• 대한화장품학회:학술대회논문집
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• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
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• pp.765-779
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• 2003

Physiological lipid mixtures comprised of cholesterol, ceramide and free fatty acid better maintain epidermal homeostasis and have been recently used for dermatoses induced by skin barrier damage, for example for atopic dermatitis and xerotic skin. Itching and dry atopic dermatitis of the skin may be related to altered skin barrier function. In a previous study, the use of multi-lamellar emulsion (MLE), which is a lipid mixtures containing cholesterol, pseudoceramide and free fatty acid, has been shown to accelerate the recovery of the epidermal permeability barrier. In this study, we assessed the efficacy of MLE compared with a currently used anti-itch moisturizer (AIM), the active ingredients of which are menthol and camphor, on barrier recovery after barrier disruption. To clarify the effect of MLE and AIM after acute barrier perturbation, we measured the relation between transepidermal water loss (TEWL) and the barrier recovery rate at 3, 6, 24, and 48 hours after tape stripping hairless mice and then observed changes in the stratum corneum (SC), including the intercellular lipid structure and secretion of lamellar bodies, by electron microscopy. MLE treated skin recover skin barrier function more rapidly, and AIM treated skin delayed barrier repair. Morphological changes in the epidermis, of MLE treated skin revealed well-conserved lipid multi-lamellar structures at 24 h after tape stripping, whereas AIM treated skin showed altered lamellar bilayers within the SC interstices at 48 h. In addition, MLE treated skin showed an increase in the number of LBs and in their secretions and a decrease in the number of SC layers versus AIM treated skin. These results suggest that MLE may accelerate the production of an epidermal permeability barrier in hairless mice by increasing the number and secretion of LB and improve the dryness and itch associated with an altered epidermal permeability barrier.

• 감성과학
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• 제15권1호
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• pp.1-8
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• 2012

많은 연구에서 정서 특정적 생리 반응을 밝히기 위하여 심박률, 혈류량, 피부전도 반응 등의 지표를 사용하였으나, 안면온도를 이용한 정서 연구는 많지 않다. 본 연구는 적외선 열화상을 통해 공포 및 기쁨 자극에 대한 안면온도 변화를 관찰하고자 한다. 98명의 대학생과 중고생을 대상으로 공포 또는 기쁨을 유발하는 자극을 제시하기 전과 후의 안면온도를 측정하였다. 온도값은 이마, 눈앞, 콧등, 코끝, 그리고 뺨에서 추출하였다. 공포자극을 제시한 조건에서는 콧등과 코끝의 온도가 유의하게 낮아졌다. 기쁨 자극을 제시한 조건에서는 이마, 눈앞의 온도 상승이 유의하였으며, 코끝에서 온도가 유의하게 낮아졌다. 두 조건에서 코의 온도가 유의하게 낮아졌는데, 이는 공포 또는 기쁨을 경험할 때 각성수준이 증가하여 코 혈관의 혈류량이 감소함으로써 온도가 낮아진 것으로 볼 수 있다. 공포나 기쁨을 경험할 때 나타나는 온도 변화는 정서를 경험할 때 손가락온도를 측정한 선행 연구결과와 일치한다. 이런 연구결과는 정서 측정기법의 개발과, 인간의 정서를 탐지하는 컴퓨터 시스템의 기초를 확립하는데 기여하는 바가 있을 것이다.

• 한국안전학회지
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• 제35권1호
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• pp.62-69
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• 2020

Most people suffer from stress during day life because modernized society is very complex and changes fast. Because stress can affect to many kind of physiological phenomena it is even considered as a disease. Therefore, it should be detected earlier, then must be released. When a person is being stressed several bio-signals such as heart rate, etc. are changed. So, those can be detected using medical electronics techniques. In this paper, stress assessment system is studied using random forest algorithm based on heart rate, RR interval and Galvanic skin response. The random forest model was trained and tested using the data set obtained from the bio-signals. It is found that the stress assessment procedure developed in this paper is very useful.

• 한국의류학회지
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• 제35권1호
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• pp.1-12
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• 2011

This study tests the performance of the recommended winter dress OnMapsi for an office worker through the analysis of skin temperature changes according to the heating environment. We tested and compared the effects of with/without undergarments for 4 male subjects in an artificial-climate chamber with two air temperatures of $19^{\circ}C$ and $22^{\circ}C$, $50{\pm}10%$ R.H. During the 60 minute experiment that simulated office work, the subjective feelings (that included thermal, humidity and comfort sensation, and skin temperature) were measured at equal intervals. The results show that the forehead and chest skin temperatures were not affected by air temperature or clothing type, while the hand and foot skin temperatures were affected at $0.3-0.9^{\circ}C$ depending on clothing type and $1.9-2.2^{\circ}C$ depending on air temperature. The mean skin temperature was decreased by the experimental time pass more with regular formal wear than with OnMapsi. The second experiment located the ambient temperature in which subjects wearing OnMapsi show equal skin temperaturesto those without undergarments at $22^{\circ}C$. Therefore it is possible to decrease heating temperatures to $18-21^{\circ}C$ in the office for winter OnMapsi wear that produces a skin temperature and thermal sensation that is the same as those at $22^{\circ}C$.

