• Biomolecules & Therapeutics
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• v.31 no.4
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• pp.411-416
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• 2023

Methamphetamine (METH) is a powerful neurotoxic psychostimulant affecting dopamine transporter (DAT) activity and leading to continuous excess extracellular dopamine levels. Despite recent advances in the knowledge on neurobiological mechanisms underlying METH abuse, there are few effective pharmacotherapies to prevent METH abuse leading to brain damage and neuropsychiatric deficits. α-Pinene (APN) is one of the major monoterpenes derived from pine essential oils and has diverse biological properties including anti-nociceptive, anti-anxiolytic, antioxidant, and anti-inflammatory actions. In the present study, we investigated the therapeutic potential of APN in a METH abuse mice model. METH (1 mg/kg/day, i.p.) was injected into C57BL/6 mice for four alternative days, and a conditioned place preference (CPP) test was performed. The METH-administered group exhibited increased sensitivity to place preference and significantly decreased levels of dopamine-related markers such as dopamine 2 receptor (D2R) and tyrosine hydroxylase in the striatum of the mice. Moreover, METH caused apoptotic cell death by induction of inflammation and oxidative stress. Conversely, APN treatment (3 and 10 mg/kg, i.p.) significantly reduced METH-mediated place preference and restored the levels of D2R and tyrosine hydroxylase in the striatum. APN increased the anti-apoptotic Bcl-2 to pro-apoptotic Bax ratio and decreased the expression of inflammatory protein Iba-1. METH-induced lipid peroxidation was effectively mitigated by APN by up-regulation of antioxidant enzymes such as manganese-superoxide dismutase and glutamylcysteine synthase via activation of nuclear factor-erythroid 2-related factor 2. These results suggest that APN may have protective potential and be considered as a promising therapeutic agent for METH-induced drug addiction and neuronal damage.

• Journal of the Korea Society of Computer and Information
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• v.6 no.1
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• pp.45-50
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• 2001

Congestion may take place in the ATM network because of high-speed cell transmission features, and cell delay and loss also can be caused by unexpected traffic variation. Thus. traffic control mechanisms are needed. One of them to decrease congestion is the cell shaping. This paper proposes a hybrid type cell shaper composed of a Leaky Bucket with token pool, EWMA with time window, and a spacing control buffer. The simulator BONeS with the ON/OFF traffic source model evaluates the performance of the proposed cell shaping method. Simulation results show that the cell shaping concerning the respective source traffics is adapted to and then controlled on the mean bit rate.

• Advances in Energy Research
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• v.4 no.4
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• pp.275-284
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• 2016

In the present work, ZnO nanoparticles (NPs) have been dispersed alone in the same solvent of the active layer for improving performance parameters of the organic solar cells. Different concentrations of the ZnO NPs have been blended inside active layer of the solar cell based on poly(3-hexylthiophene) (P3HT), which forms the hole-transport network, and [6,6]-phenyl-C61-butyric acid methyl ester (PCBM), which forms the electron-transport network. In the present investigations, the ZnO NPs may represent an efficient tool for improving light harvesting through light scattering inside active layer, electron mobility, and electron acceptance strength which tend to improve photocurrent and performance parameters of the investigated solar cell. The fill factor (FF) of the ZnO-doped solar cell increases nearly 14% compared to the non-doped solar cell when the doping is 50%. The present investigations show that ZnO NPs improve power conversion efficiency of the solar cell from 1.23% to 1.64% with increment around 25% that takes place after incorporation of 40% as a volume ratio of the ZnO NPs inside P3HT:PCBM active layer.

• Journal of the Korea Society of Computer and Information
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• v.7 no.3
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• pp.143-148
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• 2002

Congestion may take place in the ATM network because of high-speed cell transmission features, and cell delay and loss also can be caused by unexpected traffic variation. Thus, traffic control mechanisms are needed. One of them to decrease congestion is the Cell shaping. This paper proposes a hybrid type cell shaper composed of a Leaky Bucket with token pool, Tn with time window, and a spacing control buffer. The simulator BONeS with the ON/OFF traffic source model evaluates the performance of the proposed cell shaping method. Simulation results show that the cell shaping concerning the respective source traffics is adapted to and then controlled on the mean bit rate.

