• Clinical Endoscopy
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• 제57권1호
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• pp.73-81
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• 2024

Background/Aims: Upper gastrointestinal bleeding (UGIB) is a life-threatening condition that necessitates early identification and intervention and is associated with substantial morbidity, mortality, and socioeconomic burden. However, several diagnostic challenges remain regarding risk stratification and the optimal timing of endoscopy. The PillSense System is a noninvasive device developed to detect blood in patients with UGIB in real time. This study aimed to assess the safety and performance characteristics of PillSense using a simulated bleeding model. Methods: A preclinical study was performed using an in vivo porcine model (14 animals). Fourteen PillSense capsules were endoscopically placed in the stomach and blood was injected into the stomach to simulate bleeding. The safety and sensitivity of blood detection and pill excretion were also investigated. Results: All the sensors successfully detected the presence or absence of blood. The minimum threshold was 9% blood concentration, with additional detection of increasing concentrations of up to 22.5% blood. All the sensors passed naturally through the gastrointestinal tract. Conclusions: This study demonstrated the ability of the PillSense System sensor to detect UGIB across a wide range of blood concentrations. This ingestible device detects UGIB in real time and has the potential to be an effective tool to supplement the current standard of care. These favorable results will be further investigated in future clinical studies.

• 제어로봇시스템학회논문지
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• 제18권2호
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• pp.81-86
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• 2012

Reconnaissance robots can reduce the danger of hazardous places by providing information before human personnel take action. For the usage, robot platform should be small and light. However, this fact leads to a scaling issue with terrain that landscape poses a huge obstacle for the vehicle. The problem can be solved by the inspiration of nature. This paper presents design of the locomotive mechanism inspired by Pill bugs. The mechanism was designed by the principles of a pill bug's locomotion and experiments were conducted to validate the mechanism.

• 한국인터넷방송통신학회논문지
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• 제24권1호
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• pp.9-16
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• 2024

알약 구매 후 조제약 봉투나 포장지를 잃어버린 경우 약의 효능을 알기 어렵고 많은 사람들이 시중에서 판매하는 약을 구매하여 복용한 후 보관 시 용도를 구분해서 보관하지 않는 경우가 많다. 또한 알약 부작용에 대한 정보의 접근성이 낮아 약을 오남용하는 상황이 발생하기도 한다. 기존의 알약 정보를 검색하여 정보를 알려 주는 대부분의 서비스 및 어플리케이션들은 사용자가 알약의 상세정보를 직접 입력하거나 선택해야 하는 번거로움이 존재한다. 본 논문에서는 이러한 불편한 상황들은 개선하고 보다 나은 서비스를 제공하기 위해 약학정보원에서 제공하는 알약 22,000종의 사진에 대해 제형과 색상을 학습시킨 딥러닝 모델을 구축하였다. 구축된 정보를 활용하여 촬영된 사진으로 알약을 검색하고 알약 정보를 알려주며 사용자의 약 복용을 관리해주는 기능을 갖는 시스템을 개발하였다.

• Journal of Nutrition and Health
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• 제41권6호
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• pp.493-501
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• 2008

The objectives of this study were to investigate the antihyperglycemic and hypolipidmic effects of sea oak(Eisenia bicyclis, EB) in the diabetic state and to examine the appropriateness of formulated EB pill for the effects. The various test materials obtained from EB were included in the experimental diets with 15% fat/0.5% cholesterol and fed to streptozotocin-induced diabetic mice weighing $35.0{\pm}0.7$ g for three weeks but not in the control diet having the same composition. The test materials were EB dry powder, water and ethanol extracts, viscozyme-treated EB water extract(EB enzyme-TR) and formulated pill containing dry powders of the EB, two kinds of seaweed, black soybean, sesame, onion and garlic. BG was measured during feeding period and serum insulin, lipids and thiobarbituric acid reactive substances(TBARS) and intestinal disaccharidase activities were measured at the end of the three weeks of the feeding. BG increase was lower in the EB enzyme-TR group after 10 days of the experimental diet but lower in EB pill group after 15 days compared with the control group. Serum insulin levels were higher in the EB enzyme-TR and EB pill groups. Intestinal maltase but not sucrase activity was higher in EB enzyme-TR fed group than the control group. Serum levels of total cholesterol and triglyceride were reduced by the EB enzyme-TR and EB pill compared with the control diet. HDL-/total cholesterol was increased by all EB test materials. Serum TBARS levels were lower in the EB ethanol extract and EB pill groups than in the control group and tended to be lower in the other EB groups. It is concluded that the EB enzyme-TR is the best among the EB preparations to be utilized as a functional component for improving blood glucose and lipid profile in diabetic subjects in the future. However, the pill containing low level of the EB powder is also regarded as effective and readily usable when formulated with the several other ingredients of the proper composition.(Supported by the RIC Program of MOCIE, Korea).

