the thickness and length of the side plates, the connecting length between the steel beam flange and cover plate, and the vertical-force eccentricity were carried out. The results show that the failure of all the specimens occurred through the cracking of the beam flange or the cover plate, and the beam chord rotations measured by the test were all greater than 0.085 rad. Increasing the length, thickness and width of the side plates slightly reduced the progressive collapse resistance of the substructures. The vertical-force eccentricity along the beam length reduced the progressive collapse resistance of the substructure. An increase in the connecting length between the beam flange and cover plate can significantly improve the progressive collapse resistance of substructures.