• Asian-Australasian Journal of Animal Sciences
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• 제24권7호
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• pp.912-918
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• 2011

Newly born lambs have to face challenges in a new environment totally different from that of the uterus. Adaptation to extra-uterine life involves functional changes with almost each organ and system in the body undergoing a series of metabolic and anatomical modifications. Failure to adapt the extra-uterine environment can not only lead to homeostatic disturbances but also lead to the death of the affected lambs. Hematological parameters of newly born lambs show variability that differs between breeds of lambs. The purpose of present study was to determine homeostatic responses and physiological reference values in Kajli breed lambs occurring in the neonatal period through changes in blood profile, respiratory rate, heart rate, live weight and rectal, scrotal and skin temperatures. For this purpose, sixteen clinically fit lambs (males = 10 and females = 6) with a mean body weight $6.92{\pm}0.46$ kg were selected. Physiological data of selected parameters of each Kajli lamb was recorded at three day intervals and hematological parameters at five days for a period of 30 days. In general, statistical analysis showed a significant effect of time (p<0.001) on all the studied physiological and hematological parameters except platelets counts, white blood cells and hemoglobin concentration. The results documented in the current study are an addition to existing knowledge of the physiology of Kajli sheep breed should be helpful in developing feeding, disease diagnoses and treatment protocols for newborn Kajli stock.

• 대한예방한의학회지
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• 제8권2호
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• pp.55-63
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• 2004

Objectives : This study was designed to identify the possibility of aroma oils as the complementary medical goods specially for the effects of aromatheraphy on xerosis cutis. Materials and Methods : The participants were 23 adult patients and all participants of this study use aroma oils which is known to effect on xerosis cutis. The subjects consist of voluntary patients with xerosis cutis in Seong-So Hospital in Andong Kyoungbuk, Korea. From April 1st to April 30th, 2004 for 4 weeks, the subjects massaged aroma oils on itching parts or the whole body. Aroma oils were Lavender, Losemary, Jasmine and blended drop by drop per 10ml jojoba oil which used a carrier oil. Skin pH was measured with a skin pH meter(Model : HI98110, Se-Chang instruments, made in Portuga. After 4weeks using aroma oils, the participants answered questions about the feeling of satisfaction with aroma oils. Results : Changes in the physiological indices. The mean deviation of skin pH was $5.58{\pm}0.47$ points before using aroma oils and $5.53{\pm}0.45$ points after 2 weeks, no statistical significance was found(p=0.221). MD was $5.36{\pm}0.41$ points after 4 weeks using aroma oils, which was statistically significant decrease of 0.22 points(p=0.001) Changes on the Pruritus Score Scale. A modified scale of the Pruritus Score Scale(Duo, 1987) was used to measure the severity, location, frequency, and the inconveniences of daily life due to prurius. The maximum scale of severity was 4 points, the full marks of location was 2 points, the full marks of frequency was 3 points, the full marks of inconveniences of daily life due to pruritus was 3 points. The scores ranged from 0 to 12, with 12 indicating the most severe pruritus. There was no statistical difference in severity and frequency score at 4 weeks later(severity p=0.097, frequency p=0.633). A statistically significant difference was found in the score of location and the inconveniences of daily life due to pruritus(each p=0.003). Conclusion : Generally speaking, the patient suffering from renal itch is the higher than normal in skin pH levels. that means to show alkaline condition of skin surface. In some case in this study, skin pH levels was rather lower than normal levels when measured actually patients suffering from renal itch by skin pH meter. But in this study post-test skin pH levels decreased, showing the contribution of aromathrapy to acidic condition of skin surface in suffering from renal itch. It seems to be some help to cure a pruritus and also have no ill effects on aroma oils.