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2013년도 춘계학술대회 논문집
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• pp.53-54
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• 2013

• 한국섬유공학회:학술대회논문집
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• 한국섬유공학회 1998년도 가을 학술발표회논문집
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• pp.520-523
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• 1998

Pilling 현상은 우리의 일상생활에서 볼 수 있는 흔한 일이다. 직물에 있어서 Pilling 현상은 제품의 외관과 촉감을 나쁘게 하고 제품의 수명을 저하시키는 현상 중의 하나이다. 이러한 Pilling현상의 원인은 크게 2가지 측면에서 구분되어 진다 첫째는 섬유가 정전기를 띄면서 주위의 이물질들을 끌어 들여 그러한 이물질이 pill을 형성하는 경우와 둘째는 섬유자체가 pill을 형성하기 쉬운 특성을 지니는 경우로 구분된다. (중략)

• 조명전기설비학회논문지
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• 제13권2호
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• pp.63-70
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• 1999

본 논문은 여러 설비시스템의 프로세스 제어에 사용되는 PID제어기의 최적 자동동조에 관한 새로운 방법을 제안하고자 한다. 이 방법은 먼저. 제어대상의 계단응답으로부터 모델링 된 1차 지연계를 Pad 근사화하고, Ziefler-Nichols의 한계감도법으로 초기값을 정한 후, 최대 오버슈트, 감쇠비, 상승시간, 정정시간에 대한 퍼지 평가함수를 초대로 하는 최적화되 PID 계수를 목표치로 하여 신경회로망의 역전파 알고리즘을 통해 충분히 반복, 학습시켜 새로운 K, L, T값을 입력하였을 때 근사적으로 최적화된 PID 계수를 구함으로써 퍼지추론에 의한 제어 규칙이 불필요하여 자동 동조시간이 짧다는 장점을 가지고 있다.

• BMB Reports
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• 제29권1호
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• pp.11-16
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• 1996

The present study showed that receptor-mediated activation of rabbit kidney proximal tubule cells by angiotensin II, the $Ca^{2+}$ ionophore A23187, or the protein kinase C activator phorbol myristate acetate (PMA) all stimulated phospholipase D (PLD). This was demonstrated by the increased formation of phosphatidic acid, and in the presence of 0.5% ethanol, phosphatidylethanol (PEt) accumulation. Angiotensin II leads to a rapid increase in phosphatidic acid and diacylglycerol, and phosphatidic acid formation preceeded the formation of diacylglycerol. This result suggests that some phosphatidic acid seems to be formed directly from phosphatidylcholine hydrolyzed by Pill. On the other hand, EGTA substantially attenuated angiotensin II and A23187-induced PEt formation, and when the cells were pretreated with verapamil angiotensin II-induced Pill activation was completely abolished. These results provide the evidence that calcium ion influx is essential for the agonist-induced Pill activation. In addition, staurosporine, an inhibitor of protein kinase C, strongly inhibited PMA-induced PEt formation, but was ineffective on angiotensin II-induced PEt accumulation. $GTP{\gamma}S$ also stimulates PEt formation in digitonin-permeabilized cells, but pretreatment of the cells with pertussis toxin failed to suppress angiotensin II-induced PEt formation. From these results, we conclude that in the rabbit kidney proximal tubule cells the mechanisms of angiotensin II- and PMA-induced Pill activation are different from each other and mediated via a pertussis toxin-insensitive trimeric G protein.

• 생약학회지
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• 제45권3호
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• pp.233-239
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• 2014

We evaluated the benign prostatic hyperplasia (BPH) with Yacon pill, the preparation composed of Smallanthus sonchifolius, Torilis japonica and Acorus gramineus. A total of 45 rats were divided into five groups. One group was used as a control and the other groups received subcutaneous injections of testosterone for 4 weeks to induce BPH. Yacon pill extract (200 or 400 mg/kg) was administered daily for 4 weeks to two groups by oral gavage concurrently with testosterone. The rats euthanized, the prostate and body weights were recorded, and tissues were subjected to hormone assay. In addition, we investigated proliferating cell nuclear antigen (PCNA) expression in the prostate using immunoblotting. Rats with BPH showed significantly increased prostate weights, increased dihydrotestosterone (DHT) levels in the serum and increased PCNA expression in the prostate; however, Yacon pill extracts treated rats showed significant reduction of prostate weights, DHT levels and PCNA expression compared with the BPH group. Conclusively, Yacon pill showed the possibility as ameliorable agents of BPH symptoms.

• Clinical Endoscopy
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• 제51권6호
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• pp.563-569
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• 2018

Background/Aims: To evaluate patients with portal hypertension (PH) of varied etiologies for portal hypertensive enteropathy (PHE) using the PillCam SB3 capsule endoscopy (CE) system. Methods: Consecutive patients with PH presenting with unexplained anemia and/or occult gastrointestinal bleeding were evaluated using the PillCam SB3 CE system. Abnormal findings were categorized as vascular or non-vascular. The patients with ongoing bleeding caused by PHE were treated. The correlation of the CE scores of PHE with the clinical, laboratory, and endoscopic features was determined. Results: Of the 43 patients included in the study, 41 (95.3%) showed PHE findings. These included varices (67.4%), red spots (60.5%), erythema (44.2%), villous edema (46.5%), telangiectasia (16.3%), and polyps (16.3%). The CE scores varied from 0 to 8 ($mean{\pm}standard$ deviation, $4.09{\pm}1.8$). Five patients (11.6%) showed evidence of ongoing or recent bleeding due to PHE. Three of these five patients underwent endotherapy, and one patient underwent radiological coil placement. Conclusions: The PillCam SB3 CE system revealed a high prevalence of PHE in the patients with PH. Using this system, evidence of bleeding due to PHE was found in a small but definite proportion of the patients.