• Korean Journal of Environmental Biology
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• v.23 no.4
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• pp.390-397
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• 2005

The inhibition of cell recovery might be proceeded via either the damage of the mechanism of the recovery itself or via the formation of irreversible damage which could not be repaired at all. Both these processes may take place at the same time. Any of these possibilities would result in a decrease in both the rate and extent of cell recovery. To distinguish them, a quantitative approach describing the process of recovery as a decrease in the effective radiation dose was applied to experimental data on the recovery from potentially lethal damage in Chinese hamster cells exposed to X-rays alone or combined with various chemicals (pyruvate, novobiocin, lactate, nalidixic acid, 3-aminobenzamide). For these particular cases, it is concluded that the recovery process itself is not damaged and the inhibition of the recovery is entirely due to the enhanced yield of the irreversibly damaged cells.

• Proceedings of the KIEE Conference
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• 2001.07c
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• pp.1561-1563
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• 2001

In this paper, an novel optical measuring system based on the electro-optic effect has been proposed and realized using Pockels cell with a view to detecting partial discharge taking place at the needle plane electrode. This system has the following advantages ; nonmetallic probe sensor, immune to external EMI noise and broad band response of the Pockels cell from DC to GHz. And also it is constructed by He-Ne laser, optical fiber, $LiNbO_3$ Pockels cell, photo detector, grin lens, oscilloscope and PC. The characteristics of the developed prototype sensor are investigated under AC and corona discharges.

• Journal of Microbiology and Biotechnology
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• v.11 no.6
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• pp.1055-1060
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• 2001

Experimental data for the on-line estimation of cell concentration and growth rate are presented. For this purpose, we utilized the on-line calculation of the oxygen uptake rate (OUR), which was derived from a liquid phase dynamic mass balance for the oxygen during the active growth phase in cyclosporin A (CyA) fermentation. The cell yield coefficient, based on the oxygen $(Y_{x/o})$for both suspended and immobilized cells of Tolypocladium inflatum, was estimated as $1.9 gDCW/gO_2$ from a very good linear correlation between the cell mass produced and the total oxygen consumed. The calculated yield showed a good agreement with the value of $(Y_{x/o})$ generated from the correlation between the cell growth rate and the oxygen uptake rate. In addition, further experimental data are given, which were also applied to determine the specific oxygen uptake rate of T. inflatum cells during the exponential phase of CyA fermentation. A theoretical basis for the analysis of these fermentation parameters is also provided.

• Animal cells and systems
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• v.2 no.1
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• pp.65-69
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• 1998

The hippocampus and prefrontal cortex are regarded as the highest-order association cortices. The hippocampus has been proposed to store "cognitive maps" of external environments, and the prefrontal cortex is known to be involved in the planning of behavior, among other functions. Considering the prominent functional roles played by these structures, it is not surprising to find direct monosynaptic projections from the hippocampus to the prefrontal cortex. Rhythmic stimulation of this projection patterned after the hippocampal EEG theta rhythm induced stable long-term potentiation of field potentials in the prefrontal cortex. Comparison of behavioral correlates of hippocampal and prefrontal cortical neurons during an a-arm radial maze, working memory task shows a striking contrast. Hippocampal neurons exhibit clear place-specific firing patterns, whereas prefrontal cortical neurons do not show spatial selectivity, but are correlated to different stages of the behavioral task. These data lead to the hypothesis that the role of hippocampal projection to the prefrontal cortex is not to impose spatial representations upon prefrontal activity, but to provide a mechanism for learning the spatial context in which particular behaviors are appropriate.propriate.

• Proceedings of the KSME Conference
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• 2007.05a
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• pp.179-182
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• 2007

The compressive fatigue tests on the closed cell Al-Si-Ca alloy foams with two different thicknesses were performed using a load ratio of 0.1. The quasi-static and cyclic compressive behaviors were obtained respectively. The fatigue stress-life (S-N) curves were evaluated from the obtained cyclic compressive behaviors. S-N curves were presented for the onset of progressive shortening. It turned out that the fatigue strength showed higher value for the thicker foam and the onset of shortening of thinner foam took place earlier. The crushing was found to initiate in a single band which broadens gradually with additional fatigue cycles. Progressive shortening of the specimen took place due to a combination of low cycle fatigue failure and cyclic ratcheting.

• KIEAE Journal
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• v.16 no.1
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• pp.95-101
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• 2016

This study aims to analyze the satisfaction targeted community space for public rental housing tenants a real community space. and community space is analyzed only through the factor analysis of the effects of satisfaction, multiple regression analysis etc. As a result, the space community and public rental housing will only affect the satisfaction, factors affecting such analysis was 'common space', 'exercise place', 'resting place'. Thus, a variety of political and institutional efforts and practical research for interactive spatial planning public rental housing estates satisfaction for the improvement and community activation moving away from passive concept of the one-way ever to supply that community space in the past, provider centers and considering the tenant characteristics is required.