• Fisheries and Aquatic Sciences
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• 제15권3호
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• pp.233-239
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• 2012

Hematological analysis can provide crucial information for monitoring the health of fish. However, there is no current information available regarding hematological changes in olive flounder following infection by Vibrio scophthalmi. In this study, hematological and biochemical alterations were determined in olive flounder infected by the high virulence strain (HVS) and low virulence strain (LVS) of V. scophthalmi. Survival in serum, skin mucus, and macrophages of olive flounder was also compared between the HVS and LVS. The results demonstrated that the hematocrit value in infected fish declined from 23.4% at 0 h to 18.0% at 168 h post infection. The total protein concentration in fish infected with the HVS was significantly higher than in fish infected with the LVS and a non-infected control. Lysozyme activity was significantly different between infected and control fish. The HVS survived in serum and cell numbers increased substantially, while cell numbers of the LVS in serum decreased. These changes in hematological characteristics in fish infected by V. scophthalmi can be used as an effective and sensitive index to monitor the physiological and pathological conditions of fish. The survival and reproduction of V. scophthalmi in host serum, skin mucus, and macrophages play a major role in systemic infection and can serve as a virulence indicator for different strains.

• 대한수의학회지
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• 제56권4호
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• pp.215-221
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• 2016

Due to the shortage of the fingerling/juvenile mud loach, Misgurnus mizolepis in Korea, these fish have been imported from China. However, the mortality rate during and after their transportation is very high. In this study, we examined various physiological and histological parameters to evaluate the effect of salt treatment on the survival and recovery of mud loaches in holding farms during the quarantine process. Glucose, osmolality, $Na^+$, $Cl^-$, and histological changes were assessed for three different salinities. Non-treated fish (control 0.0%) exhibited lower levels of osmolality, and $Na^+$ and $Cl^-$ concentrations compared with those kept in solar salt solution (0.5% and 1.0%). Glucose levels in control fish were higher than those in fish exposed to 0.5% and 1.0% solar salt solution. Histologically, control fish showed thinner epidermis of skin, branchial hyperplasia and lamellar fusion with an abundance of eosinophilic granule cell-like cells. After solar salt solution treatment, damaged gill structures in the fish almost recovered within 5 days. The present study demonstrates that mud loaches transported from China suffer from skin and gill damage and physiological dysfunction which may increase the mortality and morbidity. Moreover, saline treatment might alleviate the stress responses and ionic/osmotic imbalances, and help heal gill damage.

• Journal of Pharmaceutical Investigation
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• 제11권4호
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• pp.1-11
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• 1981

In order to elucidate the effects of Panax Ginseng on the pharmacokinetics of sulfobromophthalein (BSP) in a pathological condition, patho-physiological changes, the kinetics of the disappearance of BSP from the blood and appearance in the bile were studied in rats. Group I , the control group, was produced by repeated injection of olive oil 0.1ml/100g under the skin of the back twice a week for 9 weeks. Group II , the Ginseng pretreated group, was produced by administration of Ginseng total saponin 200mg/kg/day P.O. for 10 days and subsequent injection of $CCl_4$ 0.1ml/100g under the skin of the back twice a week for 9 weeks. Group III , the chronically intoxicated group, was produced by repeated injection of $CCl_4$ 0.1ml/100g under the skin of the back twice a week for 9 weeks. The results obtained were summarized as follows; 1. The activities of GOT GPT of rat blood serum, body weight, and liver weight were affected by the pretreatment with Ginseng saponin. 2. The kinetics of the disappearance of BSP from the blood were affected by the pretreatment with Ginseng saponin. 3. The appearance of BSP in the bile was significantly affected by the pretreatment with Ginseng saponin.

• 한국의류학회지
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• 제18권3호
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• pp.339-347
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• 1994

In this study the physiological significance of the upper and lower body on thermoregulation and sensation are examined. Experiments were carried out on 4 females in a climatic chamber conditioned at $25\pm1^{circ}C, 50\pm5%$ R.H.. Before the measurements, subjects were exposed to 3 types of enviromental temperature: 1) $25\pm1^{\circ}C$ for 60 min.(ST), 2) $25^{\circ}C$\rightarrow35^{circ}C\rightarrow25^{\circ}C$ for about 40 min.(HT), 3) $25^{\circ}C$\rightarrow15^{circ}C\rightarrow25^{\circ}C$ for about 40 min.(LT) covering the upper body (U) or lower body (L) with garments. 1) $T_{re}$ was significantly higher in L than in U only in 57 condition. $T_{sk}$ and Temp. under the clothing were higher in U than in L in all three conditions. Thermal sensation was warmer in U than in L, and comport sensation was most comfortable in HT condition. 2) When the upper or lower body was covered or exposed, the mean skin temperature of the upper body was higher than that of the lower body. Following covering and uncovering the same area, the changes in skin temperature were greater in the upper body than in lower body, and covering the upper body produced a greater difference of skin temperature between body and lower body than covering the lower body. 3) In all environmental conditions, when the upper body was uncovered, the skin temperatures of the chest, upper arms and forearms dropped to a considerable degree, and when the lower body was uncovered, skin temperatures of the legs showed the same pattern. On the other hand, skin temperature of the thinghs showed only little change in all cases except forehead and back uncovered or covered in two clothing types.